Repeated courses of intratympanic dexamethasone injection are effective for intractable Meniere's disease.


CONCLUSION:Intra-tympanic dexamethasone injection (ITD) could serve as a first-line intra-tympanic (IT) treatment for Meniere's disease (MD), regardless of hearing level. Even if the response to initial ITD course was unsatisfactory, a repeated course may be beneficial with some patients. OBJECTIVES:This study examined the effect of repeated courses of ITD administered on demand and investigated the possibility of ITD as an initial IT treatment for medically intractable MD patients. METHOD:Fifty-one patients who had been diagnosed with definite MD and given course(s) of ITD treatment were included. Vertigo control, pure tone average and functional disability scores were evaluated against the American Academy of Otolaryngology-Head and Neck Surgery guidelines for MD. RESULTS:Vertigo disappeared or was substantially controlled in 58.8% and 23.5% of the patients, respectively, after the first ITD course. A repeated course further raised the complete vertigo control rate by 15.7% and intra-tympanic gentamycin injection could be postponed or avoided in 78.6% of the patients who required repeated IT treatment. Hearing was unchanged after the first course of ITD (p > .05). No significant differences were detected in the clinical profiles or laboratory findings between patients receiving single course of ITD and those on multiple courses (p > .05).


Acta Otolaryngol


Acta oto-laryngologica


Leng Y,Liu B,Zhou R,Liu J,Liu D,Zhang SL,Kong WJ




Has Abstract


2017-02-01 00:00:00












  • Increased levels of urokinase receptor in plasma of head and neck squamous cell carcinoma patients.

    abstract::Urokinase-type plasminogen activator (uPA) is important for matrix degradation and motility of cancer cells. The binding of uPA to its cell surface receptor on cancer cells is essential for effective invasion. A soluble form of urokinase receptor (suPAR) has been described in serum and ascites of ovarian cancer patien...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Schmidt M,Hoppe F

    更新日期:1999-01-01 00:00:00

  • Microdrill stapedotomy for otosclerosis with small and large preoperative air-bone gap: a retrospective comparison of results.

    abstract::Background: In otosclerosis mixed hearing loss is the most frequent symptom and arises when the focus involves the stapes footplate. Surgeons usually prefer to wait a minimum air-bone gap of 25 - 35 dB before surgery.Objectives: To evaluate the outcome of microdrill stapedotomy for otosclerosis in patients with a preo...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Canale A,Albera A,Macocco F,Caranzano F,Albera R

    更新日期:2020-09-01 00:00:00

  • Embryogenesis of the inner ear. II. The late differentiation of the mammalian crista ampullaris in vivo and in vitro.

    abstract::The embryonic development of the crista ampullaris of the CBA/CBA mouse was followed both in organ culture of explanted inner ears of the 16th gestational day and in vivo from the 16th gestational day until the 21st day, an age corresponding to birth. Cytodifferentiation of the sensory epithelium of the crista ampulla...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Nordemar H

    更新日期:1983-07-01 00:00:00

  • Management of the neck in node-positive tonsillar cancer.

    abstract:CONCLUSION:Neck dissection (ND) may not be warranted for those patients with complete response in the neck. Human papillomavirus (HPV)-positive or -negative tumour does not affect this recommendation. OBJECTIVES:Treatment of tonsillar cancer varies considerably worldwide, although non-surgical treatment, e.g. radiothe...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Marklund L,Lundberg B,Hammarstedt-Nordenvall L

    更新日期:2014-10-01 00:00:00

  • Nasal obstruction and rhinorrhea reflect nonspecific nasal hyper-reactivity as evaluated by cold dry air provocation.

    abstract:CONCLUSION:Nasal obstruction, rhinorrhea, and the amount of rhinorrhea that confidently reflect the parasympathetic stimulation can be used to more precisely predict nonspecific nasal hyper-reactivity (NHR). OBJECTIVE:We aimed to identify factors that confidently reflected the presence and the degree of NHR, measured ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Kim YH,Jang TY

    更新日期:2012-10-01 00:00:00

  • Quinine-induced hearing loss in the guinea pig is not affected by the Ca2+ channel antagonist verapamil.

