Supernumerary outer hair cells arise external to the last row of sensory cells in the organ of corti.

Abstract:

:During the development of the mammalian inner ear, the number of hair cells produced is highly regulated and remains constant throughout life. The mechanism underlying this regulation is beginning to be understood although many aspects still remain obscure. When late embryonic or early postnatal rat organs of Corti were cultured, the production of supernumerary hair cells was observed. This overproduction of sensory cells could be modulated by the addition of several growth factors. In this study, we examined explants of rat organs of Corti that produced supernumerary hair cells. In the supernumerary hair cell region, up to two rows of inner hair cells and five rows of outer hair cells were observed. Morphological evaluation of these specimens revealed that less mature hair cells were located in the most external rows of these sensory cells. When a supernumerary hair cell was produced, a supporting cell (i.e. Deiters' cell) was also produced, strongly suggesting that the conversion of a Deiters' cell into a hair cell was not the mechanism that produced these extra hair cells. Based on these results, we propose that prosensory cells located at the external edge of the organ of Corti retain a capacity to form hair cells and that it is these prosensory cells that differentiate into supernumerary hair cells and Deiters' cells.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Lefebvr PP,Malgrange B,Thiry M,Breuskin I,Van De Water TR,Moonen G

doi

10.1080/000164801300043325

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

164-8

issue

2

eissn

0001-6489

issn

1651-2251

journal_volume

121

pub_type

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