Abstract:
CONCLUSIONS:This study confirms a high prevalence of human papillomavirus (HPV)-positive tonsillar tumours (52%). The survival of the HPV-positive group was significantly better in males. OBJECTIVES:We assessed the prevalence of HPV in 137 patients with tonsillar carcinomas, measured the p53- and Ki-67-positive tumour cell fractions and correlated the results with clinical variables. PATIENTS AND METHODS:Tumour DNA from patients with squamous cell carcinoma of the tonsillar region was amplified by PCR and sequenced for detection of HPV subtypes. RESULTS:HPV was found in 71/137 (52%) of the tumours; HPV-16 was the most frequent subtype (87%). HPV positivity did not correlate with gender, stage, T- and N categories, Ki-67 expression or p53 positivity. The HPV-positive group had a significantly better survival (p < 0.01) compared with the HPV-negative group in males. In a multivariate analysis HPV status gave prognostic information in addition to the earlier established factors, i.e. age, gender and stage (p < 0.05).
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Hannisdal K,Schjølberg A,De Angelis PM,Boysen M,Clausen OPdoi
10.3109/00016480903071377subject
Has Abstractpub_date
2010-02-01 00:00:00pages
293-9issue
2eissn
0001-6489issn
1651-2251pii
913899438journal_volume
130pub_type
杂志文章abstract::Experimental animals (cats) were exposed to tones of 125, 1000, 2000, and 4000 Hz at sound pressure levels in the range 120 to 157.5 dB, and for durations of one hour (1000, 2000, 4000 Hz) or four hours (125 Hz). Pure tone audiograms were obtained for each animal before and after exposure. Post-exposure tests were con...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487509121336
更新日期:1975-11-01 00:00:00
abstract:CONCLUSION:This study revealed that endolymphatic hydrops (EH) reduced in some cases with Ménière's disease (MD) treated conservatively. It appears that the EH reduction was associated with improvement of the clinical symptoms. OBJECTIVES:The relationship between the degree of EH and clinical symptoms is not clear at ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1015607
更新日期:2015-09-01 00:00:00
abstract::Acid base balance changes were observed during 72 h following bilateral nasal obstruction in rats. Mouth breathing caused acute respiratory acidosis and marked aerophagia, leading to spontaneous death of the experimental animal 80 to 90 h postoperatively. Stenotic oropharyngeal airway, due to palatal-epiglottic approx...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109137406
更新日期:1991-01-01 00:00:00
abstract::Earlier investigation did not show any clear distinctive pathological features that differentiate vocal polyps from vocal nodules. The light microscopic distinctive features between the two lesions point in the direction of a more pronounced epithelial reaction and a more fibrous stromal change in vocal nodules. In th...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809119505
更新日期:1988-05-01 00:00:00
abstract::The biocompatibility of commercially available polyimides was examined in relation to the sensory and neural structures of the cochlea. Thin films of four different polyimides were prepared as substrates for photolithographically produced scala tympani electrode arrays and implanted in 32 cat cochleae. Following at le...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488909127474
更新日期:1989-01-01 00:00:00
abstract:CONCLUSION:The results suggested mercury (Hg)-induced anomalies in the brainstem-mediated acoustic stapedius muscle reflex in children. OBJECTIVES:Hg exposure has been associated with hearing impairment and brainstem anomalies. Acoustic stapedius reflex (ASR) thresholds, growth functions, decay/adaptation times, and b...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.617778
更新日期:2012-01-01 00:00:00
abstract:CONCLUSIONS:Homeostasis of endolymph volume is a complex mechanism, in which the endolymphatic sac (ES) may play an important role. OBJECTIVES:To elucidate the effect of acute endolymphatic hydrops (EH) on the ES and to gain further information about the volume and pressure regulative function of the ES. MATERIALS AN...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701497428
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:The balloon catheter has been used for a decade to dilate paranasal sinus outflow tracts. The question is: how wide and how durable is the dilation of drainage pathways in patients in long-term observations after this procedure? OBJECTIVE:The objective of our study was to observe the changes occurring in th...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2017.1300941
更新日期:2017-09-01 00:00:00
