Di-K19Hc, an antimicrobial peptide as new ototopical agent for treatment of otitis media.

abstract：:In a previous communication, we demonstrated that the introduction of air into the scala tympani of the cochlea causes a decrease of cochlear potentials; however, the change in endocochlear dc potential (EP) was mild and the decreased cochlear microphonics (CM) and compound action potentials (CAP) were, at least parti...

journal_title：Acta oto-laryngologica

authors： Kobayashi T,Sakurada T,Ohyama K,Takasaka M

更新日期：1993-11-01 00:00:00

abstract：:In a previous study (1) it was found that in healthy subjects Ocular (Counter) Rotation is mainly due to otolith stimulation and only to a minor extent induced by slanted visual structures. Stimulation of the neck by tilting the trunk laterally upwards did not result in a systematic rotation of the eyes. In the presen...

journal_title：Acta oto-laryngologica

authors： Bles W,de Graaf B

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:To ascertain whether a daily nasal spray with physiological saline could prevent symptoms of common cold in a population of otherwise healthy adults. MATERIAL AND METHODS:This was study involving 10 weeks of daily use of a nasal saline spray and 10 weeks of only recording symptoms. Young adults eligible for ...

journal_title：Acta oto-laryngologica

authors： Tano L,Tano K

更新日期：2004-11-01 00:00:00

abstract：CONCLUSION:Cochlear implantation assessment is possible using commercially available standard flat-detector computed tomography (FD-CT) protocols. Image quality is superior to multislice CT (MSCT). The radiation dose of FD-CT is lower in comparison with MSCT standard protocols and may therefore overcome the limitations...

journal_title：Acta oto-laryngologica

authors： Struffert T,Hertel V,Kyriakou Y,Krause J,Engelhorn T,Schick B,Iro H,Hornung J,Doerfler A

更新日期：2010-04-01 00:00:00

abstract：CONCLUSION:Our findings suggest that there exists a Na(+) transport system in the cochlea consisting of SGK1, Nedd4 isoforms and ENaC, which may work in concert to transport Na(+) and to maintain homeostasis in the inner ear as they do in other tight epithelia. OBJECTIVES:It has been well demonstrated that the epithel...

journal_title：Acta oto-laryngologica

authors： Zhong SX,Liu ZH

更新日期：2009-09-01 00:00:00

abstract：:Cochlear microphonics (CM) were recorded in the guinea pig using differential recording from the first and third cochlear turns as well as by using a 10-electrode array inserted in the scala tympani of the basal turn. The excitation profile as represented by the CM was quantified by amplitude and phase data, and was m...

journal_title：Acta oto-laryngologica

authors： de Brey HB,Eggermont JJ

更新日期：1978-05-01 00:00:00

abstract：OBJECTIVE:To determine the clinical usefulness of the dichotic multiple-frequency (MF) auditory steady-state response (ASSR) technique for estimating normal hearing compared to a 0.5-kHz tone burst and broadband click auditory brainstem response (ABR) protocol in a sample of adults. MATERIAL AND METHODS:A comparative ...

journal_title：Acta oto-laryngologica

authors： Swanepoel D,Schmulian D,Hugo R

更新日期：2004-01-01 00:00:00

abstract：CONCLUSION:Nitric oxide synthase (NOS) II induction is a protective mechanism against age-related degeneration of the cochlea. OBJECTIVES:An induction of NOS II has been described in different inner ear pathologies. The objective was to examine the role of NOS II in age-related degeneration of the cochlea. METHODS:Th...

journal_title：Acta oto-laryngologica

authors： Labbé D,Bloch W,Schick B,Michel O

更新日期：2016-10-01 00:00:00

abstract：:Background： Atoh1, also named Math1, is essential for the development of inner ear hair cells. Many studies have confirmed that the absence of Atoh1 resulted in a total loss of inner ear hair cells, which indicates that Atoh1 plays very similar roles in the development of hair cells in the cochlea and vestibule. Objec...

journal_title：Acta oto-laryngologica

authors： Zhang Y,Tang Q,Xue R,Gao J,Yang H,Gao Z,Lin G

更新日期：2018-11-01 00:00:00

abstract：:Eight patients with dystrophia myotonica (Steinert) were studied. They all had myotonia and pathological EMG and in some cases other signs of the disease. The 50% relaxation times of the stapedius reflex were significantly prolonged compared with a control group of 40 healthy, young subjects with normal hearing and no...

