Abstract:
CONCLUSIONS:The expression of phosphorylcholine (ChoP) in the surface of nontypeable Haemophilus influenzae (NTHi) is an important factor in the pathogenesis of persistent otitis media with effusion (OME) in humans. OBJECTIVES:Lipooligosaccharide (LOS) in NTHi undergoes phase variation in expression of the ChoP epitope. In this study, we examined the phase variation of NTHi isolated from the nasopharynx of children who suffer from OME, and investigated the relationship between the phase variation and the pathogenesis of OME. SUBJECTS AND METHODS:Forty NTHi strains were isolated from the nasopharynx of children with OME, and the ChoP expression of NTHi was examined by colony immunoblot analysis. The NTHi strains were classified into three groups according to the level of ChoP expression, i.e. strong, moderate, and weak expression groups. An adherence assay was also performed. RESULTS:The NTHi strains expressing ChoP(+) LOS glycoforms accounted for 63% of all NTHi tested. Clinically, the strong expression group of ChoP were related to prolongation of the duration of OME. The adherence assay with the CCL 20.2 cell line revealed that the strong expression group attached more easily to the cell surface than the weak expression group.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Fujita K,Hirano T,Kodama S,Suzuki Mdoi
10.1080/00016480802468195subject
Has Abstractpub_date
2009-08-01 00:00:00pages
832-8issue
8eissn
0001-6489issn
1651-2251pii
904383804journal_volume
129pub_type
杂志文章abstract:CONCLUSIONS:A new method for noninvasive standard evaluation of normal endolymphatic space and endolymphatic hydrops using magnetic resonance imaging (MRI) is indicated. OBJECTIVE:To standardize the evaluation of endolymphatic space in the cochlea and the vestibule in healthy volunteers by applying noninvasive intraty...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,随机对照试验
doi:10.3109/00016489.2010.524938
更新日期:2011-03-01 00:00:00
abstract::We report the case of a young male patient with ankylosing spondylitis treated with sulphasalazine who developed bilateral sensorineural hearing loss with tinnitus. Discontinuation of sulphasalazine led to complete resolution of tinnitus and an improvement in hearing loss. We discuss the features of this case and also...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,评审
doi:10.1080/00016480510026962
更新日期:2005-06-01 00:00:00
abstract:CONCLUSION:Cochleostomy is the most efficient approach in delivering PEG-b-PCL polymersomes (PMs) to the inner ear. PMs can be delivered to the vestibule by transtympanic injection or cochleostomy. OBJECTIVE:To evaluate the efficiency of delivering PEG-b-PCL PMs into the inner ear using different approaches. METHODS:...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.615066
更新日期:2011-12-01 00:00:00
abstract::Human secretory leucocyte proteinase inhibitor (SLPI) is a low-molecular weight, acid-stable inhibitor of polymorph-nuclear granulocyte elastase and cathepsin G. Previous reports have demonstrated the existence of SLPI in the respiratory tract, salivary glands and cervical mucosa. Positive staining for SLPI using immu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489409126042
更新日期:1994-03-01 00:00:00
abstract:CONCLUSIONS:The results of this study confirm that both smoking of tobacco and alcohol consumption are risk factors for oral and oropharyngeal squamous cell carcinoma (OOSCC). The use of moist snuff had no effect on the risk of OOSCC, probably due to the low levels of tobacco-specific N-nitrosamines in Swedish moist sn...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480510043440
更新日期:2005-09-01 00:00:00
abstract::Nontypeable Haemophilus influenzae (NTHi) lipooligosaccharide, the major component of H. influenzae endotoxin, was localized in the middle and inner ear subsequent to the resolution of experimental otitis media induced by this pathogen. A monoclonal antibody specific for the lipooligosaccharide of this strain was used...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950180838
更新日期:1999-01-01 00:00:00
abstract::The effect of adaptation of the ear on the SISI test was studied at 500 Hz and 2000 Hz in 43 patients with chronic otitis and in 20 patients with otosclerosis. The mean adaptation was slightly over 10 dB, except in the otosclerosis group at 2000 Hz, for which the value was nearly 20 dB after continuous stimulation at ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487509121302
更新日期:1975-07-01 00:00:00
abstract:CONCLUSION:L-N-Acetylcysteine (L-NAC) significantly reduced reactive oxygen species (ROS) generation and cochlear cell apoptosis after irradiation. The safe and effective use of L-NAC in reducing radiation-induced sensorineural hearing loss (SNHL) should be verified by further in vivo studies. OBJECTIVES:Radiation-ind...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701762490
