Laryngeal abductor muscle reinnervation in a pig model.

Abstract:

OBJECTIVE:To develop a large animal model for studies of laryngeal abductor reinnervation. MATERIAL AND METHODS:Six minipigs underwent unilateral anastomosis of the phrenic nerve-abductor branch of the recurrent laryngeal nerve (RLN). Polyhydroxybutyrate (PHB) conduits were used for repair. At each of 30, 60 and 120 days, 2 animals underwent video laryngeal endoscopy (VLE) and were then killed. VLE was also performed in the 120-day pair at 60 days. Nerve-conduit-nerve-muscle samples were fixed for light and immunofluorescence (pan-neurofilaments, S-100) microscopy. Laryngeal muscles were harvested (myosin heavy chain analysis). RESULTS:VLE showed recovery of abductor function in 1 animal at 60 days and in 1 at 120 days. Haematoxylin-eosin staining demonstrated a complex inflammatory response. Eosinophil recruitment was observed. Stepwise regeneration and reorganization of the distal nerve between 30 and 120 days was observed with pan-NF staining. The mean minimum diameter in the reinnervated posterior crico-arytenoids tended to increase for up to 120 days. CONCLUSIONS:Anastomosis of the phrenic nerve-abductor branch of the RLN with a PHB conduit in a pig can result in functional and histological recovery within 2-4 months and appears to at least sustain abductor muscle fibre morphology. Recovery occurs despite a complex inflammatory response, which may be an essential part of healing rather than inhibitory.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Birchall M,Idowu B,Murison P,Jones A,Burt R,Ayling S,Stokes C,Pope L,Terenghi G

doi

10.1080/00016480410022507

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

839-46

issue

7

eissn

0001-6489

issn

1651-2251

pii

D8L3JT2QX13VQUVK

journal_volume

124

pub_type

杂志文章
  • Breathing disorders in sleep associated with "microarousals' in patients with allergic rhinitis.

    abstract::The influence of obstructed nasal passages was investigated in l4 patients with allergic rhinitis. Disordered breathing in sleep was found in all patients in the form of periodic breathing, and hypopneic and hyperpneic episodes, associated with characteristic "microarousals' from sleep. Patients had an average of 50 "...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488109133292

    authors: Lavie P,Gertner R,Zomer J,Podoshin L

    更新日期:1981-11-01 00:00:00

  • The alteration of ultrastructure and immunoreactivity of human embryonic organ of Corti tissue culture after exposure to aminoglycoside (neomycin) ototoxicity.

    abstract::Using electron microscopy and GABA immunohistochemistry we evaluated the effects on human embyronic organ of Corti tissue culture of exposure to the ototoxic aminoglycoside antibiotic neomycin at a dose of 1 mM for 48 to 96 hrs. Neomycin induces the formation of multilamellar myeloid structures. These lesions, found o...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489609137929

    authors: Mu MY,Pao X,Jie T,Yu YJ

    更新日期:1996-11-01 00:00:00

  • Social handicap among workers with noise-induced hearing loss.

    abstract::A thorough examination of hearing and hearing loss among workers in the saw- and papermill industries in northern Sweden showed that even a serious hearing loss does not give the expected social handicap. ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487609119960

    authors: Diamant H

    更新日期:1976-03-01 00:00:00

  • Heterotransplantation of human head and neck tumours into nude mice.

    abstract::Multimodality therapy of advanced malignant tumours of the head and neck includes surgery, radiotherapy and chemotherapy. However, the cure rate for these tumours is low and guidelines for the selection and timing of therapy are needed. For such guidelines, tumour cell kinetic parameter studies, e.g. cell proliferatio...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488309130933

    authors: Wennerberg J,Tropé C,Biörklund A

    更新日期:1983-01-01 00:00:00

  • Strial prostaglandins and leukotrienes. Biochemical characteristics and interrelationship with furosemide.

    abstract::Synthesis of prostaglandins (PGs) was characterized in the lateral wall (LW) of guinea-pig cochlea. Basal synthesis at 37 degrees C was about 480 pg/LW (12.8 ng X mg-1 protein) for PGI2 and 85 pg/LW (2.3 ng X mg-1 protein) for PGE2, levelling out after 10 min of incubation. Incubation with arachidonic acid (10(-5) M) ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:

    authors: Tran Ba Huy P,Ferrary E,Escoubet B,Sterkers O

    更新日期:1987-05-01 00:00:00

  • Radix Astragali injection enhances recovery from acute acoustic trauma.

