Circadian rhythm dependent kanamycin-induced hearing loss in rodents assessed by auditory brainstem responses.

Abstract:

:An antimicrobial agent, kanamycin, has been shown to produce as an untoward effect, ototoxicity. The purpose of this study was to investigate differential effects of kanamycin ototoxicity as a function of Rx timing with regard to circadian rhythms. Four groups of comparable weight Sprague-Dawley rats received a daily subcutaneous dosage of 225 mg/kg kanamycin sulfate with each receiving the antibiotic at a different time: 8 AM (8A), 2 PM (2P), 8 PM (8P), and 2 AM (2A). The rats were housed in separate cages, in a room on a light-dark (12:12) illumination cycle with light between 6 AM and 6 PM. Hearing loss was assessed with the auditory brainstem response (ABR) using pure tone stimuli at 8, 16, 24, and 32 kHz. ABR measures were obtained before dosing began and 2, 4, and 6 weeks after the initial dosing. Kanamycin produced a hearing loss which reflected the total dosage given to each group. Significant differences in physiologic thresholds were observed for both timing of the daily dosage (p less than 0.05), and the 2, 4 and 6 week testings (p less than 0.001). After 2 weeks, the 8A group showed an average hearing loss of 11.5 dB at 32 kHz, with the other timed treatment groups exhibiting minimal effects (3.0-6.5 dB). For the 8A group at this frequency, the loss progressed at 4 (19.5 dB) and 6 (22.5 dB) weeks. The 2P group after 4 weeks exhibited similar losses as the 8A group for this frequency, with the loss at 6 weeks being even greater (34.0 dB). The 8P and 2A groups exhibited only slight losses over all frequencies.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Yonovitz A,Fisch JE

doi

10.3109/00016489109100749

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

1006-12

issue

6

eissn

0001-6489

issn

1651-2251

journal_volume

111

pub_type

杂志文章
  • Electrocochleography used as a clinical hearing test in difficult-to-test children.

    abstract::Thirty difficult-to-test children have been tested with transtympanic ECoG. When possible, informal hearing tests and/or free-field testing were performed. Children in whom no action potential (AP) could be recorded were submitted to conventional radiography of the inner ear, and vestibular tests. The correlation betw...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487709123981

    authors: Bergholtz LM,Arlinger SD,Kylén P,Jerlvall LB

    更新日期:1977-11-01 00:00:00

  • Six cases of Forestier syndrome, a rare cause of dysphagia.

    abstract::Dysphagia is a common presenting complaint in otolaryngology practice, and there are many causes. Forestier syndrome is a rare cause of dysphagia. It is also known as diffuse idiopathic skeletal hyperostosis (DISH) syndrome or vertebral ankylosing hyperostosis. Forestier syndrome consists of anterolateral perivertebra...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480500504192

    authors: Aydin E,Akdogan V,Akkuzu B,Kirbaş I,Ozgirgin ON

    更新日期:2006-07-01 00:00:00

  • Expression of Toll-like receptors in cultured nasal epithelial cells.

    abstract:CONCLUSIONS:Nasal epithelial cells are constitutively equipped with all Toll-like receptors (TLRs) which are essential for innate immunity. Both mRNA and protein levels of TLR3 expression increased in more differentiated nasal epithelial cells. Considering that the ligand for TLR3 is viral dsRNA, this result is in good...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480601089416

    authors: Lin CF,Tsai CH,Cheng CH,Chen YS,Tournier F,Yeh TH

    更新日期:2007-04-01 00:00:00

  • Expression of vascular cell adhesion molecule-1, alpha4-integrin and L-selectin during inner ear immunity reaction.

    abstract::The expression of vascular cell adhesion molecule-1 (VCAM-1), alpha4-integrin and L-selectin was dynamically observed using an immunohistochemical approach during labyrinthitis induced by inoculation of keyhole limpet hemocyanin into the scala tympani of animals that had been systemically sensitized to it. At the same...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/000164800750000414

    authors: Zhang C,Huang W,Song H

    更新日期:2000-08-01 00:00:00

  • Nasal obstruction and rhinorrhea reflect nonspecific nasal hyper-reactivity as evaluated by cold dry air provocation.

    abstract:CONCLUSION:Nasal obstruction, rhinorrhea, and the amount of rhinorrhea that confidently reflect the parasympathetic stimulation can be used to more precisely predict nonspecific nasal hyper-reactivity (NHR). OBJECTIVE:We aimed to identify factors that confidently reflected the presence and the degree of NHR, measured ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2012.681798

    authors: Kim YH,Jang TY

    更新日期:2012-10-01 00:00:00

  • Clinical profile of hearing loss in children with congenital cytomegalovirus (CMV) infection: CMV DNA diagnosis using preserved umbilical cord.

    abstract:CONCLUSIONS:Congenital cytomegalovirus (CMV) infection is a major cause of bilateral and unilateral sensorineural hearing loss (SNHL) in children, accounting for 9.0% of SNHL cases. The diagnostic rate using combined genetic deafness test and CMV DNA detection test was determined to be 46.4% in bilateral profound SNHL....

