Tracheal transplantation: demonstration of HLA class II subregion gene products on human trachea.

Abstract:

:The present morphological study was designed to investigate the expression of HLA class II subregion gene products on human trachea. Frozen sections from the tracheas of 20 cadavers not suffering from ear, nose or throat diseases were studied immunohistochemically using monoclonal antibodies which recognize monomorphic determinants of HLA-DR, -DP and -DQ molecules. Positive reactions could be detected in the airway epithelium and mixed glands. HLA-DR and -DP showed a stronger presence than HLA-DQ. Our results indicate that tracheal mucosa may be the major antigenic structure of the trachea and therefore responsible for the immunogenic action of allogenic tracheal transplants.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Bujia J,Wilmes E,Hammer C,Kastenbauer E

doi

10.3109/00016489009122530

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

149-54

issue

1-2

eissn

0001-6489

issn

1651-2251

journal_volume

110

pub_type

杂志文章
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  • How effect is educational counseling prior to middle ear surgery for patients with both middle ear diseases and consistent tinnitus?

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