Abstract:
CONCLUSION:SOD1 is an important gene related to noise-induced hearing loss (NIHL), and its effect is dependent on noise exposure levels. OBJECTIVES:To test whether the polymorphisms in the CuZn-superoxide dismutase gene (SOD1) are associated with susceptibility to NIHL in the Chinese population. METHODS:Audiometric data from 2400 Chinese Han people exposed to occupational noise were analyzed. DNA samples were collected from the 10% most susceptible and the 10% most resistant individuals. Four SNPs in the introns of SOD1 were genotyped and their effects and interactions with noise exposure were analyzed. RESULTS:Genotype AA of rs2070424 conferred protection against NIHL (adjusted OR = 0.45, p = 0.005), while GG of rs10432782 was a risk genotype (adjusted OR = 1.88, p = 0.026). One protective haplotype TATG (OR = 0.56, p = 0.003) and two risk haplotypes, CATG and TGGA (OR = 1.58, 28.75 and p = 0.017, <0.001, respectively) were identified. Significant interactions between SOD1 SNPs and noise levels were found. Further analysis of effects of SOD1 SNPs found that those carrying GG genotype of rs10432782 had significantly higher SOD1 activity (p = 0.022), but a significantly lower level of malondialdehyde in plasma, compared with TT carriers (p = 0.007).
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Liu YM,Li XD,Guo X,Liu B,Lin AH,Rao SQdoi
10.3109/00016480903253587subject
Has Abstractpub_date
2010-04-01 00:00:00pages
477-86issue
4eissn
0001-6489issn
1651-2251pii
10.3109/00016480903253587journal_volume
130pub_type
杂志文章abstract:CONCLUSION:These findings indicate a strong protective effect of ALCAR and NAC on impulse noise-induced cochlear damage, and suggest the feasibility of using clinically available antioxidant compounds to protect the ear from acute acoustic injury. OBJECTIVE:Reactive oxygen species have been shown to play a significant...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480410023038
更新日期:2005-03-01 00:00:00
abstract::Biopsy samples from the maxillary sinus mucosa of patients with purulent, non-purulent and recurrent sinusitis were studied histologically and compared with those from a maxillary sinus of patients with no previous history of sinus disease on the side of sampling. Basement membrane thickening, atypical gland formation...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489009107468
更新日期:1990-11-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between hearing loss and vestibular dysfunction in patients with sudden sensorineural hearing loss (SSHL). METHODS:Clinical data including the symptom of vertigo of 149 SSHL patients were investigated retrospectively. Pure tone audiometry, ocular vestibular-evoked myogenic pot...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1110750
更新日期:2016-01-01 00:00:00
abstract::Dynamic range (DR) of cochlear implant electrodes and speech recognition scores (SRS) were chronologically studied in 23 post-lingually deaf subjects over a period of one year. DR significantly increased over one year (ANOVA, p = 0.03). When DR was compared among three groups of electrodes which were located in the in...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489609137829
更新日期:1996-03-01 00:00:00
abstract:OBJECTIVE:Mutations in the fibrillar collagen genes COL11A1 and COL11A2 can cause sensorineural hearing loss associated with Stickler syndrome. There is a correlation of hearing loss severity, onset, progression and affected frequencies with the underlying mutated collagen gene. We sought to determine whether differenc...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480410016162
更新日期:2004-04-01 00:00:00
abstract::In 6 pigs a bronchoscopical resection of the tracheal mucosa was performed using CO2-laser on one side, and an electric high-frequency cutting loop (ECL) on the other. The pigs were sacrificed 3 months later. On macroscopic examination the tracheal mucosa appeared almost normal on the laser-resected side, while severe...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488909127514
更新日期:1989-03-01 00:00:00
abstract::Laryngoscopy in cases of sulcus vocalis reveals bowed vocal folds, resulting in a spindle-shaped chink with glottal incompetence. The anatomic and functional problems and resulting incomplete glottal closure during phonation lead to the presenting symptoms of breathy hoarseness, decrease in maximum phonation time (MPT...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,评审
doi:10.3109/00016489.2014.999873
更新日期:2015-06-01 00:00:00
abstract::We examined the expressions of alpha-subunits of very late antigen (VLA)-4 (alpha4) and VLA-5 (alpha5) on tonsillar lymphocytes and the interaction between these integrin receptors and their ligand, fibronectin (FN). Immunohistological and flow cytometric analyses showed that alpha4 and alpha5 were expressed in the ly...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489609137722
