Abstract:
:This study combined ultrastructural and statistical methods to learn the effects of weightlessness on rat utricular maculae. A principle aim was to determine whether weightlessness chiefly affects ribbon synapses of type II cells, since the cells communicate predominantly with branches of primary vestibular afferent endings. Maculae were microdissected from flight and ground control rat inner ears collected on day 13 of a 14-day spaceflight (F13), landing day (R0) and day 14 postflight (R14) and were prepared for ultrastructural study. Ribbon synapses were counted in hair cells examined in a Zeiss 902 transmission electron microscope. Significance of synaptic mean differences was determined for all hair cells contained within 100 section series, and for a subset of complete hair cells, using SuperANOVA software. The synaptic mean for all type II hair cells of F13 flight rats increased by 100%, and that for complete cells by 200%. Type I cells were less affected, with synaptic mean differences statistically insignificant in complete cells. Synapse deletion began within 8 h upon return to Earth. Additionally, hair cell laminated rough endoplasmic reticulum of flight rats was reversibly disorganized on R0. Results support the thesis that synapses in type II hair cells are uniquely affected by altered gravity. Type II hair cells may be chiefly sensors of gravitational and type I cells of translational linear accelerations.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Ross MDdoi
10.1080/000164800750045983subject
Has Abstractpub_date
2000-06-01 00:00:00pages
490-9issue
4eissn
0001-6489issn
1651-2251journal_volume
120pub_type
杂志文章abstract:CONCLUSION:The results of this study suggest that treatment with radical scavengers has the potential to become an effective new therapy for age-related hearing loss. OBJECTIVE:To assess the efficacy of treatment with radical scavengers for age-related hearing loss. SUBJECTS AND METHODS:Rebamipide (300 mg/day), alpha...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480802008215
更新日期:2009-01-01 00:00:00
abstract::The activity of central vestibular neurons (Vn) of the horizontal canal system was recorded in chronically hemilabyrinthectomized cats and compared with that of labyrinth intact animals. In both groups the cerebellar vermis was removed in order to assess the efficacy of the vestibular brainstem commissure alone by mea...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409107529
更新日期:1984-07-01 00:00:00
abstract::Beta 2-microglobulin (beta 2m) is a small polypeptide, related to the immunoglobulins and present on nucleated cells as part of the strong transplantation antigens. Elevated plasma levels have been recorded in patients with various malignant diseases. Human beta 2m has also been detected immunohistochemically in carci...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409107571
更新日期:1984-09-01 00:00:00
abstract:CONCLUSION:Defective utricular function, reflected by deviation of the perceived visual horizontal or vertical, cannot by itself explain increased postural sway in the lateral direction for patients with unilateral vestibular deafferentation (uVD). OBJECTIVE:It is not known why some patients with chronic uVD report di...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480600684423
更新日期:2006-12-01 00:00:00
abstract:CONCLUSION:Reconstruction with a vascularized bone flap provided superior postoperative outcomes compared with reconstruction with a soft tissue free flap. However, patients obtained acceptable long-term functional outcomes even with a soft tissue free flap and this method is an option in selected patients. A multidisc...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.824111
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the capability of indirect computed tomography and magnetic resonance lymphography (CT/MR-LG) with gadolinium-loaded, polyethylenimine-entrapped gold nanoprobes (Gd-Au PENPs) for assessing lingual sentinel lymph node (SLN) metastasis in a tongue VX2 carcinoma model. MATERIALS AND METHODS:Seventee...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2018.1441544
更新日期:2018-08-01 00:00:00
abstract::Earlier investigation did not show any clear distinctive pathological features that differentiate vocal polyps from vocal nodules. The light microscopic distinctive features between the two lesions point in the direction of a more pronounced epithelial reaction and a more fibrous stromal change in vocal nodules. In th...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809119505
更新日期:1988-05-01 00:00:00
