Abstract:
CONCLUSION:Changes in the metabolism of arachidonic acid (AA) might be part of a noise-induced compensatory mechanism with regional specificity. OBJECTIVES:The released imbalance of prostaglandins and leukotrienes, both AA metabolites, might result in altered blood flow regulation in the inner ear and probably contributes to noise-induced hearing loss. The aim of this study was to gain further information about noise-dependent changes in AA metabolism in the mammalian cochlea. METHODS:In this prospective animal study, 10 male guinea pigs were exposed to tone bursts for 1 h at 70 dB sound pressure level (SPL) (n = 5) or 90 dB SPL (n = 5). Five animals were used as controls. Alterations in cyclooxygenase 1 (COX-1) and 5-lipoxygenase (5-LO) expression were determined by quantitative immunohistochemical analysis in 11 cochlear regions. RESULTS:COX-1 expression was decreased after both 70 dB SPL and 90 dB SPL exposure in most cell types of the organ of Corti and increased in the nerve fibers of the osseous spiral lamina. 5-LO was lowered after 90 dB SPL exposure, preferentially in the third cochlear turn in the organ of Corti, in the first and second turn in spiral ganglion cells, and in all turns in the stria vascularis.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Heinrich UR,Selivanova O,Schmidtmann I,Feltens R,Brieger J,Mann WJdoi
10.1080/00016480903168066subject
Has Abstractpub_date
2010-03-01 00:00:00pages
358-65issue
3eissn
0001-6489issn
1651-2251pii
913926199journal_volume
130pub_type
杂志文章abstract:CONCLUSION:Compared with normal-weight individuals, obese young adults exhibited a significantly higher taste threshold for salty taste. Smoking also affected taste functions in this population. OBJECTIVE:The aim of this study was to investigate the differences in taste detection thresholds between normal-weight and o...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.975370
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To determine the clinical usefulness of the dichotic multiple-frequency (MF) auditory steady-state response (ASSR) technique for estimating normal hearing compared to a 0.5-kHz tone burst and broadband click auditory brainstem response (ABR) protocol in a sample of adults. MATERIAL AND METHODS:A comparative ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310015902
更新日期:2004-01-01 00:00:00
abstract:CONCLUSIONS:1. The principle of bilateral symmetry depends on the chordal cartilage that is the keystone in cranial base ossification in rats and humans, due to its anatomical situation and for the production of the chordin protein that regulates the bone morphogenetic protein BMP-7. 2. In humans and in rats, foramen l...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.642814
更新日期:2012-04-01 00:00:00
abstract:CONCLUSIONS:Intratympanic steroid (ITS) treatment groups exhibited better outcomes in PTA improvement and recovery rate than systemic steroid therapy (SST) groups. Whether initial hearing loss severity would influence the PTA improvement and recovery rate still requires further research. OBJECTIVE:This article was aim...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,meta分析
doi:10.1080/00016489.2016.1260157
更新日期:2017-06-01 00:00:00
abstract:CONCLUSION:The improved biocompatibility of Bioverit II coated with a nanostructured surface shows promising qualities for use in human reconstructive middle ear surgery. In the case of chitosan-hydroxyapatite composite prostheses, further investigations regarding composition of the material, degree of purity and desig...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480601053032
更新日期:2007-08-01 00:00:00
abstract::Patients with Bell's palsy were investigated with regard to the cellular immune response during the acute and convalescent stages with the purpose of acquiring information concerning the etiology of the condition. In order to ascertain whether there was activation of the immune system, the proportion of activated T ce...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809119452
更新日期:1988-01-01 00:00:00
abstract::Utilizing an enlarged middle cranial fossa approach to the cerebello-pontine angle without destruction of the labyrinth or cochlea the authors have since 1981 operated on 263 unilateral acoustic neurinomas. Tumour sizes ranged between 3 mm intrameatal and 35 mm within the cerebello-pontine angle. Complete tumour remov...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489209137419
更新日期:1992-01-01 00:00:00
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journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480903510742
更新日期:2010-07-01 00:00:00
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journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.763180
更新日期:2013-06-01 00:00:00
abstract::Overexpression of epidermal growth factor receptor (EGF-R) is a common characteristic of epidermoid tumors and its expression in head and neck squamous cell carcinoma biopsies and cell lines has been reported previously by several authors. With the aim to provide more structural and functional details about the protei...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489309135902
更新日期:1993-11-01 00:00:00
abstract:CONCLUSIONS:Patients with sudden hearing loss and dizziness after barotrauma should be suspected of barotraumatic perilymph fistula (PLF). Early surgical repair of PLF showed better hearing outcomes. Therefore, diagnostic criteria should help surgical indications of barotraumatic PLF. OBJECTIVES:The aim of this study ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1213419
更新日期:2017-01-01 00:00:00
abstract:CONCLUSION:Saccular and utricular maculae can provide information on the supine static position, considering that both have pronounced curved structures with hair cells having a variety of polarization vectors that enable them to sense an inverted position and thus direct the righting reflex. OBJECTIVE:The vestibular ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480510036448
更新日期:2005-05-01 00:00:00
abstract:CONCLUSION:In the present study, about one-third of patients with Meniere's disease developed benign paroxysmal positional vertigo (BPPV)-like attacks. Additionally, more than one-third of all vertigo attacks were BPPV-like attacks. Thus, vertigo attacks in patients with Meniere's disease must be carefully treated beca...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.936624
更新日期:2014-11-01 00:00:00
