Strial dysfunction in a melanocyte deficient mutant rat (Ws/Ws rat).

Abstract:

:A homozygous mutant rat at the white spotting (Ws) locus showing a deficiency of melanocytes has recently been found (4, 5). The function and morphology of the inner ear of the Ws/Ws rat were examined by auditory brainstem response (ABR), endocochlear DC potential (EP), and electron microscopy. The mean ABR threshold of the Ws/Ws rat was significantly higher than that of the control +/+ rat. Most Ws/Ws rats showed no or very little EP. In electron microscopy, the stria vascularis of the Ws/Ws rat proved to be very thin and flat with poor interdigitation of marginal cells, and absence of intermediate cells. The organ of Corti appeared to be intact in both the +/+ rat and the Ws/Ws rat. These electrophysiological and morphological findings suggest that the Ws/Ws rat suffered from severe hearing loss caused by strial dysfunction.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Kitamura K,Sakagami M,Umemoto M,Takeda N,Doi K,Kasugai T,Kitamura Y

doi

10.3109/00016489409126038

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

177-81

issue

2

eissn

0001-6489

issn

1651-2251

journal_volume

114

pub_type

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