Abstract:
:This report shows the changes that occurred in consecutive audiograms of a patient who underwent chemotherapy and radiotherapy for nasopharyngeal cancer and the histopathological examination of the temporal bones. Both conductive and sensorineural hearing loss developed, but followed different modes of progression. In the left ear, an air-bone gap appeared and deepened, while in the right ear, severe conductive hearing loss was present upon admission and improved after treatment. Sensorineural hearing loss was worse in the right ear, but deteriorated gradually in both ears. Histology revealed tumor invasion in the right temporal bone. Both middle ears showed effusion, but no radiation-induced changes that may be responsible for the conductive loss. The main changes in the cochlea were vascular stria degeneration, spiral ligament atrophy, and spiral ganglion cell depletion, while the hair cells were only occasionally missing. Apart from confirming what has been established previously by other authors, some interesting findings were observed: (1) in addition to the high frequency hearing loss typically caused by cis-platinum and by radiation, there was also low frequency hearing loss, and (2) the cochlear damage was most severe in the vascular stria and spiral ganglions, sparing the hair cells.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Asenov DR,Kaga K,Tsuzuku Tdoi
10.1080/00016480601127026subject
Has Abstractpub_date
2007-10-01 00:00:00pages
1105-10issue
10eissn
0001-6489issn
1651-2251pii
772865995journal_volume
127pub_type
杂志文章abstract::To investigate the pathogenesis of swimmers' sinusitis we questioned and examined a group of 20 swimmers and 20 controls. Clinical examination was followed by rhinomanometry, sonography of the maxillary sinuses, a saccharine test to assess mucociliary transport in the nose, and a viable cytological sampling of the nas...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489009122550
更新日期:1990-09-01 00:00:00
abstract:CONCLUSION:Our results show a significant difference between skin and cholesteatoma biology in vitro. OBJECTIVES:Cholesteatoma disease is a process of destruction characterized by uncontrolled growth of squamous epithelial cells in the middle ear or temporal bone. The pathophysiology behind the cholesteatoma developme...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480903413657
更新日期:2010-07-01 00:00:00
abstract:CONCLUSIONS:Congenital cytomegalovirus (CMV) infection is a major cause of bilateral and unilateral sensorineural hearing loss (SNHL) in children, accounting for 9.0% of SNHL cases. The diagnostic rate using combined genetic deafness test and CMV DNA detection test was determined to be 46.4% in bilateral profound SNHL....
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.583268
更新日期:2011-09-01 00:00:00
abstract::Using electron microscopy and GABA immunohistochemistry we evaluated the effects on human embyronic organ of Corti tissue culture of exposure to the ototoxic aminoglycoside antibiotic neomycin at a dose of 1 mM for 48 to 96 hrs. Neomycin induces the formation of multilamellar myeloid structures. These lesions, found o...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489609137929
更新日期:1996-11-01 00:00:00
abstract:CONCLUSIONS:Intratympanic steroid (ITS) treatment groups exhibited better outcomes in PTA improvement and recovery rate than systemic steroid therapy (SST) groups. Whether initial hearing loss severity would influence the PTA improvement and recovery rate still requires further research. OBJECTIVE:This article was aim...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,meta分析
doi:10.1080/00016489.2016.1260157
更新日期:2017-06-01 00:00:00
abstract:CONCLUSION:The aetiology of Zenker's diverticulum is likely to be multifactorial. The geographical and racial variation in the prevalence and the rare familial cases suggest that genetic predisposition might have a role in the pathogenesis. The mode of inheritance in the rare possible familial cases seems to be autosom...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701813822
更新日期:2008-09-01 00:00:00
abstract:CONCLUSIONS:The presented results add further support to the observation that laser microsurgery is the preferential surgical treatment for recurrent respiratory papillomatosis (RRP). A meticulous follow-up for early recognition of local recurrence and malignant transformation is recommended. OBJECTIVES:Endoscopic mic...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701200350
更新日期:2007-11-01 00:00:00
