Polyp formation by experimental tubal occlusion in the rat.

Abstract:

:The purpose of this study was to show the early stages of polyp formation, as part of our studies on the pathogenesis of nasal polyps. Two and 4 weeks after experimental tubal occlusion in 18 Wistar rats, 13 showed signs of bacterial infection, respective acute otitis media. In the majority of these rats polypouslike protrusions of the middle ear mucosa were found in whole-mount specimens. All polypouslike protrusions were investigated by cross sections, which revealed localised accumulation of fluid and inflammatory cells in the lamina propria. The polyps were covered with a flattened epithelium, compared to the epithelium in the surroundings. In some of the bigger polyps the apical part was without epithelial covering. The findings suggest that the epithelium by fast polyp growth may be distended and may burst, or that a primary epithelial defect has not been sufficiently covered.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Larsen PL,Tos M

doi

10.3109/00016489109138432

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

926-33

issue

5

eissn

0001-6489

issn

1651-2251

journal_volume

111

pub_type

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