Abstract:
:In the present study, the protective effect of dexamethasone was analysed following exposure of the cochlea to Pseudomonas aeruginosa Exotoxin A (PaExoA). Four groups of albino Sprague-Dawley rats were used. 20 microl saline was instilled through the tympanic membrane into the round window niche (group A, n = 4); 1 microg/20 microl dexamethasone sodium 21-phosphate (dexamethasone) solution was instilled (group B, n = 4); 1 microg/20 microl PaExoA solution was initially instilled followed 1 h later by 20 microl saline (group C, n = 6); and 1 microg/20 microl PaExoA solution was initially instilled followed 1 h later by 1 microg/20 microl dexamethasone solution (group D, n = 6). Frequency-specific (4, 8, 10, 12, 16 and 20 kHz) auditory brainstem responses (ABR) were used to ascertain the threshold prior to exposure and 1, 2, 3, and 5 days and 1 and 2 weeks afterwards. No threshold change was observed in groups A and B, whereas the animals in groups C and D showed some threshold elevation, that in D being smaller than that in C. There was a significant difference at the frequencies 12, 16 and 20 kHz, 2 and 5 days after exposure. The intensity-latency (I-L) curve showed that in group D the cochlear component almost disappeared at high frequency one week after exposure. Our results indicate that dexamethasone can modify the effect of PaExoA caused by non-specific inflammation.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Takeuchi N,Anniko Mdoi
10.1080/000164800750000577subject
Has Abstractpub_date
2000-03-01 00:00:00pages
363-8issue
3eissn
0001-6489issn
1651-2251journal_volume
120pub_type
杂志文章abstract:CONCLUSION:We demonstrated an early increase in aquaporin 2 (AQP2) expression in a motor nerve (extratemporal facial nerve, FN) following acute peripheral compression (crush), concomitant to effective development of motor dysfunction (facial palsy). The early increase in AQP2 expression that occurred concomitantly with...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1010104
更新日期:2015-07-01 00:00:00
abstract::Detection of immune complexes (ICs) of IgG, IgM, or IgA isotypes in middle ear effusions (MEEs) by the solid-phase anti-C3 ELISA and cytologic analyses of MEEs were done in 245 patients with otitis media with effusion (OME). In 320 ears, the clinical classification was acute, 10.3%; subacute, 16.6%; chronic, 73.1%. In...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709128278
更新日期:1987-11-01 00:00:00
abstract::Three hundred and fifty-four patients with squamous cell carcinoma of the oral cavity, oropharynx, supraglottic larynx, hypopharynx or maxillary sinus have been randomized for preoperative radiation therapy and surgery versus surgery and postoperative radiation therapy plus, in the case of patients with lesions of the...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016488109138548
更新日期:1981-05-01 00:00:00
abstract:CONCLUSIONS:Our preliminary results indicate that mastoidectomy by reconstruction of the posterior wall and obliteration (MAPRO) avoided the disadvantages of a canal-wall-down mastoidectomy. MAPRO effectively prevented cholesteatoma recurrence, provided an excellent basis for hearing restoration, and was generally wate...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.643456
更新日期:2012-04-01 00:00:00
abstract:CONCLUSION:A simple measuring box to determine lip-shift angle and eye-width narrowing offered simultaneous and objective data on outcome dysfunction. The method is as easy as visual approaches. The method is objective and as easy as visual access. It is practical for routine clinical use in any clinic. OBJECTIVES:The...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.626793
更新日期:2012-01-01 00:00:00
abstract::An analysis of auditory brainstem response (ABR) thresholds and ABR-based frequency tuning curves was performed in 15 Sprague-Dawley rats exposed to Haemophilus influenzae type b endotoxin; 5 microg/50 microl toxin was instilled every second day, altogether five times, into the middle ear cavity through a small perfor...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709113406
更新日期:1997-05-01 00:00:00
abstract::We have recorded auditory evoked potentials, of both neurogenic and myogenic origin, in cats having neonatal high frequency cochlear hearing loss. Using frequency specific stimuli (tone pips) and by measuring responses near to threshold, we have probed tonotopic (or cochleotopic) representation within the brainstem-mi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489309135763
更新日期:1993-01-01 00:00:00