journal_title：Acta oto-laryngologica

authors： Zakrisson JE,Blom S

更新日期：1982-11-01 00:00:00

abstract：:Urokinase-type plasminogen activator (uPA) is important for matrix degradation and motility of cancer cells. The binding of uPA to its cell surface receptor on cancer cells is essential for effective invasion. A soluble form of urokinase receptor (suPAR) has been described in serum and ascites of ovarian cancer patien...

journal_title：Acta oto-laryngologica

authors： Schmidt M,Hoppe F

更新日期：1999-01-01 00:00:00

abstract：CONCLUSION:The approach described in this paper may be helpful in establishing an early-warning, evidence-based mechanism for diagnosing vertigo, which can be utilized in medical education to reduce medical uncertainty. OBJECTIVE:To use an evidence-based medicine approach to evaluate the probability of having vertigo ...

journal_title：Acta oto-laryngologica

authors： Yuan BC,Tzeng HM

更新日期：2006-01-01 00:00:00

abstract：:The postnatal development of the Eustachian tube (ET) and its surrounding structures was investigated by means of computer-aided three-dimensional (3-D) reconstruction methods in 13 normal human temporal bones, obtained from individuals 3 months to 71 years old. The cross-sectional area, width and height of the lumen ...

journal_title：Acta oto-laryngologica

authors： Suzuki C,Balaban C,Sando I,Sudo M,Ganbo T,Kitagawa M

更新日期：1998-11-01 00:00:00

abstract：:Paclitaxel (Taxol) is an antimicrotubular agent which blocks the cells in the G2/M phase of the cell cycle. Because of this mechanism it is presumed that this drug could function as a radiation sensitizer. The cytotoxic and genotoxic effects of paclitaxel and a combination of paclitaxel and radiation were studied in t...

journal_title：Acta oto-laryngologica

authors： Preisler VK,Stopper H,Schindler D,Friedl R,Pfreundner L,Hoppe F,Hagen R

更新日期：1998-07-01 00:00:00

abstract：:Cell proliferation in the endolymphatic sac (ES) after immunostimulation was assessed immunohistochemically. Guinea pigs were employed as experimental animals and keyhole limpet hemocyanin was used as the antigen. After i.p. injection of 5-bromo-2'-deoxyuridine (BrdUrd), the BrdUrd+ cells were counted to assess the nu...

journal_title：Acta oto-laryngologica

authors： Takahashi M,Tomiyama S

更新日期：1995-05-01 00:00:00

abstract：CONCLUSION:GABA-mediated inhibition is responsible for the duration tuning in the inferior colliculus (IC) of guinea pigs, a non-echo-locating mammal. Duration tuning in this species is better demonstrated in an appropriate short time window. OBJECTIVES:To investigate the role of GABA-mediated inhibition in duration t...

journal_title：Acta oto-laryngologica

authors： Yin S,Chen Z,Feng Y,Wang J

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:Proteomic analysis with 2D electrophoresis and matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) may be a powerful tool for identifying and characterizing the specific proteins relating to the pathogenesis of some diseases, including cholesteatoma. The purpose of ...

journal_title：Acta oto-laryngologica

authors： Kim JL,Jung HH

更新日期：2004-09-01 00:00:00

abstract：:Background: Chronic rhinosinusitis (CRS) is an inflammatory disease of the nose and the paranasal sinuses, often associated with an infection by Staphylococcus aureus (S. aureus). Disturbance in the function of ion channels is regarded as an etiological factor for pathogenesis of CRS. Aims: The study aims to measure t...

journal_title：Acta oto-laryngologica

authors： Saber A,Nakka SS,Hussain R,Hugosson S

更新日期：2019-07-01 00:00:00

abstract：:Organophosphorus compounds in the form of insecticides are in widespread use and have recently attracted considerable interest as environmentally toxic agents. As little is known about the effect of environmental toxins on the tubal function in the ear, we studied the middle ear pressure necessary to force the eustach...

journal_title：Acta oto-laryngologica

authors： Bergler W,Juncker C,Petroianu G,Keilmann A,Hörmann K

更新日期：1995-07-01 00:00:00

abstract：:The nasal airways of 94 healthy term infants (37-42 weeks gestational age) were examined by continuous wide-band noise acoustic rhinometry under standardized conditions on the second or third day postpartum. Validation of the flexible infant probe on tubular plastic models with dimensions similar to the nasal cavity o...

journal_title：Acta oto-laryngologica

authors： Djupesland PG,Lyholm B

更新日期：1997-05-01 00:00:00

abstract：CONCLUSIONS:This study showed that macrophages, B cells, and T cells occurred at different frequencies, localizations, and times after acute laser tympanic membrane perforation. Immunological cells were most prevalent in the proliferative mass adjacent to the annulus region. The cellular immunological response in fresh...

