Interleukin 2 receptors on squamous cell carcinomas of the head and neck. Characterization and functional role.

Abstract:

:IL2Rs, in the presence of IL2, mediate activation and proliferation of human normal lymphocytes and modulate functional changes of some human leukocytic malignancies. IL2Rs have been demonstrated also on human neoplastic and fetal non-hematologic cells in vitro, although their functional role has not been described. We describe the presence of high affinity IL2Rs on squamous cell carcinoma of the head and neck (SCCHN) lines in vitro. Expression of 200 binding sites for IL2 with an affinity of 17 x 10(-12) was demonstrated by radiobinding experiments. When cytocentrifuged SCCHN cells were studied by immunoperoxidase staining, strong positive staining was repeatedly obtained using a monoclonal antibody to the p70 subunit of the IL2Rs. Experiments in vitro and in vivo, in a nude mouse model, showed a functional role for these receptors. In fact, low doses (8-500 U/ml) of IL2 were able to inhibit growth of 11 of the 16 SCCHN lines tested. Our observations may have broad implications for the immunotherapy of cancer in general, showing the complementary immunomodulatory and direct effects of IL2.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Cortesina G,Sacchi M,Galeazzi E,Johnson JT,Whiteside TL

doi

10.1080/00016489.1992.11665436

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

370-5

issue

2

eissn

0001-6489

issn

1651-2251

journal_volume

112

pub_type

杂志文章
  • Sound quality in adult cochlear implant recipients using the HISQUI19.

    abstract:CONCLUSION:On average, adult CI recipients report a moderate sound quality using the Dutch version of the HISQUI19 questionnaire. These results are correlated with their age, speech perception scores, CI aided hearing thresholds, and the SSQ5 and the APHAB questionnaire. BACKGROUND:The general aim of the study was to ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2015.1066934

    authors: Mertens G,Kleine Punte A,De Bodt M,Van de Heyning P

    更新日期:2015-01-01 00:00:00

  • Immunohistological analysis of eotaxin and RANTES in the model animal of eosinophilic otitis media.

    abstract:BACKGROUND:The most crucial clinical problem of Eosinophilic Otitis Media (EOM) is sensorineural hearing loss. A previous report revealed that repeated antigen stimulation of middle ear causes eosinophilic inflammation not only in the middle ear but also in the inner ear. OBJECTIVE:The purpose of the present study was...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2016.1266508

    authors: Kudo N,Matsubara A,Nishizawa H,Miura T

    更新日期:2017-05-01 00:00:00

  • Lactobacillus rhamnosus GG in adenoid tissue: Double-blind, placebo-controlled, randomized clinical trial.

    abstract:CONCLUSION:Lactobacillus rhamnosus GG (L.GG) was present in all adenoids of children receiving the L. GG product. However, since L.GG was also found from the placebo group, one cannot confirm its effect on the occurrence of rhinovirus (RV) or enterovirus (EV). OBJECTIVES:The present study was conducted to determine wh...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/00016489.2015.1027412

    authors: Swanljung E,Tapiovaara L,Lehtoranta L,Mäkivuokko H,Roivainen M,Korpela R,Pitkäranta A

    更新日期:2015-08-01 00:00:00

  • CD73 expression in lymph node metastases in patients with head and neck cancer.

    abstract:INTRODUCTION:CD73 is an enzyme crucial in the metabolism of immunosuppressive adenosine. In cancer, it has various functions including tumor growth and metastases. Squamous cell carcinoma of the head and neck has an overall poor prognosis, also due to early spread of metastatic cells. MATERIALS AND METHODS:Tumor and l...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2017.1378436

    authors: Mandapathil M,Boduc M,Netzer C,Güldner C,Roessler M,Wallicek-Dworschak U,Jahns E,Stuck B

    更新日期:2018-02-01 00:00:00

  • Expression of Toll-like receptors in cultured nasal epithelial cells.

    abstract:CONCLUSIONS:Nasal epithelial cells are constitutively equipped with all Toll-like receptors (TLRs) which are essential for innate immunity. Both mRNA and protein levels of TLR3 expression increased in more differentiated nasal epithelial cells. Considering that the ligand for TLR3 is viral dsRNA, this result is in good...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480601089416

    authors: Lin CF,Tsai CH,Cheng CH,Chen YS,Tournier F,Yeh TH

    更新日期:2007-04-01 00:00:00

  • Pathology of acoustic nerve Schwannoma in vivo and in vitro.

