Combining acoustic and electrical speech processing: Iowa/Nucleus hybrid implant.

Abstract:

OBJECTIVES:In this paper we test the concept of combining electrical stimulation for high-frequency sound with acoustic hearing for low-frequency information in the same ear. In addition, we test whether residual hearing can be preserved when an electrode is placed up to 10 mm into the inner ear, and whether the site of electrical stimulation influences speech perception. MATERIAL AND METHODS:Nine post-lingual adults with severe high-frequency hearing impairment were recruited to participate in the study. A single-subject clinical trial design was employed. A unique six-channel cochlear implant was designed for this clinical trial. The intracochlear electrodes were either 6 or 10 mm in length based on a Nucleus CI-24 multichannel implant. Monosyllabic word understanding and consonant identification in a recorded sound-only condition were used to assess changes in speech perception. Follow-up was > 12 months. RESULTS:Acoustic hearing was preserved in all nine subjects. Preoperative monosyllabic word and sentence scores were unchanged in all subjects following implantation. A 30-40% improvement in consonant recognition occurred with the 10-mm electrode. The 10-mm electrode subjects were able to understand 83-90% of the monosyllabic words using the implant plus binaural hearing aids. Scores were more than doubled when compared to preoperative scores achieved with hearing aids only. CONCLUSIONS:The human ear has the capability to integrate both acoustic and high-frequency electrically processed speech information. Placement of a short 10-mm electrode does not appear to damage residual low-frequency inner ear hair cell function, interfere with the micro-mechanics of normal cochlear vibration or decrease residual speech perception. The improvement in speech recognition was due primarily to the increased perception of higher-frequency consonantal speech cues. Such a device can provide a substantial benefit in terms of speech understanding to those with severe high-frequency hearing loss, while still maintaining the benefits of the residual lower-frequency acoustic hearing. The position of the electrode and the site of frequency information within the cochlea are shown to be important factors in the success of such a device.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Gantz BJ,Turner C

doi

10.1080/00016480410016423

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

344-7

issue

4

eissn

0001-6489

issn

1651-2251

journal_volume

124

pub_type

杂志文章
  • Tonsils and lympho-epithelial structures in the pharynx as immuno-barriers.

    abstract::The tonsils are mucosa-associated lymphoid organs. Several details regarding their normal function and pathological alteration are still unknown. In this review the relationship of the tonsils to similar lymphoid organs is discussed, the possibilities of antigen uptake (M cells and micropores of the crypt epithelium) ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,评审

    doi:

    authors: Surján L Jr

    更新日期:1987-05-01 00:00:00

  • Type 2 thyroplasty for spasmodic dysphonia: fixation using a titanium bridge.

    abstract:OBJECTIVE:In order to facilitate surgery for spasmodic dysphonia, i.e. type 2 thyroplasty, a device was designed to fix the incised edges of the thyroid cartilage firmly. MATERIAL AND METHODS:Various types and sizes of titanium bridge were developed for clinical use. RESULTS:The results of surgery for spasmodic dysph...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480410016261

    authors: Isshiki N,Yamamoto I,Fukagai S

    更新日期:2004-04-01 00:00:00

  • Elective neck dissection vs observation in transorally treated early head and neck carcinomas with cN0 neck.

    abstract:CONCLUSION:This study showed that elective neck dissection (ND) resulted in reduced regional recurrences in a selected group of surgically treated patients with pT1-2 carcinomas but did not show any benefit for disease-specific survival (DSS). Furthermore, the importance of pN classification was also verified for this ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2012.743032

    authors: Psychogios G,Mantsopoulos K,Koch M,Klintworth N,Kapsreiter M,Zenk J,Iro H

    更新日期:2013-03-01 00:00:00

  • Electromagnetic interference of bone-anchored hearing aids by cellular phones revisited.

    abstract::The electromagnetic interference of the recently introduced bone-anchored hearing aid (BAHA) model "BAHA Compact" by digital cellular phones is investigated and compared with that of the older "BAHA Classic 300" model. Measurements with two different digital cellular phones in a laboratory setting indicated that the n...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480260092318

    authors: Kompis M,Häusler R

    更新日期:2002-07-01 00:00:00

  • Noise exposure alters cyclooxygenase 1 (COX-1) and 5-lipoxygenase (5-LO) expression in the guinea pig cochlea.