abstract:INTRODUCTION:Bilateral cochlear implants are seen to improve hearing capabilities. OBJECTIVE:To assess the auditory outcome of paediatric bilateral cochlear implant in Universiti Kebangsaan Malaysia. MATERIALS AND METHODS:This was a cross-sectional and descriptive study single centre analysis. Categories of Auditory ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1775887
更新日期:2020-10-01 00:00:00
abstract::Background: Increasing arterial stiffness is associated with atherosclerosis and there is an association between atherosclerosis and tinnitus may occur.Objectives: The aim of this study was to investigate the relationship between arterial stiffness and tinnitus using the central pulse-wave analysis method.Methods: Thi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2019.1668569
更新日期:2020-02-01 00:00:00
abstract::The most common cause of seasonal allergic rhinitis in Japan is the Japanese cedar (JC). Recently, a pullulan-conjugated antigen (CS-560) has been developed to reduce adverse effects and to enhance the effect of JC-specific immunotherapy (IT). If the mechanism of IT can be fully elucidated and the treatment can be use...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章
doi:10.1080/00016480252775742
更新日期:2002-01-01 00:00:00
abstract:CONCLUSION:Our results indicate that siRNA E6 and/or E7 may have potential as a gene-specific therapy for human papillomavirus (HPV) type 16 (HPV16)-related squamous cell carcinoma of the head and neck (HNSCC). OBJECTIVES:To evaluate the effectiveness of siRNA targeting E6 and/or E7 on the in vitro and in vivo growth ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.773405
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVES:The authors would like to confirm a fluid pathway from the scala tympani to the organ of Corti, and to observe its morphological changes. METHODS:A staining solution for succinic dehydrogenase was perfused with phenazine methosulfate in the scala tympani of living guinea pigs (n = 5) under deep anesthesia. ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1185541
更新日期:2016-11-01 00:00:00
abstract::We investigated the effect of prolonged hypergravity on the otoconial layer of the maculae utriculi and the maculae sacculi in hamsters. The animals were placed in a centrifuge under conditions of 2.5 G, and remained there for 6 months. We then determined the calcium contents of the otoconia with energy dispersive X-r...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509139297
更新日期:1995-03-01 00:00:00
abstract::There have been many morphological investigations on the generation of respiratory epithelium. However, the mucociliary activity of fetal respiratory epithelium has never yet been discussed. In the present work, ciliary activity and mucociliary function in the nose and the trachea of fetal rabbits were studied and, mo...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409130999
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND:Posterior tympanotomy (PT) is an important step in cochlear implant (CI) surgery, as it is the main access to the round window. Some CI candidates, especially children, may have concomitant otitis media with effusion (OME) which may result in technical issues during PT. There is still a debate whether to wai...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1813905
更新日期:2021-01-01 00:00:00
abstract::The effects of two simulated hearing impairments (presbyacusis) on speech perception were investigated in two groups of normally hearing subjects (30 and 48 subjects, respectively). Eight patients with presbyacusis with similar hearing impairment to those in the latter simulation served as the clinical material. Word ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800750000991
更新日期:2000-03-01 00:00:00
abstract::Macrolides have been used for decades as an important chemotherapeutic agent in the treatment of infectious diseases. In the last 10 years there has also been increasing interest in the interaction between macrolide antibiotics and the immune system. The aim of this review is to focus on the anti-inflammatory action o...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,评审
doi:10.1080/000164801300006326
更新日期:2001-01-01 00:00:00
abstract::Malignant laryngeal tumours with spindle-cell morphology are relatively rare. Differential diagnosis of spindle-cell carcinoma, leiomyosarcoma, fibrosarcoma, rhabdomyosarcoma, malignant melanoma and inflammatory myofibroblastic tumour may be particularly difficult. Ambiguous and indeterminate diagnoses are also possib...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/0036554021000028070
更新日期:2003-01-01 00:00:00
abstract:CONCLUSIONS:Available multichannel cochlear implants (CIs) provide effective tinnitus suppression. More sophisticated speech strategies are more effective than analogue or slow strategies. The mechanisms by which tinnitus is suppressed by CIs are unclear; however, both acoustic masking and reorganization of the right a...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701387173
