Evaluation of new treatment methods for head and neck cancer: a challenge.

Abstract:

:Surgery and radiotherapy are still the best local and regional treatments for the majority of head and neck cancer patients, each alone having an impressive cure rate. However, it appears that surgery and radiotherapy have reached their upper limits. To improve the results obtained by surgery and radiotherapy, combined approaches with chemotherapy or immunotherapy must be further explored. Prospective randomized trials are essential for the evaluation of the efficacy of such multimodality treatments. Although there is an increasing commitment to this type of clinical research amongst otolaryngologists/head and neck surgeons, we still lag considerably behind other surgical and medical disciplines. Broad peer support is the conditio sine qua non that prospective randomized studies will be successfully conducted in head and neck oncology. Such studies, irrespective of their outcome in terms of which treatment is best, will provide data on important issues like that of failure sites. Accurate evaluation of the magnitude of the failure problem at respectively the local, the regional and the distant level are essential for estimating the potential for gains and establishing priorities for clinical research.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Snow GB

doi

10.3109/00016488909127520

subject

Has Abstract

pub_date

1989-05-01 00:00:00

pages

352-6

issue

5-6

eissn

0001-6489

issn

1651-2251

journal_volume

107

pub_type

临床试验,杂志文章,评审
  • Noise exposure alters cyclooxygenase 1 (COX-1) and 5-lipoxygenase (5-LO) expression in the guinea pig cochlea.

    abstract:CONCLUSION:Changes in the metabolism of arachidonic acid (AA) might be part of a noise-induced compensatory mechanism with regional specificity. OBJECTIVES:The released imbalance of prostaglandins and leukotrienes, both AA metabolites, might result in altered blood flow regulation in the inner ear and probably contrib...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480903168066

    authors: Heinrich UR,Selivanova O,Schmidtmann I,Feltens R,Brieger J,Mann WJ

    更新日期:2010-03-01 00:00:00

  • The problem of nodal disease in squamous cell carcinoma of the temporal bone.

    abstract:CONCLUSION:The prognosis of the clinically positive neck in temporal bone squamous cell carcinoma is bad and failures never occur in the neck but at the site of the primary. A clinically positive neck at presentation is a sign of aggressiveness of the primary and, in such cases, therapeutic neck dissection is to be per...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016480903390152

    authors: Zanoletti E,Danesi G

    更新日期:2010-08-01 00:00:00

  • Contrast-enhanced MRI of the inner ear after intratympanic injection of meglumine gadopentetate or gadodiamide hydrate.

    abstract:CONCLUSION:The degree of contrast enhancement of the cochlea after intratympanic administration of meglumine gadopentetate (Gd-DTPA) or gadodiamide hydrate (Gd-DTPA-BMA) varies widely among patients with inner ear diseases. There was no morphological change in the stria vascularis after Gd-DTPA or Gd-DTPA-BMA was place...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2010.507781

    authors: Suzuki H,Teranishi M,Naganawa S,Nakata S,Sone M,Nakashima T

    更新日期:2011-02-01 00:00:00

  • Investigation of resectability degree for adenoidal surgery in OSA children with the method of computational fluid dynamics.

    abstract:CONCLUSION:From aspect of fluid dynamics, expanding patients' nasopharyngeal coronal-sectional area to 48.3-54.7% of normal area will bring the airflow velocity back to normal in adenoidal hypertrophy children. It might provide a suggestion for adenoidectomy range selection and whether total resection is necessary. OB...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2016.1212266

    authors: Hu C,Han D,Zhou B,Zhang L,Li Y,Zang H,Li L

    更新日期:2017-01-01 00:00:00

  • A comparison of vocal fold closure in rigid telescopic and flexible fiberoptic laryngostroboscopy.

    abstract::Fifteen normal speakers (7 women and 8 men), ranging in age from 21 to 35 years, were examined consecutively with rigid telescopy and flexible fiberscopy during sustained phonation at 3 loudness levels. The endoscopes were connected to a stroboscope and video equipment. The purpose was to investigate whether the two l...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489209100796

    authors: Södersten M,Lindestad PA

    更新日期:1992-01-01 00:00:00

  • Congenital unilateral lower lip palsy.

