Abstract:
CONCLUSIONS:The findings of this study demonstrated that the wait-and-watch strategy for neck metastasis from squamous cell carcinoma (SCC) of oral tongue is a reliable option and that salvage by surgical treatment is effective. However, younger patients should be closely monitored for recurrence. Adjuvant therapy may be recommended for patients with pathologically advanced disease. OBJECTIVES:Metastatic involvement of cervical lymph nodes is the most important prognostic indicator in patients with oral tongue SCC. With the objective of determining the most appropriate treatment strategy for regional recurrence, we conducted a retrospective review of clinicopathologic factors. METHODS:The clinicopathologic features of 103 patients with oral tongue SCC, in whom the local lesions were treated successfully by low-dose interstitial brachytherapy (LD-IBT), but who subsequently developed cervical lymph node metastases and were treated by salvage surgery, were reviewed. RESULTS:In the patients who underwent surgical treatment at our hospital, 5-year disease-free survival and regional control rates were 69.3% and 85.3%, respectively. The clinicopathologic factors significantly associated with unfavorable disease-free survival were the presence of extracapsular spread (hazard ratio (HR) = 3.005, p = 0.045), multiple and large lymph nodes (HR = 2.850, p = 0.010 and HR = 3.112, p = 0.007, respectively), younger age (HR = 2.429, p = 0.048), and shorter interval from the LD-IBT to detection of neck metastasis (HR = 1.749, p = 0.013).
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Yuasa-Nakagawa K,Shibuya H,Yoshimura R,Miura M,Watanabe H,Kishimoto S,Omura Kdoi
10.3109/00016489.2012.748988subject
Has Abstractpub_date
2013-05-01 00:00:00pages
544-51issue
5eissn
0001-6489issn
1651-2251journal_volume
133pub_type
杂志文章abstract::Overexpression of epidermal growth factor receptor (EGF-R) is a common characteristic of epidermoid tumors and its expression in head and neck squamous cell carcinoma biopsies and cell lines has been reported previously by several authors. With the aim to provide more structural and functional details about the protei...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489309135902
更新日期:1993-11-01 00:00:00
abstract::This paper describes an investigation performed to study the middle ear events ensuing from Staphylococcus aureus induced infection in the middle ear cavity of the rat. To obtain an evaluation at both the cell and the tissue level, scanning electron microscopy, transmission electron microscopy and histology were used....
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409107560
更新日期:1984-09-01 00:00:00
abstract:CONCLUSION:Vibrant Soundbridge (VSB) application to the middle ear windows yields better functional outcomes than conventional hearing aids. However, speech discrimination scores obtained with VSB and conventional hearing aids are similar. OBJECTIVE:To assess audiological outcomes of round and oval window applications...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.702353
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To report on the long-term results, focusing on prosthesis lifetime, achieved with the VoiceMaster prosthesis in an outpatient population. MATERIAL AND METHODS:The VoiceMaster prosthesis was used over a 40-month period. Average prosthesis lifetimes were calculated both individually and for the group as a who...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310001330
更新日期:2003-06-01 00:00:00
abstract::A retrospective study was carried out on repeated audio-vestibular examinations in 53 patients with unilateral Meniere's disease, between the vertiginous spells. Most patients showed no change in the caloric response reduction of the afflicted ear in the subsequent tests compared with the first one. These patients had...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488109133278
更新日期:1981-11-01 00:00:00
abstract:OBJECTIVE:Ischemic vascular damage of the inner ear is one of the known causes of sensorineural sudden hearing loss (SSHL). Folate is an emerging risk factor associated with an increased risk of vascular damage. The aim of this study was to investigate whether low serum folate levels are associated with SSHL. MATERIAL...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480410016216
更新日期:2004-06-01 00:00:00
abstract:CONCLUSIONS:Our results confirm that supracricoid laryngectomies (SL) are reliable techniques for glottosupraglottic tumors, even for selected T3 and T4 cases, if the indications are correct. These surgical techniques allow a good quality of life with the preservation of the larynx. OBJECTIVE:SL with cricohyoidoepiglo...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480500469024
更新日期:2006-06-01 00:00:00