    abstract::The ultrastructural pattern of the acoustic nerve Schwannoma was studied on surgically excised tumours and on explants cultured in vitro. The typical neoplastic cell is elongated, spindle-shaped, coated with basement membrane and numerous protruding cellular processes. Cells demonstrating numerous microfilaments are a...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488509108909

    authors: Manolidis L,Baloyannis SJ

    更新日期:1985-03-01 00:00:00

  • Peripheral facial palsy caused by the Borrelia spirochete.

    abstract::Forty-three consecutive patients with peripheral facial palsy were examined to evaluate the incidence of facial palsy caused by the tick-borne Borrelia spirochete in a non-coastal area in the south of Sweden. Six (14%) of the patients were found to have a Borrelia infection. The incidence of Borrelia-induced facial pa...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488909125548

    authors: Bjerkhoel A,Carlsson M,Ohlsson J

    更新日期:1989-11-01 00:00:00

  • Is there a deafness duration limit for cochlear implants in post-lingual deaf adults?

    abstract:CONCLUSION:Patients with post-lingual deafness should not be excluded from cochlear implantation (CI) on the basis of duration of deafness. We found that the prognosis was favorable in patients who developed deafness after adolescence, even in those with extremely long-term deafness. OBJECTIVES:CI is an effective trea...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2013.850175

    authors: Moon IS,Park S,Kim HN,Lee WS,Kim SH,Kim JH,Choi JY

    更新日期:2014-02-01 00:00:00

  • Effect of tumor necrosis factor alpha and interleukin 1-alpha on the adherence of Streptococcus pneumoniae to chinchilla tracheal epithelium.

    abstract::The trachea whole organ perfusion technique was used to study the effect of tumor necrosis factor alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha) on the adherence of otitis media pathogen Streptococcus pneumoniae (Spn) type 6A. Tracheas were removed from chinchillas and divided equally. One-half trachea was act...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489950181981

    authors: Tong HH,Fisher LM,Kosunick GM,Demaria TF

    更新日期:1999-01-01 00:00:00

  • The inner laryngeal lymphatics. A lymphangioscopical and electron microscopical study.

    abstract::Lymphangioscopical and ultrastructural studies of the larynx reveal a lymphatic capillary and a collecting vessel system. Collecting vessels show luminal valves and elastic structural components within the wall. Lymphangioscopy reveals that a strict compartmentation of different laryngeal areas is unjustifiable with t...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488009127137

    authors: Beck C,Mann W

    更新日期:1980-03-01 00:00:00

  • Acute otitis media. An animal experimental study.

    abstract::This paper describes an investigation performed to study the middle ear events ensuing from Staphylococcus aureus induced infection in the middle ear cavity of the rat. To obtain an evaluation at both the cell and the tissue level, scanning electron microscopy, transmission electron microscopy and histology were used....

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488409107560

    authors: Grote JJ,van Blitterswijk CA

    更新日期:1984-09-01 00:00:00

  • Safety of 125iodine and 192iridium implants to the canine carotid artery. Long-term results.

    abstract::Thirty-nine healthy dogs underwent a simulated radical neck dissection followed by implantation of either 125Iodine (125I) or 192Iridium (192Ir) in various dose regimes randomized prospectively from 3,000 to 30,000 rad. Bilateral selective carotid angiography was performed immediately postoperatively and at 6, 12, 18,...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:

    authors: Fee WE Jr,Goffinet DR,Fajardo LF,Guthaner D,Handen C

    更新日期:1987-05-01 00:00:00

  • Following eye movements on the absence of central vision.

    abstract::Following responses to constant velocity and sinusoidally oscillating movements of the whole visual environment were examined in normal subjects wearing blinkers to obscure central vision or subjected to a photo flash to induce a central scotoma, in patients with central scotomas of pathological origin and in one pati...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487909126455

    authors: Gresty M,Halmagyi M

    更新日期:1979-05-01 00:00:00

  • Postnatal development of vestibular receptor surfaces in the rat.

    abstract::The development of vestibular receptor surfaces was studied during the postnatal period in the rat on the 1st, 7th, 13th, 32nd and 75th days after birth. Cristae and utricles increase and change their shapes, up to day 13 for the cristae and day 32 for the utricles. Cristae hair bundles are less developed than those o...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488609108602

    authors: Dechesne C,Mbiene JP,Sans A

    更新日期:1986-01-01 00:00:00

  • Comparison of different mobile telephones in Combi40+ users.

