Penetration of erythromycin stearate into maxillary sinus mucosa and secretion in chronic maxillary sinusitis.

Abstract:

:The penetration of oral erythromycin stearate (Abboticin), administered in a dosage of 500 mg three times a day, into the maxillary sinus mucosa and secretion was studied in 15 patients (22 sinuses) operated on for chronic maxillary sinusitis. The average concentration in serum was 2.3 microgram/ml, 1.2 microgram/ml in secretion, and 1.8 microgram/ml in mucosa. These concentrations are highly effective against diplococci and most aerobic and anaerobic streptococci (MIC value 0.06 microgram/ml) but not against Haemophilus influenzae (MIC value for 80% of 2 microgram/ml).

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Paavolainen M,Kohonen A,Palva T,Renkonen OV

doi

10.3109/00016487709123970

subject

Has Abstract

pub_date

1977-09-01 00:00:00

pages

292-5

issue

3-4

eissn

0001-6489

issn

1651-2251

journal_volume

84

pub_type

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