Abstract:
:Although the association between gastroesophageal reflux disease (GERD) and laryngeal disorders in adults is well established there is still a lack of information concerning the true extent of the laryngeal complications of GERD in children. The aim of this study was to determine the laryngeal status of children with diagnosed GERD. We sought to identify the initial appearance of their larynges and then to determine the clinical response to antireflux therapy. GERD was recognized in 90/100 children examined. Using 24-h pH monitoring we found that most of the patients experienced episodes of gastroesophageal reflux during the daytime when they were in an upright position. The hallmark of GERD affecting the larynx in our group was posterior laryngitis, which is characterized by erythema of the mucous membrane overlying the arytenoid cartilages and the posterior mucosal wall of the glottis. The findings regarding the effectiveness of therapy were that, in children with severe laryngeal alterations, voice quality improved significantly after 12 weeks of antireflux treatment (p < 0.001) and laryngeal status was significantly better after 6 weeks of treatment (p < 0.001). This study provides evidence that gastroesophageal reflux in children is the underlying cause of inflammatory and morphological lesions, and that antireflux treatment is effective in reducing or eliminating these lesions.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Zalesska-Krecicka M,Krecicki T,Iwanczak B,Blitek A,Horobiowska Mdoi
10.1080/000164802753648213subject
Has Abstractpub_date
2002-04-01 00:00:00pages
306-10issue
3eissn
0001-6489issn
1651-2251journal_volume
122pub_type
杂志文章abstract::Cochlear microphonics (CM) were recorded in the guinea pig using differential recording from the first and third cochlear turns as well as by using a 10-electrode array inserted in the scala tympani of the basal turn. The excitation profile as represented by the CM was quantified by amplitude and phase data, and was m...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487809121465
更新日期:1978-05-01 00:00:00
abstract::The expression of vascular cell adhesion molecule-1 (VCAM-1), alpha4-integrin and L-selectin was dynamically observed using an immunohistochemical approach during labyrinthitis induced by inoculation of keyhole limpet hemocyanin into the scala tympani of animals that had been systemically sensitized to it. At the same...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800750000414
更新日期:2000-08-01 00:00:00
abstract::Based on the experimental results of thyroplasty, thyroplasty type I which aims at medical shifting the vocal cord was performed on 8 patients with dysphonia, 6 with vocal cord paralysis and 2 with vocal cord atrophy. The surgery was conducted on either in- or out-patient basis and local anesthesia was used. Usually, ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487509121353
更新日期:1975-11-01 00:00:00
abstract:HYPOTHESIS:To examine the cellular events following induced superficial lesions of the human tympanic membrane (TM). Such information could lead to enhanced appreciation of repair mechanisms and novel strategies to restore TM perforations. BACKGROUND:Persistent perforation of the TM in chronic otitis media is a major ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2017.1321139
更新日期:2017-09-01 00:00:00
abstract:CONCLUSION:The addition of transoral robotic surgery (TORS) in the diagnostic management of patients classified with head and neck squamous cell carcinoma of unknown primary (SCCUP) is promising and appears to improve detection rates of the primary tumour. The approach presented in this first Scandinavian study could p...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1052983
更新日期:2015-01-01 00:00:00
abstract::Acute and late phase (dual) symptomatic responses after allergen challenge commonly occur in allergic asthma. The aim of the present study was to explore the occurrence of allergen challenge-induced biphasic responses in patients with chronic perennial allergic rhinitis living in an area with high house dust mite (HDM...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164801300102950
更新日期:2001-04-01 00:00:00
abstract::The activity of central vestibular neurons (Vn) of the horizontal canal system was recorded in chronically hemilabyrinthectomized cats and compared with that of labyrinth intact animals. In both groups the cerebellar vermis was removed in order to assess the efficacy of the vestibular brainstem commissure alone by mea...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409107529
更新日期:1984-07-01 00:00:00
