Abstract:
CONCLUSIONS:Nasal epithelial cells are constitutively equipped with all Toll-like receptors (TLRs) which are essential for innate immunity. Both mRNA and protein levels of TLR3 expression increased in more differentiated nasal epithelial cells. Considering that the ligand for TLR3 is viral dsRNA, this result is in good accordance with previous reports demonstrating that more differentiated airway epithelial cells have increased resistance to rhinovirus infection. OBJECTIVE:Nasal epithelial cells use innate immune responses to combat inspired potential pathogens. TLRs are receptors that recognize pathogen-associated molecular patterns of microbes. Therefore, we investigated the expression of TLRs in cultured nasal epithelial cells obtained from nasal polyps. MATERIALS AND METHODS:Submerged single layer (SSL) and air-liquid interface (ALI) nasal epithelial cell cultures with or without 10(-7) M retinoid acid (+/- RA) were created. RESULTS:ALI + RA culture developed ciliary differentiation as observed by light and scanning electron microscopic examination in 3 weeks. It had higher interleukin (IL)-8 basal secretion (21.9 vs 0.82-1.45 ng/ml) and transepithelial potential (-20.4 mV). TLR1-10 mRNA expression in cultured nasal epithelial cells was determined by RT-PCR. Only TLR3 mRNA significantly increased at day 20 vs day 1 (n=5, p=0.02) in ALI + RA cell culture. Higher TLR3 protein was also expressed at day 20 in ALI + RA cell culture but not in SSL culture by western blotting.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Lin CF,Tsai CH,Cheng CH,Chen YS,Tournier F,Yeh THdoi
10.1080/00016480601089416subject
Has Abstractpub_date
2007-04-01 00:00:00pages
395-402issue
4eissn
0001-6489issn
1651-2251pii
777066536journal_volume
127pub_type
杂志文章abstract:OBJECTIVES:To investigate the outcome of pediatric tracheostomy and identify predictive factors for successful decannulation. METHODS:We performed a retrospective chart review of a series of 42 consecutive patients of less than 24 months of age who underwent a tracheostomy between 2012 and 2015. RESULTS:Successful de...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2017.1326064
更新日期:2017-10-01 00:00:00
abstract::The submucosal glands in the rat nose are characterized by the presence of both neutral and acid glycoproteins, which are important constituents of nasal and tracheobronchial secretions. This study is an attempt to gain a better insight into the secretion of these two types of glycoproteins and its neural regulation. ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709128287
更新日期:1987-11-01 00:00:00
abstract::Background: The various pathological types of non-squamous cell carcinomas (nSCCs) of the larynx accounted for about 5% laryngeal malignancies, but the knowledge regarding these pathological behaviors, therapeutic models and prognostic factors was limited.Objectives: To investigate the clinical characteristics and the...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2019.1700305
更新日期:2020-02-01 00:00:00
abstract::The change in the EP, CM, SP and AP during perilymphatic perfusion of vasopressin (antidiuretic hormone) was examined in the guinea pig. The EP was recorded with a microelectrode through the spiral ligament of the second turn. The CM, SP and AP were measured with the differential electrodes in the basal turn. The perf...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488609132830
更新日期:1986-03-01 00:00:00
abstract::Normal human subjects were exposed to repeated optokinetic afternystagmus (OKAN) testing in either one direction or alternating directions of stripe movement. Sessions were conducted at intervals of either one week or several weeks. Repeated exposure to OKAN stimulation in one direction produced significant response d...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488509119150
更新日期:1985-01-01 00:00:00
abstract::To elucidate immune mechanisms in otitis media, middle ear infection was induced in 12 rats by intratympanic inoculation of Streptococcus pneumoniae type 3, either the ipsilateral or the contralateral middle ear being re-challenged 4 weeks later. Otomicroscopy inspection confirmed the presence of acute otitis media (A...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109100760
更新日期:1991-01-01 00:00:00
abstract::The objective of this study was to examine the outcome of unilateral stapes surgery in one patient group with bilateral hearing loss and one group with unilateral hearing loss. The patients' own estimations of improvement in hearing ability and the occurrence of other ear-related symptoms were examined retrospectively...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950180982
更新日期:1999-01-01 00:00:00