abstract::The ultrastructure of the epithelial cells of the endolymphatic duct in the rat is described, following vascular perfusion-fixation of live, anaesthetised and artificially respirated animals. The animals were fixed by means of a pressure feed-back controlled peristaltic pump and an isotonic perfusate-fixative containi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489409126013
更新日期:1994-01-01 00:00:00
abstract:CONCLUSION:Idiopathic otolithic vertigo (IOV) with relatively long duration of attacks might be caused by endolymphatic hydrops in the otolith organ. OBJECTIVES:To clarify the pathophysiology underlying IOV, episodic tilting or translational sensation attacks by unknown causes, especially the possibility of endolympha...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1022834
更新日期:2015-01-01 00:00:00
abstract:CONCLUSIONS:Quality of hearing is one of the key conditions promoting habitual sniffing associated with closing failure of the Eustachian tube and sniffing may stop with deterioration of hearing due to progression of the disease. OBJECTIVE:To examine habitual sniffing associated with closing failure of the Eustachian ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480500469008
更新日期:2006-06-01 00:00:00
abstract:CONCLUSION:Mouse embryonic stem cells (ESCs) transplanted into the scala tympani are able to migrate in the cochlea of rats deafened with aminoglycoside and partly restore the structure of sensory epithelia of the inner ear. OBJECTIVES:To explore the migration and differentiation of enhanced green fluorescence protein...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.720029
更新日期:2013-02-01 00:00:00
abstract:CONCLUSIONS:Protocol limitations were identified and accounted for in the analysis. Percent gradient equilibrated (PGE) was affected by driving gradient direction in a similar manner to other efficiency measures. A finer resolution of possible age-related changes in eustachian tube opening efficiency is expected with t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.882017
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Li quick repositioning maneuver for treatment of geotropic horizontal canal benign paroxysmal positional vertigo (HC-BPPV) was reported in the literature. OBJECTIVE:The aim of this study is to observe the clinical efficacy of the Li quick repositioning maneuver for the treatment of geotropic HC-BPPV. METHO...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,随机对照试验
doi:10.1080/00016489.2018.1476778
更新日期:2018-09-01 00:00:00
abstract:CONCLUSIONS:Endoscopic laser microsurgery (ELM) provides comparable oncological outcomes, and improved functional recovery and laryngeal preservation compared with open partial laryngopharyngectomy (OPLP) in patients with early squamous cell carcinoma of the hypopharynx (HPSCC). The use of open surgery is declining. Th...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.805341
更新日期:2013-10-01 00:00:00
abstract::Cisplatin ototoxicity is known to involve mainly the organ of Corti. Outer hair cells (OHCs). especially in the basal turn, are preferentially involved. One possible mechanism of ototoxicity might be alteration of the antioxidant system causing an increase in free radicals. It has been demonstrated that heat shock pro...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800750000793
更新日期:2000-03-01 00:00:00
abstract::In order to study the connection between occupation and sinonasal cancer we have reviewed the files and histological sections of 70 patients (24 females and 46 males) treated at the Department of Oto-rhino-laryngology, National Hospital of Norway. Detailed information concerning previous occupations was obtained by te...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488509119160
更新日期:1985-01-01 00:00:00
abstract:CONCLUSION:Compared with normal-weight individuals, obese young adults exhibited a significantly higher taste threshold for salty taste. Smoking also affected taste functions in this population. OBJECTIVE:The aim of this study was to investigate the differences in taste detection thresholds between normal-weight and o...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.975370
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Intratympanic corticosteroid (IC), intravenous batroxobin (IB) as the treatment for sudden sensorineural hearing loss (SSNHL) has been reported. However, the data on combination therapy (CT) was scarce. OBJECTIVE:The aim of this retrospective study was to compare the efficacy of IC, IB, and CT in the treatm...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2019.1592221
更新日期:2019-06-01 00:00:00
