Expression of transient receptor potential channel melastin (TRPM) 1-8 and TRPA1 (ankyrin) in mouse inner ear.

Abstract:

CONCLUSIONS:It has been shown that TRPMs may play a functional role in sensory cell physiology, fluid homeostasis, sensory cell death, and thermosensation in the inner ear, while TRPA1 plays an important role in sensory transduction. OBJECTIVE:To study expression of TRPM1-8 and TRPA1 in the mouse inner ear. MATERIALS AND METHODS:The localization of TRPM1-8 and TRPA1 in the inner ear of normal and gentamicin-treated CBA/J mice was investigated by immunohistochemistry. RESULTS:The stria vascularis displayed a positive immunofluorescent reaction to TRPM1, 2, 3, 6, and 7. In the organ of Corti, outer and inner hair cells (OHCs and IHCs) showed positive immunofluorescence to TRPM1, 2, 3, 6, 7, and 8. Spiral ganglion cells were immunoreactive to TRPM1, 2, 3, 6, 7, and 8. The nerve fibers in the spiral ganglion cells and the nerves innervating the OHCs or IHCs were noticeably immunofluorescent to TRPM8 and TRPA1. In the vestibular end organs, vestibular sensory cells showed immunofluorescence to TRPM1, 2, 3, 6, and 7. The vestibular dark cells showed immunofluorescence to TRPM1, 3, 6, and 7; only the apical portion reacted to TRPM4. The nerve fibers innervating the vestibular sensory cells were distinctly reactive to TRPM8 and TRPA1, while the vestibular ganglion cells reacted to TRPM1, 2, 3, 6, 7, and 8.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Takumida M,Ishibashi T,Hamamoto T,Hirakawa K,Anniko M

doi

10.1080/00016480802570545

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

1050-60

issue

10

eissn

0001-6489

issn

1651-2251

pii

906491044

journal_volume

129

pub_type

杂志文章
  • Participation of vascular reflex in mucosal swelling in nasal allergy.

    abstract::A study was performed to evaluate whether vascular reflex participates in mucosal swelling in nasal allergy, by measuring changes in mucosal swelling in both nasal cavities and changes in blood flow in the bilateral inferior turbinates caused by antigenic challenge in one inferior turbinate. On unilateral challenge, t...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488209128897

    authors: Konno A,Togawa K,Nishihira S

    更新日期:1982-07-01 00:00:00

  • Combination of head-up sleep and vertical recognition training may cure intractable motion-evoked dizziness with unknown origin.

    abstract::Background: It has been reported that head-up sleep (HUS) prevents free-floating otoliths from entering canals and that vertical recognition training (VRT) promotes vestibular compensation.Aims/objectives: We would like to assess HUS and VRT for intractable motion-evoked dizziness, including possible benign paroxysmal...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2020.1727566

    authors: Kitahara T,Horinaka A,Shiozaki T,Ito T,Wada Y,Yamanaka T,Nario K

    更新日期:2020-06-01 00:00:00

  • Vestibular malformation in mice lacking Na-K-2Cl cotransporter 1 and expression of Na-K-2Cl cotransporter 1 in human vestibular end organs.

    abstract:CONCLUSION:The Na-K-2Cl cotransporter-1 (NKCCl) may be essential for the maintenance and functioning of the vestibular morphology in mice and it is strongly expressed in human vestibular end organs. OBJECTIVE:NKCCl is a member of the cation-coupled chloride transporter which participates in salt transport and cell vol...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480510012309

    authors: Young Choi J,Ho Jung S,Namkung W,Lee JH,Jin Son E,Wook Shin J,Park HY,Sang Lee W,Kim HN

    更新日期:2005-12-01 00:00:00

  • The effect of Japanese cedar-specific immunotherapy on cytokine production in peripheral blood mononuclear cells.

    abstract::The most common cause of seasonal allergic rhinitis in Japan is the Japanese cedar (JC). Recently, a pullulan-conjugated antigen (CS-560) has been developed to reduce adverse effects and to enhance the effect of JC-specific immunotherapy (IT). If the mechanism of IT can be fully elucidated and the treatment can be use...