    abstract:CONCLUSION:Changes in the metabolism of arachidonic acid (AA) might be part of a noise-induced compensatory mechanism with regional specificity. OBJECTIVES:The released imbalance of prostaglandins and leukotrienes, both AA metabolites, might result in altered blood flow regulation in the inner ear and probably contrib...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480903168066

    authors: Heinrich UR,Selivanova O,Schmidtmann I,Feltens R,Brieger J,Mann WJ

    更新日期:2010-03-01 00:00:00

  • Effects of age, sex and stimulus parameters upon vestibulo-ocular responses to sinusoidal rotation.

    abstract::We evaluated the vestibulo-ocular reflex (VOR) in 50 normal human subjects, uniformly distributed in age 20-59 years, and evenly distributed in sex by decade, using sinusoidal rotation over the frequency range of 0.005 to 1.0 Hz and three peak amplitudes of 25, 50, and 100 deg/sec. Age variations. The gain magnitude o...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488409107563

    authors: Wall C 3rd,Black FO,Hunt AE

    更新日期:1984-09-01 00:00:00

  • Embryogenesis of the inner ear. II. The late differentiation of the mammalian crista ampullaris in vivo and in vitro.

    abstract::The embryonic development of the crista ampullaris of the CBA/CBA mouse was followed both in organ culture of explanted inner ears of the 16th gestational day and in vivo from the 16th gestational day until the 21st day, an age corresponding to birth. Cytodifferentiation of the sensory epithelium of the crista ampulla...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488309132868

    authors: Nordemar H

    更新日期:1983-07-01 00:00:00

  • Penetration of erythromycin stearate into maxillary sinus mucosa and secretion in chronic maxillary sinusitis.

    abstract::The penetration of oral erythromycin stearate (Abboticin), administered in a dosage of 500 mg three times a day, into the maxillary sinus mucosa and secretion was studied in 15 patients (22 sinuses) operated on for chronic maxillary sinusitis. The average concentration in serum was 2.3 microgram/ml, 1.2 microgram/ml i...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487709123970

    authors: Paavolainen M,Kohonen A,Palva T,Renkonen OV

    更新日期:1977-09-01 00:00:00

  • Fibroblast growth factor improves the healing of experimental tympanic membrane perforations.

    abstract::Topical application of FGF (fibroblast growth factor), a potent mitogen for mesodermal and neuroectodermal cells, was given to promote the healing of tympanic membrane perforations in rats. Calibrated tympanic membrane perforations were performed in 30 rats. At day 0, each rat received 40 microliters of placebo in the...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489109137397

    authors: Mondain M,Saffiedine S,Uziel A

    更新日期:1991-01-01 00:00:00

  • Unique penetrance of hearing loss in a five-generation Chinese family with the mitochondrial 12S rRNA 1555A > G mutation.

    abstract:CONCLUSIONS:Analysis of the complete mtDNA genome and X-linkage of this five-generation Chinese family revealed that the 1555A > G mutation may lead to deafness. OBJECTIVES:Mutations in mitochondrial DNA (mtDNA) have been found to be associated with sensorineural hearing loss. However, the variable clinical phenotype ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2011.575794

    authors: Men M,Jiang L,Wang H,Liu Y,Hu Z,He C,Feng Y

    更新日期:2011-09-01 00:00:00

  • Endoscopic management of recurrent epistaxis: the experience of two metropolitan hospitals in Italy.

    abstract:CONCLUSION:Endoscopic cauterization of the sphenopalatine artery and anterior ethmoid artery is a first-line standard of care in managing intractable epistaxis, after the failure of previous packing. Epistaxis occurs in 12% of the population. Treatment is often based on nasal packing that could be poorly effective in t...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,多中心研究

    doi:10.3109/00016481003621538

    authors: Minni A,Dragonetti A,Gera R,Barbaro M,Magliulo G,Filipo R

    更新日期:2010-09-01 00:00:00

  • Accuracy evaluation of a numerical simulation model of nasal airflow.

    abstract:CONCLUSION:Our numerical simulation model provides an accurate reflection of nasal airflow, and the results were validated by clinical measurements. OBJECTIVES:To evaluate the accuracy of a numerical simulation model of nasal airflow. METHODS:Ten volunteers with normal nasal cavities underwent CT, acoustic rhinometry...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2013.863430

    authors: Lu J,Han D,Zhang L

    更新日期:2014-05-01 00:00:00

  • Auditory potentials in profoundly deaf subjects.

    abstract::In 12 healthy volunteers, and 5 prelingually and 5 postlingually profoundly deaf subjects, a 500 Hz filtered click stimulus was applied to the mastoid via the bone conductor. In all the healthy volunteers, middle latency response (MLR) was recorded. Among all profoundly deaf subjects, MLR was recorded only in 2 with p...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488509108929

    authors: Ribarić K,Padovan I,Prevec TS

    更新日期:1985-03-01 00:00:00

  • Comparison of vestibular function between large cerebellopontine angle meningioma and schwannoma.

