Abstract:
CONCLUSION:Systemic application of human mesenchymal stem cells (hMSCs) may be another effective tool for stem cell supply to the inner ear. OBJECTIVES:Most researchers have used local application to provide the inner ear with stem cells. In spite of their efficacy, these methods can potentially cause irreversible damage to the inner ear. A homing phenomenon of systemically administered MSCs to the ischemic myocardium and brain was recently reported. Moreover, hMSCs have several advantages over conventional neural or embryonic stem cells. Thus we hypothesized that intense noise or ototoxic injury to the cochlea could induce the homing of hMSCs. METHODS:We harvested hMSCs from bone marrow of the iliac crest of five normal individuals. Then hMSCs at a dose of 4 × 10(6) cells were given via intravenous injection of cell suspension into rats with cochleae damaged by noise or ototoxic drugs. Histological analysis was undertaken 30 days later. RESULTS:Systemically delivered hMSCs were usually largely entrapped in the lungs. However, we documented the homing of some hMSCs to the cochlea with degenerated inner hair cells. The recruitment of hMSCs was limited to the spiral ganglion area only. The migration of donor cells into the cochlea was accompanied by the expression of brain-derived neurotrophic factor (BDNF).
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Choi BY,Song JJ,Chang SO,Kim SU,Oh SHdoi
10.3109/00016489.2012.660731subject
Has Abstractpub_date
2012-06-01 00:00:00pages
S94-102eissn
0001-6489issn
1651-2251journal_volume
132 Suppl 1pub_type
杂志文章abstract::In this experimental study in the rat, compound 48/80--a potent degranulating drug of mast cells--was instilled in the external auditory meatus towards the tympanic membrane. Moreover, effusion material was produced in the attic space by blocking the tympanic isthmus with a piece of Gelfoam applied through the tympani...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209128942
更新日期:1982-11-01 00:00:00
abstract::The transitional zone of the saccule and the utricle--has been studied by transmission electron microscope in rats, days before birth. A noticeable secretory activity has been observed in their cells as well as the presence of inorganic spicular bodies that have also been observed in the lumen, some of them integrated...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309139436
更新日期:1983-05-01 00:00:00
abstract::45CaCl2 was injected into gerbils in single or multiple doses, and the resulting radioactivity in serum, otoconial CaCO3, bone samples, and selected labyrinthine epithelium was determined by liquid scintillation spectrometry. Incorporation into both utricular and saccular otoconia occurred at the rate of 0.06-0.07 nmo...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487509121327
更新日期:1975-09-01 00:00:00
abstract::Based on a single-chip DSP (TMS320C25, Texas Instruments) a programmable battery-operated sound processor with a digital encoder interface for the Nucleus-22 cochlear implant (CI) was built. The number of quasi-simultaneously addressed electrodes is only limited by the selected pulse width and the maximum rate of stim...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.1990.12088418
更新日期:1990-01-01 00:00:00
abstract::The DBA/2 strain of mice have genetically induced vestibular dysfunction that presents grossly at an early age as circling behavior and abnormal righting reflexes. The vestibular morphology of this strain has not previously been examined. DBA/2 mice of different ages that showed circling behavior were sacrificed and t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489409126075
更新日期:1994-07-01 00:00:00
abstract:INTRODUCTION:This study showed that short and long interval treatments achieved comparable success rates. There was no statistically significant difference in the rate of early and late recurrences between the two groups. Modified Epley maneuver can be applied in a short interval time with comparable success and recurr...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1252852
更新日期:2017-05-01 00:00:00
abstract::Caloric responses from 50 consecutive patients, referred routinely for investigation of hearing and/or balance problems, were evaluated by computer and manual methods of analysis. Using measures of nystagmic slow-phase velocity, there was found to be a high degree of correlation between the two methods. Of the 50 pati...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709128267
更新日期:1987-11-01 00:00:00
abstract:CONCLUSIONS:Cyclo-oxygenase-2 (COX-2) enzyme would not appear to be constitutively expressed in human perilymph while it is always induced in the perilymph of patients affected by sensorineural hearing loss (SNHL). The COX-2 isoform may be involved in hearing loss and, therefore, pathological states of the inner ear sh...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2010.522593