    abstract:CONCLUSION:Telephone usage is a difficult challenge for cochlear implanted patients. A significant number of cochlear implanted patients are able to carry on a land-line or mobile telephone conversation. The telephone model may be a critical factor for telephone performance. OBJECTIVES:The goals of this study were to ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480500469552

    authors: Castro A,Lassaletta L,Bastarrica M,Prim MP,De Sarriá MJ,Gavilán J

    更新日期:2006-07-01 00:00:00

  • The use of Preyer's reflex in evaluation of hearing in mice.

    abstract::Preyer's reflex, the elicitation of startle response to auditory stimuli, has been widely used for the evaluation of hearing in rodents and other animals. Surprisingly, however, the sensitivity and specificity of Preyer's reflex in the assessment of hearing has not been adequately studied. The aim of this study was to...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:

    authors: Jero J,Coling DE,Lalwani AK

    更新日期:2001-07-01 00:00:00

  • Sandwich technique for sigmoid sinus wall reconstruction for treatment of pulsatile tinnitus caused by sigmoid sinus diverticulum/dehiscence.

    abstract::Background: If the pulsatile tinnitus caused by sigmoid sinus diverticulum/dehiscence cannot be diagnosed and treated, it can lead to significant morbidity and mortality.Aim: To assess the sandwich surgical technique for sigmoid sinus wall reconstruction for the treatment of pulsatile tinnitus caused by sigmoid sinus ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2019.1668960

    authors: Sun J,Sun J

    更新日期:2019-12-01 00:00:00

  • Suppression of the vertical vestibulo-ocular reflex in older persons at risk of falling.

    abstract::A case-control design was used to assess eye-head-trunk coordination for community-dwelling elders performing a stand-walk task. Eighteen elders with a high risk of falling were matched to 18 subjects with low risk on the basis of age, living status (living alone or with someone) and category of residence (independent...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480152583656

    authors: Di Fabio RP,Emasithi A,Greany JF,Paul S

    更新日期:2001-09-01 00:00:00

  • Psychometric properties of the Standard-Chinese lexical neighborhood test.

    abstract:CONCLUSION:The psychometric characteristics of Standard-Chinese lexical neighborhood test (LNT) confirmed the lexical effects of the four word categories. The established normative baseline can be used in evaluating the word-recognition performance of the hearing-impaired listeners. OBJECTIVES:The purpose of the prese...

    journal_title:Acta oto-laryngologica

    pub_type: 临床试验,杂志文章

    doi:10.3109/00016489.2013.840923

    authors: Wang S,Liu S,Kong Y,Liu H,Feng J,Li S,Yang Y

    更新日期:2014-01-01 00:00:00

  • Contrast enhancement of the inner ear in magnetic resonance images taken at 10 minutes or 4 hours after intravenous gadolinium injection.

    abstract:CONCLUSION:Contrast enhancement of the inner ear by three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (3D-FLAIR MRI) taken 4 h after intravenous gadolinium (Gd) injection was better than when taken at 10 min. Using heavily T2-weighted 3D-FLAIR MRI, visualization of endolymphatic hydrops (...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2011.639085

    authors: Sano R,Teranishi M,Yamazaki M,Isoda H,Naganawa S,Sone M,Hiramatsu M,Yoshida T,Suzuki H,Nakashima T

    更新日期:2012-03-01 00:00:00

  • Intermediate filament proteins in the embryonic inner ear of mice under normal conditions and after exposure to ototoxic drugs.

    abstract::The expression of the intermediate filament subclasses cytokeratins (CKs), vimentin, and neurofilament triplet proteins (NFs) was analysed in the embryonic inner ear of the CBA/CBA mouse, in vivo and in vitro, using well-defined monoclonal antibodies. Some of the cultured inner ears were exposed to 1-10 micrograms/ml ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489009107415

    authors: Berggren D,Anniko M,Thornell LE,Ramaekers FC,Virtanen I

    更新日期:1990-01-01 00:00:00

  • Prevalence of human immunodeficiency virus seropositivity in head and neck malignancies in sub-Saharan Africa.

    abstract:CONCLUSION:Salivary gland diseases should be handled with a high index of suspicion. Although an inference could be drawn it is not clear from this study if primary head and neck cancers (HNCs) have a significant association with HIV/AIDS. OBJECTIVE:HIV/AIDS manifestations and malignancies do occur in the head and nec...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480701230936

    authors: Nwaorgu O,Kokong D,Onakoya P,Adoga S,Ibekwe T

    更新日期:2007-11-01 00:00:00

  • Improved speech reception and sound quality with the DUET2 audio processor for electric acoustic stimulation.