abstract::Conclusion Neck dissection after radiotherapy increased the risk of aspiration as a late effect in a sub-sample of patients treated for head and neck cancer in the ARTSCAN study. Patients treated with accelerated fractionation (AF) developed aspiration, with or without coughing, more frequently than patients treated w...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3109/00016489.2015.1113439
更新日期:2016-01-01 00:00:00
abstract::The efflux of Na-24 was investigated in isolated labyrinths from a membrane section containing stria vascularis and spiral ligament in artificial endolymph medium. The efflux curves were calculated and compartmental analyses were made. The theoretical possibility of a exchange of sodium between compartments connected ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487509121308
更新日期:1975-07-01 00:00:00
abstract::The postnatal development of lower stations in the auditory pathway was studied in the guinea pig by recording auditory brainstem potentials. At birth, the brainstem responses of young guinea pigs already have thresholds corresponding to those of adult animals. However, the latencies of the individual potentials are s...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409130965
更新日期:1984-01-01 00:00:00
abstract::The ultrastructural pattern of the acoustic nerve Schwannoma was studied on surgically excised tumours and on explants cultured in vitro. The typical neoplastic cell is elongated, spindle-shaped, coated with basement membrane and numerous protruding cellular processes. Cells demonstrating numerous microfilaments are a...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488509108909
更新日期:1985-03-01 00:00:00
abstract::The transitional zone of the saccule and the utricle--has been studied by transmission electron microscope in rats, days before birth. A noticeable secretory activity has been observed in their cells as well as the presence of inorganic spicular bodies that have also been observed in the lumen, some of them integrated...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309139436
更新日期:1983-05-01 00:00:00
abstract::One hundred and fifty-five patients with complaints indicating acute sinusitis were examined and their symptoms and signs registered. The final diagnosis--maxillary sinus empyema versus not empyema--was established by means of antral aspiration. A computer-based analysis of clinical data demonstrated the significance ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809097017
更新日期:1988-03-01 00:00:00
abstract::Human secretory leucocyte proteinase inhibitor (SLPI) is a low-molecular weight, acid-stable inhibitor of polymorph-nuclear granulocyte elastase and cathepsin G. Previous reports have demonstrated the existence of SLPI in the respiratory tract, salivary glands and cervical mucosa. Positive staining for SLPI using immu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489409126042
更新日期:1994-03-01 00:00:00
abstract::In order to determine the characteristics of the vestibulo-ocular reflexes (VORs) as a function of age and posturo-motor development, a group of 26 normal children (6 to 25 months old) were tested at three different stages of posturo-motor control: prior to as well as during the first attempts to walk without support,...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract:CONCLUSION:Utricular dysfunction in patients with posterior canal benign paroxysmal positional vertigo (pBPPV) was supported by findings for ocular vestibular evoked myogenic potential (oVEMP). OBJECTIVE:To evaluate the utricular and saccular function in patients with pBPPV. METHODS:This study focused on 12 patients ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.720030
更新日期:2013-02-01 00:00:00
abstract::Background: The treatments of horizontal semicircular canal benign paroxysmal positional vertigo (HSC-BPPV) have low remission rates ranging between 60% and 90%, connected to the difficulty in correctly identifying the affected side of HSC-BPPV. Objective: To propose and compare the efficacy of the latency test (LT) i...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2019.1635712
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between hearing loss and vestibular dysfunction in patients with sudden sensorineural hearing loss (SSHL). METHODS:Clinical data including the symptom of vertigo of 149 SSHL patients were investigated retrospectively. Pure tone audiometry, ocular vestibular-evoked myogenic pot...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1110750
更新日期:2016-01-01 00:00:00
abstract::An influence of complete mechanical obstruction of the nasal passages was investigated in 6 apneic-free sons of fullblown sleep apnea patients and in 4 age-matched normal young adults without a familial history of sleep apnea. Nasal obstruction caused a significant increase in the number of sleep apneas in the sons of...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409130972
