Abstract:
BACKGROUND:Intratympanic corticosteroid (IC), intravenous batroxobin (IB) as the treatment for sudden sensorineural hearing loss (SSNHL) has been reported. However, the data on combination therapy (CT) was scarce. OBJECTIVE:The aim of this retrospective study was to compare the efficacy of IC, IB, and CT in the treatment of SSNHL with diabetes. MATERIAL AND METHODS:A total of 212 SSNHL patients with diabetes, who were initially treated within 14 days of onset of disease, were divided into three groups by treatment modality. The hearing recovery was evaluated by the results of pure-tone test after completion of treatment. The prognostic factors, including age, severity of initial hearing loss, duration to onset of treatment, and audiometric curve type, were further compared. RESULTS:There was a significant difference in hearing recovery by the treatment (p < .05). Recovery rates in the CT group were significantly higher in patients with early treatment than with delayed treatment (p = .021). However, duration and recovery rate was not significantly correlated in IC and IB group (p > .05). In patients recieving early treatment, the recovery rate in CT group was significantly higher than that in IC (p = .013) and IB group (p = .029). Regardless of treatment, the recovery rates were higher in patients with flat and ascending audiograms (p < .05). CONCLUSIONS AND SIGNIFICANCE:Patients receiving combined therapy, especially in the early stage of SSNHL, could achieve significantly superior recovery in the treatment of SSNHL with diabetes, compared with those using IC or IB alone.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Jia H,Yu Z,Li X,Wang J,Ge X,Chen ZT,Huang X,Wei Ydoi
10.1080/00016489.2019.1592221subject
Has Abstractpub_date
2019-06-01 00:00:00pages
522-528issue
6eissn
0001-6489issn
1651-2251journal_volume
139pub_type
杂志文章abstract::Metal intoxication (mercury and arsenic) in guinea pigs may cause damage to labyrinthine blood vessels by swelling of the endothelial cells, mitochondrial disintegration and sometimes protrusion of endothelial cell cytoplasm herniating into the blood vessel lumen. Chronic mercury intoxication resulted in distorted end...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487709128869
更新日期:1977-05-01 00:00:00
abstract:CONCLUSION:An 18-mer peptide derived from the neurotrophic region of prosaposin (PS-pep) prevents hearing loss and cochlear damage due to transient cochlear ischaemia by activating an anti-apoptotic pathway. PS-pep is a potent candidate molecule for alleviating ischaemia-induced hearing loss. OBJECTIVE:PS-pep was inve...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.750430
更新日期:2013-05-01 00:00:00
abstract::Background: Increasing arterial stiffness is associated with atherosclerosis and there is an association between atherosclerosis and tinnitus may occur.Objectives: The aim of this study was to investigate the relationship between arterial stiffness and tinnitus using the central pulse-wave analysis method.Methods: Thi...
journal_title:Acta oto-laryngologica
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doi:10.1080/00016489.2019.1668569
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:To ascertain whether a daily nasal spray with physiological saline could prevent symptoms of common cold in a population of otherwise healthy adults. MATERIAL AND METHODS:This was study involving 10 weeks of daily use of a nasal saline spray and 10 weeks of only recording symptoms. Young adults eligible for ...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/00016480410017657
更新日期:2004-11-01 00:00:00
abstract:CONCLUSION:The Esteem(®) device proved to offer beneficial results in subjects suffering from high frequency, severe bilateral sensorineural hearing loss (SNHL) and may be considered as an alternative procedure to conventional hearing aids (HAs) or electroacoustic stimulation (EAS) systems. OBJECTIVES:Since the Esteem...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2010.536994
更新日期:2011-04-01 00:00:00
abstract::During the development of the mammalian inner ear, the number of hair cells produced is highly regulated and remains constant throughout life. The mechanism underlying this regulation is beginning to be understood although many aspects still remain obscure. When late embryonic or early postnatal rat organs of Corti we...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164801300043325
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journal_title:Acta oto-laryngologica
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doi:10.1080/00016489.2017.1321139
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abstract:BACKGROUND:Many patients with coronavirus disease 2019 (COVID-19) complain from olfactory dysfunction (OD). Aims/objectives: To evaluate the prevalence, prognosis, and recovery from OD in COVID-19 patients. MATERIAL AND METHODS:In this study, patients with COVID-19 symptoms who were referred to six different tertiary ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1836397
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journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709117761
更新日期:1997-03-01 00:00:00
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journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1186833
更新日期:2016-11-01 00:00:00
abstract:CONCLUSION:The results suggested mercury (Hg)-induced anomalies in the brainstem-mediated acoustic stapedius muscle reflex in children. OBJECTIVES:Hg exposure has been associated with hearing impairment and brainstem anomalies. Acoustic stapedius reflex (ASR) thresholds, growth functions, decay/adaptation times, and b...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.617778
更新日期:2012-01-01 00:00:00
abstract::Seven to eight years after a disease period of vestibular neuritis 19 patients previously examined at our department were given a questionnaire about whether they had experienced any audiovestibular symptoms since they first fell ill. All 19 patients responded and 18 consented to participate in the long-term follow-up...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950180243
更新日期:1999-01-01 00:00:00
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journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.653668
更新日期:2012-08-01 00:00:00
abstract::The influence of cigarette smoke on the pharyngeal mucosa was investigated in a clinical study and in an experiment on animals. Histologic reports were evaluated according to the Kambic-Lenart classification of hyperplastic aberrations of the throat mucosa. A close dependence of the degree of hyperplasia and the numbe...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487809121433
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doi:10.3109/00016489309135811
更新日期:1993-05-01 00:00:00
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journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2010.514007
更新日期:2011-01-01 00:00:00
abstract::The ultrastructure of the epithelial cells of the endolymphatic duct in the rat is described, following vascular perfusion-fixation of live, anaesthetised and artificially respirated animals. The animals were fixed by means of a pressure feed-back controlled peristaltic pump and an isotonic perfusate-fixative containi...
journal_title:Acta oto-laryngologica
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doi:10.3109/00016489409126013
更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Acta oto-laryngologica
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doi:10.3109/00016489409126075
更新日期:1994-07-01 00:00:00
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更新日期:1995-03-01 00:00:00
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journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.1992.11665405
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abstract::The nystagmus and motion perception of two astronauts were recorded during Earth-vertical axis rotation and during off-vertical axis rotation (OVAR) before and after 7 days of spaceflight. Postflight, the peak velocity and duration of per- and postrotatory nystagmus during velocity steps about the Earth-vertical axis ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509139374
更新日期:1995-09-01 00:00:00
abstract:CONCLUSION:A simple measuring box to determine lip-shift angle and eye-width narrowing offered simultaneous and objective data on outcome dysfunction. The method is as easy as visual approaches. The method is objective and as easy as visual access. It is practical for routine clinical use in any clinic. OBJECTIVES:The...
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doi:10.3109/00016489.2011.626793
更新日期:2012-01-01 00:00:00
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