Lactobacillus rhamnosus GG in adenoid tissue: Double-blind, placebo-controlled, randomized clinical trial.

Abstract:

CONCLUSION:Lactobacillus rhamnosus GG (L.GG) was present in all adenoids of children receiving the L. GG product. However, since L.GG was also found from the placebo group, one cannot confirm its effect on the occurrence of rhinovirus (RV) or enterovirus (EV). OBJECTIVES:The present study was conducted to determine whether a 3-week oral consumption of L.GG would lead to presence of the probiotic in adenoid tissue. Furthermore, nasopharyngeal RV and EV findings and symptom data were investigated. METHOD:The tissue samples were collected from 40 children aged 1-5 years about to undergo adenotomy due to recurrent acute/secretory otitis media, chronic rhinitis, or recurrent sinusitis after a 3-week daily consumption of L.GG (n = 20) or placebo (n = 20). Strain-specific real-time PCR was used to detect RV, EV, and L.GG in adenoid tissue. RESULTS:L.GG was recovered in the adenoid sample in 100% of children in the L.GG group and in 76% in the placebo group (p = 0.07). Both RV and EV were found in 31% of children in the L.GG group and in 18% of children in the placebo group (p = 0.67). The majority of the positive samples were positive for both RV and EV. Study diaries showed no differences in symptoms between the groups.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Swanljung E,Tapiovaara L,Lehtoranta L,Mäkivuokko H,Roivainen M,Korpela R,Pitkäranta A

doi

10.3109/00016489.2015.1027412

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

824-30

issue

8

eissn

0001-6489

issn

1651-2251

journal_volume

135

pub_type

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