    abstract::Thirty-nine cases of congenital facial asymmetry, in which one corner of the mouth does not dip downward symmetrically with the other, are presented. The author has termed this condition 'congenital unilateral lower lip palsy' (CULLP). CULLP was the most frequent condition in congenital facial anomalies seen in our cl...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487909137173

    authors: Kobayashi T

    更新日期:1979-01-01 00:00:00

  • Spindle cell carcinoma of the larynx.

    abstract::Histology, histogenesis, biology and treatment of the rare spindle cell carcinoma of the larynx are presented. The histogenesis of spindle cell tumours has been much debated, but electron microscopic investigations have shown that most of the laryngeal lesions are squamous epithelial carcinomas that have undergone tra...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488409107550

    authors: Katholm M,Krogdahl A,Hainau B,Bretlau P

    更新日期:1984-07-01 00:00:00

  • Elective neck dissection vs observation in transorally treated early head and neck carcinomas with cN0 neck.

    abstract:CONCLUSION:This study showed that elective neck dissection (ND) resulted in reduced regional recurrences in a selected group of surgically treated patients with pT1-2 carcinomas but did not show any benefit for disease-specific survival (DSS). Furthermore, the importance of pN classification was also verified for this ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2012.743032

    authors: Psychogios G,Mantsopoulos K,Koch M,Klintworth N,Kapsreiter M,Zenk J,Iro H

    更新日期:2013-03-01 00:00:00

  • Freeze-fracture study of the cell junctions in the utricle and saccule.

    abstract::The maculae sacculi and utriculi of the chinchilla vestibular labyrinth have been studied by freeze-fracture method. In the replicas extensive zonulae occludentes have been found between sensory and supporting cells at the endolymphatic surface. Gap junctions are located between the supporting cells. Some intramembran...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487709128816

    authors: Laciano L,Franke K,Iurato S,Reale E

    更新日期:1977-01-01 00:00:00

  • Psychometric properties of the Standard-Chinese lexical neighborhood test.

    abstract:CONCLUSION:The psychometric characteristics of Standard-Chinese lexical neighborhood test (LNT) confirmed the lexical effects of the four word categories. The established normative baseline can be used in evaluating the word-recognition performance of the hearing-impaired listeners. OBJECTIVES:The purpose of the prese...

    journal_title:Acta oto-laryngologica

    pub_type: 临床试验,杂志文章

    doi:10.3109/00016489.2013.840923

    authors: Wang S,Liu S,Kong Y,Liu H,Feng J,Li S,Yang Y

    更新日期:2014-01-01 00:00:00

  • Laryngeal abductor muscle reinnervation in a pig model.

    abstract:OBJECTIVE:To develop a large animal model for studies of laryngeal abductor reinnervation. MATERIAL AND METHODS:Six minipigs underwent unilateral anastomosis of the phrenic nerve-abductor branch of the recurrent laryngeal nerve (RLN). Polyhydroxybutyrate (PHB) conduits were used for repair. At each of 30, 60 and 120 d...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480410022507

    authors: Birchall M,Idowu B,Murison P,Jones A,Burt R,Ayling S,Stokes C,Pope L,Terenghi G

    更新日期:2004-09-01 00:00:00

  • Effects of nasal occlusion on respiration in sleep. Evidence of inheritability of sleep apnea proneness.

    abstract::An influence of complete mechanical obstruction of the nasal passages was investigated in 6 apneic-free sons of fullblown sleep apnea patients and in 4 age-matched normal young adults without a familial history of sleep apnea. Nasal obstruction caused a significant increase in the number of sleep apneas in the sons of...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488409130972

    authors: Lavie P,Rubin AE

    更新日期:1984-01-01 00:00:00

  • Association between ABO blood group status and cochlear/neural function: auditory brainstem response findings.

    abstract:BACKGROUND:ABO blood group status may be a risk factor for some diseases, including hearing loss. Individuals with blood group O show a higher prevalence of hearing loss after industrial noise exposure. Group O individuals with normal hearing show reduced amplitudes in otoacoustic emission recordings. Whether blood gro...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2020.1858236

    authors: Yang Y,Hood LJ,McPherson B

    更新日期:2021-01-11 00:00:00

  • Auditory nerve and brainstem responses in the newborn and in preschool children.