更新日期:2008-04-01 00:00:00
abstract::A large American family has been mapped to the DFNA2 locus. However, mutation screening of CX31 and KCNQ4, the two genes associated with deafness at this locus, did not identify any mutations. The purpose of this report was to characterize the otologic and audiometric phenotype of this large American family with non-s...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:2002-10-01 00:00:00
abstract::Laryngoscopy in cases of sulcus vocalis reveals bowed vocal folds, resulting in a spindle-shaped chink with glottal incompetence. The anatomic and functional problems and resulting incomplete glottal closure during phonation lead to the presenting symptoms of breathy hoarseness, decrease in maximum phonation time (MPT...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,评审
doi:10.3109/00016489.2014.999873
更新日期:2015-06-01 00:00:00
abstract::The influence of neck and leg proprioceptive inputs on optokinetic-induced quick phases was studied in humans. Ten subjects received unidirectional horizontal optokinetic stimulation (10-20%/s) during sinusoidal neck, leg and combined neck + leg proprioceptive stimulation. The optokinetic reflex was measured by electr...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164801300043523
更新日期:2001-01-01 00:00:00
abstract:CONCLUSION:Early intervention may change the natural course of allergic rhinitis, preventing the progression to asthma. In particular, immunotherapy guarantees remission of local symptoms and valid protection against local and bronchial complications. Symptomatic treatment represents a valid alternative; it is always t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.815362
更新日期:2013-11-01 00:00:00
abstract::Cisplatin ototoxicity is known to involve mainly the organ of Corti. Outer hair cells (OHCs). especially in the basal turn, are preferentially involved. One possible mechanism of ototoxicity might be alteration of the antioxidant system causing an increase in free radicals. It has been demonstrated that heat shock pro...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800750000793
更新日期:2000-03-01 00:00:00
abstract::An in vivo method for the study of mucociliary activity in the human trachea and bronchi is presented. The method is based on a two-way fibre-optic system whereby reflections of light emitted by one glass-fibre and reflected by the cilia are picked up by a second glass fibre and transmitted to a recording unit. The gl...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489309135885
更新日期:1993-09-01 00:00:00
abstract::A 50-year-old woman presented with a 10-year history of swelling of the left cheek during and after meals. She regularly pushed the cheek hard to decrease the swelling by excreting the saliva. She did not have pain or fever. She also complained of bronchial asthma and allergic rhinitis. Magnetic resonance imaging (MRI...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480600621680
更新日期:2006-10-01 00:00:00
abstract::Vestibular microphonics in response to acoustical stimulation were recorded in cochlea-deprived pigeons. Endolymph flow in the semicircular canals alters this response. A caloric stimulus was applied to the horizontal canal or the posterior vertical canal close to the ampulla. To minimize the influence of gravity, the...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809097016
更新日期:1988-03-01 00:00:00
abstract::Lymphangioscopical and ultrastructural studies of the larynx reveal a lymphatic capillary and a collecting vessel system. Collecting vessels show luminal valves and elastic structural components within the wall. Lymphangioscopy reveals that a strict compartmentation of different laryngeal areas is unjustifiable with t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488009127137
更新日期:1980-03-01 00:00:00
abstract::Two speech processing schemes have been implemented on a real-time laboratory speech processor for speech perception studies on normal-hearing subjects. The first scheme presents the information of two spectral components, the first and second formant of the speech signal, and will be referred to as the ZC (zero-cross...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.1990.12088420
更新日期:1990-01-01 00:00:00
abstract::This work describes the different patterns of expression of integrins and extracellular matrix proteins in normal and transformed mucosa in laryngeal and oropharyngeal carcinomas. Samples from each tumor group were sectioned and examined by immunohistochemistry using monoclonal antibodies raised against integrin chain...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480252814298