abstract::In 82 patients with acute tonsillitis studied, beta-hemolytic group A streptococci were isolated from 30 (37%), and group C or G streptococci from 12 (15%). In the 40 patients with non-streptococcal tonsillitis there was a significantly higher isolation rate of pneumococci, H. influenzae and/or B. catarrhalis, as comp...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709107339
更新日期:1987-09-01 00:00:00
abstract::Background: The development of hearing and plasticity of brain after cochlear implantation (CI) for prelingually deaf children with white matter changes (group A) is unclear.Objective: To investigate the development of hearing for children in group A during 1 year after CI activation, compared with non-complicated pee...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1720285
更新日期:2020-05-01 00:00:00
abstract:CONCLUSIONS:The incidence rate of hypothyroidism after treatment for laryngeal and hypopharyngeal cancer is high, especially after combination treatment. An association between hypothyroidism and autoantibodies was found. OBJECTIVES:The incidences of hypothyroidism and autoantibodies were assessed retrospectively in 1...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480600818096
更新日期:2007-03-01 00:00:00
abstract::Localization of elements at the cellular and sub-cellular levels was performed with the energy dispersive X-ray microanalysis technique, using shock-frozen, freeze-dried and araldite-embedded mouse (CBA/CBA) cochleae sectioned dry. Anatomical identification occurred in the STEM (scanning transmission electron microsco...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409107585
更新日期:1984-11-01 00:00:00
abstract::Aspartate and alanine aminotransferase (ASAT, ALAT) activities were measured in human post-mortem sera, cerebrospinal fluid (CSF), perilymph and endolymph. Due to heart and/or liver morbidity during a terminal illness, the ASAT and ALAT serum activities were considerably increased as compared with normal and both were...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487609107478
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare the radiologic findings with histological results of anatomically matched whole organ sections and to analyze the accuracy of pretherapeutic radiologic staging of glottic cancers. METHODS:The histologic findings of surgical specimens of 30 patients who had undergone tota...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.562538
更新日期:2011-08-01 00:00:00
abstract::Many techniques have been proposed for reconstruction of the posterior canal wall and/or obliteration of the mastoid bowl after radical mastoidectomy. The variety of materials that have been used, biological as well as foreign materials of different kinds, indicates that the ideal solution has yet to be found. Plaster...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809122254
更新日期:1988-11-01 00:00:00
abstract::We studied the pathological changes in the temporal bone and brainstem, with particular attention to the autolysis of red blood cells in and around the blood vessels, in six cases of brainstem death determined by auditory brainstem responses (ABRs). Our findings showed that the cochlea, the visceral organs and the spi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509139287
更新日期:1995-03-01 00:00:00
abstract::Undifferentiated giant and spindle cell carcinoma is an unusual and high-grade malignant type of cancer of the thyroid. The results of surgical and/or radiotherapeutic treatment have been discouraging. Only a few patients respond to therapy, usually for a short time. Recently, a few reports have been published on the ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487709128859
更新日期:1977-03-01 00:00:00
abstract::The authors carried out immunological investigations in 96 patients with laryngeal cancer. The following tests were applied: DNCB, PPD, phyto-test and the lymphocyte count. The patients were divided into three groups: 1) cured, one year following treatment; 2) relapses; 3) died during the first year. The separate grou...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487909126438
更新日期:1979-03-01 00:00:00
abstract::The author presents a study of the personality structure, youth development and the role of interhuman conflicts in the work situation and the family, in the causation and course of Menière's disease, the somatopsychic reactions of the patients to the illness, and the principles of a form of psychotherapy which was co...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309139423
更新日期:1983-05-01 00:00:00
abstract::Unilateral vestibular hypofunction (UVH) is a common vestibular dysfunction. Its influence upon the vestibulospinal reflex (VSR) is studied by posturography. The postural sway is disturbed when the VSR is disregulated because of the UVH. The degree of disturbance depends on the effectivity of the central compensation....