    abstract::The practicability of recording auditory nerve and brainstem responses during early childhood is demonstrated. This paper reports our experience with two different electrode locations: ear-canal/ear-lobe and ear-lobe/vertex. The test is performed with a light portable stimulus-generating and response-recording system ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487909126421

    authors: Montandon PB,Cao MH,Engel RT,Grajew T

    更新日期:1979-03-01 00:00:00

  • Peripheral facial palsy caused by the Borrelia spirochete.

    abstract::Forty-three consecutive patients with peripheral facial palsy were examined to evaluate the incidence of facial palsy caused by the tick-borne Borrelia spirochete in a non-coastal area in the south of Sweden. Six (14%) of the patients were found to have a Borrelia infection. The incidence of Borrelia-induced facial pa...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488909125548

    authors: Bjerkhoel A,Carlsson M,Ohlsson J

    更新日期:1989-11-01 00:00:00

  • Myringotomy in the treatment of acute otitis media in children.

    abstract::The treatment of acute otitis media was studied in 158 children. All children (mean age 4 years) received penicillin orally 80 000--100 000 IU per day for 10 days. Myringotomy was performed on 68 children at the time of the diagnosis. The other 90 children were treated with penicillin and ear drops. The bacteriologica...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487909137149

    authors: Puhakka H,Virolainen E,Aantaa E,Tuohimaa P,Eskola J,Ruuskanen O

    更新日期:1979-01-01 00:00:00

  • Clinical outcome and comparison between squamous and non-squamous cell carcinoma of the larynx.

    abstract::Background: The various pathological types of non-squamous cell carcinomas (nSCCs) of the larynx accounted for about 5% laryngeal malignancies, but the knowledge regarding these pathological behaviors, therapeutic models and prognostic factors was limited.Objectives: To investigate the clinical characteristics and the...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2019.1700305

    authors: Chen L,Deng W,Li C,Lau H,Tao L,Wang S,Zhou L,Zhang M

    更新日期:2020-02-01 00:00:00

  • Laser irradiation of the semicircular canal: occlusion of the canal or duct.

    abstract::The aim of this study was to evaluate the effects of argon laser irradiation of the semicircular canals using computed tomography (CT) images and to examine the basis for laser treatment for benign paroxysmal positional vertigo (BPPV). CT images of the posterior canal were evaluated postoperatively in a patient with i...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2011.622292

    authors: Nomura Y,Kobayashi H

    更新日期:2012-01-01 00:00:00

  • Vestibulo-ocular responses during static head roll and three-dimensional head impulses after vestibular neuritis.

    abstract::This study aimed to investigate whether unilateral vestibular neuritis (VN) causes the same deficits of ocular counter-roll during static head roll (OCR(S)) and dynamic vestibulo-ocular reflex gains during head impulses (VOR(HI)) as unilateral vestibular deafferentation (VD). Ten patients with acute and 14 patients wi...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489950180379

    authors: Schmid-Priscoveanu A,Straumann D,Böhmer A,Obzina H

    更新日期:1999-01-01 00:00:00

  • Olfactory dysfunction in patients after recovering from COVID-19.

    abstract:BACKGROUND:Smell and taste disorders occur in COVID-19 with a high prevalence, but little is known about the duration of the symptoms. In particular, studies using validated olfactory tests are very rare to date. AIMS/OBJECTIVES:The aim of this study was to determine the olfactory function of COVID-19 recoveries by a ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2020.1811999

    authors: Otte MS,Eckel HNC,Poluschkin L,Klussmann JP,Luers JC

    更新日期:2020-12-01 00:00:00

  • Topical treatment with growth factors for tympanic membrane perforations: progress towards clinical application.

    abstract::Basic scientific research has demonstrated that epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), platelet-derived growth factor-AA (PDGF-AA) and transforming growth factor-alpha (TGF-alpha) are induced by acute tympanic membrane (TM) perforation. The expression of these growth factors peaks during...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,评审

    doi:10.1080/000164802320396259

    authors: Ma Y,Zhao H,Zhou X

    更新日期:2002-09-01 00:00:00

  • The effects of fatal hemorrhage on the cochlear vasculature.

    abstract::The condition of the cochlear vasculature was evaluated in 7 normal guinea pigs subsequent to fatal aortic hemorrhage. The cochleas were prepared for histological analysis using a soft surface preparation technique. The data analysis revealed two statistically significant differences: an increase in the number of aggr...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488409130986

    authors: Jones-Mumby C,Axelsson A

    更新日期:1984-03-01 00:00:00

  • Wearable Digital Speech Processor for Cochlear Implants Using a TMS320C25.

