Intermediate filament proteins in the embryonic inner ear of mice under normal conditions and after exposure to ototoxic drugs.

abstract：CONCLUSION:Mouse embryonic stem cells (ESCs) transplanted into the scala tympani are able to migrate in the cochlea of rats deafened with aminoglycoside and partly restore the structure of sensory epithelia of the inner ear. OBJECTIVES:To explore the migration and differentiation of enhanced green fluorescence protein...

journal_title：Acta oto-laryngologica

authors： Zhao LD,Li L,Wu N,Li DK,Ren LL,Guo WW,Sun JH,Liu HZ,Chen ZT,Xing GQ,Yang SM

更新日期：2013-02-01 00:00:00

abstract：:Unilateral vestibular hypofunction (UVH) is a common vestibular dysfunction. Its influence upon the vestibulospinal reflex (VSR) is studied by posturography. The postural sway is disturbed when the VSR is disregulated because of the UVH. The degree of disturbance depends on the effectivity of the central compensation....

journal_title：Acta oto-laryngologica

authors： Norré ME,Forrez G,Beckers A

更新日期：1987-07-01 00:00:00

abstract：:The present paper presents monopolar recording of facial nerve antidromic potentials as an alternative technique to facial electromyography for the continuous monitoring of the facial nerve during acoustic neuroma surgery. The investigation involved 22 patients undergoing acoustic neuroma surgery via a retrosigmoid ap...

journal_title：Acta oto-laryngologica

authors： Colletti V,Fiorino F,Policante Z,Bruni L

更新日期：1997-09-01 00:00:00

abstract：:The present morphological study was designed to investigate the expression of HLA class II subregion gene products on human trachea. Frozen sections from the tracheas of 20 cadavers not suffering from ear, nose or throat diseases were studied immunohistochemically using monoclonal antibodies which recognize monomorphi...

journal_title：Acta oto-laryngologica

authors： Bujia J,Wilmes E,Hammer C,Kastenbauer E

更新日期：1990-07-01 00:00:00

abstract：:This work describes the different patterns of expression of integrins and extracellular matrix proteins in normal and transformed mucosa in laryngeal and oropharyngeal carcinomas. Samples from each tumor group were sectioned and examined by immunohistochemistry using monoclonal antibodies raised against integrin chain...

journal_title：Acta oto-laryngologica

authors： Ricci E,Cavalot AL,Sanvito F,Bussi M,Albera R,Staffieri A,Cortesina G,Marchisio PC

更新日期：2002-03-01 00:00:00

abstract：:During the period 1967-1985, 95 primary tracheal carcinomas occurred in Finland. The mean annual incidence rate was one per one million inhabitants, the male:female ratio being 7:3. There was a significant increase of the disease by increasing age with the exception of 70-79 years. The most common location was the low...

journal_title：Acta oto-laryngologica

authors： Manninen MP,Antila PJ,Pukander JS,Karma PH

更新日期：1991-01-01 00:00:00

abstract：:This study combined ultrastructural and statistical methods to learn the effects of weightlessness on rat utricular maculae. A principle aim was to determine whether weightlessness chiefly affects ribbon synapses of type II cells, since the cells communicate predominantly with branches of primary vestibular afferent e...

journal_title：Acta oto-laryngologica

authors： Ross MD

更新日期：2000-06-01 00:00:00

abstract：:We evaluated the vestibulo-ocular reflex (VOR) in 50 normal human subjects, uniformly distributed in age 20-59 years, and evenly distributed in sex by decade, using sinusoidal rotation over the frequency range of 0.005 to 1.0 Hz and three peak amplitudes of 25, 50, and 100 deg/sec. Age variations. The gain magnitude o...

journal_title：Acta oto-laryngologica

authors： Wall C 3rd,Black FO,Hunt AE

更新日期：1984-09-01 00:00:00

abstract：:An experimental model of sinusitis in the rabbit was developed, using type 3 pneumococci. The superior parts of the rabbit maxillary sinuses were surgically exposed and the maxillary ostium was unilaterally blocked. The following day a challenge dose of 10(7)-10(9) colony-forming units of Streptococcus pneumoniae, cap...

journal_title：Acta oto-laryngologica

authors： Drettner B,Johansson P,Kumlien J

更新日期：1987-05-01 00:00:00

abstract：CONCLUSION:Alterations within a novel putative Exon 1a within the gap junction beta 2 (GJB2) gene may play a role in the development of genetic hearing impairment in Austria. OBJECTIVES:Mutations in the GJB2 gene are the most common cause of hereditary sensorineural deafness. Genome-wide screening for alternative tran...

