Combined therapy for undifferentiated giant and spindle cell carcinoma of the thyroid.

Abstract:

:Undifferentiated giant and spindle cell carcinoma is an unusual and high-grade malignant type of cancer of the thyroid. The results of surgical and/or radiotherapeutic treatment have been discouraging. Only a few patients respond to therapy, usually for a short time. Recently, a few reports have been published on the effect of chemotherapy or a combined treatment of surgery, radiotherapy and chemotherapy. In the present paper the results of combining radiotherapy and chemotherapy, 5-FU and cyclophosphamide, are reported. For the future a more aggressive approach is discussed. The therapy should include surgical resection of the main bulk of the tumour, followed by radiotherapy and concomitant chemotherapy and thereafter prolonged adjuvant chemotherapy.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Andersson T,Biörklund A,Landberg T,Akerman M,Aspegren K,Ingemansson S

doi

10.3109/00016487709128859

subject

Has Abstract

pub_date

1977-03-01 00:00:00

pages

372-7

issue

3-4

eissn

0001-6489

issn

1651-2251

journal_volume

83

pub_type

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