Abstract:
:Beta 2-microglobulin (beta 2m) is a small polypeptide, related to the immunoglobulins and present on nucleated cells as part of the strong transplantation antigens. Elevated plasma levels have been recorded in patients with various malignant diseases. Human beta 2m has also been detected immunohistochemically in carcinomas transplanted into nude mice, and in the plasma of tumour-bearing mice. In the present study the occurrence of human beta 2m was studied in the plasma of 26 patients with squamous cell carcinoma (SCC) of the head and neck and in six heterotransplanted carcinoma lines. Extractable beta 2m was measured in seven SCC of the head and neck and in the six heterotransplanted tumour lines. Immunohistochemically detectable beta 2m was studied in 20 SCC and in six heterotransplanted tumour lines. Only 3 of 26 patients (12%) had elevated p-beta 2m levels. Stage IV tumours seemed to have more p-beta 2m (though within the normal range) than did less advanced tumours. There was no correlation between the total amount of extractable beta 2m in the patients' tumours and p-beta 2m. However, there was an association between the concentration of beta 2m in the tumours and p-beta 2m. Human beta 2m could be detected in the plasma of mice with tumours from all tumour lines, and there was a tendency toward an association between tumour size and p-beta 2m. The ratio of p-beta 2m/tumour volume differed between the tumour lines. Tumour volume doubling time (DT) was determined for the various tumour lines, and there was a correlation between DT and beta 2m concentration of the tumours.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Wennerberg J,Alm P,Lögdberg L,Tropé Cdoi
10.3109/00016488409107571subject
Has Abstractpub_date
1984-09-01 00:00:00pages
335-42issue
3-4eissn
0001-6489issn
1651-2251journal_volume
98pub_type
杂志文章abstract::Otorrhea of leaked cerebrospinal fluid and meningitis in a 33-year-old male originated from an encephalic herniation into the middle ear following traumatic temporal bone fracture. CT demonstrated a mixed-type fracture consisting of a longitudinal fracture and a posterior oblique fracture of the left temporal bone. Th...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480510029266
更新日期:2005-08-01 00:00:00
abstract:CONCLUSION:SOD1 is an important gene related to noise-induced hearing loss (NIHL), and its effect is dependent on noise exposure levels. OBJECTIVES:To test whether the polymorphisms in the CuZn-superoxide dismutase gene (SOD1) are associated with susceptibility to NIHL in the Chinese population. METHODS:Audiometric d...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480903253587
更新日期:2010-04-01 00:00:00
abstract::In the present study, the protective effect of dexamethasone was analysed following exposure of the cochlea to Pseudomonas aeruginosa Exotoxin A (PaExoA). Four groups of albino Sprague-Dawley rats were used. 20 microl saline was instilled through the tympanic membrane into the round window niche (group A, n = 4); 1 mi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800750000577
更新日期:2000-03-01 00:00:00
abstract:CONCLUSION:Intra-tympanic dexamethasone injection (ITD) could serve as a first-line intra-tympanic (IT) treatment for Meniere's disease (MD), regardless of hearing level. Even if the response to initial ITD course was unsatisfactory, a repeated course may be beneficial with some patients. OBJECTIVES:This study examine...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1224920
更新日期:2017-02-01 00:00:00
abstract::Evaluation of some 200 endolymph proteins indicates that they are predominantly derived from plasma. However, the profile of endolymph proteins is remarkably similar to that of perilymph and entirely different from that of plasma. This supports the current consensus that perilymph rather than plasma is the (direct) so...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,评审
doi:10.1080/00016489950181260
更新日期:1999-01-01 00:00:00
abstract::An X-ray energy dispersive analysis was performed on the mature serial sectioned freeze-dried mammalian labyrinth (CBA/CBA mouse). The elemental distribution in the endolymphatic and perilymphatic spaces revealed similar results as have been reported in the literature when withdrawing fluid for microanalysis. The cupu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488009131744
更新日期:1980-11-01 00:00:00
