The effect of Japanese cedar-specific immunotherapy on cytokine production in peripheral blood mononuclear cells.

Abstract:

:The most common cause of seasonal allergic rhinitis in Japan is the Japanese cedar (JC). Recently, a pullulan-conjugated antigen (CS-560) has been developed to reduce adverse effects and to enhance the effect of JC-specific immunotherapy (IT). If the mechanism of IT can be fully elucidated and the treatment can be used safely and with specificity, IT should be reconsidered as a superior treatment for JC pollinosis. Thirteen patients with JC pollinosis who received IT were compared to 10 patients who did not receive IT. All patients were followed through two pollen seasons by means of allergy diaries. Peripheral blood mononuclear cells (PBMC) were collected before IT and just before each pollen season, and these were stimulated with pollen extract. The concentrations of IL-4, IL-5, IL-13 and IFN-gamma in the culture supernatants were determined using an ELISA. Furthermore, messenger (m)RNA expressions of IL-4 and IL-5 from cultured PBMC were also studied. As a result of the allergy diaries, we confirmed the clinical efficacy of CS-560. The symptom-medication scores were significantly decreased by IT. The levels of IL-4, IL-5 and IL-13 declined only in the IT group. However, the level of IFN-gamma did not change in either group. IL-4 and IL-5 mRNA expressions were inhibited in the IT group compared to that in the non-IT group. In conclusion, specific IT for JC pollinosis using CS-560 clearly modified cytokine expression by PBMC.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Nakano A,Nakano K,Okawa T,Yamakoshi T,Terada N,Numata T,Konno A

doi

10.1080/00016480252775742

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

54-60

issue

1

eissn

0001-6489

issn

1651-2251

journal_volume

122

pub_type

临床试验,杂志文章
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    abstract:CONCLUSION:Mouse embryonic stem cells (ESCs) transplanted into the scala tympani are able to migrate in the cochlea of rats deafened with aminoglycoside and partly restore the structure of sensory epithelia of the inner ear. OBJECTIVES:To explore the migration and differentiation of enhanced green fluorescence protein...

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    authors: Zhao LD,Li L,Wu N,Li DK,Ren LL,Guo WW,Sun JH,Liu HZ,Chen ZT,Xing GQ,Yang SM

    更新日期:2013-02-01 00:00:00

  • Hereditary deafness in the cat. An electron microscopic study of the spiral ganglion.

    abstract::The spiral ganglion from white cats with hereditary deafness has been studied with the transmission electron microscope, and comparisons made with hearing animals at different ages. Ganglion cell loss occurs secondary to destruction of the organ of Corti, but only after the lapse of several months. Prior to neuronal l...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488009131737

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    更新日期:1980-11-01 00:00:00

  • Improved speech reception and sound quality with the DUET2 audio processor for electric acoustic stimulation.

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    更新日期:2015-01-01 00:00:00

  • Microarray analysis of the effect of dexamethasone on murine cochlear explants.

    abstract:CONCLUSIONS:The microarray analysis identified 39 genes up- or down-regulated by dexamethasone in the cultured tissue of mice cochlea. Of the eight genes most highly affected, several are suggested to have protective effects in the traumatized inner ear (Fkbp5, Glucocorticoid-induced leucine zipper (Gilz), glutathione ...

    journal_title:Acta oto-laryngologica

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    authors: Maeda Y,Fukushima K,Hirai M,Kariya S,Smith RJ,Nishizaki K

    更新日期:2010-12-01 00:00:00

  • Direction of lateral traction in Ejnell's technique: an experimental study and case report of bilateral vocal cord paralysis.

    abstract::In order to develop the method of laterofixation of the vocal cord (Ejnell's method) in cases of bilateral vocal cord paralysis, six autopsy specimens of normal larynx were obtained. We inserted traction sutures under conditions of direct visualization and studied the relationship between the direction of the traction...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480260000120

    authors: Tamura E,Kitahara S,Ogura M,Hiroi S

    更新日期:2002-06-01 00:00:00

  • Sympathetic nerve pathways to the nasal vasculature of the cat.