    abstract:CONCLUSION:The average recovery of hearing and cessation of tinnitus was significantly better after treatment with Radix Astragali (RA) than after non-treatment with RA. RA can be valuable adjuvant therapy for patients with acute acoustic trauma (AAT). OBJECTIVES:AAT is one of the early indications for the use of RA. ...

    journal_title:Acta oto-laryngologica

    pub_type: 临床试验,杂志文章

    doi:10.3109/00016489.2011.591823

    authors: Xiong M,He Q,Lai H,Huang W,Wang L,Yang C,Wang J

    更新日期:2011-10-01 00:00:00

  • Frequency-specific hearing results after stapes surgery for Chinese population otosclerosis with different degrees of hearing loss.

    abstract::Background: Frequency-specific hearing studies are important for predicting hearing results and the prognosis after stapes surgery, to prepare for the rehabilitation of frequency-specific hearing in patients with otosclerosis.Objectives: To evaluate outcomes of stapes surgery of Chinese otosclerosis patients with diff...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2020.1724331

    authors: Zhang K,Fang Y,Wang B,Cheng X,Chen B,Shu Y

    更新日期:2020-05-01 00:00:00

  • The totally implantable middle ear device 'Esteem' for rehabilitation of severe sensorineural hearing loss.

    abstract:CONCLUSION:The Esteem(®) device proved to offer beneficial results in subjects suffering from high frequency, severe bilateral sensorineural hearing loss (SNHL) and may be considered as an alternative procedure to conventional hearing aids (HAs) or electroacoustic stimulation (EAS) systems. OBJECTIVES:Since the Esteem...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2010.536994

    authors: Barbara M,Biagini M,Monini S

    更新日期:2011-04-01 00:00:00

  • Ionic mechanisms sustaining activity in ampullar receptors of the frog.

    abstract::Ionic mechanisms sustaining sensory transduction in crista ampullaris sensory cells have been investigated chiefly by replacing the endolymph with solutions with K+ and Ca++ chelators added. The effects of the modified solutions were evaluated by extracellular and intracellular recordings of both and the presynaptic a...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488209130893

    authors: Zucca G,Valli P,Casella C

    更新日期:1982-05-01 00:00:00

  • Contrast-enhanced MRI of the inner ear after intratympanic injection of meglumine gadopentetate or gadodiamide hydrate.

    abstract:CONCLUSION:The degree of contrast enhancement of the cochlea after intratympanic administration of meglumine gadopentetate (Gd-DTPA) or gadodiamide hydrate (Gd-DTPA-BMA) varies widely among patients with inner ear diseases. There was no morphological change in the stria vascularis after Gd-DTPA or Gd-DTPA-BMA was place...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2010.507781

    authors: Suzuki H,Teranishi M,Naganawa S,Nakata S,Sone M,Nakashima T

    更新日期:2011-02-01 00:00:00

  • Efficacy of intratympanic corticosteroid, intravenous batroxobin and combined treatment for sudden sensorineural hearing loss with type-2 diabetes.

    abstract:BACKGROUND:Intratympanic corticosteroid (IC), intravenous batroxobin (IB) as the treatment for sudden sensorineural hearing loss (SSNHL) has been reported. However, the data on combination therapy (CT) was scarce. OBJECTIVE:The aim of this retrospective study was to compare the efficacy of IC, IB, and CT in the treatm...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2019.1592221

    authors: Jia H,Yu Z,Li X,Wang J,Ge X,Chen ZT,Huang X,Wei Y

    更新日期:2019-06-01 00:00:00

  • The effect of vasopressin upon the cochlear potentials in the guinea pig.

    abstract::The change in the EP, CM, SP and AP during perilymphatic perfusion of vasopressin (antidiuretic hormone) was examined in the guinea pig. The EP was recorded with a microelectrode through the spiral ligament of the second turn. The CM, SP and AP were measured with the differential electrodes in the basal turn. The perf...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488609132830

    authors: Mori N,Ohta K,Matsunaga T

    更新日期:1986-03-01 00:00:00

  • Following eye movements on the absence of central vision.

    abstract::Following responses to constant velocity and sinusoidally oscillating movements of the whole visual environment were examined in normal subjects wearing blinkers to obscure central vision or subjected to a photo flash to induce a central scotoma, in patients with central scotomas of pathological origin and in one pati...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487909126455

    authors: Gresty M,Halmagyi M

    更新日期:1979-05-01 00:00:00

  • Elemental composition of the mature inner ear.