    journal_title:Acta oto-laryngologica

    pub_type: 临床试验,杂志文章

    doi:10.1080/00016480252775742

    authors: Nakano A,Nakano K,Okawa T,Yamakoshi T,Terada N,Numata T,Konno A

    更新日期:2002-01-01 00:00:00

  • Vestibular and optokinetic responses of the white cat.

    abstract::The vestibular and optokinetic responses of a group of white cats were evaluated and compared with the responses from a control group of pigmented animals. The results indicate that in all cases the white cats exhibited varying degrees of vestibular and/or optokinetic dysfunction, which in some animals varied from tes...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487709123944

    authors: Waldorf RA,Polsinelli DJ,Knister JR,Kohut RI

    更新日期:1977-07-01 00:00:00

  • The effect of batroxobin on cochlear blood flow.

    abstract::Cochlear blood flow is considered to be closely related to cochlear function. Among several etiologic factors implicated in inner ear diseases, disturbance of local blood flow is held to be one of the most important. With this in view, various pharmaceuticals are currently being used to increase local blood flow in pa...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489209137500

    authors: Kawakami M,Makimoto K,Yamamoto H,Takahashi H

    更新日期:1992-11-01 00:00:00

  • Evaluation of phenotype of mononuclear host cells isolated from primary tumour and peripheral blood of patients with laryngeal carcinoma.

    abstract::Mononuclear host cells isolated from primary laryngeal carcinoma were assessed by means of indirect immunofluorescence with a panel of monoclonal antibodies against various lymphocyte subsets and macrophages. Tumours of various staging groups were examined in parallel with cells isolated from patient and donor periphe...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488809119459

    authors: Zeromski J,Pietrzak J,Szmeja Z,Jezewska E,Górny MK,Kruk-Zagajewska A

    更新日期:1988-01-01 00:00:00

  • Cell proliferation in the endolymphatic sac in situ after inner ear immunostimulation.

    abstract::Cell proliferation in the endolymphatic sac (ES) after immunostimulation was assessed immunohistochemically. Guinea pigs were employed as experimental animals and keyhole limpet hemocyanin was used as the antigen. After i.p. injection of 5-bromo-2'-deoxyuridine (BrdUrd), the BrdUrd+ cells were counted to assess the nu...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489509139336

    authors: Takahashi M,Tomiyama S

    更新日期:1995-05-01 00:00:00

  • Proprioceptive influence on the optokinetic nystagmus.

    abstract::The influence of neck and leg proprioceptive inputs on optokinetic-induced quick phases was studied in humans. Ten subjects received unidirectional horizontal optokinetic stimulation (10-20%/s) during sinusoidal neck, leg and combined neck + leg proprioceptive stimulation. The optokinetic reflex was measured by electr...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/000164801300043523

    authors: Botti F,Anastasopoulos D,Kostadima V,Bambagioni D,Pettorossi VE

    更新日期:2001-01-01 00:00:00

  • Laryngeal paraganglioma: an updated critical review.

    abstract::Laryngeal paragangliomas are rare submucosal lesions that arise from paraganglion cells located in the false vocal fold and subglottic larynx. To date, 76 recognized cases have been reported in the world literature. Symptoms arise when the lesions become large enough to impair function. Supraglottic paragangliomas cau...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,评审

    doi:10.1080/00016480410017576

    authors: Myssiorek D,Rinaldo A,Barnes L,Ferlito A

    更新日期:2004-11-01 00:00:00

  • Outcomes of surgically treated rhinogenic optic neuropathy.

    abstract:CONCLUSION:The visual outcomes of endoscopic treatment of optic neuropathy are favorable. However, no specific prognostic factor was associated with good outcome. OBJECTIVE:To investigate visual outcomes of patients with optic neuropathy caused by paranasal mucocele or sinusitis. METHODS:The clinical course in 38 pat...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2011.557837

    authors: Nakaya K,Oshima T,Kudo T,Ikeda R,Hidaka H,Kobayashi T

    更新日期:2011-08-01 00:00:00

  • Postinflammatory acquired atresia of the external auditory canal.