更新日期:1984-01-01 00:00:00
abstract:INTRODUCTION:Bilateral cochlear implants are seen to improve hearing capabilities. OBJECTIVE:To assess the auditory outcome of paediatric bilateral cochlear implant in Universiti Kebangsaan Malaysia. MATERIALS AND METHODS:This was a cross-sectional and descriptive study single centre analysis. Categories of Auditory ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1775887
更新日期:2020-10-01 00:00:00
abstract:CONCLUSION:Cochlear implantation (CI) for Japanese single-sided deafness patients resulted in improved speech perception, increased sound localization accuracy, and reduced tinnitus handicap. OBJECTIVES:This study reports results for five adult SSD cases with CI, focusing on the benefits they obtained in terms of spee...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,多中心研究
doi:10.3109/00016489.2015.1116046
更新日期:2016-01-01 00:00:00
abstract::683 tumour fragments from 63 head and neck carcinoma patients were cultured in vitro. Two laryngeal carcinomas and two salivary gland carcinomas were established into permanent cell lines. Malignancy of these cultured cells was proved by cloning, by chromosomal analysis and by transplantation into athymic (nu/nu) mice...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309130956
更新日期:1983-03-01 00:00:00
abstract::Visuo-vestibular interaction during randomized and sinusoidal head oscillations (0.5-5.0 Hz) was measured by power spectral analysis. It was shown that visual eye movement programmes can adjust the vestibulo-ocular reflex (VOR) gain at frequencies exceeding the dynamic range of visual tracking: above 3 Hz, gains excee...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209128889
更新日期:1982-07-01 00:00:00
abstract::We investigated the redistribution of facial motor neurons after recovery from a crush injury of the facial nerve in the mongolian gerbil, with the retrograde transportation of horseradish peroxidase (HRP) technique. The facial nerve at the vertical segment was crushed unilaterally for 10 s with forceps. After 1 month...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509139307
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVE:Proteomic analysis with 2D electrophoresis and matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) may be a powerful tool for identifying and characterizing the specific proteins relating to the pathogenesis of some diseases, including cholesteatoma. The purpose of ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480410017882
更新日期:2004-09-01 00:00:00
abstract::EMG recordings of the neck muscles (biventer cervicis, complexus, splenius, longus capitis) of decerebrate cats were obtained during pitch and roll stimulations (sinusoidal stimulation: 30 degrees p-p amplitude, 0.2 Hz frequency). Most of the EMG responses to pitch showed activation peaks leading the position stimuli ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489309135800
更新日期:1993-05-01 00:00:00
abstract::The efficacy of diclofenac suppositories was estimated in a two-centre, double-blind, placebo-controlled study comprising 97 patients (47 in the diclofenac group and 50 in the placebo group). The series from the two centres and patients in the two treatment groups were comparable. Immediately postoperatively, the pati...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016488409107553
更新日期:1984-07-01 00:00:00
abstract::As part of an early intervention study on the acceptability of auditory rehabilitative intervention, we examined patient complaints and clinical findings of balance disorders. Hallam et al. have discussed desynchrony between such findings in hospital patient populations, and the aim of the present study was to investi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109137373
更新日期:1991-01-01 00:00:00
abstract::Ionic mechanisms sustaining sensory transduction in crista ampullaris sensory cells have been investigated chiefly by replacing the endolymph with solutions with K+ and Ca++ chelators added. The effects of the modified solutions were evaluated by extracellular and intracellular recordings of both and the presynaptic a...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209130893
更新日期:1982-05-01 00:00:00
abstract::Experimental animals (cats) were exposed to tones of 125, 1000, 2000, and 4000 Hz at sound pressure levels in the range 120 to 157.5 dB, and for durations of one hour (1000, 2000, 4000 Hz) or four hours (125 Hz). Pure tone audiograms were obtained for each animal before and after exposure. Post-exposure tests were con...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487509121336
更新日期:1975-11-01 00:00:00