Abstract:
:The objective of this study was to develop and test an endolabyrinthic microsurgical procedure for treatment of vertigo, the utriculostomy. This involves the application of local heat for obtaining a fistula in the membranous labyrinth, so as to establish communication between the endolymphatic and perilymphatic spaces at the utricle level. Before the procedure, an experimental model using quail eggs was built for pre-evaluation, and macroscopic and histological studies were performed in the temporal bones of three healthy sheep. Following this, the utriculostomy was performed through the oval window in 12 sheep. A microthermocautery was conceived by the first author and developed at Hospital de Clinicas de Porto Alegre. This equipment allows for control of temperature and duration of exposure to heat. Three months after the surgery, the animals were killed. A histological study of the temporal bones was performed to assess whether communication had been created between the endolymphatic and perilymphatic spaces, or whether a neomembrane had developed in the cauterized region. Histological sections of the vestibule of eight animals (three normal, five surgical) were analysed. All non-surgical cases presented a normal utricle wall. Three surgical cases (60%) presented a neomembrane. The absence of identifiable perforations in the utricle wall and the presence of neomembrane areas in 60% of the operated bones suggest that utriculostomy is a promising procedure for the treatment of Meniere's disease.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Lavinsky L,Goycoolea M,Gananca MM,Zwetsch Ydoi
10.1080/00016489950180739subject
Has Abstractpub_date
1999-01-01 00:00:00pages
522-7issue
5eissn
0001-6489issn
1651-2251journal_volume
119pub_type
杂志文章abstract:CONCLUSIONS:Congenital cytomegalovirus (CMV) infection is a major cause of bilateral and unilateral sensorineural hearing loss (SNHL) in children, accounting for 9.0% of SNHL cases. The diagnostic rate using combined genetic deafness test and CMV DNA detection test was determined to be 46.4% in bilateral profound SNHL....
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.583268
更新日期:2011-09-01 00:00:00
abstract::The aim of this study was to evaluate histologic changes after long-term administration of the topical nasal decongestants phenylephrine and oxymetazoline. Ninety healthy rabbits were divided into 3 groups for topical administration for 1 week, 2 weeks, and 4 weeks. Each group was subdivided into 3 subgroups by topica...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509139384
更新日期:1995-09-01 00:00:00
abstract::In precollicular decerebrate cats, activation of limb extensors during side-down roll tilt of the animal depends on both an increased discharge of excitatory vestibulospinal neurons and a reduced discharge of inhibitory medullary reticulospinal (mRS) neurons. These inhibitory neurons are tonically excited by a choline...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:1987-05-01 00:00:00
abstract::This study combined ultrastructural and statistical methods to learn the effects of weightlessness on rat utricular maculae. A principle aim was to determine whether weightlessness chiefly affects ribbon synapses of type II cells, since the cells communicate predominantly with branches of primary vestibular afferent e...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800750045983
更新日期:2000-06-01 00:00:00
abstract:CONCLUSIONS:Our results confirm that supracricoid laryngectomies (SL) are reliable techniques for glottosupraglottic tumors, even for selected T3 and T4 cases, if the indications are correct. These surgical techniques allow a good quality of life with the preservation of the larynx. OBJECTIVE:SL with cricohyoidoepiglo...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480500469024
更新日期:2006-06-01 00:00:00
abstract:CONCLUSION:Extensive bone erosion correlated with a worse prognosis of the squamous cell carcinoma (SCC) of the temporal bone but extensive soft tissue involvement did not correlate with prognosis in this study. Resectability of the tumor seems to be major prognostic factor of temporal bone SCC. OBJECTIVE:Prognostic f...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480802642096
更新日期:2009-11-01 00:00:00
abstract::Patients with chronic otitis media (COM) were divided into two groups, one to be given Cephalexin (CEX) orally and the other to be given CEX ear drops locally. The counts of viable bacteria in otorrheal samples collected before and after CEX administration were determined. The incidence of decrease in the count of bac...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488109133264
更新日期:1981-09-01 00:00:00
abstract:CONCLUSIONS:We describe a Japanese family with high-frequency sensorineural hearing loss (SNHL) harboring a c.211delC mutation in the KCNQ4 gene. Families showing progressive high-frequency SNHL should be investigated for mutations in the KCNQ4 gene. OBJECTIVE:To determine the responsible deafness gene in a Japanese f...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.890740
更新日期:2014-06-01 00:00:00
abstract::From a study of nitric oxide (NO) output in the nose and sinuses it seems that: (i) the results obtained regarding the regulation of NO output in the nose do not necessarily apply to the sinuses; (ii) the results obtained for one group of sinuses may not apply to another; and (iii) NO output in the sinuses does not be...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480510031524
