Amplification of int-2 and bcl-1 genes in squamous cell carcinoma of the larynx.

Abstract:

:We studied int-2 and bcl-1 gene amplification in 21 operated patients with cancer of the larynx. In 9 cases, the int-2 gene was amplified (42.9%) and in 4 cases. the bcl-1 gene was amplified (25.0%). Co-amplification of int-2 and bcl-1 was observed in three cases (18.8%), all of which were glottic carcinomas. Other amplified cases were supraglottic carcinomas. Tumor specimens with int-2 amplification were associated with a significantly worse prognosis. We suggest that int-2 amplification is one of the prognostic factors in laryngectomized patients with cancer of the larynx.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Miyahara H,Naito H,Ueda K,Yane K,Matsunaga T,Okaichi K,Ohnishi T

doi

10.1080/00016489850183331

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

763-8

issue

5

eissn

0001-6489

issn

1651-2251

journal_volume

118

pub_type

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