    abstract::An X-ray energy dispersive analysis was performed on the mature serial sectioned freeze-dried mammalian labyrinth (CBA/CBA mouse). The elemental distribution in the endolymphatic and perilymphatic spaces revealed similar results as have been reported in the literature when withdrawing fluid for microanalysis. The cupu...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488009131744

    authors: Anniko M,Wroblewski R

    更新日期:1980-11-01 00:00:00

  • Comparison of different mobile telephones in Combi40+ users.

    abstract:CONCLUSION:Telephone usage is a difficult challenge for cochlear implanted patients. A significant number of cochlear implanted patients are able to carry on a land-line or mobile telephone conversation. The telephone model may be a critical factor for telephone performance. OBJECTIVES:The goals of this study were to ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480500469552

    authors: Castro A,Lassaletta L,Bastarrica M,Prim MP,De Sarriá MJ,Gavilán J

    更新日期:2006-07-01 00:00:00

  • Malignant eccrine poroma invading the parotid gland.

    abstract::Malignant eccrine poroma was first described by Pinkus and Mehregon in 1963. Because of the histologic characteristics of the tumor, these authors concluded that the tumor was likely of eccrine origin. Malignant eccrine poroma originates from the intraepidermal ductal portion of the eccrine gland. Like other tumors of...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480500395187

    authors: Aydin E,Akdogan V,Akkuzu G,Ilgici D

    更新日期:2006-04-01 00:00:00

  • Protease-dependent activation of nasal polyp epithelial cells by airborne fungi leads to migration of eosinophils and neutrophils.

    abstract:CONCLUSIONS:Proteases in fungi interact with nasal epithelial cells and enhance the production of inflammatory cytokines in vitro. These cytokines induced the migration of eosinophils and neutrophils. Protease-activated receptors (PARs) might also play a role in the process of epithelial cell activation. OBJECTIVE:The...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480500395179

    authors: Shin SH,Lee YH,Jeon CH

    更新日期:2006-12-01 00:00:00

  • Quantum type bone remodeling in the otic capsule of the pig.

    abstract::Normal quantum type bone remodeling was studied in temporal bones of young domestic pigs by means of combined microradiography, osteofluorochrome labelling and osteoid staining. Evolving secondary osteons were morphologically normal although much less in the otic capsule than in the surrounding compacta of the tempora...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489009122540

    authors: Sørensen MS,Bretlau P,Jørgensen MB

    更新日期:1990-09-01 00:00:00

  • Effect of physical exercise upon nystagmus and locomotor dysequilibrium after labyrinthectomy in experimental primates.

    abstract::Spontaneous nystagmus and locomotor equilibrium function were repeatedly tested before and after unilateral labyrinthectomy in 12 squirrel monkeys in order to study the effect of physical exercise on the vestibulo-oculomotor and vestibulo-locomotor compensation. Post-operatively, 6 of the monkeys received forced physi...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487509124676

    authors: Igarashi M,Alford BR,Kato Y,Levy JK

    更新日期:1975-03-01 00:00:00

  • Treatment outcomes of sinonasal inverted papillomas according to surgical approaches.

    abstract:CONCLUSIONS:The midfacial degloving approach is a favorable option for advanced sinonasal inverted papilloma with a fair recurrence rate, and can replace the lateral rhinotomy approach, which is considered too invasive for benign tumor due to its facial scar. OBJECTIVE:This study aimed to assess the treatment outcomes...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016480903311211

    authors: Kim WS,Hyun DW,Kim CH,Yoon JH

    更新日期:2010-04-01 00:00:00

  • Quantification of vestibular compensation in unilateral Meniere's disease.

    abstract::The main parameters of the vestibulo-ocular reflex (i.e. the gain or reflectivity, the long-time constant of the semicircular canals, the time constant of the mechano-neural transduction, and that of the central leaky integrator) were computed from the post-rotational nystagmic responses of unilateral Meniere's patien...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487809121469

    authors: Stefanelli M,Mira E,Schmid R,Lombardi R

    更新日期:1978-05-01 00:00:00

  • Tonsils and lympho-epithelial structures in the pharynx as immuno-barriers.

