T3N0 glottic carcinoma: DNA S-phase as a predictor of the outcome after radiotherapy.

Abstract:

:In consecutive series of 326 laryngeal cancer patients, of 29 (9%) with stage T3N0 glottic carcinomas, 23 achieved complete local remission after curative radiotherapy and form the basis of the present investigation. Flow cytometry determinations of DNA-ploidy status and the S-phase fraction, and a "histopathological malignancy grading system" were evaluated as possible patient- and/or tumor-related predictors of local recurrence. Twelve patients (52%) were continuously disease-free after radiotherapy, whereas 10 (43%) manifested local recurrence, and one distant metastasis. The radiotherapy delivered to patients who later suffered from a local recurrence did not differ from those being continuously disease-free. The frequency of local recurrence was significantly correlated to patients whose primary tumours manifested a low S-phase fraction (p < 0.05). A low S-phase fraction may indicate slowly proliferating tumour-cells, which become more radioresistant on exposure to a series of fractionated doses, as their reassortment into sensitive phases will be proportionately slower.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Tennvall J,Wennerberg J,Willén R,Ask A,Baldetorp B,Fernö M

doi

10.3109/00016489309135796

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

220-4

issue

2

eissn

0001-6489

issn

1651-2251

journal_volume

113

pub_type

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