abstract::The effect of adaptation of the ear on the SISI test was studied at 500 Hz and 2000 Hz in 43 patients with chronic otitis and in 20 patients with otosclerosis. The mean adaptation was slightly over 10 dB, except in the otosclerosis group at 2000 Hz, for which the value was nearly 20 dB after continuous stimulation at ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487509121302
更新日期:1975-07-01 00:00:00
abstract::To elucidate the effects of CO2 in the middle ear upon the cochlea, measurements were made of the cochlear potentials (compound action potential and endocochlear potential) and of the pH of the inner ear fluids and the organ of Corti. Gas containing CO2 did not affect the AP threshold, except for a slight decrease in ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488909107397
更新日期:1989-07-01 00:00:00
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journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480500312570
更新日期:2006-02-01 00:00:00
abstract:CONCLUSION:The reduced caliber of the anterior inferior cerebellar artery (AICA) on the affected side in patients with sudden unilateral profound hearing loss (SUPHL) may reflect a perfusion deficit which, combined to a lesser degree with anatomic abnormalities in the vertebrobasilar system, would be implicated in the ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480510029275
更新日期:2005-08-01 00:00:00
abstract::We have developed a new technique for analyzing the rotation vector of eye movement in three dimensions with an infrared CCD camera based on the following four assumptions; i) the eye rotates on a point; ii) the pupil edge is a circle; iii) the distance from the center of eye rotation to pupil circle remains unchanged...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950181882
更新日期:1999-01-01 00:00:00
abstract::Seventeen cases of postinflammatory acquired artresia of the external auditory canal in 14 women are described and analysed. Fourteen of these cases were solid atresias in which the auditory canal was more or less filled with fibrous tissue. Three patients had partial membranous atresia. The aetiology was external oti...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487509124663
更新日期:1975-01-01 00:00:00
abstract::Background: Intratympanic and intravenous gadolinium administration is used to visualise endolymphatic hydrops. Aims/objectives: The goal of this study was to compare the image quality between intratympanic (IT-method) and intravenous (IV-method) gadolinium administration using three-dimensional inversion recovery wit...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章
doi:10.1080/00016489.2019.1600719
更新日期:2019-08-01 00:00:00
abstract:CONCLUSION:Our findings suggest that there exists a Na(+) transport system in the cochlea consisting of SGK1, Nedd4 isoforms and ENaC, which may work in concert to transport Na(+) and to maintain homeostasis in the inner ear as they do in other tight epithelia. OBJECTIVES:It has been well demonstrated that the epithel...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480802552501
更新日期:2009-09-01 00:00:00
abstract::The existence of primary thyroid sarcomas represents a contentious issue. Some authors believe that thyroid sarcomas are, in fact, anaplastic carcinomas with sarcomatous (spindle cell) features. From the standpoint of treatment and prognosis, the histogenesis of thyroid 'sarcomas' is academic, because these tumors, ir...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480500527193
更新日期:2008-03-01 00:00:00
abstract:CONCLUSION:Cochlear implantation (CI) for Japanese single-sided deafness patients resulted in improved speech perception, increased sound localization accuracy, and reduced tinnitus handicap. OBJECTIVES:This study reports results for five adult SSD cases with CI, focusing on the benefits they obtained in terms of spee...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,多中心研究
doi:10.3109/00016489.2015.1116046
更新日期:2016-01-01 00:00:00
abstract::The authors carried out immunological investigations in 96 patients with laryngeal cancer. The following tests were applied: DNCB, PPD, phyto-test and the lymphocyte count. The patients were divided into three groups: 1) cured, one year following treatment; 2) relapses; 3) died during the first year. The separate grou...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487909126438
更新日期:1979-03-01 00:00:00
abstract::This report shows the changes that occurred in consecutive audiograms of a patient who underwent chemotherapy and radiotherapy for nasopharyngeal cancer and the histopathological examination of the temporal bones. Both conductive and sensorineural hearing loss developed, but followed different modes of progression. In...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480601127026
更新日期:2007-10-01 00:00:00
abstract::Specimens from the epithelium on the lateral wall of the human nose were examined under the electron microscope using a lipid and carbohydrate retaining method. In many of the ciliated epithelial cells and in some of the cells in the mucosal glands we identified multilamellated granules. These structures resembled lam...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489009107447
更新日期:1990-03-01 00:00:00
abstract:CONCLUSIONS:Sensorineural hearing loss must be considered within the clinical picture of systemic lupus erythematosus. The results confirm the usefulness of extended high-frequency audiometry in the audiologic testing of these patients, enabling the possibility of modifying or applying a preventive treatment for a poss...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1219049
更新日期:2017-02-01 00:00:00
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journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1224920
更新日期:2017-02-01 00:00:00
abstract:CONCLUSION:These findings indicate a strong protective effect of ALCAR and NAC on impulse noise-induced cochlear damage, and suggest the feasibility of using clinically available antioxidant compounds to protect the ear from acute acoustic injury. OBJECTIVE:Reactive oxygen species have been shown to play a significant...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480410023038
更新日期:2005-03-01 00:00:00
abstract:CONCLUSION:In patients with early glottic squamous cell carcinoma (SCC) submitted to CO2 laser endoscopic resection, local disease recurrence was significantly correlated with the presence of positive additional surgical margins on permanent sections. OBJECTIVES:To evaluate the rate of cancer recurrence in patients wi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480500316985
更新日期:2006-03-01 00:00:00