Effects of aging on normal hearing loss and noise-induced threshold shift in albino and pigmented guinea pigs.

Abstract:

:In a previous investigation into noise-induced hearing loss by comparing 2-month-old albino with pigmented guinea pigs, albinos displayed significantly greater shifts in cochlear microphonic (CM) threshold and less recovery than the pigmented animals 7 days after noise exposure. The present study compared the responses of 14-month-old albino and pigmented guinea pigs to the same noise parameters used previously. Thresholds for the first detectable elicitation of CM for three pure tones were recorded prior to, at 90 min and at 7 days after a 45-min exposure to 126 dB broadband noise. Before exposure to noise, thresholds for pigmented guinea pigs were 24 dB higher than those in the albinos. Following noise exposure, the pigmented animals showed less than half the amount of threshold shift displayed by the albinos. This change ws attributed to the higher pre-exposure thresholds in the pigmented guinea pigs. Converging lines of evidence suggest that cochlear pigmentation may have both protective and toxic influences on the inner ear.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Conlee JW,Abdul-Baqi KJ,McCandless GA,Creel DJ

doi

10.3109/00016488809107372

subject

Has Abstract

pub_date

1988-07-01 00:00:00

pages

64-70

issue

1-2

eissn

0001-6489

issn

1651-2251

journal_volume

106

pub_type

杂志文章
  • Ultrastructural features of the interferon-treated adult laryngeal papilloma.

    abstract::The ultrastructural features of the interferon-treated adult laryngeal papillomas are described. Compared with untreated papillomas, no differences in ultrastructure were found by transmission electron microscopy. By scanning electron microscopy, significant alterations comprising a smooth and oedematous surface with ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488509104793

    authors: Bomholt A,Horn T

    更新日期:1985-09-01 00:00:00

  • MASPIN tumour-suppressing activity in head and neck squamous cell carcinoma: emerging evidence and therapeutic perspectives.

    abstract:CONCLUSIONS:A large series confirmation may suggest elective neck dissection in cN0 MASPIN-negative oral squamous cell carcinomas (SCCs). Re-activated nuclear MASPIN in association with anti-angiogenic or cytotoxic drugs may be extremely effective in the treatment of laryngeal SCC. OBJECTIVES:MASPIN is a serpin showin...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,评审

    doi:10.1080/00016480802256079

    authors: Marioni G,Staffieri C,Staffieri A,De Filippis C,Blandamura S

    更新日期:2009-05-01 00:00:00

  • Outcome of primary treatment of early laryngeal malignancies using photodynamic therapy.

    abstract:CONCLUSION:Photodynamic therapy (PDT) is a viable and safe option for early laryngeal cancer that would be less suitably treated with radiation or trans-oral laser surgery (TLS). The cure rates with PDT appear to be comparable to those of conventional therapy, and the voice outcomes are also comparable. In the case of ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2014.906748

    authors: von Beckerath MP,Reizenstein JA,Berner AL,Nordqvist KW,Landström FJ,Löfgren AL,Möller CG

    更新日期:2014-08-01 00:00:00

  • Clinical analysis of 21 cases of cervical tuberculous lymphadenitis without active pulmonary lesion.

    abstract:CONCLUSION:The necessity of considering cervical tuberculous lymphadenitis (CTL) should be emphasized even today for the differential diagnosis of cervical lymphadenopathy, particularly when it is located in the posterior triangle and supraclavicular regions even in patients without active pulmonary tuberculosis (PTB)....

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2013.789927

    authors: Iguchi H,Wada T,Matsushita N,Teranishi Y,Yamane H

    更新日期:2013-09-01 00:00:00

  • Meniére's disease. Electron microscopy of the vestibular ganglion and end organs after ultrasound.

    abstract::Material for electron microscopy study was obtained from a patient previously suffering from Meniere's disease and treated by ultrasound. It consisted of parts of the membranous labyrinth as well as the vestibular ganglion. The neuro-epithelium of the macula showed degenerative changes and there was marked vacuolation...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487509124674

    authors: Colman BH,Friedmann I,Wright JL

    更新日期:1975-03-01 00:00:00

  • Intravenous administration of human mesenchymal stem cells after noise- or drug-induced hearing loss in rats.

    abstract:CONCLUSION:Systemic application of human mesenchymal stem cells (hMSCs) may be another effective tool for stem cell supply to the inner ear. OBJECTIVES:Most researchers have used local application to provide the inner ear with stem cells. In spite of their efficacy, these methods can potentially cause irreversible dam...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2012.660731

    authors: Choi BY,Song JJ,Chang SO,Kim SU,Oh SH

    更新日期:2012-06-01 00:00:00

  • Auditory evoked potentials in cats with neonatal high frequency hearing loss. Evidence of abnormal frequency representation in the midbrain.

