Abstract:
:This study combined ultrastructural and statistical methods to learn the effects of weightlessness on rat utricular maculae. A principle aim was to determine whether weightlessness chiefly affects ribbon synapses of type II cells, since the cells communicate predominantly with branches of primary vestibular afferent endings. Maculae were microdissected from flight and ground control rat inner ears collected on day 13 of a 14-day spaceflight (F13), landing day (R0) and day 14 postflight (R14) and were prepared for ultrastructural study. Ribbon synapses were counted in hair cells examined in a Zeiss 902 transmission electron microscope. Significance of synaptic mean differences was determined for all hair cells contained within 100 section series, and for a subset of complete hair cells, using SuperANOVA software. The synaptic mean for all type II hair cells of F13 flight rats increased by 100%, and that for complete cells by 200%. Type I cells were less affected, with synaptic mean differences statistically insignificant in complete cells. Synapse deletion began within 8 h upon return to Earth. Additionally, hair cell laminated rough endoplasmic reticulum of flight rats was reversibly disorganized on R0. Results support the thesis that synapses in type II hair cells are uniquely affected by altered gravity. Type II hair cells may be chiefly sensors of gravitational and type I cells of translational linear accelerations.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Ross MDdoi
10.1080/000164800750045983subject
Has Abstractpub_date
2000-06-01 00:00:00pages
490-9issue
4eissn
0001-6489issn
1651-2251journal_volume
120pub_type
杂志文章abstract::POLGON (Polarized light goniometer) was used to evaluate ataxia during stepping movements in patients with spinocerebellar degeneration (SCD) and Parkinson's disease. The measurements included mean angular change of shoulders (M.A.C.S.) and its coefficient of variation (C.V.). In patients with SCD, the values of M.A.C...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489309135847
更新日期:1993-07-01 00:00:00
abstract:CONCLUSIONS:Our preliminary results indicate that mastoidectomy by reconstruction of the posterior wall and obliteration (MAPRO) avoided the disadvantages of a canal-wall-down mastoidectomy. MAPRO effectively prevented cholesteatoma recurrence, provided an excellent basis for hearing restoration, and was generally wate...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.643456
更新日期:2012-04-01 00:00:00
abstract:CONCLUSION:Transforming growth factor β1 gene (TGFβ1) genotype is a potential p16 independent prognostic factor predicting response to chemoradiotherapy in head and neck squamous cell carcinoma (HNSCC). OBJECTIVES:Expression of p16 and epidermal growth factor receptor (EGFR) has been reported to be associated with sur...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.678944
更新日期:2012-09-01 00:00:00
abstract:CONCLUSION:Candidates for hearing preservation cochlear implant (CI) surgery can be divided into: those who benefit from electrical complement (EC) to remaining hearing and don't require additional amplification, those using a combined electric-acoustic stimulation (EAS) and those with the least amount of residual hear...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480903567189
更新日期:2010-08-01 00:00:00
abstract::As a continuation of our previous work, where we have demonstrated that in chronic otitis media the picture in the submucosa-bone marginal zone is dominated by capillary proliferation and occurrence of a mononuclear, histiocyte-like cell containing lysosome-like cytoplasmatic bodies, we now report the presence of cons...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487509124704
更新日期:1975-05-01 00:00:00
abstract:BACKGROUND:The graviceptive otolith function can be measured using subjective visual horizontal (SVH) testing. Nevertheless, more research efforts are required to understand the essential variables affecting SVH. OBJECTIVE:The aim of the present study was to determine the effects of type of visual image and gender on ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1817552
更新日期:2021-01-01 00:00:00
abstract:CONCLUSION:This study shows that, in cochlear implantation (CI) surgery, pre-operative caloric test results are not correlated with post-operative outcomes of dizziness or speech perception. OBJECTIVES:To determine the role of pre-operative caloric tests in CI. METHODS:The records of 95 patients who underwent unilate...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2016.1172731
更新日期:2016-09-01 00:00:00
