Abducent nerve paralysis: first clinical sign of clivus metastasis from tonsillar carcinoma.

Abstract:

:It is known that 15-20% of oropharyngeal carcinomas develop distant metastases that involve most commonly lung, liver and bone. Clival metastasis from oropharyngeal squamous cell carcinoma has not been previously reported in the English literature. We describe the rare occurrence of clival metastasis from tonsillar carcinoma presenting with abducent paralysis and discuss diagnostic and therapeutic rational approaches. Despite neoadjuvant chemotherapy (cisplatinum/etoposide/epirubicin followed by taxotere), extended left tonsillectomy and ipsilateral radical neck dissection and external radiotherapy (60 Gy) for tonsillar carcinoma, the patient developed clival metastasis and died of disease. The overall prognosis of patients with clival metastases is extremely poor, with an overall median survival of about 2.5 years. Cranial nerve palsy occurrence is associated with a poorer prognosis with an average survival of only 5 months.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Marchese-Ragona R,Maria Ferraro S,Marioni G,Staffieri C,Manara R,Restivo DA,Staffieri A

doi

10.1080/00016480701687283

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

713-6

issue

6

eissn

0001-6489

issn

1651-2251

pii

788790309

journal_volume

128

pub_type

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