Noninvasive evaluation of endolymphatic space in healthy volunteers using magnetic resonance imaging.

Abstract:

CONCLUSIONS:A new method for noninvasive standard evaluation of normal endolymphatic space and endolymphatic hydrops using magnetic resonance imaging (MRI) is indicated. OBJECTIVE:To standardize the evaluation of endolymphatic space in the cochlea and the vestibule in healthy volunteers by applying noninvasive intratympanic gadolinium (Gd) perfusion through the eustachian tube and three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (3D-FLAIR MRI). METHODS:This was a prospective study. 3D-FLAIR MRI was performed with a 3 Tesla (3 T) unit 24 h after intratympanic administration of Gd through the eustachian tube in 20 healthy volunteers. Pure tone test and tympanometry were performed 24 h before Gd was administered, and 24 h and 1 month after Gd administration. RESULTS:Gd was present in the perilymph of the inner ear, which clearly displayed the endolymphatic space on 3D-FLAIR MRI with a visible borderline between the perilymph and the endolymph. In healthy volunteers, the normal value for the endolymphatic space in the cochlea ranged between 9% and 28%, and that in the vestibule was between 14% and 40%. No significant changes in pure tone test and tympanometry were noted.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Liu F,Huang W,Wang Z,Chen Q,Liu X,Li S,Wang S

doi

10.3109/00016489.2010.524938

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

247-57

issue

3

eissn

0001-6489

issn

1651-2251

journal_volume

131

pub_type

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