    abstract::We have recorded auditory evoked potentials, of both neurogenic and myogenic origin, in cats having neonatal high frequency cochlear hearing loss. Using frequency specific stimuli (tone pips) and by measuring responses near to threshold, we have probed tonotopic (or cochleotopic) representation within the brainstem-mi...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489309135763

    authors: Harrison RV,Gordon DC,Nagasawa A,Stanton S,Ibrahim D,Mount RJ

    更新日期:1993-01-01 00:00:00

  • Usefulness of acoustic studies on the differential diagnostics of organic and functional dysphonia.

    abstract::Phoniatric and acoustic examinations were carried out in a group of 30 patients with dysphonia, including 15 with organic type and 15 with functional type. A complex phoniatric assessment offered the possibility to differentiate between these two groups of pathological voices. This was achieved also on the basis of ac...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489109137412

    authors: Pruszewicz A,Obrebowski A,Swidziński P,Demeńko G,Wika T,Wojciechowska A

    更新日期:1991-01-01 00:00:00

  • Pilot study of a device for measuring instrument forces during endoscopic sinus surgery.

    abstract::ESS is a form of minimal access surgery that includes different tasks and manoeuvres requiring sophisticated psychomotor coordination with varying levels of force application. The avoidance of complications is partially dependent upon reducing surgical force application when operating against vital barriers such as th...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480410016568

    authors: White PS,Nassif R,Saleh H,Drew T

    更新日期:2004-03-01 00:00:00

  • Imaging of cochlear implant electrode array with flat-detector CT and conventional multislice CT: comparison of image quality and radiation dose.

    abstract:CONCLUSION:Cochlear implantation assessment is possible using commercially available standard flat-detector computed tomography (FD-CT) protocols. Image quality is superior to multislice CT (MSCT). The radiation dose of FD-CT is lower in comparison with MSCT standard protocols and may therefore overcome the limitations...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016480903292700

    authors: Struffert T,Hertel V,Kyriakou Y,Krause J,Engelhorn T,Schick B,Iro H,Hornung J,Doerfler A

    更新日期:2010-04-01 00:00:00

  • The totally implantable middle ear device 'Esteem' for rehabilitation of severe sensorineural hearing loss.

    abstract:CONCLUSION:The Esteem(®) device proved to offer beneficial results in subjects suffering from high frequency, severe bilateral sensorineural hearing loss (SNHL) and may be considered as an alternative procedure to conventional hearing aids (HAs) or electroacoustic stimulation (EAS) systems. OBJECTIVES:Since the Esteem...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2010.536994

    authors: Barbara M,Biagini M,Monini S

    更新日期:2011-04-01 00:00:00

  • The effect of Japanese cedar-specific immunotherapy on cytokine production in peripheral blood mononuclear cells.

    abstract::The most common cause of seasonal allergic rhinitis in Japan is the Japanese cedar (JC). Recently, a pullulan-conjugated antigen (CS-560) has been developed to reduce adverse effects and to enhance the effect of JC-specific immunotherapy (IT). If the mechanism of IT can be fully elucidated and the treatment can be use...

    journal_title:Acta oto-laryngologica

    pub_type: 临床试验,杂志文章

    doi:10.1080/00016480252775742

    authors: Nakano A,Nakano K,Okawa T,Yamakoshi T,Terada N,Numata T,Konno A

    更新日期:2002-01-01 00:00:00

  • Transcription analysis of cochlear development in minipigs.

    abstract:CONCLUSIONS:The critical stage for cochlear gene regulation in the embryo is E49-E56. These data provide a valuable resource to help elucidate gene regulation in cochlear development and will benefit ear-related studies, especially those that focus on gene and stem cell therapies in hearing loss. OBJECTIVES:To investi...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2017.1341641

    authors: Wang Q,Zhang Y,Guo W,Liu Y,Wei H,Yang S

    更新日期:2017-11-01 00:00:00

  • Histological reaction to polyimide films in the cochlea.

    abstract::The biocompatibility of commercially available polyimides was examined in relation to the sensory and neural structures of the cochlea. Thin films of four different polyimides were prepared as substrates for photolithographically produced scala tympani electrode arrays and implanted in 32 cat cochleae. Following at le...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488909127474

    authors: Haggerty HS,Lusted HS

    更新日期:1989-01-01 00:00:00

  • Effects of topical nasal decongestants on histology of nasal respiratory mucosa in rabbits.