abstract::The ultrastructural pattern of the acoustic nerve Schwannoma was studied on surgically excised tumours and on explants cultured in vitro. The typical neoplastic cell is elongated, spindle-shaped, coated with basement membrane and numerous protruding cellular processes. Cells demonstrating numerous microfilaments are a...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488509108909
更新日期:1985-03-01 00:00:00
abstract:CONCLUSION:Surgery remains the preferred option for large vestibular schwannoma (VS). The presence of unpredictable intraoperative difficulties may convince the operator to suspend the surgery to avoid risks to patient life. Additional surgeries may be mandatory and are better performed using a transcochlear approach. ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1040170
更新日期:2015-09-01 00:00:00
abstract::The sympathetic nerve pathways to the nasal vasculature were examined in 8 cats by recoding the effects of section of the orbital nerves on vasoconstriction produced by cervical sympathetic nerve stimulation. No sympathetic fibres were found in the sphenopalatine and infraorbital nerves. The majority were conveyed by ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487709123967
更新日期:1977-09-01 00:00:00
abstract::This paper presents the results of an investigation into the possibility that gangliosides (brain cortex glycosphingolipids) are capable of being functionally incorporated into cell membranes and of interfering with enzymatic activity of the ATPase system on the stria vascularis and spiral ligament in the guinea pig. ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488109133282
更新日期:1981-11-01 00:00:00
abstract::In electrocochleography (ECochG) compound action potential (CAP) and summation potential (SP) are usually separated from the cochlear microphonic (CM) by the CM cancellation technique consisting in averaging the responses evoked by rarefaction and condensation clicks. With the aim of analysing the ECochG responses evo...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800750000892
更新日期:2000-03-01 00:00:00
abstract::IL2Rs, in the presence of IL2, mediate activation and proliferation of human normal lymphocytes and modulate functional changes of some human leukocytic malignancies. IL2Rs have been demonstrated also on human neoplastic and fetal non-hematologic cells in vitro, although their functional role has not been described. W...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.1992.11665436
更新日期:1992-01-01 00:00:00
abstract::The vascular pattern of the rat cochlea was demonstrated by the aid of Berlin Blue (Prussian Blue) contrast. The vascular anatomy is similar to other mammals. The infrequent occurrence of the vessel of the basilar membrane under the organ of Corti is interesting in respect to its presumed importance for the oxygen sup...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488009127102
更新日期:1980-01-01 00:00:00
abstract::Between 1992 and 1996 14 patients with a squamous cell carcinoma of the laryngohypopharynx underwent tumour resection and primary reconstruction with the free volar forearm flap. Tumour resection was performed by a head and neck surgeon and reconstruction by a plastic surgeon. Preoperative radiotherapy was given to 13...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489850183548
更新日期:1998-06-01 00:00:00
abstract::Juvenile nasopharyngeal angiofibroma is a disease afflicting mainly adolescent males. The lesion is benign but characterized by local aggressive growth. In advanced cases the tumour may extend intracranially. In this study 18 cases of juvenile nasopharyngeal angiofibroma were investigated. Tumour extension was assesse...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809119456
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:Ischemic vascular damage of the inner ear is one of the known causes of sensorineural sudden hearing loss (SSHL). Folate is an emerging risk factor associated with an increased risk of vascular damage. The aim of this study was to investigate whether low serum folate levels are associated with SSHL. MATERIAL...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480410016216
更新日期:2004-06-01 00:00:00
abstract::Head and neck surgeons hesitate to resect the carotid artery because of the postoperative risk of neurologic sequelae. However, there is no curative therapeutic option for head and neck neoplasms involving the carotid artery, with the exception of complete tumor removal. To evaluate the benefits and risks of carotid r...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480260092417
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVES:The aim of this prospective study was to assess the usefulness of nasal smear eosinophilia compared with a skin sensitivity test for the diagnosis of allergic rhinitis and to determine the degree of correlation between the tests. MATERIAL AND METHODS:Fifty patients with a clinical history suggestive of nasa...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310002159
