Abstract:
CONCLUSIONS:The microarray analysis identified 39 genes up- or down-regulated by dexamethasone in the cultured tissue of mice cochlea. Of the eight genes most highly affected, several are suggested to have protective effects in the traumatized inner ear (Fkbp5, Glucocorticoid-induced leucine zipper (Gilz), glutathione peroxidase 3) and for others, a plausible mechanism of action can be offered (claudin 10, glutamate-ammonia ligase). The present data may support the use of dexamethasone to treat acute sensorineural hearing loss. It is warrantable to test these results in the in vivo cochlea. OBJECTIVES:To identify genes whose expression is markedly up- or down-regulated by dexamethasone in the cochlear tissue. METHODS:Murine cochlear tissue was cultured with or without dexamethasone for 48 h in vitro. The gene expression profiles were compared between the dexamethasone-treated and untreated cochlear tissue using a microarray that covers 33 696 transcripts (24 878 genes) of mice and quantitative real-time RT-PCR. RESULTS:The microarray analysis identified 39 genes that are up- or down-regulated by more than twofold in the presence of dexamethasone in the cochlear culture. Genes up- or down-regulated by at least threefold include Fkbp5, Gilz, glutathione peroxidase 3, claudin 10, glutamate-ammonia ligase, proteoglycan 1, integrin beta-like 1, and alpha subunit of glycoprotein hormone.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Maeda Y,Fukushima K,Hirai M,Kariya S,Smith RJ,Nishizaki Kdoi
10.3109/00016489.2010.498836subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1329-34issue
12eissn
0001-6489issn
1651-2251journal_volume
130pub_type
杂志文章abstract:CONCLUSION:Human adipose-derived stem cells (ASCs), encapsulated in a fibrin-collagen hydrogel for the coating of an electrode array, produce sufficient amounts of neurotrophic factors and may be suitable for enhancing the bioelectric interface of cochlear implants (CIs). OBJECTIVES:To evaluate different hydrogel comp...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.878809
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:Although community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections have recently become an increasing problem in various fields of medicine, they have rarely been studied in the ear. The purpose of this study was to determine the prevalence of community-acquired MRSA infections in disc...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/0036554021000028076
更新日期:2002-12-01 00:00:00
abstract::The Dynamic Illegible E (DIE) test measures visual acuity with head held still while reading a specially designed visual acuity chart of E's. The head is then moved passively and the change in visual acuity is recorded. The DIE test has previously been shown to be very useful for assessing patients with aminoglycoside...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00
abstract:CONCLUSION:Endoscopic cauterization of the sphenopalatine artery and anterior ethmoid artery is a first-line standard of care in managing intractable epistaxis, after the failure of previous packing. Epistaxis occurs in 12% of the population. Treatment is often based on nasal packing that could be poorly effective in t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,多中心研究
doi:10.3109/00016481003621538
更新日期:2010-09-01 00:00:00
abstract:CONCLUSIONS:Congenital cytomegalovirus (CMV) infection is a major cause of bilateral and unilateral sensorineural hearing loss (SNHL) in children, accounting for 9.0% of SNHL cases. The diagnostic rate using combined genetic deafness test and CMV DNA detection test was determined to be 46.4% in bilateral profound SNHL....