    abstract::Seventeen cases of postinflammatory acquired artresia of the external auditory canal in 14 women are described and analysed. Fourteen of these cases were solid atresias in which the auditory canal was more or less filled with fibrous tissue. Three patients had partial membranous atresia. The aetiology was external oti...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487509124663

    authors: Bonding P,Tos M

    更新日期:1975-01-01 00:00:00

  • Brain cortex gangliosides and (Na+, K+)ATPase system of the stria vascularis in guinea pig.

    abstract::This paper presents the results of an investigation into the possibility that gangliosides (brain cortex glycosphingolipids) are capable of being functionally incorporated into cell membranes and of interfering with enzymatic activity of the ATPase system on the stria vascularis and spiral ligament in the guinea pig. ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488109133282

    authors: Aporti F,Facci L,Pastorello A,Siliprandi R,Savastano M,Molinari G

    更新日期:1981-11-01 00:00:00

  • Suppressive action of picrotoxin, a GABA antagonist, on labyrinthine spontaneous nystagmus and vertigo in man.

    abstract::There is evidence that GABA acts as the excitatory neurotransmitter at synapses between vestibular hair cells and the afferent fibres in the mammalian labyrinth. The question arose as to whether certain vestibular dysfunctions such as labyrinthine vertigo could be treated in patients by influencing the peripheral GABA...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488209130882

    authors: Ehrenberger K,Benkoe E,Felix D

    更新日期:1982-01-01 00:00:00

  • The influence of an insecticide on the function of the eustachian tube.

    abstract::Organophosphorus compounds in the form of insecticides are in widespread use and have recently attracted considerable interest as environmentally toxic agents. As little is known about the effect of environmental toxins on the tubal function in the ear, we studied the middle ear pressure necessary to force the eustach...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489509139361

    authors: Bergler W,Juncker C,Petroianu G,Keilmann A,Hörmann K

    更新日期:1995-07-01 00:00:00

  • Bone marrow cells as an origin of immune-mediated hearing loss.

    abstract::The MRL/lpr mouse, which is homozygous for the recessive lpr genes and has a mutation in the Fas gene encoding a cell-surface receptor for apoptosis, exhibits severe lymphadenopathy and develops systemic lupus erythematosus (SLE)-like disease. It has recently been reported that this mouse also manifests sensorineural ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480310015344

    authors: Iwai H,Lee S,Baba S,Tomoda K,Inaba M,Ikehara S,Yamashita T

    更新日期:2004-01-01 00:00:00

  • Auditory plasticity in cochlear implant patients.

    abstract::Dynamic range (DR) of cochlear implant electrodes and speech recognition scores (SRS) were chronologically studied in 23 post-lingually deaf subjects over a period of one year. DR significantly increased over one year (ANOVA, p = 0.03). When DR was compared among three groups of electrodes which were located in the in...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489609137829

    authors: Kubo T,Iwaki T,Ohkusa M,Doi K,Uno A,Yamamoto K,Fujii K

    更新日期:1996-03-01 00:00:00

  • Morphometric analysis using automated image analysis of CD34-positive vessels in salivary gland acinic cell carcinoma.

    abstract:CONCLUSIONS:In computer-assisted analysis of acinic cell cancer (ACC) morphological characteristics of CD34 immunoreactivity were detected. Bigger vessel size, vessel irregularity, and lower intensity of CD34-positive vessel staining may indicate unfavorable prognosis. OBJECTIVES:Salivary gland cancer (SGC) is a morph...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480601053099

    authors: Luukkaa H,Laitakari J,Vahlberg T,Klemi P,Grénman R

    更新日期:2007-08-01 00:00:00

  • Prosaposin-derived peptide alleviates ischaemia-induced hearing loss.

    abstract:CONCLUSION:An 18-mer peptide derived from the neurotrophic region of prosaposin (PS-pep) prevents hearing loss and cochlear damage due to transient cochlear ischaemia by activating an anti-apoptotic pathway. PS-pep is a potent candidate molecule for alleviating ischaemia-induced hearing loss. OBJECTIVE:PS-pep was inve...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2012.750430

    authors: Terashita T,Saito S,Nabeka H,Hato N,Wakisaka H,Shimokawa T,Kobayashi N,Gyo K,Matsuda S