    abstract::Based on a single-chip DSP (TMS320C25, Texas Instruments) a programmable battery-operated sound processor with a digital encoder interface for the Nucleus-22 cochlear implant (CI) was built. The number of quasi-simultaneously addressed electrodes is only limited by the selected pulse width and the maximum rate of stim...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.1990.12088418

    authors: Dillier N,Senn C,Schlatter T,Stöckli M,Utzinger U

    更新日期:1990-01-01 00:00:00

  • Tensor tympani, a 'tuner' of tensor palati muscle.

    abstract::The author has proved experimentally (in two dogs) that there is reflex hypertonia of the tensor palati muscle, synchronous with the 'shortening' reaction of the tensor tympani muscle in response to its "static" relaxation during the gradual passive inward displacement of the drum resulting from the negative intratymp...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487609120926

    authors: Misurya VK

    更新日期:1976-11-01 00:00:00

  • Transcription analysis of cochlear development in minipigs.

    abstract:CONCLUSIONS:The critical stage for cochlear gene regulation in the embryo is E49-E56. These data provide a valuable resource to help elucidate gene regulation in cochlear development and will benefit ear-related studies, especially those that focus on gene and stem cell therapies in hearing loss. OBJECTIVES:To investi...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2017.1341641

    authors: Wang Q,Zhang Y,Guo W,Liu Y,Wei H,Yang S

    更新日期:2017-11-01 00:00:00

  • The recovery of vascular changes following brief noise exposure.

    abstract::Histological measures of cochlear vasculature and blood flow were examined in 20 guinea pigs. Sixteen were exposed to octave band noise at 120 dB SPL for 30 min and then permitted to survive after the exposure for 6 h, 18 h, 48 h, or 4 weeks (N = 4 in each group). Control animals were exposed to the laboratory and app...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488509108582

    authors: Dengerink H,Miller J,Axelsson A,Vertes D,Van Dalfsen P

    更新日期:1985-07-01 00:00:00

  • The vascular anatomy of the rat cochlea.

    abstract::The vascular pattern of the rat cochlea was demonstrated by the aid of Berlin Blue (Prussian Blue) contrast. The vascular anatomy is similar to other mammals. The infrequent occurrence of the vessel of the basilar membrane under the organ of Corti is interesting in respect to its presumed importance for the oxygen sup...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488009127102

    authors: Hornstrand C,Axelsson A,Vertes D

    更新日期:1980-01-01 00:00:00

  • The development of medial geniculate body in man: changes in the cholinesterase (CHE) activity during fetal and perinatal life.

    abstract::In the present study cholinesterase histochemical (ChE) techniques have been used to demonstrate differentiation and maturation of the medial geniculate body (MGB) in the human fetuses (ranging between 10.5 to 28 weeks) and infants (premature and three postnatal months). In the youngest specimens examined (10.5 to 15 ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488309139464

    authors: Krmpotić-Nemanić J,Kostović I,Nemanić D

    更新日期:1983-05-01 00:00:00

  • Experimental acute sinusitis in rabbits. Energy metabolism in sinus mucosa and secretion.

    abstract::In previous studies, sinus secretions have been analysed concerning pO2, pCO2 and pH. In this study the energy metabolism in the maxillary sinus mucosa and secretion was studied in 33 New Zealand White rabbits. In freeze-dried samples, glucose and lactate were analysed by enzymatic assays and ATP by HPLC. In the purul...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488809122271

    authors: Johansson P,Kumlien J,Söderlund K,Hultman E

    更新日期:1988-11-01 00:00:00

  • Patterns of framework invasion in patients with laryngeal cancer: correlation of in vitro magnetic resonance imaging and pathological findings.

    abstract::Total laryngectomy for laryngeal squamous cell carcinoma means a drastic change in the way of living for a patient. New surgical techniques such as laser surgery attempt to save the voice. To be oncologically correct, an accurate assessment of the tumor extent is necessary. Imaging is especially important in determini...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489850182648

    authors: Declercq A,Van den Hauwe L,Van Marck E,Van de Heyning PH,Spanoghe M,De Schepper AM

    更新日期:1998-11-01 00:00:00