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2011.583268

    authors: Furutate S,Iwasaki S,Nishio SY,Moteki H,Usami S

    更新日期:2011-09-01 00:00:00

  • Inflammatory cells and mediator concentrations in nasal secretions of patients with cystic fibrosis.

    abstract::In this study, cytological examination of nasal secretions of 17 patients with cystic fibrosis (CF) was combined with quantitative determination of common inflammatory mediators. Results showed a normal cytogram in these patients. However, obvious mucosal inflammation is evidenced by significantly higher concentration...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489609137875

    authors: Wang D,Brihaye P,Smitz J,De Waele M,Clement P

    更新日期:1996-05-01 00:00:00

  • Effects of Semont maneuver on benign paroxysmal positional vertigo: a meta-analysis.

    abstract:BACKGROUND:Benign paroxysmal positional vertigo (BPPV) is the most common type of peripheral vertigo. This study aimed to evaluate the effects of the Semont maneuver (SM) for BPPV treatment, compared with other methods. METHODS:Studies were selected in relevant databases under pre-defined criteria up to June 2015. The...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,meta分析

    doi:10.1080/00016489.2016.1212265

    authors: Zhang X,Qian X,Lu L,Chen J,Liu J,Lin C,Gao X

    更新日期:2017-01-01 00:00:00

  • The prevalence of hypothyroidism after treatment for laryngeal and hypopharyngeal carcinomas: are autoantibodies of influence?

    abstract:CONCLUSIONS:The incidence rate of hypothyroidism after treatment for laryngeal and hypopharyngeal cancer is high, especially after combination treatment. An association between hypothyroidism and autoantibodies was found. OBJECTIVES:The incidences of hypothyroidism and autoantibodies were assessed retrospectively in 1...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480600818096

    authors: Lo Galbo AM,de Bree R,Kuik DJ,Lips PT,Mary B,Von Blomberg E,Langendijk JA,Leemans CR

    更新日期:2007-03-01 00:00:00

  • Diagnostic airway pressure recording in sleep apnea syndrome.

    abstract::A comparison was made between polysomnographic recordings and recordings of airflow pressures in the pharynx and respiratory pressures in the esophagus of 10 adult sleeping subjects with differing degrees of apnea. Pressure measurements were obtained by microsensors mounted on a 7F gauge flexible catheter which sited ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489509139346

    authors: Tvinnereim M,Cole P,Haight JS,Hoffstein V

    更新日期:1995-05-01 00:00:00

  • Spindle-cell tumours of the larynx: diagnostic pitfalls. A case report and review of the literature.

    abstract::Malignant laryngeal tumours with spindle-cell morphology are relatively rare. Differential diagnosis of spindle-cell carcinoma, leiomyosarcoma, fibrosarcoma, rhabdomyosarcoma, malignant melanoma and inflammatory myofibroblastic tumour may be particularly difficult. Ambiguous and indeterminate diagnoses are also possib...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/0036554021000028070

    authors: Marioni G,Bottin R,Staffieri A,Altavilla G

    更新日期:2003-01-01 00:00:00

  • Ultrastructural features of vocal fold nodules and polyps.

    abstract::Earlier investigation did not show any clear distinctive pathological features that differentiate vocal polyps from vocal nodules. The light microscopic distinctive features between the two lesions point in the direction of a more pronounced epithelial reaction and a more fibrous stromal change in vocal nodules. In th...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488809119505

    authors: Kotby MN,Nassar AM,Seif EI,Helal EH,Saleh MM

    更新日期:1988-05-01 00:00:00

  • Cholesteatoma in an Asian population.

    abstract::Two hundred Malaysian patients representing 227 ears with previously untreated cholesteatoma disease were analysed retrospectively in terms of i) type of disease, i.e. primary acquired attic defect or posterior superior retraction pocket and secondary acquired type cholesteatoma; ii) positive history of previous middl...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489109138380

    authors: Lee ST

    更新日期:1991-01-01 00:00:00

  • The totally implantable middle ear device 'Esteem' for rehabilitation of severe sensorineural hearing loss.

