Involvement of round and oval windows in the vestibular response to pressure changes in the middle ear of guinea pigs.

Abstract:

:Changes in ambient pressure can elicit the vertigo and bodily disequilibrium known clinically as alternobaric vertigo. Our previous studies showed that changes in middle ear pressure altered the activity of the primary vestibular neuron, and the finding suggests that the pressure-induced vestibular response causes alternobaric vertigo. To investigate the roles played by the round window (RW) and the oval window (OW) in the vestibular response induced by pressure, we measured the change in perilymphatic pressure and the firing rates of primary vestibular neurons after the application of positive or negative pressure to the middle ear. We found an increase in the pressure-induced vestibular response in the group with a closed OW, and a decrease in the group with a closed RW. Measurements showed that the amplitude of the change in perilymphatic pressure in the group with a closed OW did not differ from that in the control group, whereas the amplitude of the perilymphatic pressure change in the group with a closed RW was significantly reduced. A discrepancy between the number of neurons responding and the amplitude of the perilymphatic pressure change in the closed OW group suggests that the vestibular response induced by the change in middle ear pressure was not related solely to the magnitude of the pressure change in the inner ear, but also involved the oval and round windows.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Suzuki M,Kitano H,Yazawa Y,Kitajima K

doi

10.1080/00016489850183232

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

712-6

issue

5

eissn

0001-6489

issn

1651-2251

journal_volume

118

pub_type

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