更新日期:2002-03-01 00:00:00
abstract::Explants of basilar papillae from 6-7 days posthatch chicks were cultured in growth medium for a period of 1-8 days. Hair cells were counted following staining of stereocilia bundles with FITC-phalloidin, and the percentage of hair cell survival was determined by comparison to control (i.e. uncultured) specimens. Hair...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489850183133
更新日期:1998-09-01 00:00:00
abstract::A study was performed to evaluate whether vascular reflex participates in mucosal swelling in nasal allergy, by measuring changes in mucosal swelling in both nasal cavities and changes in blood flow in the bilateral inferior turbinates caused by antigenic challenge in one inferior turbinate. On unilateral challenge, t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209128897
更新日期:1982-07-01 00:00:00
abstract::The objective of this study was to examine the outcome of unilateral stapes surgery in one patient group with bilateral hearing loss and one group with unilateral hearing loss. The patients' own estimations of improvement in hearing ability and the occurrence of other ear-related symptoms were examined retrospectively...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950180982
更新日期:1999-01-01 00:00:00
abstract::IL2Rs, in the presence of IL2, mediate activation and proliferation of human normal lymphocytes and modulate functional changes of some human leukocytic malignancies. IL2Rs have been demonstrated also on human neoplastic and fetal non-hematologic cells in vitro, although their functional role has not been described. W...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.1992.11665436
更新日期:1992-01-01 00:00:00
abstract::It is known that 15-20% of oropharyngeal carcinomas develop distant metastases that involve most commonly lung, liver and bone. Clival metastasis from oropharyngeal squamous cell carcinoma has not been previously reported in the English literature. We describe the rare occurrence of clival metastasis from tonsillar ca...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701687283
更新日期:2008-06-01 00:00:00
abstract:CONCLUSION:Patients with post-lingual deafness should not be excluded from cochlear implantation (CI) on the basis of duration of deafness. We found that the prognosis was favorable in patients who developed deafness after adolescence, even in those with extremely long-term deafness. OBJECTIVES:CI is an effective trea...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.850175
更新日期:2014-02-01 00:00:00
abstract::The nasopharyngeal microflora was monitored during a prospective study of 52 otitis-prone children and 33 age-matched controls up to the age of 30 months. The relation between nasopharyngeal culture results and corresponding otoscopic findings was investigated. In contrast to pneumococci, the rate of H. influenzae iso...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409130971
更新日期:1984-01-01 00:00:00
abstract:CONCLUSION:Endoscopic surgery improved facial pain/headache and physical-psychosocial impacts in patients with nasal polyposis. However, one fifth of patients still experienced residual pain after surgery, requiring neurologic counseling to look for the non-sinonasal cause of their symptoms. OBJECTIVE:Considering the ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1058531
更新日期:2015-01-01 00:00:00
abstract::Negative membrane potentials from the stria vascularis of the guinea pig have been recorded in vivo. Stable negative membrane potentials from the stria cells have also been recorded for as long as 2 minutes in vitro. They varied from -20 mV to -49 mV, irrespective of whether the stria vascularis was immersed in Ring...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487909137159
更新日期:1979-01-01 00:00:00
abstract:CONCLUSION:Vibrant Soundbridge (VSB) application to the middle ear windows yields better functional outcomes than conventional hearing aids. However, speech discrimination scores obtained with VSB and conventional hearing aids are similar. OBJECTIVE:To assess audiological outcomes of round and oval window applications...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.702353
更新日期:2012-12-01 00:00:00
abstract:CONCLUSION:The psychometric characteristics of Standard-Chinese lexical neighborhood test (LNT) confirmed the lexical effects of the four word categories. The established normative baseline can be used in evaluating the word-recognition performance of the hearing-impaired listeners. OBJECTIVES:The purpose of the prese...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章
doi:10.3109/00016489.2013.840923
更新日期:2014-01-01 00:00:00