abstract::Middle ear lesions were produced in chinchillas by introducing fascia, Gelfoam, silastic or a combination of these materials into the labyrinthine and mastoid bullae. After 1-2 months, conventional 226 Hz and multifrequency tympanometry (MFT) were performed and the animals were sacrificed for histopathological analysi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489850154937
更新日期:1998-03-01 00:00:00
abstract::Background: The treatments of horizontal semicircular canal benign paroxysmal positional vertigo (HSC-BPPV) have low remission rates ranging between 60% and 90%, connected to the difficulty in correctly identifying the affected side of HSC-BPPV. Objective: To propose and compare the efficacy of the latency test (LT) i...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2019.1635712
更新日期:2019-10-01 00:00:00
abstract:CONCLUSION:The Esteem(®) device proved to offer beneficial results in subjects suffering from high frequency, severe bilateral sensorineural hearing loss (SNHL) and may be considered as an alternative procedure to conventional hearing aids (HAs) or electroacoustic stimulation (EAS) systems. OBJECTIVES:Since the Esteem...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2010.536994
更新日期:2011-04-01 00:00:00
abstract:CONCLUSION:Human adipose-derived stem cells (ASCs), encapsulated in a fibrin-collagen hydrogel for the coating of an electrode array, produce sufficient amounts of neurotrophic factors and may be suitable for enhancing the bioelectric interface of cochlear implants (CIs). OBJECTIVES:To evaluate different hydrogel comp...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.878809
更新日期:2014-05-01 00:00:00
abstract::Transitory hearing impairment has been well documented in humans during basilar migraine attacks. Ischemia induced by activation of central nervous system adrenoreceptors by cAMP is one of the mechanisms that has been implicated, as well as calcium metabolism alterations. Propranolol-HCl has proven to be an effective ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109137383
更新日期:1991-01-01 00:00:00
abstract::The cochlea of the inner ear is no longer regarded exclusively as a passive mechanical signal analyser. Active mechanical processes are thought to influence the vibration pattern of the basilar membrane. The source of these active mechanical processes is sought in the outer hair cells (OHC). These auditory sensory cel...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809119443
更新日期:1988-01-01 00:00:00
abstract::The symptoms of postural instability and dizziness associated with decompression sickness could be ascribed to either damage of the vestibular apparatus or to central nervous system damage. However, a histological study of monkeys exposed to decompression reveals that these symptoms primarily result from damage to the...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488009131707
更新日期:1980-01-01 00:00:00
abstract::The ultrastructure of the epithelial cells of the endolymphatic duct in the rat is described, following vascular perfusion-fixation of live, anaesthetised and artificially respirated animals. The animals were fixed by means of a pressure feed-back controlled peristaltic pump and an isotonic perfusate-fixative containi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489409126013
更新日期:1994-01-01 00:00:00
abstract::A retrospective study was carried out on repeated audio-vestibular examinations in 53 patients with unilateral Meniere's disease, between the vertiginous spells. Most patients showed no change in the caloric response reduction of the afflicted ear in the subsequent tests compared with the first one. These patients had...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488109133278
更新日期:1981-11-01 00:00:00
abstract::The DBA/2 strain of mice have genetically induced vestibular dysfunction that presents grossly at an early age as circling behavior and abnormal righting reflexes. The vestibular morphology of this strain has not previously been examined. DBA/2 mice of different ages that showed circling behavior were sacrificed and t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489409126075
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVE:To quantitatively analyze modifications of the paratubal muscles in developing Wistar rats following nasal obstruction. MATERIAL AND METHODS:Twenty-four Wistar rats were used. Twelve were examined at 6, 8 and 12 weeks after birth and were considered normal controls. The nostrils of the remaining 12 rats were...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310001141
更新日期:2003-01-01 00:00:00
abstract::The distribution of fibronectin (FN) in operative specimens of maxillary sinus mucosa from 35 patients with chronic sinusitis was examined immunohistochemically. Mouse monoclonal antibody to human FN was used for the peroxidase-antiperoxidase staining technique. FN was found in most of the serous cells and in some (ab...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109137365