    abstract::The tonsils are mucosa-associated lymphoid organs. Several details regarding their normal function and pathological alteration are still unknown. In this review the relationship of the tonsils to similar lymphoid organs is discussed, the possibilities of antigen uptake (M cells and micropores of the crypt epithelium) ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,评审

    doi:

    authors: Surján L Jr

    更新日期:1987-05-01 00:00:00

  • Tensor tympani, a 'tuner' of tensor palati muscle.

    abstract::The author has proved experimentally (in two dogs) that there is reflex hypertonia of the tensor palati muscle, synchronous with the 'shortening' reaction of the tensor tympani muscle in response to its "static" relaxation during the gradual passive inward displacement of the drum resulting from the negative intratymp...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487609120926

    authors: Misurya VK

    更新日期:1976-11-01 00:00:00

  • Production of otoconia in the endolymphatic sac in the Japanese red-bellied newt, Cynops pyrrhogaster: light and transmission electron microscopic study.

    abstract::The formation of otoconia in the endolymphatic sac (ES) of the larval newt, Cynops pyrrhogaster, has been studied by light and transmission electron microscopy. Some of the epithelial cells of the ES contain an abundance of swollen vesicles, Golgi complexes, rough endoplasmic reticula and ribosomes at the late larval ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489850154694

    authors: Gao W,Wiederhold ML,Hejl R

    更新日期:1998-07-01 00:00:00

  • Definitive re-irradiation using intensity-modulated radiation therapy in cancers of the head and neck, focusing on rare tumors.

    abstract:PURPOSE:To analyze the outcomes following re-irradiation for local recurrence of rare head and neck tumors. MATERIAL AND METHODS:We retrospectively analyzed 11 patients who had received intensity-modulated radiation therapy (IMRT) for recurrent tumors in the head and neck except for laryngopharynx. RESULTS:Primary tu...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2018.1438662

    authors: Doi H,Uemoto K,Masai N,Tatsumi D,Shiomi H,Oh RJ

    更新日期:2018-08-01 00:00:00

  • Histamine regulates mucin expression through H1 receptor in airway epithelial cells.

    abstract:CONCLUSION:The data suggest that histamine up-regulates MUC2 gene regulation and mucin production in airway epithelial cells through histamine 1 receptor (H1R). Histamine appears to play an important role in the early phase of mucin regulation, which might be effectively blocked by an H1R antagonist. OBJECTIVE:Histami...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2012.661075

    authors: Kim HM,Lee CH,Rhee CS

    更新日期:2012-06-01 00:00:00

  • Ultrastructure of the stria vascularis and Reissner's membrane in experimental hydrops.

    abstract::A time-sequence study was made of the early ultrastructural changes of the stria vascularis and Reissner's membrane in the guinea pig after obliteration of the endolymphatic sac and duct. Pathological alterations of both the stria vascularis and Reissner's membrane were found to start in the apex of the cochlea. The m...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488709107319

    authors: Albers FW,de Groot JC,Veldman JE,Huizing EH

    更新日期:1987-09-01 00:00:00

  • Impaired membrane targeting and aberrant cellular localization of human Cx26 mutants associated with inherited recessive hearing loss.

    abstract:CONCLUSION:This study demonstrated that five Cx26 mutations (R32H, S199F, 572delT, 631-632delGT, and Y155X) affect gap junction (GJ) functions by causing impaired membrane targeting and aberrant cellular localization, and one mutation (R165W) leads to a constriction of the channel pore with no dye coupling. OBJECTIVE:...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2010.506885

    authors: Xiao Z,Yang Z,Liu X,Xie D

    更新日期:2011-01-01 00:00:00

  • Schwannoma (neurilemmoma) of the tongue.

    abstract:CONCLUSION:Schwannoma of the tongue always presents as a painless mass on the lingual surface and exhibits no gender preference. A schwannoma on the base of tongue is usually larger at presentation than one on the tongue itself, since it is asymptomatic initially. Complete resection is achievable and recurrence is unco...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480500527219

    authors: Hsu YC,Hwang CF,Hsu RF,Kuo FY,Chien CY

    更新日期:2006-08-01 00:00:00

  • The influence of cochlear temperature on the electrical travelling wave pattern in the guinea pig cochlea.

    abstract::Cochlear microphonics (CM) were recorded in the guinea pig using differential recording from the first and third cochlear turns as well as by using a 10-electrode array inserted in the scala tympani of the basal turn. The excitation profile as represented by the CM was quantified by amplitude and phase data, and was m...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487809121465

    authors: de Brey HB,Eggermont JJ

    更新日期:1978-05-01 00:00:00