abstract::The sympathetic nerve pathways to the nasal vasculature were examined in 8 cats by recoding the effects of section of the orbital nerves on vasoconstriction produced by cervical sympathetic nerve stimulation. No sympathetic fibres were found in the sphenopalatine and infraorbital nerves. The majority were conveyed by ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487709123967
更新日期:1977-09-01 00:00:00
abstract::A prospective study was carried out to objectively quantificate the most important predictive factors in idiopathic facial paralysis (Bell's palsy). Stepwise discriminant analysis was applied to data prospectively obtained from 570 patients with Bell's palsy treated at the ENT Department of La Paz Hospital between Jan...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809106436
更新日期:1988-09-01 00:00:00
abstract:CONCLUSIONS:The risk factors for methicillin-resistant Staphylococcus aureus (MRSA) detection in head and neck cancer patients are the duration of hospitalization, intravenous hyperalimentation, prior antibiotic use, and the coexistence of other pathogens. OBJECTIVES:To shed light on the clinical characteristics of MR...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480600750018
更新日期:2007-02-01 00:00:00
abstract::Dysphagia is a common presenting complaint in otolaryngology practice, and there are many causes. Forestier syndrome is a rare cause of dysphagia. It is also known as diffuse idiopathic skeletal hyperostosis (DISH) syndrome or vertebral ankylosing hyperostosis. Forestier syndrome consists of anterolateral perivertebra...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480500504192
更新日期:2006-07-01 00:00:00
abstract::The ultrastructural features of the interferon-treated adult laryngeal papillomas are described. Compared with untreated papillomas, no differences in ultrastructure were found by transmission electron microscopy. By scanning electron microscopy, significant alterations comprising a smooth and oedematous surface with ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488509104793
更新日期:1985-09-01 00:00:00
abstract::A homozygous mutant rat at the white spotting (Ws) locus showing a deficiency of melanocytes has recently been found (4, 5). The function and morphology of the inner ear of the Ws/Ws rat were examined by auditory brainstem response (ABR), endocochlear DC potential (EP), and electron microscopy. The mean ABR threshold ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489409126038
更新日期:1994-03-01 00:00:00
abstract::We examined the serial changes of intravenously applied dye leakage and preliminary examined histamine release into nasal lavage fluid after topical stimulation with capsaicin in guinea pigs. A significant increase in the dye leakage response was detected for 30-40 min, with the maximum response occurring between 5 an...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489209137438
更新日期:1992-01-01 00:00:00
abstract::Many techniques have been proposed for reconstruction of the posterior canal wall and/or obliteration of the mastoid bowl after radical mastoidectomy. The variety of materials that have been used, biological as well as foreign materials of different kinds, indicates that the ideal solution has yet to be found. Plaster...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809122254
更新日期:1988-11-01 00:00:00
abstract:CONCLUSION:The Finnish Matrix Test is the first sentence test in noise for the Finnish language. It was developed according to the HearCom standards and provides reliable speech intelligibility measurements with highly comparable results with the other international matrix tests. OBJECTIVES:The aim of the study was to...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章
doi:10.3109/00016489.2014.898185
更新日期:2014-07-01 00:00:00
abstract:CONCLUSIONS:Osteomas of the incus were found in surprisingly high numbers in ancient and modern populations. The coexistence of osteoma formation and unique vascularization on the medial surface of the incus alludes to a relationship between the two findings. OBJECTIVE:Osteomas involving the middle ear ossicles are ra...
journal_title:Acta oto-laryngologica
pub_type: 历史文章,杂志文章
doi:10.1080/00016480510043431
更新日期:2005-11-01 00:00:00
abstract::Utilizing an enlarged middle cranial fossa approach to the cerebello-pontine angle without destruction of the labyrinth or cochlea the authors have since 1981 operated on 263 unilateral acoustic neurinomas. Tumour sizes ranged between 3 mm intrameatal and 35 mm within the cerebello-pontine angle. Complete tumour remov...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489209137419
更新日期:1992-01-01 00:00:00