abstract:BACKGROUND:Many patients with coronavirus disease 2019 (COVID-19) complain from olfactory dysfunction (OD). Aims/objectives: To evaluate the prevalence, prognosis, and recovery from OD in COVID-19 patients. MATERIAL AND METHODS:In this study, patients with COVID-19 symptoms who were referred to six different tertiary ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1836397
更新日期:2020-11-11 00:00:00
abstract::To investigate whether the crossed olivo-cochlear bundle (COCB) functions in a protective manner, albino guinea pigs were exposed to sounds of varying intensity (110-130 dB SPL, 3-30 min) with or without electric stimulation of COCB, and the threshold shifts of the compound action potential (CAP) were examined. A stat...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.1992.11665405
更新日期:1992-01-01 00:00:00
abstract:CONCLUSIONS:The microarray analysis identified 39 genes up- or down-regulated by dexamethasone in the cultured tissue of mice cochlea. Of the eight genes most highly affected, several are suggested to have protective effects in the traumatized inner ear (Fkbp5, Glucocorticoid-induced leucine zipper (Gilz), glutathione ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2010.498836
更新日期:2010-12-01 00:00:00
abstract:CONCLUSION:Success and complication rates of endoscopic dacrycystorhinostomy (DCR) creating a window with a drill and without using mucosal flaps are similar to those of external DCR. Moreover, any intranasal or paranasal disease can be treated simultaneously and a superior cosmetic result is achieved. OBJECTIVES:To p...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480802495396
更新日期:2009-09-01 00:00:00
abstract:CONCLUSION:Cochlear implant (CI) recipients' performance of lexical tone identification and consonant recognition can be enhanced by providing greater spectral details. OBJECTIVE:To evaluate the effects of increasing the number of total spectral channels on the lexical tone identification and consonant recognition by ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480802032793
更新日期:2009-06-01 00:00:00
abstract::The treatment of acute otitis media was studied in 158 children. All children (mean age 4 years) received penicillin orally 80 000--100 000 IU per day for 10 days. Myringotomy was performed on 68 children at the time of the diagnosis. The other 90 children were treated with penicillin and ear drops. The bacteriologica...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487909137149
更新日期:1979-01-01 00:00:00
abstract::Retropharyngeal haematomas (RPHs) are rare but potentially life-threatening conditions that require a prompt diagnosis. However, the clinical scenario is not always straightforward as their presentation may be insidious, with no specific signs or symptoms. Treatment of RPH is conservative in the majority of cases, wit...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480410017233
更新日期:2005-04-01 00:00:00
abstract::Forty-three consecutive patients with peripheral facial palsy were examined to evaluate the incidence of facial palsy caused by the tick-borne Borrelia spirochete in a non-coastal area in the south of Sweden. Six (14%) of the patients were found to have a Borrelia infection. The incidence of Borrelia-induced facial pa...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488909125548
更新日期:1989-11-01 00:00:00
abstract:CONCLUSIONS:The heparin-binding epidermal growth factor-like growth factor (HB-EGF) plays an essential role in the development and invasiveness of cholesteatoma. This study may help to realize the molecular mechanisms underlying the pathogenesis of cholesteatoma and make HB-EGF a promising target for drug intervention ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2017.1284343
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Smell and taste disorders occur in COVID-19 with a high prevalence, but little is known about the duration of the symptoms. In particular, studies using validated olfactory tests are very rare to date. AIMS/OBJECTIVES:The aim of this study was to determine the olfactory function of COVID-19 recoveries by a ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1811999
更新日期:2020-12-01 00:00:00
abstract:CONCLUSION:It is thought that oxidative stress may be the major cause of the increase in the oxide thiol form in the study group. The relationship between oxidative stress status and dynamic thiol/disulphide in nasal polyposis now needs to be investigated. OBJECTIVES:The purpose of this study was to evaluate the relat...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1186833
更新日期:2016-11-01 00:00:00