journal_title：Acta oto-laryngologica

authors： Parzefall T,Lucas T,Koenighofer M,Ramsebner R,Frohne A,Czeiger S,Baumgartner WD,Schoefer C,Gstoettner W,Frei K

更新日期：2017-04-01 00:00:00

abstract：CONCLUSIONS:The incidence of tonsillar cancer in Sweden is increasing, particularly among men. Risk factors other than smoking may have contributed to the observed secular trend in men. In women, however, smoking can be a part of the explanation. Further studies to look at changes in other environmental factors, such a...

journal_title：Acta oto-laryngologica

authors： Hammarstedt L,Dahlstrand H,Lindquist D,Onelöv L,Ryott M,Luo J,Dalianis T,Ye W,Munck-Wikland E

更新日期：2007-09-01 00:00:00

abstract：:Cochlear endolymph, scala tympani perilymph, and scala vestibuli perilymph were collected from fetal, neonatal, and mature guinea pigs. The concentrations of Na and K in these fluids were then assessed using a microflame photometer. The electrolyte composition in the endolymph was already characterized by a high conce...

journal_title：Acta oto-laryngologica

authors： Kanoh N,Ohmura M,Fukazawa T,Hirono Y,Makimoto K

更新日期：1985-05-01 00:00:00

abstract：:Earlier investigation did not show any clear distinctive pathological features that differentiate vocal polyps from vocal nodules. The light microscopic distinctive features between the two lesions point in the direction of a more pronounced epithelial reaction and a more fibrous stromal change in vocal nodules. In th...

journal_title：Acta oto-laryngologica

authors： Kotby MN,Nassar AM,Seif EI,Helal EH,Saleh MM

更新日期：1988-05-01 00:00:00

abstract：:Human secretory leucocyte proteinase inhibitor (SLPI) is a low-molecular weight, acid-stable inhibitor of polymorph-nuclear granulocyte elastase and cathepsin G. Previous reports have demonstrated the existence of SLPI in the respiratory tract, salivary glands and cervical mucosa. Positive staining for SLPI using immu...

journal_title：Acta oto-laryngologica

authors： Westin U,Fryksmark U,Polling A,Ohlsson K

更新日期：1994-03-01 00:00:00

abstract：CONCLUSIONS:The microarray analysis identified 39 genes up- or down-regulated by dexamethasone in the cultured tissue of mice cochlea. Of the eight genes most highly affected, several are suggested to have protective effects in the traumatized inner ear (Fkbp5, Glucocorticoid-induced leucine zipper (Gilz), glutathione ...

journal_title：Acta oto-laryngologica

authors： Maeda Y,Fukushima K,Hirai M,Kariya S,Smith RJ,Nishizaki K

更新日期：2010-12-01 00:00:00

abstract：:The aim of the present study is to construct a reference model with the indication for the attitude, the requirements and the resources needed in order to be able to deal with deafness in the presence of disabilities or associated problems. The study group consisted of 13 adults and 18 children affected by profound de...

journal_title：Acta oto-laryngologica

authors： Filipo,Bosco,Mancini,Ballantyne

更新日期：2004-04-01 00:00:00

abstract：CONCLUSION:Utricular dysfunction in patients with posterior canal benign paroxysmal positional vertigo (pBPPV) was supported by findings for ocular vestibular evoked myogenic potential (oVEMP). OBJECTIVE:To evaluate the utricular and saccular function in patients with pBPPV. METHODS:This study focused on 12 patients ...

journal_title：Acta oto-laryngologica

authors： Nakahara H,Yoshimura E,Tsuda Y,Murofushi T

更新日期：2013-02-01 00:00:00

abstract：:The records of 627 patients with inflammatory disease of the tonsils and 310 patients undergoing dissection tonsillectomy are analysed. The majority of the tonsil population in our study group are adults, and there is a high incidence of rheumatic fever and rheumatic heart disease. The study population is apt to recei...

journal_title：Acta oto-laryngologica

authors： Okafor BC

更新日期：1983-11-01 00:00:00

abstract：:The present paper investigates the hearing function in chronic otitis media vs. tympanoplasty in 41 patients with bilateral chronic otitis media, operated on unilaterally. The auditory evaluation was performed immediately before surgery and at a follow-up time varying from 1 to 14 years (mean = 5 years). Results were ...

journal_title：Acta oto-laryngologica

authors： Colletti V,Fiorino FG,Indelicato T

更新日期：1991-01-01 00:00:00

abstract：CONCLUSION:The Na-K-2Cl cotransporter-1 (NKCCl) may be essential for the maintenance and functioning of the vestibular morphology in mice and it is strongly expressed in human vestibular end organs. OBJECTIVE:NKCCl is a member of the cation-coupled chloride transporter which participates in salt transport and cell vol...