更新日期:2008-02-01 00:00:00
abstract::In experimentally damaged inner ears the structural alterations were correlated to electrocochleographic responses of the ear. Sectioning of the cochlear nerve with degeneration of the type I neurons but intact sensory cells results in normal cochlear microphonics but very weak and atypical nerve responses. By contras...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487709128822
更新日期:1977-01-01 00:00:00
abstract::Rhinomanometric observations of nasal airway patency were obtained for each nasal passage every 10 min throughout an uninterrupted 8-h session. The 49 airflow observations for each nasal passage were subjected to autocorrelation analysis, a statistical technique for quantifying periodicities in a temporal sequence of ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709109065
更新日期:1987-07-01 00:00:00
abstract::The nystagmus and motion perception of two astronauts were recorded during Earth-vertical axis rotation and during off-vertical axis rotation (OVAR) before and after 7 days of spaceflight. Postflight, the peak velocity and duration of per- and postrotatory nystagmus during velocity steps about the Earth-vertical axis ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509139374
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:Many patients with coronavirus disease 2019 (COVID-19) complain from olfactory dysfunction (OD). Aims/objectives: To evaluate the prevalence, prognosis, and recovery from OD in COVID-19 patients. MATERIAL AND METHODS:In this study, patients with COVID-19 symptoms who were referred to six different tertiary ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1836397
更新日期:2020-11-11 00:00:00
abstract::Middle ear lesions were produced in chinchillas by introducing fascia, Gelfoam, silastic or a combination of these materials into the labyrinthine and mastoid bullae. After 1-2 months, conventional 226 Hz and multifrequency tympanometry (MFT) were performed and the animals were sacrificed for histopathological analysi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489850154937
更新日期:1998-03-01 00:00:00
abstract::Vestibular microphonics in response to acoustical stimulation were recorded in cochlea-deprived pigeons. Endolymph flow in the semicircular canals alters this response. A caloric stimulus was applied to the horizontal canal or the posterior vertical canal close to the ampulla. To minimize the influence of gravity, the...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809097016
更新日期:1988-03-01 00:00:00
abstract::We examined the expressions of alpha-subunits of very late antigen (VLA)-4 (alpha4) and VLA-5 (alpha5) on tonsillar lymphocytes and the interaction between these integrin receptors and their ligand, fibronectin (FN). Immunohistological and flow cytometric analyses showed that alpha4 and alpha5 were expressed in the ly...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489609137722
更新日期:1996-01-01 00:00:00
abstract:CONCLUSION:This study provides evidence that histamine induced MUC5AC mRNA expression through the activation of the core region of its promoter. It may also help in approaching new therapeutic strategies in airway mucins hypersecretory diseases. OBJECTIVE:Mucin hypersecretion characterizes several respiratory diseases...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1017890
更新日期:2015-07-01 00:00:00
abstract:CONCLUSION:There is no increased risk of postoperative haemorrhage for abscess tonsillectomies in comparison to elective tonsillectomies. OBJECTIVE:There is still controversy as regards the optimal management of peritonsillar abscess. Opponents of tonsillectomy à chaud cite an increased postoperative bleeding risk. Mo...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480510012336
更新日期:2005-12-01 00:00:00
abstract::Synthesis of prostaglandins (PGs) was characterized in the lateral wall (LW) of guinea-pig cochlea. Basal synthesis at 37 degrees C was about 480 pg/LW (12.8 ng X mg-1 protein) for PGI2 and 85 pg/LW (2.3 ng X mg-1 protein) for PGE2, levelling out after 10 min of incubation. Incubation with arachidonic acid (10(-5) M) ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:1987-05-01 00:00:00
abstract::In the last few years the use of ABR in the dysmetabolic encephalopathies has aroused considerable interest. Even though brainstem involvement in these syndromes is not yet entirely understood, ABR techniques have provided new and important insights. We studied 60 insulin-dependent diabetic subjects, 29 females and 31...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:1987-05-01 00:00:00