abstract::Nasal polyps is a chronic inflammatory disease of the upper airway characterized by structural abnormalities including stromal fibrosis. Fibroblasts are a rich source of cytokines and inflammatory mediators and are thought to play an important role in the development of fibrosis. In addition, there is considerable evi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950180478
更新日期:1999-01-01 00:00:00
abstract::Gamma-aminobutyric acid (GABA) is presumed to be a neurotransmitter candidate in the vestibular periphery of mammals. However, experimental reports about the localization of GABA in afferents or efferents of the vestibular systems are contradictory. It is an open question whether there are species differences in the a...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489850155198
更新日期:1998-01-01 00:00:00
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journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.715751
更新日期:2013-01-01 00:00:00
abstract::The influence of obstructed nasal passages was investigated in l4 patients with allergic rhinitis. Disordered breathing in sleep was found in all patients in the form of periodic breathing, and hypopneic and hyperpneic episodes, associated with characteristic "microarousals' from sleep. Patients had an average of 50 "...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488109133292
更新日期:1981-11-01 00:00:00
abstract:CONCLUSION:Neck dissection (ND) may not be warranted for those patients with complete response in the neck. Human papillomavirus (HPV)-positive or -negative tumour does not affect this recommendation. OBJECTIVES:Treatment of tonsillar cancer varies considerably worldwide, although non-surgical treatment, e.g. radiothe...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.920516
更新日期:2014-10-01 00:00:00
abstract:CONCLUSION:The data suggest that histamine up-regulates MUC2 gene regulation and mucin production in airway epithelial cells through histamine 1 receptor (H1R). Histamine appears to play an important role in the early phase of mucin regulation, which might be effectively blocked by an H1R antagonist. OBJECTIVE:Histami...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.661075
更新日期:2012-06-01 00:00:00
abstract:CONCLUSION:Photodynamic therapy (PDT) is a viable and safe option for early laryngeal cancer that would be less suitably treated with radiation or trans-oral laser surgery (TLS). The cure rates with PDT appear to be comparable to those of conventional therapy, and the voice outcomes are also comparable. In the case of ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.906748
更新日期:2014-08-01 00:00:00
abstract::The spiral ganglion from white cats with hereditary deafness has been studied with the transmission electron microscope, and comparisons made with hearing animals at different ages. Ganglion cell loss occurs secondary to destruction of the organ of Corti, but only after the lapse of several months. Prior to neuronal l...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488009131737
更新日期:1980-11-01 00:00:00
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journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488509108931
更新日期:1985-03-01 00:00:00
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journal_title:Acta oto-laryngologica
pub_type: 杂志文章,meta分析
doi:10.1080/00016489.2016.1260157
更新日期:2017-06-01 00:00:00
abstract::The influence of posture on nasal cavity geometry was studied by acoustic rhinometry in 14 normal adult subjects. On adopting a supine position from sitting the volume of the initially more patulous nasal cavity decreased and the volume of the less patulous side increased. These changes in volume are statistically sig...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489309135858
更新日期:1993-07-01 00:00:00
abstract::POLGON (Polarized light goniometer) was used to evaluate ataxia during stepping movements in patients with spinocerebellar degeneration (SCD) and Parkinson's disease. The measurements included mean angular change of shoulders (M.A.C.S.) and its coefficient of variation (C.V.). In patients with SCD, the values of M.A.C...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489309135847
更新日期:1993-07-01 00:00:00
abstract:CONCLUSION:Delayed facial palsy after tympanoplasty had no predisposition for gender or side. It seemed that prednisolone alone without antiviral drugs was enough for the treatment of delayed facial palsy after tympanoplasty. OBJECTIVE:To analyze the clinical characteristics and prognosis of delayed facial palsy after...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.971464
更新日期:2015-02-01 00:00:00