Diazepam reduces excitability of amygdala and further influences auditory cortex following sodium salicylate treatment in rats.

Abstract:

CONCLUSION:Diazepam can reduce the excitability of lateral amygdala and eventually suppress the excitability of the auditory cortex in rats following salicylate treatment, indicating the regulating effect of lateral amygdala to the auditory cortex in the tinnitus procedure. OBJECTIVE:To study the spontaneous firing rates (SFR) of the auditory cortex and lateral amygdala regulated by diazepam in the tinnitus rat model induced by sodium salicylate. MATERIALS AND METHODS:This study first created a tinnitus rat modal induced by sodium salicylate, and recorded SFR of both auditory cortex and lateral amygdala. Then diazepam was intraperitoneally injected and the SFR changes of lateral amygdala recorded. Finally, diazepam was microinjected on lateral amygdala and the SFR changes of the auditory cortex recorded. RESULTS:Both SFRs of the auditory cortex and lateral amygdala increased after salicylate treatment. SFR of lateral amygdala decreased after intraperitoneal injection of diazepam. Microinjecting diazepam to lateral amygdala decreased SFR of the auditory cortex ipsilaterally and contralaterally.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Song Y,Liu J,Ma F,Mao L

doi

10.1080/00016489.2016.1204664

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

1220-1224

issue

12

eissn

0001-6489

issn

1651-2251

journal_volume

136

pub_type

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