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:Temperature-controlled radiofrequency volumetric tissue reduction (RFVTR) is a minimally invasive technique used in the treatment of the tongue base, soft palate and turbinates. Complications seem to be rare, but the scope of previous studies was often limited by the small number of patients included. The aim...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310001385
更新日期:2003-05-01 00:00:00
abstract::In previous studies, sinus secretions have been analysed concerning pO2, pCO2 and pH. In this study the energy metabolism in the maxillary sinus mucosa and secretion was studied in 33 New Zealand White rabbits. In freeze-dried samples, glucose and lactate were analysed by enzymatic assays and ATP by HPLC. In the purul...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809122271
更新日期:1988-11-01 00:00:00
abstract::An X-ray energy dispersive analysis was performed on the mature serial sectioned freeze-dried mammalian labyrinth (CBA/CBA mouse). The elemental distribution in the endolymphatic and perilymphatic spaces revealed similar results as have been reported in the literature when withdrawing fluid for microanalysis. The cupu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488009131744
更新日期:1980-11-01 00:00:00
abstract::The objective of the present study was to establish the estimated incidence of symptomatic nasal polyps within a defined geographic area. Over a 6-year period all polyp patients diagnosed for the first time (n = 252; 174 males, 78 females) were prospectively registered at the study clinic. An estimated background popu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480252814199
更新日期:2002-03-01 00:00:00
abstract::Overexpression of epidermal growth factor receptor (EGF-R) is a common characteristic of epidermoid tumors and its expression in head and neck squamous cell carcinoma biopsies and cell lines has been reported previously by several authors. With the aim to provide more structural and functional details about the protei...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489309135902
更新日期:1993-11-01 00:00:00
abstract:CONCLUSIONS:Protocol limitations were identified and accounted for in the analysis. Percent gradient equilibrated (PGE) was affected by driving gradient direction in a similar manner to other efficiency measures. A finer resolution of possible age-related changes in eustachian tube opening efficiency is expected with t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.882017
更新日期:2014-06-01 00:00:00
abstract::The view current over the last 60 years or so that coniotomy often leads to subglottic stenosis has recently been called into question. In the present study 103 electively performed coniotomies have been analysed. The operation was found to be much easier than tracheotomy. There was no case of severe peroperative or p...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309132905
更新日期:1983-09-01 00:00:00
abstract::Six profoundly deaf patients were studied with mapping evoked potentials (MEP) using an acoustic signal passed through the vibrotactile prosthesis. This stimulus produced an activation of the central sulcus brain cortex. When the proSthesis was placed in the presenternal area it showed N1 P1 potentials with higher vol...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709117771
更新日期:1997-03-01 00:00:00
abstract::Middle ear lesions were produced in chinchillas by introducing fascia, Gelfoam, silastic or a combination of these materials into the labyrinthine and mastoid bullae. After 1-2 months, conventional 226 Hz and multifrequency tympanometry (MFT) were performed and the animals were sacrificed for histopathological analysi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489850154937
更新日期:1998-03-01 00:00:00
abstract:PURPOSE:To analyze the outcomes following re-irradiation for local recurrence of rare head and neck tumors. MATERIAL AND METHODS:We retrospectively analyzed 11 patients who had received intensity-modulated radiation therapy (IMRT) for recurrent tumors in the head and neck except for laryngopharynx. RESULTS:Primary tu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2018.1438662
更新日期:2018-08-01 00:00:00
abstract::Background: Intratympanic and intravenous gadolinium administration is used to visualise endolymphatic hydrops. Aims/objectives: The goal of this study was to compare the image quality between intratympanic (IT-method) and intravenous (IV-method) gadolinium administration using three-dimensional inversion recovery wit...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章