    abstract:CONCLUSION:The Esteem(®) device proved to offer beneficial results in subjects suffering from high frequency, severe bilateral sensorineural hearing loss (SNHL) and may be considered as an alternative procedure to conventional hearing aids (HAs) or electroacoustic stimulation (EAS) systems. OBJECTIVES:Since the Esteem...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2010.536994

    authors: Barbara M,Biagini M,Monini S

    更新日期:2011-04-01 00:00:00

  • Localisation of secretory leucocyte proteinase inhibitor mRNA in nasal mucosa.

    abstract::Human secretory leucocyte proteinase inhibitor (SLPI) is a low-molecular weight, acid-stable inhibitor of polymorph-nuclear granulocyte elastase and cathepsin G. Previous reports have demonstrated the existence of SLPI in the respiratory tract, salivary glands and cervical mucosa. Positive staining for SLPI using immu...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489409126042

    authors: Westin U,Fryksmark U,Polling A,Ohlsson K

    更新日期:1994-03-01 00:00:00

  • Sound lateralization ability of patients with bilateral microtia and atresia after bilateral reconstruction of auricles and external auditory canals and fitting of new canal-type hearing aids to replace a bone conduction hearing aid.

    abstract:CONCLUSION:Each of eight patients with bilateral microtia and atresia underwent bilateral reconstruction of the auricles and external auditory canals and were fitted bilateral canal-type hearing aids in the operated ears to replace a bone conduction hearing aid. The ability to discriminate inter-aural intensity differe...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2016.1249947

    authors: Kaga K,Asato H

    更新日期:2017-04-01 00:00:00

  • Application of a rapid-prototyped temporal bone model for surgical planning.

    abstract:CONCLUSION:This 3D prototyped model constructed using a selective laser sintering method serves as a good material for surgical simulation of a malformed ear. OBJECTIVE:In order to perform surgery of the malformed ear, a thorough understanding of the anatomy of the ear is required, together with sufficient experience....

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480410016874

    authors: Suzuki M,Hagiwara A,Kawaguchi S,Ono H

    更新日期:2005-01-01 00:00:00

  • Analysis of curves Na-24 efflux from membrane labyrinth containing stria vascularis.

    abstract::The efflux of Na-24 was investigated in isolated labyrinths from a membrane section containing stria vascularis and spiral ligament in artificial endolymph medium. The efflux curves were calculated and compartmental analyses were made. The theoretical possibility of a exchange of sodium between compartments connected ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487509121308

    authors: Mnich Z

    更新日期:1975-07-01 00:00:00

  • Posturographic limits of stability can predict the increased risk of falls in elderly patients with instability?

    abstract:CONCLUSIONS:There was a difference in average score of the sensory organization test (SOT) of the case group (elderly instability) compared to the control group (healthy subjects). Cases had worse scores on the limits of stability (LOS) than controls, but were only able to confirm statistically significant differences ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2016.1201591

    authors: Faraldo-García A,Santos-Pérez S,Rossi-Izquierdo M,Lirola-Delgado A,Vaamonde-Sánchez-Andrade I,Del-Río-Valeiras M,Soto-Varela A

    更新日期:2016-11-01 00:00:00

  • Di-K19Hc, an antimicrobial peptide as new ototopical agent for treatment of otitis media.

    abstract:CONCLUSION:Di-K19Hc is a promising new ototopical antibiotic for treatment of middle ear infections associated with antibiotic-resistant bacteria. OBJECTIVES:Di-K19Hc was previously shown to exert profound antimicrobial activity against a variety of antibiotic-resistant bacteria and fungi. In this study, we evaluated ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016480903536036

    authors: Lee YS,Kim YJ,Choi SH,Shin KH,Jang WS,Lee IH,Chung JW

    更新日期:2010-08-01 00:00:00

  • Cross-coupling between horizontal and vertical eye movements during optokinetic nystagmus and optokinetic afternystagmus elicited in microgravity.

    abstract::The occurrence of horizontal jerks with larger amplitudes than on Earth was observed during vertical optokinetic nystagmus in astronauts tested throughout a 7-day spaceflight. During early exposure to microgravity, a horizontal spontaneous-like nystagmus was recorded in darkness following both vertical and horizontal ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489009107432

    authors: Clement G,Berthoz A

    更新日期:1990-03-01 00:00:00

  • The dynamic illegible E-test. A technique for assessing the vestibulo-ocular reflex.

    abstract::The Dynamic Illegible E (DIE) test measures visual acuity with head held still while reading a specially designed visual acuity chart of E's. The head is then moved passively and the change in visual acuity is recorded. The DIE test has previously been shown to be very useful for assessing patients with aminoglycoside...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:

    authors: Longridge NS,Mallinson AI

    更新日期:1987-03-01 00:00:00

  • Patients' perceptions of vocal problems: results from a survey in the Tokyo area.