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.583268
更新日期:2011-09-01 00:00:00
abstract::Mononuclear host cells isolated from primary laryngeal carcinoma were assessed by means of indirect immunofluorescence with a panel of monoclonal antibodies against various lymphocyte subsets and macrophages. Tumours of various staging groups were examined in parallel with cells isolated from patient and donor periphe...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809119459
更新日期:1988-01-01 00:00:00
abstract::The subjective visual horizontal (SVH) was measured by means of a small, rotatable, luminous line in darkness in the upright head and body position and at 10, 20 and 30 degrees of tilt to the right and left before, and repeatedly during a follow-up period of 1 year after intratympanic gentamicin instillations in 12 pa...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489850154595
更新日期:1998-07-01 00:00:00
abstract:CONCLUSION:Our findings suggest that there exists a Na(+) transport system in the cochlea consisting of SGK1, Nedd4 isoforms and ENaC, which may work in concert to transport Na(+) and to maintain homeostasis in the inner ear as they do in other tight epithelia. OBJECTIVES:It has been well demonstrated that the epithel...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480802552501
更新日期:2009-09-01 00:00:00
abstract:CONCLUSIONS:Homeostasis of endolymph volume is a complex mechanism, in which the endolymphatic sac (ES) may play an important role. OBJECTIVES:To elucidate the effect of acute endolymphatic hydrops (EH) on the ES and to gain further information about the volume and pressure regulative function of the ES. MATERIALS AN...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701497428
更新日期:2008-03-01 00:00:00
abstract::The nasal airways of 94 healthy term infants (37-42 weeks gestational age) were examined by continuous wide-band noise acoustic rhinometry under standardized conditions on the second or third day postpartum. Validation of the flexible infant probe on tubular plastic models with dimensions similar to the nasal cavity o...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709113416
更新日期:1997-05-01 00:00:00
abstract:INTRODUCTION:CD73 is an enzyme crucial in the metabolism of immunosuppressive adenosine. In cancer, it has various functions including tumor growth and metastases. Squamous cell carcinoma of the head and neck has an overall poor prognosis, also due to early spread of metastatic cells. MATERIALS AND METHODS:Tumor and l...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2017.1378436
更新日期:2018-02-01 00:00:00
abstract::To elucidate the effects of CO2 in the middle ear upon the cochlea, measurements were made of the cochlear potentials (compound action potential and endocochlear potential) and of the pH of the inner ear fluids and the organ of Corti. Gas containing CO2 did not affect the AP threshold, except for a slight decrease in ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488909107397
更新日期:1989-07-01 00:00:00
abstract:CONCLUSIONS:1. The principle of bilateral symmetry depends on the chordal cartilage that is the keystone in cranial base ossification in rats and humans, due to its anatomical situation and for the production of the chordin protein that regulates the bone morphogenetic protein BMP-7. 2. In humans and in rats, foramen l...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.642814
更新日期:2012-04-01 00:00:00
abstract::In 4 cases of Meniere's disease, E.P., concentrations of Na, K, Cl, and protein, and osmolality were determined in endolymph from the basal coil of the cochlea. In 3 cases, endolymph was found normal in nature as compared with normal animals. In one long-standing (11 years) case, a strial dysfunction was evidenced. In...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409132935
更新日期:1984-05-01 00:00:00
abstract:CONCLUSION:Our results suggest that hepatocyte growth factor (HGF) may play an important role in the progression of hypopharyngeal cancer. OBJECTIVE:HGF, a potent stimulator of hepatocyte growth, stimulates the motility, invasiveness, proliferation and morphogenesis of epithelium and may be involved in physiologic and...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480510037014
更新日期:2006-01-01 00:00:00
abstract::An antimicrobial agent, kanamycin, has been shown to produce as an untoward effect, ototoxicity. The purpose of this study was to investigate differential effects of kanamycin ototoxicity as a function of Rx timing with regard to circadian rhythms. Four groups of comparable weight Sprague-Dawley rats received a daily ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109100749
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:To improve the efficacy of intratympanic therapy using perilymphatic entry through the round window membrane. MATERIAL AND METHODS:The perilymphatic entry characteristics of 2 neutral molecules, mannitol (182.2 Da) and inulin (7,000 Da), were studied. A polyethylene catheter was placed in contact with the gu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310001042
更新日期:2003-01-01 00:00:00
