Bone resorption in chronic otitis media. A light-microscopical and histochemical investigation of acid phosphatase activity.

Abstract:

:As a continuation of our previous work, where we have demonstrated that in chronic otitis media the picture in the submucosa-bone marginal zone is dominated by capillary proliferation and occurrence of a mononuclear, histiocyte-like cell containing lysosome-like cytoplasmatic bodies, we now report the presence of considerable activity of acid phosphatase in close relation to the eroded bone. The activity was localized both extracellularly, spread along the bony surface, as well as intracellularly in mononuclear, histiocyte-like cells. The acid phosphatase is the "marker" enzyme for lysosomes, and cells with these lysosomes guarantee the presence of enzymatic activity capable of attacking bone collagen. It is difficult to avoid the conclusion that the lysosomes and their enzymes are directly involved in the processes of bone resorption.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Thomsen J,Bretlau P,Kristensen HK

doi

10.3109/00016487509124704

subject

Has Abstract

pub_date

1975-05-01 00:00:00

pages

400-8

issue

5-6

eissn

0001-6489

issn

1651-2251

journal_volume

79

pub_type

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