    abstract:CONCLUSION:Abnormal caloric and vestibular evoked myogenic potential (VEMP) responses are frequently encountered with a large cerebellopontine angle (CPA) schwannoma, while normal caloric responses and abnormal VEMPs are noted with a large CPA meningioma. This difference may possibly exist because schwannoma causes ves...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480802126553

    authors: Hu YF,Cheng PW,Young YH

    更新日期:2009-02-01 00:00:00

  • Radical scavengers for elderly patients with age-related hearing loss.

    abstract:CONCLUSION:The results of this study suggest that treatment with radical scavengers has the potential to become an effective new therapy for age-related hearing loss. OBJECTIVE:To assess the efficacy of treatment with radical scavengers for age-related hearing loss. SUBJECTS AND METHODS:Rebamipide (300 mg/day), alpha...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480802008215

    authors: Takumida M,Anniko M

    更新日期:2009-01-01 00:00:00

  • Invariance of vestibulo-ocular reflex gain to head impulses in pitch at different initial eye-in-orbit elevations: implications for Alexander's law.

    abstract:CONCLUSIONS:These findings are in line with previous data on the horizontal vestibulo-ocular reflex (VOR) from this laboratory and suggest that eye position signals do not modulate natural vestibular responses. Hence, the Alexander's law (AL) phenomenon cannot be interpreted simply as a consequence of vestibular or ocu...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2012.682120

    authors: Anastasopoulos D,Anagnostou E

    更新日期:2012-10-01 00:00:00

  • Hearing in patients operated unilaterally for otosclerosis. Self-assessment of hearing and audiometric results.

    abstract::The objective of this study was to examine the outcome of unilateral stapes surgery in one patient group with bilateral hearing loss and one group with unilateral hearing loss. The patients' own estimations of improvement in hearing ability and the occurrence of other ear-related symptoms were examined retrospectively...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489950180982

    authors: Lundman L,Mendel L,Bagger-Sjöbäck D,Rosenhall U

    更新日期:1999-01-01 00:00:00

  • Di-K19Hc, an antimicrobial peptide as new ototopical agent for treatment of otitis media.

    abstract:CONCLUSION:Di-K19Hc is a promising new ototopical antibiotic for treatment of middle ear infections associated with antibiotic-resistant bacteria. OBJECTIVES:Di-K19Hc was previously shown to exert profound antimicrobial activity against a variety of antibiotic-resistant bacteria and fungi. In this study, we evaluated ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016480903536036

    authors: Lee YS,Kim YJ,Choi SH,Shin KH,Jang WS,Lee IH,Chung JW

    更新日期:2010-08-01 00:00:00

  • Induction of MUC5AC mucin expression by histamine through the activation of its core promoter region.

    abstract:CONCLUSION:This study provides evidence that histamine induced MUC5AC mRNA expression through the activation of the core region of its promoter. It may also help in approaching new therapeutic strategies in airway mucins hypersecretory diseases. OBJECTIVE:Mucin hypersecretion characterizes several respiratory diseases...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2015.1017890

    authors: Xu F,Zhang L,Gao J,Wang D

    更新日期:2015-07-01 00:00:00

  • Vestibular morphology in relation to age and circling behavior.

    abstract::The DBA/2 strain of mice have genetically induced vestibular dysfunction that presents grossly at an early age as circling behavior and abnormal righting reflexes. The vestibular morphology of this strain has not previously been examined. DBA/2 mice of different ages that showed circling behavior were sacrificed and t...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489409126075

    authors: Bloom D,Hultcrantz M

    更新日期:1994-07-01 00:00:00

  • Bone resorption in chronic otitis media. A light-microscopical and histochemical investigation of acid phosphatase activity.

    abstract::As a continuation of our previous work, where we have demonstrated that in chronic otitis media the picture in the submucosa-bone marginal zone is dominated by capillary proliferation and occurrence of a mononuclear, histiocyte-like cell containing lysosome-like cytoplasmatic bodies, we now report the presence of cons...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487509124704

    authors: Thomsen J,Bretlau P,Kristensen HK

    更新日期:1975-05-01 00:00:00

  • Association between polymorphisms in SOD1 and noise-induced hearing loss in Chinese workers.

    abstract:CONCLUSION:SOD1 is an important gene related to noise-induced hearing loss (NIHL), and its effect is dependent on noise exposure levels. OBJECTIVES:To test whether the polymorphisms in the CuZn-superoxide dismutase gene (SOD1) are associated with susceptibility to NIHL in the Chinese population. METHODS:Audiometric d...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016480903253587

    authors: Liu YM,Li XD,Guo X,Liu B,Lin AH,Rao SQ

    更新日期:2010-04-01 00:00:00

  • Aspiration as a late complication after accelerated versus conventional radiotherapy in patients with head and neck cancer.