abstract::In previous studies, sinus secretions have been analysed concerning pO2, pCO2 and pH. In this study the energy metabolism in the maxillary sinus mucosa and secretion was studied in 33 New Zealand White rabbits. In freeze-dried samples, glucose and lactate were analysed by enzymatic assays and ATP by HPLC. In the purul...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809122271
更新日期:1988-11-01 00:00:00
abstract::The muscle fiber content of the stapedius muscle of the cat was determined histochemically using a combination of oxidative enzymes and glycolytic markers. The major fiber type present was determined to be the fast oxidative glycolytic type (FOG; 77%). Two other types of fiber were found that could not be placed into ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209128894
更新日期:1982-07-01 00:00:00
abstract::Two hundred Malaysian patients representing 227 ears with previously untreated cholesteatoma disease were analysed retrospectively in terms of i) type of disease, i.e. primary acquired attic defect or posterior superior retraction pocket and secondary acquired type cholesteatoma; ii) positive history of previous middl...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109138380
更新日期:1991-01-01 00:00:00
abstract:CONCLUSIONS:This study shows that heavy drinking is a risk factor for prolonged delay in presenting with head and neck cancer and for presenting with a large tumour in the head and neck region. Excessive smoking is only a risk factor for being diagnosed with a large tumour, although there is a weak association between ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480510028456
更新日期:2005-05-01 00:00:00
abstract::Observations of Hallpike (1967) suggested that the neural mechanism responsible for positional nystagmus of central type, the direction-changing type of Nylén, was dependent upon derangement of compensatory eye reflexes subserved by neck proprioceptors and/or otolith organs in the presence of damage to the medial vest...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309139447
更新日期:1983-05-01 00:00:00
abstract::The cochlea of the inner ear is no longer regarded exclusively as a passive mechanical signal analyser. Active mechanical processes are thought to influence the vibration pattern of the basilar membrane. The source of these active mechanical processes is sought in the outer hair cells (OHC). These auditory sensory cel...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809119443
更新日期:1988-01-01 00:00:00
abstract::Background: Betahistine is used worldwide to treat patients with Menière's disease. However, despite it being used for decades, diverging opinions on the effect of betahistine on Menière's symptomatology still exist.Aims: The objective of this systematic review was to provide an overview and rate the certainty of the ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1777326
更新日期:2020-10-01 00:00:00
abstract::Background: It has been reported that head-up sleep (HUS) prevents free-floating otoliths from entering canals and that vertical recognition training (VRT) promotes vestibular compensation.Aims/objectives: We would like to assess HUS and VRT for intractable motion-evoked dizziness, including possible benign paroxysmal...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1727566
更新日期:2020-06-01 00:00:00
abstract::Recent investigations of children with specific language impairment (SLI) have found deviant anatomical asymmetry of the perisylvian cortex. These studies argue that this deviant anatomical asymmetry is linked to the language disorders of SLI children. To date no studies have examined whether deviant functional asymme...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164801300043929
更新日期:2001-01-01 00:00:00
abstract:CONCLUSIONS:The incidence of tonsillar cancer in Sweden is increasing, particularly among men. Risk factors other than smoking may have contributed to the observed secular trend in men. In women, however, smoking can be a part of the explanation. Further studies to look at changes in other environmental factors, such a...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480601110170
更新日期:2007-09-01 00:00:00
abstract::In 12 healthy volunteers, and 5 prelingually and 5 postlingually profoundly deaf subjects, a 500 Hz filtered click stimulus was applied to the mastoid via the bone conductor. In all the healthy volunteers, middle latency response (MLR) was recorded. Among all profoundly deaf subjects, MLR was recorded only in 2 with p...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488509108929
更新日期:1985-03-01 00:00:00
abstract:CONCLUSION:The approach described in this paper may be helpful in establishing an early-warning, evidence-based mechanism for diagnosing vertigo, which can be utilized in medical education to reduce medical uncertainty. OBJECTIVE:To use an evidence-based medicine approach to evaluate the probability of having vertigo ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480510043468
更新日期:2006-01-01 00:00:00
abstract::Nitric oxide synthase (NOS) isoforms I and III were localized in the guinea pig cochlea by indirect immunohistochemistry using frozen sections and paraffin sections. NOS I staining was observed in the cytoplasm of outer hair cells, in nerve cell somata and fibers of the spiral ganglion, and in axonal profiles of the s...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489609137914
更新日期:1996-09-01 00:00:00