Abstract:
:An antimicrobial agent, kanamycin, has been shown to produce as an untoward effect, ototoxicity. The purpose of this study was to investigate differential effects of kanamycin ototoxicity as a function of Rx timing with regard to circadian rhythms. Four groups of comparable weight Sprague-Dawley rats received a daily subcutaneous dosage of 225 mg/kg kanamycin sulfate with each receiving the antibiotic at a different time: 8 AM (8A), 2 PM (2P), 8 PM (8P), and 2 AM (2A). The rats were housed in separate cages, in a room on a light-dark (12:12) illumination cycle with light between 6 AM and 6 PM. Hearing loss was assessed with the auditory brainstem response (ABR) using pure tone stimuli at 8, 16, 24, and 32 kHz. ABR measures were obtained before dosing began and 2, 4, and 6 weeks after the initial dosing. Kanamycin produced a hearing loss which reflected the total dosage given to each group. Significant differences in physiologic thresholds were observed for both timing of the daily dosage (p less than 0.05), and the 2, 4 and 6 week testings (p less than 0.001). After 2 weeks, the 8A group showed an average hearing loss of 11.5 dB at 32 kHz, with the other timed treatment groups exhibiting minimal effects (3.0-6.5 dB). For the 8A group at this frequency, the loss progressed at 4 (19.5 dB) and 6 (22.5 dB) weeks. The 2P group after 4 weeks exhibited similar losses as the 8A group for this frequency, with the loss at 6 weeks being even greater (34.0 dB). The 8P and 2A groups exhibited only slight losses over all frequencies.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Yonovitz A,Fisch JEdoi
10.3109/00016489109100749subject
Has Abstractpub_date
1991-01-01 00:00:00pages
1006-12issue
6eissn
0001-6489issn
1651-2251journal_volume
111pub_type
杂志文章abstract::Thirty difficult-to-test children have been tested with transtympanic ECoG. When possible, informal hearing tests and/or free-field testing were performed. Children in whom no action potential (AP) could be recorded were submitted to conventional radiography of the inner ear, and vestibular tests. The correlation betw...
journal_title:Acta oto-laryngologica
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doi:10.3109/00016487709123981
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pub_type: 杂志文章,meta分析
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更新日期:1995-05-01 00:00:00
abstract::Malignant laryngeal tumours with spindle-cell morphology are relatively rare. Differential diagnosis of spindle-cell carcinoma, leiomyosarcoma, fibrosarcoma, rhabdomyosarcoma, malignant melanoma and inflammatory myofibroblastic tumour may be particularly difficult. Ambiguous and indeterminate diagnoses are also possib...
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更新日期:2003-01-01 00:00:00
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doi:10.3109/00016488809119505
更新日期:1988-05-01 00:00:00
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更新日期:1991-01-01 00:00:00
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更新日期:2011-04-01 00:00:00
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更新日期:1994-03-01 00:00:00
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更新日期:2017-04-01 00:00:00
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更新日期:2005-01-01 00:00:00
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更新日期:1975-07-01 00:00:00
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doi:
更新日期:1987-03-01 00:00:00
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更新日期:2015-07-01 00:00:00
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更新日期:1988-05-01 00:00:00
abstract::Cell proliferation in the endolymphatic sac (ES) after immunostimulation was assessed immunohistochemically. Guinea pigs were employed as experimental animals and keyhole limpet hemocyanin was used as the antigen. After i.p. injection of 5-bromo-2'-deoxyuridine (BrdUrd), the BrdUrd+ cells were counted to assess the nu...
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更新日期:1995-05-01 00:00:00
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doi:10.3109/00016489.2015.1022834
更新日期:2015-01-01 00:00:00
abstract::Serial Thermal Vestibulometry with the application of increasing caloric stimuli (corresponding to decreasing temperature of water at successive irrigration of the ears) was performed on normal subjects and patients with lesions in the central nervous system involving the statoacoustic subsystem. The normal values and...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487909137164
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:To determine factors influencing help-seeking behaviour in hearing-impaired persons aged > or = 55 years MATERIAL AND METHODS:The study comprised 1,419 persons (480 females, 939 males) aged > or = 55 years who participated voluntarily in a driving test. Pure-tone audiometry was performed in all subjects. Par...
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pub_type: 杂志文章
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更新日期:2003-09-01 00:00:00