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709109046
更新日期:1987-07-01 00:00:00
abstract::The postnatal development of lower stations in the auditory pathway was studied in the guinea pig by recording auditory brainstem potentials. At birth, the brainstem responses of young guinea pigs already have thresholds corresponding to those of adult animals. However, the latencies of the individual potentials are s...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409130965
更新日期:1984-01-01 00:00:00
abstract:CONCLUSION:Cochleostomy is the most efficient approach in delivering PEG-b-PCL polymersomes (PMs) to the inner ear. PMs can be delivered to the vestibule by transtympanic injection or cochleostomy. OBJECTIVE:To evaluate the efficiency of delivering PEG-b-PCL PMs into the inner ear using different approaches. METHODS:...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.615066
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:Temperature-controlled radiofrequency volumetric tissue reduction (RFVTR) is a minimally invasive technique used in the treatment of the tongue base, soft palate and turbinates. Complications seem to be rare, but the scope of previous studies was often limited by the small number of patients included. The aim...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310001385
更新日期:2003-05-01 00:00:00
abstract::The effects of two simulated hearing impairments (presbyacusis) on speech perception were investigated in two groups of normally hearing subjects (30 and 48 subjects, respectively). Eight patients with presbyacusis with similar hearing impairment to those in the latter simulation served as the clinical material. Word ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800750000991
更新日期:2000-03-01 00:00:00
abstract:CONCLUSION:Abnormal caloric and vestibular evoked myogenic potential (VEMP) responses are frequently encountered with a large cerebellopontine angle (CPA) schwannoma, while normal caloric responses and abnormal VEMPs are noted with a large CPA meningioma. This difference may possibly exist because schwannoma causes ves...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480802126553
更新日期:2009-02-01 00:00:00
abstract::The early development of human otoconial membranes was studied by scanning electron microscopy and X-ray microanalysis; 87 specimens, ranging from 7 to 12 weeks gestational age were examined. A few otoconia, which contained calcium, were present in the utricle by the end of the seventh week. By 8 weeks, both the saccu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209128884
更新日期:1982-07-01 00:00:00
abstract::Caloric responses from 50 consecutive patients, referred routinely for investigation of hearing and/or balance problems, were evaluated by computer and manual methods of analysis. Using measures of nystagmic slow-phase velocity, there was found to be a high degree of correlation between the two methods. Of the 50 pati...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709128267
更新日期:1987-11-01 00:00:00
abstract::The aim of this study was to investigate the influence of weather conditions on the frequency of acute laryngitis in adults. The medical records of 825 patients with a diagnosis of acute laryngitis obtained over a 5-year period were reviewed. Meteorological data reviewed included the daily values of 13 parameters. The...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164802320396358
更新日期:2002-09-01 00:00:00
abstract::The influence of cigarette smoke on the pharyngeal mucosa was investigated in a clinical study and in an experiment on animals. Histologic reports were evaluated according to the Kambic-Lenart classification of hyperplastic aberrations of the throat mucosa. A close dependence of the degree of hyperplasia and the numbe...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487809121433
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVES:Hearing loss after spinal anesthesia has been reported to be related to the transmission of a reduced subarachnoid pressure to the inner ear via the cochlear aqueduct due to loss of spinal fluid. However, there are also some controversies related to this phenomenon, which require systematic investigation. M...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480410017143
更新日期:2004-12-01 00:00:00
abstract:CONCLUSION:It is thought that oxidative stress may be the major cause of the increase in the oxide thiol form in the study group. The relationship between oxidative stress status and dynamic thiol/disulphide in nasal polyposis now needs to be investigated. OBJECTIVES:The purpose of this study was to evaluate the relat...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1186833
更新日期:2016-11-01 00:00:00