abstract:CONCLUSION:The prognosis of the clinically positive neck in temporal bone squamous cell carcinoma is bad and failures never occur in the neck but at the site of the primary. A clinically positive neck at presentation is a sign of aggressiveness of the primary and, in such cases, therapeutic neck dissection is to be per...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480903390152
更新日期:2010-08-01 00:00:00
abstract::The change in the EP, CM, SP and AP during perilymphatic perfusion of vasopressin (antidiuretic hormone) was examined in the guinea pig. The EP was recorded with a microelectrode through the spiral ligament of the second turn. The CM, SP and AP were measured with the differential electrodes in the basal turn. The perf...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488609132830
更新日期:1986-03-01 00:00:00
abstract:CONCLUSION:The technology of stimulation rates between 1500 and 5000 pulses per second per channel (pps/ch) brings a benefit for all users. However, the fastest possible rate does not necessarily lead to best hearing performance in each individual subject. Individual optimization of stimulation rate is recommended. OB...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480902971239
更新日期:2010-01-01 00:00:00
abstract:CONCLUSIONS:In addition to the correlation of transforming growth factor (TGF)-beta1 levels to the radiation toxicity, both Epstein-Barr virus (EBV) infection and postoperative status play roles in the change in plasma TGF-beta1 levels in patients with head and neck cancers. OBJECTIVES:To assess the parameters involve...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701714293
更新日期:2008-10-01 00:00:00
abstract::The facial nerve of the albino rat was compressed by inserting a thin nylon thread in the facial canal. After a survival period of 1-60 days, the animal was perfused with Ringer's solution followed by a 2% periodate-lysine-paraformaldehyde fixative. Frozen sections from the brain stem containing the facial motor nucle...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489409126055
更新日期:1994-05-01 00:00:00
abstract::Lymphangioscopical and ultrastructural studies of the larynx reveal a lymphatic capillary and a collecting vessel system. Collecting vessels show luminal valves and elastic structural components within the wall. Lymphangioscopy reveals that a strict compartmentation of different laryngeal areas is unjustifiable with t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488009127137
更新日期:1980-03-01 00:00:00
abstract::Spontaneous nystagmus and locomotor equilibrium function were repeatedly tested before and after unilateral labyrinthectomy in 12 squirrel monkeys in order to study the effect of physical exercise on the vestibulo-oculomotor and vestibulo-locomotor compensation. Post-operatively, 6 of the monkeys received forced physi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487509124676
更新日期:1975-03-01 00:00:00
abstract::The effects of transdermally administered scopolamine (TTS-scopolamine) (release rate 5 micrograms/h, one and two patches) and dimenhydrinate (100 mg) on caloric, angular acceleration induced and optokinetic nystagmus were examined in 16 volunteers in a randomized double-blind study. All drugs induced a statistically ...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016488509182266
更新日期:1985-05-01 00:00:00
abstract::In a double-blind crossover trial, 24 patients with perennial rhinitis have been treated with 2% disodium cromoglycate (DSCG) nasal spray. 15 patients preferred DSCG to placebo, 9 patients showed no preference. Analysis of the diary cards showed a significant preference of DSCG in the group which received placebo firs...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016487709123969
更新日期:1977-09-01 00:00:00
abstract:BACKGROUND:Intratympanic corticosteroid (IC), intravenous batroxobin (IB) as the treatment for sudden sensorineural hearing loss (SSNHL) has been reported. However, the data on combination therapy (CT) was scarce. OBJECTIVE:The aim of this retrospective study was to compare the efficacy of IC, IB, and CT in the treatm...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2019.1592221
更新日期:2019-06-01 00:00:00
abstract::This report shows the changes that occurred in consecutive audiograms of a patient who underwent chemotherapy and radiotherapy for nasopharyngeal cancer and the histopathological examination of the temporal bones. Both conductive and sensorineural hearing loss developed, but followed different modes of progression. In...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480601127026
更新日期:2007-10-01 00:00:00
abstract::It is known that 15-20% of oropharyngeal carcinomas develop distant metastases that involve most commonly lung, liver and bone. Clival metastasis from oropharyngeal squamous cell carcinoma has not been previously reported in the English literature. We describe the rare occurrence of clival metastasis from tonsillar ca...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701687283