doi:10.1080/00016489.2019.1600719
更新日期:2019-08-01 00:00:00
abstract::Background: Frequency-specific hearing studies are important for predicting hearing results and the prognosis after stapes surgery, to prepare for the rehabilitation of frequency-specific hearing in patients with otosclerosis.Objectives: To evaluate outcomes of stapes surgery of Chinese otosclerosis patients with diff...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1724331
更新日期:2020-05-01 00:00:00
abstract::Seven to eight years after a disease period of vestibular neuritis 19 patients previously examined at our department were given a questionnaire about whether they had experienced any audiovestibular symptoms since they first fell ill. All 19 patients responded and 18 consented to participate in the long-term follow-up...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950180243
更新日期:1999-01-01 00:00:00
abstract::In a previous investigation into noise-induced hearing loss by comparing 2-month-old albino with pigmented guinea pigs, albinos displayed significantly greater shifts in cochlear microphonic (CM) threshold and less recovery than the pigmented animals 7 days after noise exposure. The present study compared the response...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809107372
更新日期:1988-07-01 00:00:00
abstract::The Pathologic changes in the inner ears of 5 patients with Cogan's syndrome were studied by a combined application of MR imaging and CT scanning. We used T1- and T2-weighted MR imaging sequences and a special three-dimensional MR imaging technique which allows a very detailed imaging of the inner ear structures. By t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489309135875
更新日期:1993-09-01 00:00:00
abstract::The gram negative bacteria, nontypable Haemophilus influenzae (NTHi) was used to induce otitis media in a total of 18 chinchillas. Three days post-inoculation, three cohorts of 6 chinchillas each were treated daily for four days with either ceftriaxone, chloramphenicol, or diluent without antibiotics. Middle ear fluid...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709118000
更新日期:1997-01-01 00:00:00
abstract::Experimental animals (cats) were exposed to tones of 125, 1000, 2000, and 4000 Hz at sound pressure levels in the range 120 to 157.5 dB, and for durations of one hour (1000, 2000, 4000 Hz) or four hours (125 Hz). Pure tone audiograms were obtained for each animal before and after exposure. Post-exposure tests were con...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487509121336
更新日期:1975-11-01 00:00:00
abstract:UNLABELLED:Abstract Conclusions: In survival analysis, the combined Charlson comorbidity index (CCI) can be considered as a prognostic factor independent of the tumor node metastasis (TNM) classification, tumor stage, and tumor location. Severe comorbidity was the factor that had the greatest impact on prognosis in cas...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.564651
更新日期:2011-08-01 00:00:00
abstract:CONCLUSION:The present study demonstrated the robustness of VEMP testing with toneburst stimuli, since it is hardly affected by head position, i.e. base or tonic excitation levels of the saccule and inferior vestibular nerve. However, the small but highly significant difference found in latency should not be neglected:...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480600740597
更新日期:2007-01-01 00:00:00
abstract:CONCLUSION:We demonstrated an early increase in aquaporin 2 (AQP2) expression in a motor nerve (extratemporal facial nerve, FN) following acute peripheral compression (crush), concomitant to effective development of motor dysfunction (facial palsy). The early increase in AQP2 expression that occurred concomitantly with...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1010104
更新日期:2015-07-01 00:00:00
abstract::The ultrastructure of the geniculate ganglion was studied in the guinea pig and monkey. Two cytologically distinct colonies of ganglion cells were seen and identified as light and dark cells. All neurons were unmyelinated and most were unipolar, although a few bipolar cells were seen. The axons, upon leaving the cell ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209130869
更新日期:1982-01-01 00:00:00
abstract::In 82 patients with acute tonsillitis studied, beta-hemolytic group A streptococci were isolated from 30 (37%), and group C or G streptococci from 12 (15%). In the 40 patients with non-streptococcal tonsillitis there was a significantly higher isolation rate of pneumococci, H. influenzae and/or B. catarrhalis, as comp...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709107339
更新日期:1987-09-01 00:00:00