    abstract::Laryngoscopy in cases of sulcus vocalis reveals bowed vocal folds, resulting in a spindle-shaped chink with glottal incompetence. The anatomic and functional problems and resulting incomplete glottal closure during phonation lead to the presenting symptoms of breathy hoarseness, decrease in maximum phonation time (MPT...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,评审

    doi:10.3109/00016489.2014.999873

    authors: Tsunoda K,Fujimaki Y,Nito T,Yamasoba T,Tayama N,Makiyama K,Murofushi T,Tsunoda A,Ohshima K,Nishiyama K,Kano S,Niimi S

    更新日期:2015-06-01 00:00:00

  • Induction of MUC5AC mucin expression by histamine through the activation of its core promoter region.

    abstract:CONCLUSION:This study provides evidence that histamine induced MUC5AC mRNA expression through the activation of the core region of its promoter. It may also help in approaching new therapeutic strategies in airway mucins hypersecretory diseases. OBJECTIVE:Mucin hypersecretion characterizes several respiratory diseases...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2015.1017890

    authors: Xu F,Zhang L,Gao J,Wang D

    更新日期:2015-07-01 00:00:00

  • Early detection of hearing impairment in patients with diabetes mellitus with otoacoustic emission. A systematic review and meta-analysis.

    abstract:CONCLUSIONS:The distortion product otoacoustic emission (DPOAE) amplitudes in diabetics were significantly lower than those in controls when pure tone audiometry (PTA) was within normal limits, implying cochlear function impairment in the early stage of diabetes mellitus. Retrocochlear damage was suggested by elongated...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,meta分析,评审

    doi:10.1080/00016489.2016.1223344

    authors: Hao J,Fu X,Zhang C,Zhang X,Zhao S,Li Y

    更新日期:2017-02-01 00:00:00

  • Vestibulo-oculomotor disturbances in trigeminal neuralgia and hemifacial spasm.

    abstract::Patients with hemifacial spasm and trigeminal neuralgia later treated with microvascular decompression and surgical interposition for their vascular loop disturbance were investigated preoperatively with electronystagmography, saccade test and audiometry. Some of them underwent an extended investigation including comp...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488809119522

    authors: Odkvist LM,Thell J,von Essen C

    更新日期:1988-05-01 00:00:00

  • Cell proliferation in the endolymphatic sac in situ after inner ear immunostimulation.

    abstract::Cell proliferation in the endolymphatic sac (ES) after immunostimulation was assessed immunohistochemically. Guinea pigs were employed as experimental animals and keyhole limpet hemocyanin was used as the antigen. After i.p. injection of 5-bromo-2'-deoxyuridine (BrdUrd), the BrdUrd+ cells were counted to assess the nu...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489509139336

    authors: Takahashi M,Tomiyama S

    更新日期:1995-05-01 00:00:00

  • Frequency preference in cervical vestibular evoked myogenic potential of idiopathic otolithic vertigo patients. Does it reflect otolithic endolymphatic hydrops?

    abstract:CONCLUSION:Idiopathic otolithic vertigo (IOV) with relatively long duration of attacks might be caused by endolymphatic hydrops in the otolith organ. OBJECTIVES:To clarify the pathophysiology underlying IOV, episodic tilting or translational sensation attacks by unknown causes, especially the possibility of endolympha...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2015.1022834

    authors: Murofushi T,Komiyama S,Hayashi Y,Yoshimura E

    更新日期:2015-01-01 00:00:00

  • Vestibular recruitment and decruitment.

    abstract::Serial Thermal Vestibulometry with the application of increasing caloric stimuli (corresponding to decreasing temperature of water at successive irrigration of the ears) was performed on normal subjects and patients with lesions in the central nervous system involving the statoacoustic subsystem. The normal values and...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487909137164

    authors: Ghosh P,Kacker SK

    更新日期:1979-01-01 00:00:00

  • Help-seeking behaviour of hearing-impaired persons aged > or = 55 years; effect of complaints, significant others and hearing aid image.

    abstract:OBJECTIVE:To determine factors influencing help-seeking behaviour in hearing-impaired persons aged > or = 55 years MATERIAL AND METHODS:The study comprised 1,419 persons (480 females, 939 males) aged > or = 55 years who participated voluntarily in a driving test. Pure-tone audiometry was performed in all subjects. Par...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/0001648031000719

    authors: Duijvestijn JA,Anteunis LJ,Hoek CJ,Van Den Brink RH,Chenault MN,Manni JJ

    更新日期:2003-09-01 00:00:00