journal_title：Acta oto-laryngologica

authors： Tahar Aissa J,Hultcrantz M

更新日期：2009-11-01 00:00:00

abstract：:Although doxorubicin [adriamycin (ADM)] ototoxicity has not been detected to date, it has been reported that neurotoxicity in the central nervous system was induced by chemotherapy with ADM in patients receiving chronic cyclosporin A (CsA) treatment. ADM ototoxicity may be induced by combination therapy with CsA becau...

journal_title：Acta oto-laryngologica

authors： Saito T,Zhang ZJ,Tokuriki M,Shibamori Y,Yamamoto T,Noda I,Ohtsubo T,Saito H

更新日期：2001-10-01 00:00:00

abstract：:Background: Amyloidosis is a benign, slowly progressive disease. However, the treatment of laryngeal amyloidosis (LA) has not been studied systematically.Objectives: To investigate the treatment results of cold micro forceps or carbon dioxide laser under microlaryngoscope in the treatment of LA.Methods: A retrospectiv...

journal_title：Acta oto-laryngologica

authors： Wu X,Zhang J,Wei C

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVES:Hearing loss after spinal anesthesia has been reported to be related to the transmission of a reduced subarachnoid pressure to the inner ear via the cochlear aqueduct due to loss of spinal fluid. However, there are also some controversies related to this phenomenon, which require systematic investigation. M...

journal_title：Acta oto-laryngologica

authors： Cosar A,Yetiser S,Sizlan A,Yanarates O,Yildirim A

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:To investigate the hearing prognosis of idiopathic sudden sensorineural hearing loss (SSNHL) treated with different initial therapies. METHODS:Subjects consisted of patients diagnosed with idiopathic SSNHL within 7 days from onset and showing severe hearing loss (≥60 dB), who were registered in a Japanese mu...

journal_title：Acta oto-laryngologica

authors： Okada M,Hato N,Nishio SY,Kitoh R,Ogawa K,Kanzaki S,Sone M,Fukuda S,Hara A,Ikezono T,Ishikawa K,Iwasaki S,Kaga K,Kakehata S,Matsubara A,Matsunaga T,Murata T,Naito Y,Nakagawa T,Nishizaki K,Noguchi Y,Sano H,Sato

更新日期：2017-01-01 00:00:00

abstract：:In this experimental study in the rat, compound 48/80--a potent degranulating drug of mast cells--was instilled in the external auditory meatus towards the tympanic membrane. Moreover, effusion material was produced in the attic space by blocking the tympanic isthmus with a piece of Gelfoam applied through the tympani...

journal_title：Acta oto-laryngologica

authors： Alm PE,Bloom GD,Hellström S,Salén B,Stenfors LE

更新日期：1982-11-01 00:00:00

abstract：:Multimodality therapy of advanced malignant tumours of the head and neck includes surgery, radiotherapy and chemotherapy. However, the cure rate for these tumours is low and guidelines for the selection and timing of therapy are needed. For such guidelines, tumour cell kinetic parameter studies, e.g. cell proliferatio...

journal_title：Acta oto-laryngologica

authors： Wennerberg J,Tropé C,Biörklund A

更新日期：1983-01-01 00:00:00

abstract：CONCLUSION:The study showed that surgery in the maxillary sinus can affect its development. OBJECTIVE:To quantitatively evaluate the long-term impact of sinus surgery on its development in the rabbit. MATERIALS AND METHODS:This was an experimental study performed at an academic tertiary medical center using 20 4-week...

journal_title：Acta oto-laryngologica

authors： Bahadir O,Bahadir A,Kosucu P,Livaoglu M

更新日期：2008-05-01 00:00:00

abstract：:Substance P has been proved an important neurotransmitter and neuromodulator, serving not only as an excitatory transmitter of the first afferent synapse of pain pathways but as a valuable neuromodulator in the primary cortical areas of sensosensorial integration. In the human acoustic cortex, substance P has been fou...

journal_title：Acta oto-laryngologica

authors： Manolidis L,Baloyannis S,Manolidis S

更新日期：1989-05-01 00:00:00

abstract：:Mucormycosis is a rare acute fatal fungal infection. It is typically observed in diabetic or immunocompromised patients but not in systemically healthy individuals. Here, we describe an unusual mucormycosis case in an immunocompetent patient who had clinical signs of a maxillary sinusitis and associated osteomyelitis ...

journal_title：Acta oto-laryngologica

authors： Deboni MC,Pozzani VR,Lisboa T,Hiraki K,Viplich R,Naclério-Homem MG

更新日期：2006-09-01 00:00:00