Effect of acute endolymphatic hydrops overload on the endolymphatic sac.

Abstract:

CONCLUSIONS:Homeostasis of endolymph volume is a complex mechanism, in which the endolymphatic sac (ES) may play an important role. OBJECTIVES:To elucidate the effect of acute endolymphatic hydrops (EH) on the ES and to gain further information about the volume and pressure regulative function of the ES. MATERIALS AND METHODS:Distilled water was injected into the middle ear cavity of adult CBA/J mice. The ESs were studied morphologically by light and transmission electron microscopy. RESULTS:Mild EH was found, particularly in the upper turn of the cochlea. Acute EH led to an increase in the size of the ES lumen, accompanied by collapse of the lateral intercellular spaces and dense perisaccular tissue, changes which had reversed 2 h after the injection.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Akagi N,Takumida M,Anniko M

doi

10.1080/00016480701497428

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

239-44

issue

3

eissn

0001-6489

issn

1651-2251

pii

781482132

journal_volume

128

pub_type

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