    abstract::Conclusion Neck dissection after radiotherapy increased the risk of aspiration as a late effect in a sub-sample of patients treated for head and neck cancer in the ARTSCAN study. Patients treated with accelerated fractionation (AF) developed aspiration, with or without coughing, more frequently than patients treated w...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.3109/00016489.2015.1113439

    authors: Lindblom U,Nilsson P,Gärskog O,Kjellen E,Laurell G,Wahlberg P,Zackrisson B,Levring Jäghagen E

    更新日期:2016-01-01 00:00:00

  • A case of severe dilatation of the parotid duct due to fibrinous sialodochitis.

    abstract::A 50-year-old woman presented with a 10-year history of swelling of the left cheek during and after meals. She regularly pushed the cheek hard to decrease the swelling by excreting the saliva. She did not have pain or fever. She also complained of bronchial asthma and allergic rhinitis. Magnetic resonance imaging (MRI...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480600621680

    authors: Shimada T,Okano H,Hisa Y

    更新日期:2006-10-01 00:00:00

  • Association between ABO blood group status and cochlear/neural function: auditory brainstem response findings.

    abstract:BACKGROUND:ABO blood group status may be a risk factor for some diseases, including hearing loss. Individuals with blood group O show a higher prevalence of hearing loss after industrial noise exposure. Group O individuals with normal hearing show reduced amplitudes in otoacoustic emission recordings. Whether blood gro...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2020.1858236

    authors: Yang Y,Hood LJ,McPherson B

    更新日期:2021-01-11 00:00:00

  • Failure of gaze stabilization under high-frequency head oscillation.

    abstract::Gaze functions under high-frequency head oscillations with large amplitudes were investigated in 12 normal subjects. Oscillation amplitude decreased as the frequency increased (31 degrees at 2 Hz to 11 degrees at 5 Hz on average). Maximum head velocity and acceleration were 170-200 degrees/s and 2,500-5,000 degrees/s2...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488909127495

    authors: Takahashi M,Akiyama I,Tsujita N

    更新日期:1989-03-01 00:00:00

  • Tumor stromal desmoplasia and inflammatory response uniquely predict survival with and without stratification for HPV tumor infection in OPSCC patients.

    abstract:BACKGROUND:Oropharyngeal squamous cell carcinoma (OPSCC) positive for human papillomavirus (HPV) increases wolrd wide. AIMS/OBJECTIVES:The objective for this study has been to evaluate tumor phenotypes and tumor host responses with respect to five-year disease-specific survival (DSS) in HPV(+) and HPV(-) patients. MA...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2018.1497809

    authors: Haave H,Gulati S,Brekke J,Lybak S,Vintermyr OK,Aarstad HJ

    更新日期:2018-11-01 00:00:00

  • Evaluation of functional rhinoplasty using the Modified Cottle test in Asian patients.

    abstract:CONCLUSION:MCT is a useful tool to pre-operatively determine whether internal nasal valve (INV) narrowing affects a nasal obstruction. Functional rhinoplasty seemed to produce better results than septoplasty in Asian patients with a nasal obstruction, due to INV narrowing. OBJECTIVE:This study compared pre-operative m...

    journal_title:Acta oto-laryngologica

    pub_type: 评论,杂志文章

    doi:10.3109/00016489.2015.1108523

    authors: Kwun C,Yang CW,Kim SW,Lee KH

    更新日期:2016-01-01 00:00:00

  • Differences in hair bundles associated with type I and type II vestibular hair cells of the guinea pig saccule.

    abstract::Several studies have reported variations in shape and size of stereociliary bundles and in a limited number of observations have associated them to type I and type II hair cells. A systematic study has been undertaken for which a technique was developed in order to identify both cell types and their corresponding hair...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489209137453

    authors: Lapeyre P,Guilhaume A,Cazals Y

    更新日期:1992-01-01 00:00:00

  • The influence of an insecticide on the function of the eustachian tube.

    abstract::Organophosphorus compounds in the form of insecticides are in widespread use and have recently attracted considerable interest as environmentally toxic agents. As little is known about the effect of environmental toxins on the tubal function in the ear, we studied the middle ear pressure necessary to force the eustach...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489509139361

    authors: Bergler W,Juncker C,Petroianu G,Keilmann A,Hörmann K

    更新日期:1995-07-01 00:00:00