Can chronic nasal obstruction cause dysfunction of the paratubal muscles and otitis media? An experimental study in developing Wistar rats.

Abstract:

OBJECTIVE:To quantitatively analyze modifications of the paratubal muscles in developing Wistar rats following nasal obstruction. MATERIAL AND METHODS:Twenty-four Wistar rats were used. Twelve were examined at 6, 8 and 12 weeks after birth and were considered normal controls. The nostrils of the remaining 12 rats were bilaterally obstructed by means of a synthetic resin 28 days after birth. The animals were sacrificed at either 2, 4 or 8 weeks after nostril occlusion. Serial sections were made in the dorsoventral plane and stained with hematoxylin-eosin. Four 5 x 5 microm2 areas, selected within the paratubal muscles, were histologically analyzed and the number of muscular fibers was counted manually. RESULTS:The number of tensor veli palatini muscle fibers progressively decreased in the obstructed rats compared with age-matched normal controls and in those that had been obstructed for 4 and 8 weeks these reductions were statistically significant. CONCLUSION:The correct development of the paratubal muscles seems to be linked to physiological nasal breathing and is negatively affected by oral breathing.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Scarano E,Fetoni AR,Picciotti P,Cadoni G,Galli J,Paludetti G

doi

10.1080/00016480310001141

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

288-91

issue

2

eissn

0001-6489

issn

1651-2251

journal_volume

123

pub_type

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