更新日期:2005-10-01 00:00:00
abstract::We have recorded auditory evoked potentials, of both neurogenic and myogenic origin, in cats having neonatal high frequency cochlear hearing loss. Using frequency specific stimuli (tone pips) and by measuring responses near to threshold, we have probed tonotopic (or cochleotopic) representation within the brainstem-mi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489309135763
更新日期:1993-01-01 00:00:00
abstract::Explants of basilar papillae from 6-7 days posthatch chicks were cultured in growth medium for a period of 1-8 days. Hair cells were counted following staining of stereocilia bundles with FITC-phalloidin, and the percentage of hair cell survival was determined by comparison to control (i.e. uncultured) specimens. Hair...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489850183133
更新日期:1998-09-01 00:00:00
abstract::Surgery and radiotherapy are still the best local and regional treatments for the majority of head and neck cancer patients, each alone having an impressive cure rate. However, it appears that surgery and radiotherapy have reached their upper limits. To improve the results obtained by surgery and radiotherapy, combine...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章,评审
doi:10.3109/00016488909127520
更新日期:1989-05-01 00:00:00
abstract:CONCLUSION:Our results demonstrate for the first time a potentially enhanced basal secretion of monocyte chemoattractant protein-1 (MCP-1) and interleukin (IL)-17A-stimulated secretion of IL-6 from nasal polyp fibroblasts, enhanced basal secretion of IL-6 from eosinophilic nasal polyp fibroblasts, and a remarkable up-r...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.796091
更新日期:2013-10-01 00:00:00
abstract::To elucidate immune mechanisms in otitis media, middle ear infection was induced in 12 rats by intratympanic inoculation of Streptococcus pneumoniae type 3, either the ipsilateral or the contralateral middle ear being re-challenged 4 weeks later. Otomicroscopy inspection confirmed the presence of acute otitis media (A...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109100760
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The aim of this study was to demonstrate the long-term effectiveness of Expansion Sphincter Pharyngoplasty (ESP) as a standalone surgical treatment of obstructive sleep apnea-hypopnea syndrome (OSAHS) patients through a prospective multi-center study. MATERIAL AND METHODS:A prospective non-com...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,多中心研究
doi:10.1080/00016489.2018.1533992
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To determine factors influencing help-seeking behaviour in hearing-impaired persons aged > or = 55 years MATERIAL AND METHODS:The study comprised 1,419 persons (480 females, 939 males) aged > or = 55 years who participated voluntarily in a driving test. Pure-tone audiometry was performed in all subjects. Par...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/0001648031000719
更新日期:2003-09-01 00:00:00
abstract:CONCLUSION:On average, adult CI recipients report a moderate sound quality using the Dutch version of the HISQUI19 questionnaire. These results are correlated with their age, speech perception scores, CI aided hearing thresholds, and the SSQ5 and the APHAB questionnaire. BACKGROUND:The general aim of the study was to ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1066934
更新日期:2015-01-01 00:00:00
abstract:CONCLUSION:A 20 mm hole made backwards from the midpoint of the asterion to the mastoid process is suitable for a retrosigmoid keyhole approach with the aid of an endoscope. The endoscope-assisted retrosigmoid keyhole approach can be considered an effective and safe method for removal of vestibular schwannoma. OBJECTI...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.817682
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To assess paranasal sinus material histopathologically for the presence of fungus. MATERIAL AND METHODS:Paraffin-embedded archival biopsy samples of patients who underwent endonasal sinus surgery between 1992 and 2002 were retrospectively assessed for the presence of fungi. Hematoxylin-eosin-stained sections...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310001222
更新日期:2003-04-01 00:00:00
abstract::A 50-year-old woman presented with a 10-year history of swelling of the left cheek during and after meals. She regularly pushed the cheek hard to decrease the swelling by excreting the saliva. She did not have pain or fever. She also complained of bronchial asthma and allergic rhinitis. Magnetic resonance imaging (MRI...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480600621680
更新日期:2006-10-01 00:00:00
abstract::The ultrastructure of the geniculate ganglion was studied in the guinea pig and monkey. Two cytologically distinct colonies of ganglion cells were seen and identified as light and dark cells. All neurons were unmyelinated and most were unipolar, although a few bipolar cells were seen. The axons, upon leaving the cell ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209130869
更新日期:1982-01-01 00:00:00
abstract:CONCLUSION:This 3D prototyped model constructed using a selective laser sintering method serves as a good material for surgical simulation of a malformed ear. OBJECTIVE:In order to perform surgery of the malformed ear, a thorough understanding of the anatomy of the ear is required, together with sufficient experience....