    abstract::The aim of this study was to evaluate histologic changes after long-term administration of the topical nasal decongestants phenylephrine and oxymetazoline. Ninety healthy rabbits were divided into 3 groups for topical administration for 1 week, 2 weeks, and 4 weeks. Each group was subdivided into 3 subgroups by topica...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489509139384

    authors: Suh SH,Chon KM,Min YG,Jeong CH,Hong SH

    更新日期:1995-09-01 00:00:00

  • Expression of vascular cell adhesion molecule-1, alpha4-integrin and L-selectin during inner ear immunity reaction.

    abstract::The expression of vascular cell adhesion molecule-1 (VCAM-1), alpha4-integrin and L-selectin was dynamically observed using an immunohistochemical approach during labyrinthitis induced by inoculation of keyhole limpet hemocyanin into the scala tympani of animals that had been systemically sensitized to it. At the same...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/000164800750000414

    authors: Zhang C,Huang W,Song H

    更新日期:2000-08-01 00:00:00

  • Experimental recurrent pneumococcal otitis media. Protection and serum antibodies.

    abstract::To elucidate immune mechanisms in otitis media, middle ear infection was induced in 12 rats by intratympanic inoculation of Streptococcus pneumoniae type 3, either the ipsilateral or the contralateral middle ear being re-challenged 4 weeks later. Otomicroscopy inspection confirmed the presence of acute otitis media (A...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489109100760

    authors: Svinhufvud M,Prellner K,Hermansson A,Schalén C

    更新日期:1991-01-01 00:00:00

  • Characteristics of the acoustic distortion product 2f2-f1 from the normal human ear.

    abstract::The aim of this study was to determine the basic properties of the 2f2-f1 distortion product otoacoustic emissions (DPOEs) in 36 normally hearing subjects and to compare their characteristics with those of the 2f1-f2 DPOEs. The influence of stimulation parameters on 2f2-f1 DPOE behaviour was examined: i) stimulation l...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489850155099

    authors: Erminy M,Avan P,Bonfils P

    更新日期:1998-01-01 00:00:00

  • Tick-borne borreliosis and facial palsy.

    abstract::During a one-year period, 82 consecutive patients seeking medical attention for facial palsy primarily of unknown etiology were examined for underlying Ixodes ricinus-borne borreliosis. Evidence of the infection was found in 16 (20%) of the patients, most of whom had cerebrospinal fluid findings indicating meningeal i...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488809119451

    authors: Olsson I,Engervall K,Asbrink E,Carlsson-Nordlander B,Hovmark A

    更新日期:1988-01-01 00:00:00

  • Utility of 24-hour pharyngeal pH monitoring and clinical feature in laryngopharyngeal reflux disease.

    abstract:BACKGROUND:pH monitoring can reflect the changes in H+ in the airway. OBJECTIVES:To explore the utility of pharyngeal pH monitoring in the diagnosis of laryngopharyngeal reflux disease (LPRD). MATERIAL AND METHODS:Clinical data from 956 suspected LPRD patients from February 2016 to March 2018 were analyzed retrospect...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2019.1571280

    authors: Wang G,Qu C,Wang L,Liu H,Han H,Xu B,Zhou Y,Li B,Zhang Y,Sun Z,Gong J,Li L,Wu W

    更新日期:2019-03-01 00:00:00

  • Observations on the structure and the biomechanics of the cricothyroid articulation.

    abstract::We examined quantitatively the ventrodorsal gliding occurring along a sagittal plane in the cricothyroid articulation. For this purpose we used 10 fresh excised human larynges taken at autopsy. Furthermore we examined the morphology, the hydroxyproline content and collagen types of the ligaments and the articular caps...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488709134706

    authors: Vilkman EA,Pitkänen R,Suominen H

    更新日期:1987-01-01 00:00:00

  • Endolymphatic duct blockage for refractory Ménière's disease: assessment of intraoperative CSF leak on short-term surgical outcomes.

    abstract:BACKGROUND:Endolymphatic sac decompression has shown limited success for the treatment of Ménière's disease (MD). We have published a novel technique with very promising results for the treatment of refractory MD: the Endolymphatic Duct Blockage (EDB) with two titanium clips. One of the challenges of this technique was...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2018.1481524

    authors: Saliba I,Asmar MH

    更新日期:2018-10-01 00:00:00

  • Induction of MUC5AC mucin expression by histamine through the activation of its core promoter region.