    abstract::It is well documented that quinine induces reversible hearing loss and tinnitus. The purpose in this study was to induce a quinine hearing loss and to investigate if verapamil, a Ca2+ channel antagonist of L-type might affect the response. Pigmented guinea pigs (n = 24) were anaesthetized by atropine. Hypnorm and mida...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Jäger W,Idrizbegovic E,Karlsson KK,Alván G

    更新日期:1997-01-01 00:00:00

  • The coronavirus disease 2019: the prevalence, prognosis, and recovery from olfactory dysfunction (OD).

    abstract:BACKGROUND:Many patients with coronavirus disease 2019 (COVID-19) complain from olfactory dysfunction (OD). Aims/objectives: To evaluate the prevalence, prognosis, and recovery from OD in COVID-19 patients. MATERIAL AND METHODS:In this study, patients with COVID-19 symptoms who were referred to six different tertiary ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Samimi Ardestani SH,Mohammadi Ardehali M,Rabbani Anari M,Rahmaty B,Erfanian R,Akbari M,Motedayen Z,Samimi Niya F,Aminloo R,Farahbakhsh F,Hosseininasab A,Hassanlouei B,Rezaian N,Mokhtari Z

    更新日期:2020-11-11 00:00:00

  • The incidence of tonsillar cancer in Sweden is increasing.

    abstract:CONCLUSIONS:The incidence of tonsillar cancer in Sweden is increasing, particularly among men. Risk factors other than smoking may have contributed to the observed secular trend in men. In women, however, smoking can be a part of the explanation. Further studies to look at changes in other environmental factors, such a...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Hammarstedt L,Dahlstrand H,Lindquist D,Onelöv L,Ryott M,Luo J,Dalianis T,Ye W,Munck-Wikland E

    更新日期:2007-09-01 00:00:00

  • Compensatory mechanisms induced by high oropharyngeal airway resistance in rats.

    abstract::Acid base balance changes were observed during 72 h following bilateral nasal obstruction in rats. Mouth breathing caused acute respiratory acidosis and marked aerophagia, leading to spontaneous death of the experimental animal 80 to 90 h postoperatively. Stenotic oropharyngeal airway, due to palatal-epiglottic approx...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Kalogjera L,Pegan B,Petric V

    更新日期:1991-01-01 00:00:00

  • An extended approach through the middle cranial fossa to the internal auditory meatus and the cerebello-pontine angle.

    abstract::The submeningeal approach through the middle cranial fossa to the internal auditory meatus and cerebello-pontine angle after cutting the tentorium cerebelli is described. It is in some way similar to that used by Morrison & King. The approach is achieved by drilling the petrous bone to the level of the compact plate o...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Bochenek Z,Kukwa A

    更新日期:1975-11-01 00:00:00

  • Acute treatment of noise trauma with local caroverine application in the guinea pig.

    abstract::Intense sound stimulation may result in excessive glutamate release from the inner hair cells, resulting in binding to the postsynaptic glutamate receptors and leading to neuronal degeneration and functional impairment. In this study we investigated the therapeutic effect and time window of caroverine, an N-methyl-D-a...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Chen Z,Ulfendahl M,Ruan R,Tan L,Duan M

    更新日期:2003-10-01 00:00:00

  • Induction of nitric oxide synthase activity in nucleus ambiguus motoneurons after injury to the rat recurrent laryngeal nerve.

    abstract::Recent studies have implicated nitric oxide (NO) in neuronal degeneration and plasticity in the motor nervous system. In the present study, we investigated the induction of nitric oxide synthase (NOS) in the motoneurons in the nucleus ambiguus (NA) after injury to the rat recurrent laryngeal nerve (RLN) using nicotina...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Bamba H,Uno T,Koike S,Shogaki K,Hisa Y

    更新日期:2000-03-01 00:00:00

  • Hearing impairment, cochlear morphology, and peroxynitrite (ONOO(-)) formation in adult and aging NOS II knockout mice.

    abstract:CONCLUSION:Nitric oxide synthase (NOS) II induction is a protective mechanism against age-related degeneration of the cochlea. OBJECTIVES:An induction of NOS II has been described in different inner ear pathologies. The objective was to examine the role of NOS II in age-related degeneration of the cochlea. METHODS:Th...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Labbé D,Bloch W,Schick B,Michel O

    更新日期:2016-10-01 00:00:00

  • Diagnostic significance of serum periostin in eosinophilic chronic sinusitis with nasal polyps.