更新日期:1996-01-01 00:00:00
abstract:CONCLUSION:The clinical presentation and outcome of post-traumatic benign paroxysmal positional vertigo (t-BPPV) are different from those idiopathic BPPV (i-BPPV). It appears that t-BPPV is more difficult to treat than i-BPPV. OBJECTIVE:To identify the clinical presentation and outcome of t-BPPV. METHODS:We reviewed ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.657359
更新日期:2012-08-01 00:00:00
abstract::Almost all the pathological and physiological process that effect the nose will change the volume of the airspace within it. This volume has previously been difficult to measure but a new method that calculates this space has been developed. A mechanical model was built to test the physical parameters involved in maki...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709117791
更新日期:1997-03-01 00:00:00
abstract::Seven to eight years after a disease period of vestibular neuritis 19 patients previously examined at our department were given a questionnaire about whether they had experienced any audiovestibular symptoms since they first fell ill. All 19 patients responded and 18 consented to participate in the long-term follow-up...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950180243
更新日期:1999-01-01 00:00:00
abstract::It has previously been shown that simple compounds with multiple amine groups are ototoxic, the degree of ototoxicity depending on the number of amine groups in the molecule. The relationship between the number of amino groups and ototoxicity in aminoglycoside was studied using kanamycin A and kanamycin B, which conta...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709134700
更新日期:1987-01-01 00:00:00
abstract:CONCLUSION:The narrowing pattern of the upper airway in obstructive sleep apnea patients may be different in sleep as compared with awake. Three different types of obstruction were observed in these subjects during drug-induced sleep. The different obstruction pattern during drug-induced sleep suggests that different s...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480902780242
更新日期:2009-12-01 00:00:00
abstract::Nine subjects with long-term (8-30 years) occupational exposure to industrial solvents and a confirmed diagnosis of psycho-organic syndrome (POS) have been studied with audiological and otoneurological test batteries. The results were compared to a matched control group of nine industrial workers not exposed to solven...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488909127473
更新日期:1989-01-01 00:00:00
abstract::We studied int-2 and bcl-1 gene amplification in 21 operated patients with cancer of the larynx. In 9 cases, the int-2 gene was amplified (42.9%) and in 4 cases. the bcl-1 gene was amplified (25.0%). Co-amplification of int-2 and bcl-1 was observed in three cases (18.8%), all of which were glottic carcinomas. Other am...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489850183331
更新日期:1998-09-01 00:00:00
abstract:CONCLUSIONS:The transconjunctival approach to orbital floor fractures permits excellent exposure of the inferior orbit and provides a good surgical outcome, especially with regard to ocular motility. OBJECTIVE:Surgical access to orbital floor fractures can be accomplished via the transconjunctival approach. The majori...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480500395757
更新日期:2006-04-01 00:00:00
abstract:CONCLUSION:Given the phonetic balancing across lists and the validation with spectrally degraded speech, the present Mandarin disyllable recognition test (DRT) materials may be useful for assessing speech performance of Mandarin-speaking cochlear implant (CI) users. If combined with the previously developed sentence ma...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.653668
更新日期:2012-08-01 00:00:00
abstract::The aerobic and anaerobic bacterial flora of middle ear exudate (MEE) of 47 consecutive patients with chronic suppurative otitis media were studied using a quantitative bacteriological technique under strictly anaerobic conditions. Specimens from the external auditory canal (EAC) and the nasopharynx (NP) were obtained...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488609119425
更新日期:1986-11-01 00:00:00
abstract::By a careful ENT and oral examination of 111 patients with suspected chronic maxillary sinusitis, the diagnosis was verified in only 56% (62/111). In 29 of these 62 patients (47%) a relation to dental infections was found, periodontitis being as frequent as apical granulomas. In 61% of the patients, in whom the diagn...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209130865