journal_title：Acta oto-laryngologica

authors： Young Choi J,Ho Jung S,Namkung W,Lee JH,Jin Son E,Wook Shin J,Park HY,Sang Lee W,Kim HN

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:Mutations in the fibrillar collagen genes COL11A1 and COL11A2 can cause sensorineural hearing loss associated with Stickler syndrome. There is a correlation of hearing loss severity, onset, progression and affected frequencies with the underlying mutated collagen gene. We sought to determine whether differenc...

journal_title：Acta oto-laryngologica

authors： Shpargel KB,Makishima T,Griffith AJ

更新日期：2004-04-01 00:00:00

abstract：:This report shows the changes that occurred in consecutive audiograms of a patient who underwent chemotherapy and radiotherapy for nasopharyngeal cancer and the histopathological examination of the temporal bones. Both conductive and sensorineural hearing loss developed, but followed different modes of progression. In...

journal_title：Acta oto-laryngologica

authors： Asenov DR,Kaga K,Tsuzuku T

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:To quantitatively analyze modifications of the paratubal muscles in developing Wistar rats following nasal obstruction. MATERIAL AND METHODS:Twenty-four Wistar rats were used. Twelve were examined at 6, 8 and 12 weeks after birth and were considered normal controls. The nostrils of the remaining 12 rats were...

journal_title：Acta oto-laryngologica

authors： Scarano E,Fetoni AR,Picciotti P,Cadoni G,Galli J,Paludetti G

更新日期：2003-01-01 00:00:00

abstract：CONCLUSION:Given the phonetic balancing across lists and the validation with spectrally degraded speech, the present Mandarin disyllable recognition test (DRT) materials may be useful for assessing speech performance of Mandarin-speaking cochlear implant (CI) users. If combined with the previously developed sentence ma...

journal_title：Acta oto-laryngologica

authors： Zhu M,Wang X,Fu QJ

更新日期：2012-08-01 00:00:00

abstract：:Enzymatic tracer techniques to study normal and pathologic strial capillary transport pose various problems. The use of electron opaque tracers can circumvent many of these problems. Iron dextran (mol. diam 20--70 A) and ferritin (mol. diam 110 A) were injected intravenously and the mice sacrificed at intervals of 1/2...

journal_title：Acta oto-laryngologica

authors： Santos-Sacchi J,Marovitz WF

更新日期：1980-01-01 00:00:00

abstract：:The condition of the cochlear vasculature was evaluated in 7 normal guinea pigs subsequent to fatal aortic hemorrhage. The cochleas were prepared for histological analysis using a soft surface preparation technique. The data analysis revealed two statistically significant differences: an increase in the number of aggr...

journal_title：Acta oto-laryngologica

authors： Jones-Mumby C,Axelsson A

更新日期：1984-03-01 00:00:00

abstract：CONCLUSIONS:Klotho protein content decreases with increasing age, which weakens resistance to oxidative stress, resulting in induced cell death as well as modulating endolymph fluid homeostasis. Down-regulation of klotho also leads to down-regulation of TRPV5 and TRPV6, resulting in modified Ca(2+) homeostasis in the i...

journal_title：Acta oto-laryngologica

authors： Takumida M,Ishibashi T,Hamamoto T,Hirakawa K,Anniko M

更新日期：2009-12-01 00:00:00

abstract：:Alloplastic materials have been used in middle ear reconstruction since 1952. Biologically, biomaterials and specifically ceramics can be defined as being bioinert, bioactive or biodegradable; these terms being descriptive of the biochemical response provoked by the material in the host tissue. Various ceramics, carbo...

journal_title：Acta oto-laryngologica

authors： Blayney AW,Williams KR,Erre JP,Lesser TH,Portmann M

更新日期：1992-01-01 00:00:00

abstract：:In a previous investigation into noise-induced hearing loss by comparing 2-month-old albino with pigmented guinea pigs, albinos displayed significantly greater shifts in cochlear microphonic (CM) threshold and less recovery than the pigmented animals 7 days after noise exposure. The present study compared the response...

journal_title：Acta oto-laryngologica

authors： Conlee JW,Abdul-Baqi KJ,McCandless GA,Creel DJ

更新日期：1988-07-01 00:00:00

abstract：:In this study, cytological examination of nasal secretions of 17 patients with cystic fibrosis (CF) was combined with quantitative determination of common inflammatory mediators. Results showed a normal cytogram in these patients. However, obvious mucosal inflammation is evidenced by significantly higher concentration...

journal_title：Acta oto-laryngologica

authors： Wang D,Brihaye P,Smitz J,De Waele M,Clement P

更新日期：1996-05-01 00:00:00