    abstract:OBJECTIVES:Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disease. Eosinophilic CRSwNP (ENP) exhibits a strong tendency for recurrence after surgery. Given that the treatment strategy of ENP differs from that of non-eosinophilic CRSwNP (nENP), clinical diagnostic criteria that distinguish ENP from...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Xu M,Zhang W,Chen D,Zhou H,Chen L

    更新日期:2018-04-01 00:00:00

  • Contrast-enhanced MRI of the inner ear after intratympanic injection of meglumine gadopentetate or gadodiamide hydrate.

    abstract:CONCLUSION:The degree of contrast enhancement of the cochlea after intratympanic administration of meglumine gadopentetate (Gd-DTPA) or gadodiamide hydrate (Gd-DTPA-BMA) varies widely among patients with inner ear diseases. There was no morphological change in the stria vascularis after Gd-DTPA or Gd-DTPA-BMA was place...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Suzuki H,Teranishi M,Naganawa S,Nakata S,Sone M,Nakashima T

    更新日期:2011-02-01 00:00:00

  • Acoustic cues underlying auditory distance in barn owls.

    abstract:CONCLUSIONS:We conclude that: (1) among several cues examined, the monaural cue of direct-to-reverberant (D/R) ratio in the ipsilateral ear provides the most information about sound-source distance; (2) interaural level difference (ILD) provides less information about sound-source distance; and (3) a comprehensive theo...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Kim DO,Moiseff A,Turner JB,Gull J

    更新日期:2008-04-01 00:00:00

  • Further studies of the membrane potential of the stria cells of the guinea pig in vitro.

    abstract::Negative membrane potentials from the stria vascularis of the guinea pig have been recorded in vivo. Stable negative membrane potentials from the stria cells have also been recorded for as long as 2 minutes in vitro. They varied from -20 mV to -49 mV, irrespective of whether the stria vascularis was immersed in Ring...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Chou JT,Hellenbrecht D

    更新日期:1979-01-01 00:00:00

  • Early detection of hearing impairment in patients with diabetes mellitus with otoacoustic emission. A systematic review and meta-analysis.

    abstract:CONCLUSIONS:The distortion product otoacoustic emission (DPOAE) amplitudes in diabetics were significantly lower than those in controls when pure tone audiometry (PTA) was within normal limits, implying cochlear function impairment in the early stage of diabetes mellitus. Retrocochlear damage was suggested by elongated...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,meta分析,评审


    authors: Hao J,Fu X,Zhang C,Zhang X,Zhao S,Li Y

    更新日期:2017-02-01 00:00:00

  • Value of pulse oximetry watch for diagnosing pediatric obstructive sleep apnea/hypopnea syndrome.

    abstract:OBJECTIVE:To evaluate the clinical value of pulse oximetry watch (POW) for diagnosing pediatric Obstructive sleep apnea/hypopnea syndrome (OSAHS). METHODS:We selected 32 children (boys: 25, 4-16 years old) who came to the hospital for diagnosing OSAHS from July to October 2016. Polysomnography (PSG) and POW were used ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Ma JR,Huang JJ,Chen Q,Wu HT,Xiao KL,Zhang YT

    更新日期:2018-02-01 00:00:00

  • Carotid resection and reconstruction for locally advanced head and neck tumors.

    abstract::Head and neck surgeons hesitate to resect the carotid artery because of the postoperative risk of neurologic sequelae. However, there is no curative therapeutic option for head and neck neoplasms involving the carotid artery, with the exception of complete tumor removal. To evaluate the benefits and risks of carotid r...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Muhm M,Grasl MCh,Burian M,Exadaktylos A,Staudacher M,Polterauer P

    更新日期:2002-07-01 00:00:00

  • A histochemical characterization of muscle fiber types in the middle ear muscles of the cat. 1. The stapedius muscle.

    abstract::The muscle fiber content of the stapedius muscle of the cat was determined histochemically using a combination of oxidative enzymes and glycolytic markers. The major fiber type present was determined to be the fast oxidative glycolytic type (FOG; 77%). Two other types of fiber were found that could not be placed into ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Lyon MJ,Malmgren LT

    更新日期:1982-07-01 00:00:00

  • Auditory potentials in profoundly deaf subjects.