abstract:CONCLUSION:Moxifloxacin was generally well tolerated and highly effective in the treatment of acute bacterial rhinosinusitis (ABS). The incidence of adverse events (AEs) and adverse drug reactions (ADRs) was low. The effectiveness, safety, and tolerability information collected in this study confirm the clinical safety...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3109/00016481003629036
更新日期:2010-09-01 00:00:00
abstract::Overexpression of epidermal growth factor receptor (EGF-R) is a common characteristic of epidermoid tumors and its expression in head and neck squamous cell carcinoma biopsies and cell lines has been reported previously by several authors. With the aim to provide more structural and functional details about the protei...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489309135902
更新日期:1993-11-01 00:00:00
abstract::Olfactory and respiratory epithelia was prepared for thin-section and freeze-fracture replicas, and were investigated using electron microscopy. Three cell types were identified in the olfactory epithelium: olfactory receptor neurons (ORN), sustentacular cells (SC) and basal cells (BC); and respiratory epithelial cell...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488909125526
更新日期:1989-09-01 00:00:00
abstract:CONCLUSION:From aspect of fluid dynamics, expanding patients' nasopharyngeal coronal-sectional area to 48.3-54.7% of normal area will bring the airflow velocity back to normal in adenoidal hypertrophy children. It might provide a suggestion for adenoidectomy range selection and whether total resection is necessary. OB...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1212266
更新日期:2017-01-01 00:00:00
abstract::We examined quantitatively the ventrodorsal gliding occurring along a sagittal plane in the cricothyroid articulation. For this purpose we used 10 fresh excised human larynges taken at autopsy. Furthermore we examined the morphology, the hydroxyproline content and collagen types of the ligaments and the articular caps...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709134706
更新日期:1987-01-01 00:00:00
abstract:CONCLUSION:SOD1 is an important gene related to noise-induced hearing loss (NIHL), and its effect is dependent on noise exposure levels. OBJECTIVES:To test whether the polymorphisms in the CuZn-superoxide dismutase gene (SOD1) are associated with susceptibility to NIHL in the Chinese population. METHODS:Audiometric d...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480903253587
更新日期:2010-04-01 00:00:00
abstract:CONCLUSION:The risk of operation-requiring postoperative bleeding after abscess tonsillectomy is no different from the risk after elective tonsillectomy. However, the risk is higher for older than for younger patients, both for the whole cohort and for tonsillectomy à chaud. OBJECTIVE:The objective of the present stud...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.660545
更新日期:2012-07-01 00:00:00
abstract:CONCLUSION:Systemic application of human mesenchymal stem cells (hMSCs) may be another effective tool for stem cell supply to the inner ear. OBJECTIVES:Most researchers have used local application to provide the inner ear with stem cells. In spite of their efficacy, these methods can potentially cause irreversible dam...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.660731
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To assess paranasal sinus material histopathologically for the presence of fungus. MATERIAL AND METHODS:Paraffin-embedded archival biopsy samples of patients who underwent endonasal sinus surgery between 1992 and 2002 were retrospectively assessed for the presence of fungi. Hematoxylin-eosin-stained sections...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310001222
更新日期:2003-04-01 00:00:00
abstract::The author has performed clinical and follow-up studies of 80 acromegalic patients treated by transanthro-sphenoidal removal of the pituitary adenoma. Heredity for acromegaly or gigantism was recorded in 3.8% of the patients and other hereditary factors in 13.8%. Head trauma, meningitis or encephalitis was recorded in...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487609120891
更新日期:1976-09-01 00:00:00
abstract::Patients with chronic otitis media (COM) were divided into two groups, one to be given Cephalexin (CEX) orally and the other to be given CEX ear drops locally. The counts of viable bacteria in otorrheal samples collected before and after CEX administration were determined. The incidence of decrease in the count of bac...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488109133264
更新日期:1981-09-01 00:00:00
abstract:BACKGROUND:Differential diagnosis of persistent vertigo/dizziness in patients with a past history of vestibular neuritis (VN) and sudden deafness with vertigo (SDV) could sometimes be difficult for physicians due to variable vertiginous symptoms from rotatory to floating sensation. OBJECTIVES:The main purpose of the p...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1813327