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:The most crucial clinical problem of Eosinophilic Otitis Media (EOM) is sensorineural hearing loss. A previous report revealed that repeated antigen stimulation of middle ear causes eosinophilic inflammation not only in the middle ear but also in the inner ear. OBJECTIVE:The purpose of the present study was...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1266508
更新日期:2017-05-01 00:00:00
abstract::This study was performed in order to determine the immunohistochemical expression and distribution pattern as well as the electrophysiological actions of substance P in human vestibular ganglion cells. Substance P-like immunostaining was mainly found in the cytoplasm of small vestibular ganglion cells. In contrast, ne...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489609137839
更新日期:1996-03-01 00:00:00
abstract:CONCLUSION:A man-made bone tunnel of 1.5 turns around the modiolus can be created in cases of total cochlear ossification. Patients with ossified cochlea types I and II achieved satisfactory hearing results after cochlear implantation (CI). Patients with ossified cochlea type III, in which the modiolus is damaged by th...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.947656
更新日期:2014-12-01 00:00:00
abstract::Histology, histogenesis, biology and treatment of the rare spindle cell carcinoma of the larynx are presented. The histogenesis of spindle cell tumours has been much debated, but electron microscopic investigations have shown that most of the laryngeal lesions are squamous epithelial carcinomas that have undergone tra...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409107550
更新日期:1984-07-01 00:00:00
abstract:OBJECTIVE:Temperature-controlled radiofrequency volumetric tissue reduction (RFVTR) is a minimally invasive technique used in the treatment of the tongue base, soft palate and turbinates. Complications seem to be rare, but the scope of previous studies was often limited by the small number of patients included. The aim...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310001385
更新日期:2003-05-01 00:00:00
abstract::This study correlates static and flow-cytometric analysis on paraffin-embedded and fresh material of salivary gland carcinomas. Nuclear suspensions for DNA analysis were prepared from paraffin-embedded and fresh material. Comparison of the results of static and flow cytometry on paraffin-embedded material revealed no ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950181080
更新日期:1999-01-01 00:00:00
abstract::The early diagnosis of the Mondini dysplasia by means of electrocochleography and temporal bone polytomography, and the prevention of further hearing loss through the endolymphatic subarachnoid shunt operation, brought new data on the follow-up of patients with this malformation. They were found to present specific me...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309139454
更新日期:1983-05-01 00:00:00
abstract::Normal subjects were exposed to two kinds of optokinetic stimulation, viz. at speeds of 60 degrees/s and 90 degrees/s preceded by acceleration at 6 degrees/s2 and 4.5 degrees/s2, respectively. In most subjects the speed of the eye in the slow nystagmus phase equalled the speed of the rotating device during the acceler...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487709123954
更新日期:1977-09-01 00:00:00
abstract::Central origin of the vidian nerve in the dog was investigated using the retrograde tracing technique of horseradish peroxidase (HRP). After HRP was applied to the vidian nerve, labelled neurons were found in the medulla oblongata and the geniculate ganglion but could not be found in the trigeminal ganglion. Labelled ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309132883
更新日期:1983-07-01 00:00:00
abstract:UNLABELLED:Abstract Conclusions: In survival analysis, the combined Charlson comorbidity index (CCI) can be considered as a prognostic factor independent of the tumor node metastasis (TNM) classification, tumor stage, and tumor location. Severe comorbidity was the factor that had the greatest impact on prognosis in cas...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.564651
更新日期:2011-08-01 00:00:00
abstract::Cochlear microphonics (CM) were recorded in the guinea pig using differential recording from the first and third cochlear turns as well as by using a 10-electrode array inserted in the scala tympani of the basal turn. The excitation profile as represented by the CM was quantified by amplitude and phase data, and was m...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487809121465
更新日期:1978-05-01 00:00:00