The roles of local inhibition mediated by gamma-aminobutyric acid (GABA)-A receptor in duration tuning in the inferior colliculus of guinea pigs.

Abstract:

CONCLUSION:GABA-mediated inhibition is responsible for the duration tuning in the inferior colliculus (IC) of guinea pigs, a non-echo-locating mammal. Duration tuning in this species is better demonstrated in an appropriate short time window. OBJECTIVES:To investigate the role of GABA-mediated inhibition in duration tuning of neurons in the IC of guinea pigs. MATERIALS AND METHODS:Duration tuning pattern was recorded by measuring the spikes of single neurons in response to broadband noise of different durations. The effect of GABA-mediated inhibition was verified by comparing the responses with and without the use of the GABA-A receptor blocker bicuculline (BIC), which was applied using micro-iontophoresis. RESULTS:In addition to overall increase in responsiveness, the application of BIC was found to significantly reduce or eliminate the duration selectivity in 44 of the 67 neurons that showed clear duration tuning from a sample of total 340 neurons.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Yin S,Chen Z,Feng Y,Wang J

doi

10.1080/00016480701840122

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

1101-9

issue

10

eissn

0001-6489

issn

1651-2251

pii

793610233

journal_volume

128

pub_type

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