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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487709123967

    authors: Wilson H,Yates MS

    更新日期:1977-09-01 00:00:00

  • An external neck brace to support the peristomal fixation of an automatic stoma valve (ASV): 3D stereophotogrammetrical assessment.

    abstract:CONCLUSION:The external neck brace (ENB) is a new concept in the improvement of peristomal fixation of an automatic stoma valve (ASV), which was evaluated with a new imaging method. The addition of the ENB to the Flexiderm (FLD) and Xtrabase (XB) adhesives significantly reduced absolute mean differences between the spe...

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    pub_type: 杂志文章

    doi:10.3109/00016480903426600

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    更新日期:2010-07-01 00:00:00

  • The association of codeine, macrocytosis and bilateral sudden or rapidly progressive profound sensorineural deafness.

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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480802579082

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    更新日期:2009-10-01 00:00:00

  • Experimental nasal septoplasty; influence on nasomaxillary development. A roentgen cephalometric study in growing domestic cats.

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    pub_type: 杂志文章

    doi:10.3109/00016488509104794

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    更新日期:1985-09-01 00:00:00

  • Chronic maxillary sinusitis. Differential diagnosis and genesis.

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    pub_type: 杂志文章

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    更新日期:1982-01-01 00:00:00

  • Anti-adhesive properties of polytetrafluoroethylene (Gore-Tex) in middle ear surgery. An experimental study.

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    pub_type: 杂志文章

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    更新日期:2006-02-01 00:00:00

  • Basilar papilla explants: a model to study hair cell regeneration-repair and protection.

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    pub_type: 杂志文章

    doi:10.1080/00016489850183133

    authors: Frenz DA,Yoo H,Liu W

    更新日期:1998-09-01 00:00:00

  • Discriminant analysis in predicting prognosis of Bell's palsy.

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    pub_type: 杂志文章

    doi:10.3109/00016488809106436

    authors: Gavilán C,Gavilán J,Rashad M,Gavilán M

    更新日期:1988-09-01 00:00:00

  • Pilot study of a device for measuring instrument forces during endoscopic sinus surgery.

    abstract::ESS is a form of minimal access surgery that includes different tasks and manoeuvres requiring sophisticated psychomotor coordination with varying levels of force application. The avoidance of complications is partially dependent upon reducing surgical force application when operating against vital barriers such as th...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480410016568

    authors: White PS,Nassif R,Saleh H,Drew T

    更新日期:2004-03-01 00:00:00

  • Synchronous benign and malignant tumors in the ipsilateral parotid gland.

    abstract::Synchronous benign and malignant tumors in the ipsilateral salivary glands are extremely rare. We report a unique case of synchronous unilateral parotid tumors in a 71-year-old man. The main parotid lesion was preoperatively suggested to be adenocarcinoma by fine needle aspiration cytology. A coexisting Warthin's tumo...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480600606707

    authors: Roh JL,Kim JM,Park CI

    更新日期:2007-01-01 00:00:00

  • Comparative ototoxicity of furosemide and piretanide.

    abstract::The purpose of these studies was to compare the ototoxicity of piretanide to that of furosemide in the chinchilla. Chinchillas weighing 400 to 700 g were anesthetized with ketamine plus pentobarbital. Endocochlear potential (EP) was measured continuously by the round window approach using glass microelectrodes. Pireta...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488609108608

    authors: Rybak LP,Whitworth C

    更新日期:1986-01-01 00:00:00

  • Moxifloxacin in the treatment of acute bacterial rhinosinusitis: results of a multicenter, non-interventional study.

    abstract:CONCLUSION:Moxifloxacin was generally well tolerated and highly effective in the treatment of acute bacterial rhinosinusitis (ABS). The incidence of adverse events (AEs) and adverse drug reactions (ADRs) was low. The effectiveness, safety, and tolerability information collected in this study confirm the clinical safety...

    journal_title:Acta oto-laryngologica

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.3109/00016481003629036

    authors: Zhou B,Jiang X,Zhai L,Xiao S,Wang J,Xiao G,Ruan B,Liang C,Ye Q,Hu B,Wang H

    更新日期:2010-09-01 00:00:00

  • Whole-body autoradiography of [3H]dihydrostreptomycin in guinea pigs and rats: the labelling of the inner ear in relation to other tissues.

