Potentiation of noise-induced audiogenic seizure risk by salicylate in mice as a function of salicylate-noise exposure interval.

Abstract:

:Audiogenic seizure risk can be induced in genetically seizure-resistant BALB/c mice by exposure to an intense noise. Results of this experiment showed that combined exposure to noise and sodium salicylate could produce a greater priming effect than exposure to the noise alone, and the greatest potentiation effect was obtained when animals were exposed to the noise 6 hr after the intake of salicylate. The findings were taken as indirect evidence suggesting that the ototoxic action of sodium salicylate could potentiate vulnerability of the mouse cochlea to noise damage.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Chen CS,Aberdeen GC

doi

10.3109/00016488009131698

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

61-5

issue

1-2

eissn

0001-6489

issn

1651-2251

journal_volume

90

pub_type

杂志文章
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    doi:

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