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between hearing loss and vestibular dysfunction in patients with sudden sensorineural hearing loss (SSHL). METHODS:Clinical data including the symptom of vertigo of 149 SSHL patients were investigated retrospectively. Pure tone audiometry, ocular vestibular-evoked myogenic pot...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1110750
更新日期:2016-01-01 00:00:00
abstract::The author has proved experimentally (in two dogs) that there is reflex hypertonia of the tensor palati muscle, synchronous with the 'shortening' reaction of the tensor tympani muscle in response to its "static" relaxation during the gradual passive inward displacement of the drum resulting from the negative intratymp...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487609120926
更新日期:1976-11-01 00:00:00
abstract:CONCLUSIONS:Thorough otomicroscopical examination of the tympanic membrane in acute otitis media (AOM) might distinguish AOM episodes caused by different bacteria. It thus might be a way to select appropriate treatment for each patient without raising the number of dangerous complications. OBJECTIVES:The aim of this s...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480601091719
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:The role of endonasal endoscopic surgery and radiotherapy in the treatment of skull base chordomas remains unclear. OBJECTIVE:We investigated the effect of endonasal endoscopic surgery and radiotherapy as treatment for skull base chordomas. METHOD:We investigated 46 patients (2006-2018) treated at the Affi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1748225
更新日期:2020-09-01 00:00:00
abstract:CONCLUSION:Diazepam can reduce the excitability of lateral amygdala and eventually suppress the excitability of the auditory cortex in rats following salicylate treatment, indicating the regulating effect of lateral amygdala to the auditory cortex in the tinnitus procedure. OBJECTIVE:To study the spontaneous firing ra...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1204664
更新日期:2016-12-01 00:00:00
abstract:CONCLUSION:GABA-mediated inhibition is responsible for the duration tuning in the inferior colliculus (IC) of guinea pigs, a non-echo-locating mammal. Duration tuning in this species is better demonstrated in an appropriate short time window. OBJECTIVES:To investigate the role of GABA-mediated inhibition in duration t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701840122
更新日期:2008-10-01 00:00:00
abstract::Background: The development of hearing and plasticity of brain after cochlear implantation (CI) for prelingually deaf children with white matter changes (group A) is unclear.Objective: To investigate the development of hearing for children in group A during 1 year after CI activation, compared with non-complicated pee...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1720285
更新日期:2020-05-01 00:00:00
abstract::Topical application of FGF (fibroblast growth factor), a potent mitogen for mesodermal and neuroectodermal cells, was given to promote the healing of tympanic membrane perforations in rats. Calibrated tympanic membrane perforations were performed in 30 rats. At day 0, each rat received 40 microliters of placebo in the...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109137397
更新日期:1991-01-01 00:00:00
abstract:CONCLUSIONS:The incidence rate of hypothyroidism after treatment for laryngeal and hypopharyngeal cancer is high, especially after combination treatment. An association between hypothyroidism and autoantibodies was found. OBJECTIVES:The incidences of hypothyroidism and autoantibodies were assessed retrospectively in 1...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480600818096
更新日期:2007-03-01 00:00:00
abstract::Normal subjects were exposed to two kinds of optokinetic stimulation, viz. at speeds of 60 degrees/s and 90 degrees/s preceded by acceleration at 6 degrees/s2 and 4.5 degrees/s2, respectively. In most subjects the speed of the eye in the slow nystagmus phase equalled the speed of the rotating device during the acceler...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487709123954
更新日期:1977-09-01 00:00:00
abstract::Background: In clinical experience patients who do not frequently check the cochlear implant (CI) maps have poor auditory performance and poor acceptance of map variations over time.Aims: The aim of the present study was to evaluate the effect of CI map optimization on both speech perception and subjective hearing in ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2019.1700303
更新日期:2020-02-01 00:00:00