    abstract:CONCLUSION:This study provides evidence that histamine induced MUC5AC mRNA expression through the activation of the core region of its promoter. It may also help in approaching new therapeutic strategies in airway mucins hypersecretory diseases. OBJECTIVE:Mucin hypersecretion characterizes several respiratory diseases...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2015.1017890

    authors: Xu F,Zhang L,Gao J,Wang D

    更新日期:2015-07-01 00:00:00

  • A scanning electron microscopy study of post mortem autolytic changes in the human and rat cochleas.

    abstract::The use of SEM as an adjunct to TEM and electrophysiological examination of the cochlea is now well established. It has provided a relatively simple method of assessing the effect of noise, ototoxic drugs, electrical stimulation, etc. on the surface features of the organ of corti. A controlled experiment was undertake...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488509126566

    authors: Gleeson MJ

    更新日期:1985-11-01 00:00:00

  • Effect of chewing gum on static posturography in patients with balance disorders.

    abstract:CONCLUSION:The chewing gum indirectly affects postural control by influencing vestibular function to stabilize posture during upright standing. OBJECTIVES:This study aimed to evaluate the effect of chewing gum on static posturography in patients. METHODS:The subjects were 26 patients with chronic balance disorders. T...

    journal_title:Acta oto-laryngologica

    pub_type: 临床试验,杂志文章

    doi:10.3109/00016489.2011.607846

    authors: Goto F,Kushiro K,Tsutsumi T

    更新日期:2011-11-01 00:00:00

  • Caloric stimulation of the vestibular system of the pigeon under minimal influence of gravity.

    abstract::Vestibular microphonics in response to acoustical stimulation were recorded in cochlea-deprived pigeons. Endolymph flow in the semicircular canals alters this response. A caloric stimulus was applied to the horizontal canal or the posterior vertical canal close to the ampulla. To minimize the influence of gravity, the...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488809097016

    authors: Wit HP,Segenhout JM

    更新日期:1988-03-01 00:00:00

  • Can the bending forward test be used to detect a diseased anterior semi-circular canal in patients with chronic vestibular multi-canalicular canalithiasis (BPPV)?

    abstract::Introduction: Patients with chronic vestibular multi-canalicular canalithiasis (CVMCC) can have serious morbidities, for example, musculoskeletal pain, dizziness, fatigue, and cognitive difficulties. Involvement of the anterior semi-circular canal (SCC) is common in CVMCC. A mono-canalicular diseased anterior SCC is r...

    journal_title:Acta oto-laryngologica

    pub_type: 临床试验,杂志文章

    doi:10.1080/00016489.2019.1667529

    authors: Iglebekk W,Tjell C,Borenstein P

    更新日期:2019-12-01 00:00:00

  • Occurrence and distribution of VIP nerves in the nasal mucosa and tracheobronchial wall.

    abstract::Nerves displaying vasoactive intestinal peptide (VIP) immunoreactivity were detected in the upper respiratory tract of guinea pigs, rabbits and cats. VIP nerves were numerous in the cat, less numerous in the rabbit and rare in the guinea pig. In the nasal mucosa, fine varicose VIP nerves were found to surround nasal g...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487809107524

    authors: Uddman R,Alumets J,Densert O,Håkanson R,Sundler F

    更新日期:1978-11-01 00:00:00

  • Cervical lymph node metastasis from early-stage squamous cell carcinoma of the oral tongue.

    abstract:CONCLUSIONS:The findings of this study demonstrated that the wait-and-watch strategy for neck metastasis from squamous cell carcinoma (SCC) of oral tongue is a reliable option and that salvage by surgical treatment is effective. However, younger patients should be closely monitored for recurrence. Adjuvant therapy may ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2012.748988

    authors: Yuasa-Nakagawa K,Shibuya H,Yoshimura R,Miura M,Watanabe H,Kishimoto S,Omura K

    更新日期:2013-05-01 00:00:00

  • Redistribution of facial nerve motor neurons after recovery from nerve crushing injury in the gerbil.

    abstract::We investigated the redistribution of facial motor neurons after recovery from a crush injury of the facial nerve in the mongolian gerbil, with the retrograde transportation of horseradish peroxidase (HRP) technique. The facial nerve at the vertical segment was crushed unilaterally for 10 s with forceps. After 1 month...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489509139307

    authors: Park HJ,Kim HN,Kim KM

    更新日期:1995-03-01 00:00:00