    abstract:CONCLUSION:The results show that the DUET2 offers users speech perception that is equivalent to or better than the DUET. Moreover, the DUET2 offers subjective benefits above those provided by the DUET. BACKGROUND:The DUET is a combination of hearing aid and CI in one device for electric acoustic stimulation. Since its...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2015.1050605

    authors: Kleine Punte A,Mertens G,Cochet E,De Bodt M,Van de Heyning P

    更新日期:2015-01-01 00:00:00

  • The olfactory and respiratory epithelium in rhesus and squirrel monkeys studied with freeze-fracture technique.

    abstract::Olfactory and respiratory epithelia was prepared for thin-section and freeze-fracture replicas, and were investigated using electron microscopy. Three cell types were identified in the olfactory epithelium: olfactory receptor neurons (ORN), sustentacular cells (SC) and basal cells (BC); and respiratory epithelial cell...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488909125526

    authors: Engström B,Ekblom A,Hansson P

    更新日期:1989-09-01 00:00:00

  • Intratympanic methylprednisolone administration promotes the recovery of idiopathic sudden sensorineural hearing loss: a retrospective case-control study.

    abstract:BACKGROUND:Efficacy of current treatment methods in idiopathic sudden sensorineural hearing loss (ISSNHL) is still unsatisfactory. OBJECTIVE:This study aimed to discover in differences in effect between steroid applications responsible for promoting the prognosis in ISSNHL. MATERIALS AND METHODS:A study was conducted...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2018.1504170

    authors: Jiang K,Li S,Cheng L,Yang J

    更新日期:2018-11-01 00:00:00

  • Spindle-cell tumours of the larynx: diagnostic pitfalls. A case report and review of the literature.

    abstract::Malignant laryngeal tumours with spindle-cell morphology are relatively rare. Differential diagnosis of spindle-cell carcinoma, leiomyosarcoma, fibrosarcoma, rhabdomyosarcoma, malignant melanoma and inflammatory myofibroblastic tumour may be particularly difficult. Ambiguous and indeterminate diagnoses are also possib...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/0036554021000028070

    authors: Marioni G,Bottin R,Staffieri A,Altavilla G

    更新日期:2003-01-01 00:00:00

  • Angiogenesis from the eighth cranial nerve to vestibular schwannomas.

    abstract::Vascularization between vestibular schwannomas and the adjacent eighth cranial nerve was examined in order to elucidate the angiogenic effect of these tumours. Specimens from 12 patients were examined by light microscopy and immunohistochemistry (series 1), while specimens from another 17 patients were examined by lig...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489609137712

    authors: Matsunaga T,Kanzaki J,Hosoda Y

    更新日期:1996-01-01 00:00:00

  • Role of margin status in recurrence after CO2 laser endoscopic resection of early glottic cancer.

    abstract:CONCLUSION:In patients with early glottic squamous cell carcinoma (SCC) submitted to CO2 laser endoscopic resection, local disease recurrence was significantly correlated with the presence of positive additional surgical margins on permanent sections. OBJECTIVES:To evaluate the rate of cancer recurrence in patients wi...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480500316985

    authors: Crespo AN,Chone CT,Gripp FM,Spina AL,Altemani A

    更新日期:2006-03-01 00:00:00

  • Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear.

    abstract:CONCLUSIONS:Klotho protein content decreases with increasing age, which weakens resistance to oxidative stress, resulting in induced cell death as well as modulating endolymph fluid homeostasis. Down-regulation of klotho also leads to down-regulation of TRPV5 and TRPV6, resulting in modified Ca(2+) homeostasis in the i...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016480902725254

    authors: Takumida M,Ishibashi T,Hamamoto T,Hirakawa K,Anniko M

    更新日期:2009-12-01 00:00:00

  • Hydrops of the organ of Corti.

    abstract:OBJECTIVES:The authors would like to confirm a fluid pathway from the scala tympani to the organ of Corti, and to observe its morphological changes. METHODS:A staining solution for succinic dehydrogenase was perfused with phenazine methosulfate in the scala tympani of living guinea pigs (n = 5) under deep anesthesia. ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2016.1185541

    authors: Nomura Y,Kimura Y,Kobayashi H

    更新日期:2016-11-01 00:00:00