更新日期:2008-06-01 00:00:00
abstract:CONCLUSIONS:Available multichannel cochlear implants (CIs) provide effective tinnitus suppression. More sophisticated speech strategies are more effective than analogue or slow strategies. The mechanisms by which tinnitus is suppressed by CIs are unclear; however, both acoustic masking and reorganization of the right a...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701387173
更新日期:2008-02-01 00:00:00
abstract::Assessment of hearing handicap is frequently based on hearing loss in the frequency region from 0.5 to 2.0 kHz. The region above 2 kHz, however, is important for hearing, particularly when one considers speech perception in conditions with ambient noise. The present study, based on 200 individuals (400 ears) with nois...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.1990.12088407
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to analyze the safety and effectiveness of a new cochlear implant (CI) system developed in China, the Nurotron Venus device. MATERIAL AND METHODS:Fifteen post-lingually deafened patients received Nurotron Venus CIs in our hospital. The safety and effectiveness of the devices were ev...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.894250
更新日期:2014-06-01 00:00:00
abstract::The vestibulo-ocular reflex (VOR) of the alert rhesus monkey was studied using rotational acceleration in the horizontal plane. Both sinusoidal and pseudorandom binary sequence (PRBS) stimuli were used to perform parameters. Results from sinusoidal studies over the frequency range 0.01 to 1.28 Hz, with stimulus amplit...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209130856
更新日期:1982-01-01 00:00:00
abstract::Conclusion Neck dissection after radiotherapy increased the risk of aspiration as a late effect in a sub-sample of patients treated for head and neck cancer in the ARTSCAN study. Patients treated with accelerated fractionation (AF) developed aspiration, with or without coughing, more frequently than patients treated w...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3109/00016489.2015.1113439
更新日期:2016-01-01 00:00:00
abstract::The biocompatibility of commercially available polyimides was examined in relation to the sensory and neural structures of the cochlea. Thin films of four different polyimides were prepared as substrates for photolithographically produced scala tympani electrode arrays and implanted in 32 cat cochleae. Following at le...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488909127474
更新日期:1989-01-01 00:00:00
abstract::Although the association between gastroesophageal reflux disease (GERD) and laryngeal disorders in adults is well established there is still a lack of information concerning the true extent of the laryngeal complications of GERD in children. The aim of this study was to determine the laryngeal status of children with ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164802753648213
更新日期:2002-04-01 00:00:00
abstract::Introduction: Patients with chronic vestibular multi-canalicular canalithiasis (CVMCC) can have serious morbidities, for example, musculoskeletal pain, dizziness, fatigue, and cognitive difficulties. Involvement of the anterior semi-circular canal (SCC) is common in CVMCC. A mono-canalicular diseased anterior SCC is r...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章
doi:10.1080/00016489.2019.1667529
更新日期:2019-12-01 00:00:00
abstract:CONCLUSION:Patients with posterior semicircular canal dehiscence (PSCD) have low frequency conductive hearing loss similar to patients with superior semicircular canal dehiscence (SSCD) secondary to a pathologic third window. OBJECTIVES:PSCD can result in conductive hearing loss, but the magnitude of this hearing loss...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,评审
doi:10.3109/00016489.2015.1060630
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:This study showed that short and long interval treatments achieved comparable success rates. There was no statistically significant difference in the rate of early and late recurrences between the two groups. Modified Epley maneuver can be applied in a short interval time with comparable success and recurr...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1252852
更新日期:2017-05-01 00:00:00
abstract::The waltzing guinea pig exhibits genetically induced inner ear disease which develops into deafness and vestibular disorder. The type I hair cell in vestibular end organs shows specific pathology, featuring protrusion of the hair cell apex, sensory hair fusion and an intracellular actin filament rod. With the freeze-f...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309132893
更新日期:1983-09-01 00:00:00