    abstract::In 12 healthy volunteers, and 5 prelingually and 5 postlingually profoundly deaf subjects, a 500 Hz filtered click stimulus was applied to the mastoid via the bone conductor. In all the healthy volunteers, middle latency response (MLR) was recorded. Among all profoundly deaf subjects, MLR was recorded only in 2 with p...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Ribarić K,Padovan I,Prevec TS

    更新日期:1985-03-01 00:00:00

  • A novel technique for reconstruction of the posterior wall of the external auditory canal and tympanum using pedicled temporalis myofascia.

    abstract:CONCLUSIONS:The procedure cleared the lesion completely and preserved the physiological function of the external auditory canal. OBJECTIVE:To develop a novel surgical procedure to treat chronic suppurative otitis media (CSOM). To explore the merit of using pedicled temporalis myofascia (PTM) and reconstruction of the ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Yu F

    更新日期:2013-07-01 00:00:00

  • The effect of external stimuli on rat middle ear epithelium in culture. Extracellular carbon dioxide concentration.

    abstract::Serially cultivated rat middle ear epithelium was studied under exposure to various concentrations of carbon dioxide. Three experiments were performed exposing the epithelium to a gaseous environment containing 5 or 10% CO2 or to an atmosphere almost devoid of CO2. Oxygen was maintained constant at 20% and nitrogen wa...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Lutgert HW,van Blitterswijk CA,Grote JJ

    更新日期:1990-05-01 00:00:00

  • Blood-perilymph barrier and ototoxicity: an in vivo study in the rat.

    abstract::Cisplatin and gentamicin are two ototoxicants that are supposed to be transported by the paracellar route, i.e. via cellular junctions, to the perilymphatic compartment. This study was initiated to test the hypothesis that susceptive variation of individuals to ototoxic drugs may be explained by variability in transpo...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Laurell G,Viberg A,Teixeira M,Sterkers O,Ferrary E

    更新日期:2000-10-01 00:00:00

  • Prognostic factors for squamous cell carcinoma of the temporal bone: extensive bone involvement or extensive soft tissue involvement?

    abstract:CONCLUSION:Extensive bone erosion correlated with a worse prognosis of the squamous cell carcinoma (SCC) of the temporal bone but extensive soft tissue involvement did not correlate with prognosis in this study. Resectability of the tumor seems to be major prognostic factor of temporal bone SCC. OBJECTIVE:Prognostic f...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Ito M,Hatano M,Yoshizaki T

    更新日期:2009-11-01 00:00:00

  • The desynchrony between complaints and signs of vestibular disorders.

    abstract::As part of an early intervention study on the acceptability of auditory rehabilitative intervention, we examined patient complaints and clinical findings of balance disorders. Hallam et al. have discussed desynchrony between such findings in hospital patient populations, and the aim of the present study was to investi...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Stephens SD,Hogan S,Meredith R

    更新日期:1991-01-01 00:00:00

  • Investigation of the ototoxicity of gadoteridol (ProHance) and gadodiamide (Omniscan) in mice.

    abstract:CONCLUSION:In the mouse, when a tympanic perforation is present, gadoteridol does not seem to cause ototoxicity. Gadodiamide may cause mild ototoxicity other than toxicity to the outer hair cells of the cochlea. OBJECTIVES:Endolymphatic hydrops have been visualized through intra-tympanic injection of gadolinium-based ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Nonoyama H,Tanigawa T,Shibata R,Tanaka H,Katahira N,Horibe Y,Takemura K,Murotani K,Ozeki N,Ueda H

    更新日期:2016-11-01 00:00:00

  • Inflammatory cells and mediator concentrations in nasal secretions of patients with cystic fibrosis.

    abstract::In this study, cytological examination of nasal secretions of 17 patients with cystic fibrosis (CF) was combined with quantitative determination of common inflammatory mediators. Results showed a normal cytogram in these patients. However, obvious mucosal inflammation is evidenced by significantly higher concentration...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Wang D,Brihaye P,Smitz J,De Waele M,Clement P

    更新日期:1996-05-01 00:00:00

  • Postinflammatory acquired atresia of the external auditory canal.

    abstract::Seventeen cases of postinflammatory acquired artresia of the external auditory canal in 14 women are described and analysed. Fourteen of these cases were solid atresias in which the auditory canal was more or less filled with fibrous tissue. Three patients had partial membranous atresia. The aetiology was external oti...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Bonding P,Tos M

    更新日期:1975-01-01 00:00:00