更新日期:2020-12-01 00:00:00
abstract:CONCLUSION:Low-dose administration of Aspartame (Ap) did not produce a significant ototoxic effect at the end of the 6th month. However, duration of the ototoxic effect is shortened and severity of the effect is increased as dose and duration of Ap administration is increased. OBJECTIVES:While Ap toxicity has been stu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1256498
更新日期:2017-04-01 00:00:00
abstract::On-line measurement of ME gas composition in normal middle ears of 5 anesthetized guinea pigs at an established steady state was performed by mass spectrometry. The mean values for the gas composition of the middle ear were found to be: PN2: 82.4%, PO2: 7.6% and PCO2: 10.0%. This composition is very different from tha...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489309135824
更新日期:1993-05-01 00:00:00
abstract::The aim of this paper was to examine the accuracy of passive whole-body self-rotation estimate around the earth-vertical (yaw) axis. Subjects were required to reach an imposed angle of +/- 90 degrees, 180 degrees or 360 degrees (outward way), and then to rotate back to the initial position (return way), through passiv...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509133338
更新日期:1995-01-01 00:00:00
abstract::The transitional zone of the saccule and the utricle--has been studied by transmission electron microscope in rats, days before birth. A noticeable secretory activity has been observed in their cells as well as the presence of inorganic spicular bodies that have also been observed in the lumen, some of them integrated...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309139436
更新日期:1983-05-01 00:00:00
abstract::Gaze functions under high-frequency head oscillations with large amplitudes were investigated in 12 normal subjects. Oscillation amplitude decreased as the frequency increased (31 degrees at 2 Hz to 11 degrees at 5 Hz on average). Maximum head velocity and acceleration were 170-200 degrees/s and 2,500-5,000 degrees/s2...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488909127495
更新日期:1989-03-01 00:00:00
abstract::The gram negative bacteria, nontypable Haemophilus influenzae (NTHi) was used to induce otitis media in a total of 18 chinchillas. Three days post-inoculation, three cohorts of 6 chinchillas each were treated daily for four days with either ceftriaxone, chloramphenicol, or diluent without antibiotics. Middle ear fluid...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709118000
更新日期:1997-01-01 00:00:00
abstract::A prospective study was carried out to objectively quantificate the most important predictive factors in idiopathic facial paralysis (Bell's palsy). Stepwise discriminant analysis was applied to data prospectively obtained from 570 patients with Bell's palsy treated at the ENT Department of La Paz Hospital between Jan...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809106436
更新日期:1988-09-01 00:00:00
abstract:CONCLUSIONS:In our study setting nitrous oxide (N(2)O) did not show any clinical benefit in discomfort experienced when applying local anesthesia for nasal operations. Further studies with longer inhalation times are needed to elucidate the role of N(2)O in application of local anesthesia in nasal surgery. OBJECTIVES:...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,随机对照试验
doi:10.1080/00016480701714319
更新日期:2008-07-01 00:00:00
abstract::The nystagmus and motion perception of two astronauts were recorded during Earth-vertical axis rotation and during off-vertical axis rotation (OVAR) before and after 7 days of spaceflight. Postflight, the peak velocity and duration of per- and postrotatory nystagmus during velocity steps about the Earth-vertical axis ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509139374
更新日期:1995-09-01 00:00:00
abstract::We studied the influence of neck afferents on the perception of orientation. In Experiment 1, we investigated the effect of head tilt on the subjective vertical in both the visual and tactile modalities. The results showed that head tilt triggers an Aubert effect in the visual modality and a Müller effect in the tacti...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800750000261
更新日期:2000-09-01 00:00:00
abstract::While cigarette smoking and alcohol consumption are recognized covariates for head and neck squamous cell carcinoma (SCC), the role of genetic factors in determining individual susceptibility is unknown. The human tumour necrosis factor (TNF) region on chromosome 6p21 within the major histocompatibility complex (MHC) ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489850155035
更新日期:1998-03-01 00:00:00