更新日期:1982-01-01 00:00:00
abstract::The trachea whole organ perfusion technique was used to study the effect of tumor necrosis factor alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha) on the adherence of otitis media pathogen Streptococcus pneumoniae (Spn) type 6A. Tracheas were removed from chinchillas and divided equally. One-half trachea was act...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950181981
更新日期:1999-01-01 00:00:00
abstract:CONCLUSIONS:Available multichannel cochlear implants (CIs) provide effective tinnitus suppression. More sophisticated speech strategies are more effective than analogue or slow strategies. The mechanisms by which tinnitus is suppressed by CIs are unclear; however, both acoustic masking and reorganization of the right a...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701387173
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:pH monitoring can reflect the changes in H+ in the airway. OBJECTIVES:To explore the utility of pharyngeal pH monitoring in the diagnosis of laryngopharyngeal reflux disease (LPRD). MATERIAL AND METHODS:Clinical data from 956 suspected LPRD patients from February 2016 to March 2018 were analyzed retrospect...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2019.1571280
更新日期:2019-03-01 00:00:00
abstract::Background: Amyloidosis is a benign, slowly progressive disease. However, the treatment of laryngeal amyloidosis (LA) has not been studied systematically.Objectives: To investigate the treatment results of cold micro forceps or carbon dioxide laser under microlaryngoscope in the treatment of LA.Methods: A retrospectiv...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2019.1680864
更新日期:2019-12-01 00:00:00
abstract::The most common cause of seasonal allergic rhinitis in Japan is the Japanese cedar (JC). Recently, a pullulan-conjugated antigen (CS-560) has been developed to reduce adverse effects and to enhance the effect of JC-specific immunotherapy (IT). If the mechanism of IT can be fully elucidated and the treatment can be use...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章
doi:10.1080/00016480252775742
更新日期:2002-01-01 00:00:00
abstract::We examined the mucosa of 50 rat middle ears in an experimental model of acute otitis media, in order to obtain information on the mechanisms of polyp formation. The right middle ear of 25 rats was inoculated with type 3 pneumococci, and the left ear served as a control. The animals were killed, the middle ear bulla r...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509133351
更新日期:1995-01-01 00:00:00
abstract::In a double-blind crossover trial, 24 patients with perennial rhinitis have been treated with 2% disodium cromoglycate (DSCG) nasal spray. 15 patients preferred DSCG to placebo, 9 patients showed no preference. Analysis of the diary cards showed a significant preference of DSCG in the group which received placebo firs...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016487709123969
更新日期:1977-09-01 00:00:00
abstract:CONCLUSION:Low-dose administration of Aspartame (Ap) did not produce a significant ototoxic effect at the end of the 6th month. However, duration of the ototoxic effect is shortened and severity of the effect is increased as dose and duration of Ap administration is increased. OBJECTIVES:While Ap toxicity has been stu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1256498
更新日期:2017-04-01 00:00:00
abstract::A family with early-onset vestibulopathy is presented. The 34-year-old father had experienced brief attacks of vertigo and currently suffers from unsteadiness and oscillopsia during head movements. His two young sons also experience brief attacks of spontaneous vertigo. In vestibular testing all three subjects showed ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310002500
更新日期:2003-08-01 00:00:00
abstract::Craniotomy with cerebrospinal fluid (CSF) suction was performed on 18 guinea pigs to determine the effects on the inner ear morphology. Six control animals received anaesthesia only and 12 were operated on with a postoperative survival time of 1 or 24 h. The histologic examinations showed no signs of endolymphatic hyd...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016489409126116
更新日期:1994-11-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of imagining a fixed spatial reference on balance control. MATERIAL AND METHODS:Twenty-one healthy subjects were asked to remain as stable as possible while standing on a sway-referenced platform (NeuroCom Equitest posturography system). Subjects were instructed to keep their eyes o...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480410017503
更新日期:2004-10-01 00:00:00