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480410016874
更新日期:2005-01-01 00:00:00
abstract::The distribution of the Substance P (SP) immunoreactive nerve fibres in the canine larynx and laryngeal nerves was studied by PAP immunohistochemistry. Many individual SP immunoreactive nerve fibres with varicosities were observed within the epithelial layer and in the connective tissue below the epithelium of the lar...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488509108597
更新日期:1985-07-01 00:00:00
abstract::The symptoms of postural instability and dizziness associated with decompression sickness could be ascribed to either damage of the vestibular apparatus or to central nervous system damage. However, a histological study of monkeys exposed to decompression reveals that these symptoms primarily result from damage to the...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488009131707
更新日期:1980-01-01 00:00:00
abstract::Nitric oxide synthase (NOS) isoforms I and III were localized in the guinea pig cochlea by indirect immunohistochemistry using frozen sections and paraffin sections. NOS I staining was observed in the cytoplasm of outer hair cells, in nerve cell somata and fibers of the spiral ganglion, and in axonal profiles of the s...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489609137914
更新日期:1996-09-01 00:00:00
abstract::This report shows the changes that occurred in consecutive audiograms of a patient who underwent chemotherapy and radiotherapy for nasopharyngeal cancer and the histopathological examination of the temporal bones. Both conductive and sensorineural hearing loss developed, but followed different modes of progression. In...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480601127026
更新日期:2007-10-01 00:00:00
abstract:CONCLUSIONS:The adenovirus-5 vector specifically transduced spiral ganglion cells with high efficiency, suggesting that it is a potential gene therapeutic tool for the survival of spiral ganglion cells with secondary injury. OBJECTIVES:This study aimed to find a suitable viral vector allowing efficient transduction to...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480903510742
更新日期:2010-07-01 00:00:00
abstract::In a previous study, the authors described a technique for recording ipsilateral EABRs using the DIGISONIC MXM cochlear implant (Gallégo et al, Acta Otolaryngol (Stockh) 1996; 116: 228-33) and showed that the EABR input/output functions were very similar across electrodes. In the present study a test of electrode func...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709117761
更新日期:1997-03-01 00:00:00
abstract::The purpose of this study was to show the early stages of polyp formation, as part of our studies on the pathogenesis of nasal polyps. Two and 4 weeks after experimental tubal occlusion in 18 Wistar rats, 13 showed signs of bacterial infection, respective acute otitis media. In the majority of these rats polypouslike ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109138432
更新日期:1991-01-01 00:00:00
abstract::The aerobic and anaerobic bacterial flora of middle ear exudate (MEE) of 47 consecutive patients with chronic suppurative otitis media were studied using a quantitative bacteriological technique under strictly anaerobic conditions. Specimens from the external auditory canal (EAC) and the nasopharynx (NP) were obtained...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488609119425
更新日期:1986-11-01 00:00:00