    abstract::[3H]Dihydrostreptomycin was given intramuscularly to young pigmented guinea pigs and rats. Whole-body autoradiography, combined with densitometric measurement of the blackening of the autoradiograms, and liquid scintillation counting were used to determine the levels of radioactivity in the inner ear in relation to bl...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488609132834

    authors: Nilsson Tammela M,Tjälve H

    更新日期:1986-03-01 00:00:00

  • Ultrastructure of the stria vascularis and Reissner's membrane in experimental hydrops.

    abstract::A time-sequence study was made of the early ultrastructural changes of the stria vascularis and Reissner's membrane in the guinea pig after obliteration of the endolymphatic sac and duct. Pathological alterations of both the stria vascularis and Reissner's membrane were found to start in the apex of the cochlea. The m...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488709107319

    authors: Albers FW,de Groot JC,Veldman JE,Huizing EH

    更新日期:1987-09-01 00:00:00

  • Middle ear effusion induced by a stream of air in the external auditory canal. A temperature-related phenomenon.

    abstract::The blowing of chilled (14 degrees C) air into the external auditory canal (EAC) resulted in a profuse middle ear fluid production. The stimulation caused marked changes in the pars flaccida of the tympanic membrane. A slight vasodilatation was noted in the oedematous loose connective tissue layer of the pars flaccida...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488609108674

    authors: Goldie P,Hellström S

    更新日期:1986-09-01 00:00:00

  • Aminotransferases in post-mortem cochlear fluids.

    abstract::Aspartate and alanine aminotransferase (ASAT, ALAT) activities were measured in human post-mortem sera, cerebrospinal fluid (CSF), perilymph and endolymph. Due to heart and/or liver morbidity during a terminal illness, the ASAT and ALAT serum activities were considerably increased as compared with normal and both were...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487609107478

    authors: Palva T,Nousiainen R,Raunio V

    更新日期:1976-01-01 00:00:00

  • An evaluation of normal strial capillary transport using the electron-opaque tracers ferritin and iron dextran.

    abstract::Enzymatic tracer techniques to study normal and pathologic strial capillary transport pose various problems. The use of electron opaque tracers can circumvent many of these problems. Iron dextran (mol. diam 20--70 A) and ferritin (mol. diam 110 A) were injected intravenously and the mice sacrificed at intervals of 1/2...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488009127103

    authors: Santos-Sacchi J,Marovitz WF

    更新日期:1980-01-01 00:00:00

  • Familial Zenker's diverticulum.

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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480701813822

    authors: Klockars T,Sihvo E,Mäkitie A

    更新日期:2008-09-01 00:00:00

  • Concurrent chemoradiotherapy with carboplatin and uracil-f tegafur (UFT) for patients with poor performance status with locally advanced squamous cell carcinoma of the head and neck (SCCHN).

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    pub_type: 杂志文章,随机对照试验

    doi:10.1080/00016480701200251

    authors: Katori H,Tsukuda M,Taguchi T

    更新日期:2007-10-01 00:00:00

  • Substance P in the acoustic area of the cortex during neuronal development and maturation.

    abstract::Substance P has been proved an important neurotransmitter and neuromodulator, serving not only as an excitatory transmitter of the first afferent synapse of pain pathways but as a valuable neuromodulator in the primary cortical areas of sensosensorial integration. In the human acoustic cortex, substance P has been fou...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488909127525

    authors: Manolidis L,Baloyannis S,Manolidis S

    更新日期:1989-05-01 00:00:00

  • Evoked potentials from the auditory nerve following sinusoidal electrical stimulation of the cochlea: new possibilities for preoperative testing in cochlear-implant candidates?

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    pub_type: 杂志文章

    doi:10.3109/00016489409126093

    authors: Hartmann R,Pfennigdorff T,Klinke R

    更新日期:1994-09-01 00:00:00

  • Induction of MUC5AC mucin expression by histamine through the activation of its core promoter region.

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    更新日期:2015-07-01 00:00:00

  • Digital subtraction angiography abnormalities in sudden unilateral profound hearing loss.

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    pub_type: 杂志文章

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    doi:

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    更新日期:1987-03-01 00:00:00

  • Racial considerations in acoustic neuroma removal with hearing preservation via the retrosigmoid approach.

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    doi:10.3109/00016489509139402

    authors: Low WK,Fenton JE,Fagan PA,Gibson WP

    更新日期:1995-11-01 00:00:00