    更新日期:2013-05-01 00:00:00

  • Association between polymorphisms in SOD1 and noise-induced hearing loss in Chinese workers.

    abstract:CONCLUSION:SOD1 is an important gene related to noise-induced hearing loss (NIHL), and its effect is dependent on noise exposure levels. OBJECTIVES:To test whether the polymorphisms in the CuZn-superoxide dismutase gene (SOD1) are associated with susceptibility to NIHL in the Chinese population. METHODS:Audiometric d...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016480903253587

    authors: Liu YM,Li XD,Guo X,Liu B,Lin AH,Rao SQ

    更新日期:2010-04-01 00:00:00

  • Middle ear transmission losses caused by tympanic membrane perforations in cats.

    abstract::Losses (determined by measuring microphonic responses) were essentially identical, regardless of whether produced by admittance of sound into the middle ear via perforations in the tympanic membrane (TM) or in the bulla. With SPLs monitored directly at the TM, losses increased at 12 dB/oct with inverse frequency for f...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487609119970

    authors: Tonndorf J,McArdle F,Kruger B

    更新日期:1976-03-01 00:00:00

  • Posture and nasal geometry.

    abstract::The influence of posture on nasal cavity geometry was studied by acoustic rhinometry in 14 normal adult subjects. On adopting a supine position from sitting the volume of the initially more patulous nasal cavity decreased and the volume of the less patulous side increased. These changes in volume are statistically sig...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489309135858

    authors: O'Flynn P

    更新日期:1993-07-01 00:00:00

  • Effect of vibration on the vestibular system in noisy and noise-free environments in heavy industry.

    abstract::Background: Chronic exposure to whole body vibration can affect the gastrointestinal system, the lumbar spine, the peripheral veins and the vestibulocochlear system. Aims/Objectives: The aim of this study was to evaluate the effects of vibration on the vestibular system in noisy and noise-free environments using the v...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2019.1666213

    authors: Yilmaz N,Ila K

    更新日期:2019-11-01 00:00:00

  • Source and role of endolymph macromolecules.

    abstract::Evaluation of some 200 endolymph proteins indicates that they are predominantly derived from plasma. However, the profile of endolymph proteins is remarkably similar to that of perilymph and entirely different from that of plasma. This supports the current consensus that perilymph rather than plasma is the (direct) so...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,评审

    doi:10.1080/00016489950181260

    authors: Thalmann R,Thalmann I

    更新日期:1999-01-01 00:00:00

  • Evidence of direct communication of bone marrow cells with the endolymphatic sac in experimental autoimmune labyrinthitis.

    abstract::In experimental autoimmune labyrinthitis, we found that the guinea pigs sensitized with bovine inner ear antigen (IEAg) developed cellular infiltration within the endolymphatic sac (E. sac). In this study, we investigated the distribution of immune mediated cells within bony vascular channels. The channels, which are ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489309135786

    authors: Yamanobe S,Harris JP,Keithley EM

    更新日期:1993-03-01 00:00:00

  • Establishment and characterization of nine new head and neck cancer cell lines.

    abstract::We established new cell lines from head and neck cancer patients for studies of adhesion molecules and cellular behavior in nine patients with primary or metastatic cancer treated at the Asan Medical Center. Explant cultures of fresh tumor tissue were used to develop new permanent tumor cell lines. Lines were tested f...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489709113477

    authors: Kim SY,Chu KC,Lee HR,Lee KS,Carey TE

    更新日期:1997-09-01 00:00:00

  • Acoustic cues underlying auditory distance in barn owls.

    abstract:CONCLUSIONS:We conclude that: (1) among several cues examined, the monaural cue of direct-to-reverberant (D/R) ratio in the ipsilateral ear provides the most information about sound-source distance; (2) interaural level difference (ILD) provides less information about sound-source distance; and (3) a comprehensive theo...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480701840114

    authors: Kim DO,Moiseff A,Turner JB,Gull J

    更新日期:2008-04-01 00:00:00

  • Disodium cromoglycate nasal spray in the treatment of perennial rhinitis.

    abstract::In a double-blind crossover trial, 24 patients with perennial rhinitis have been treated with 2% disodium cromoglycate (DSCG) nasal spray. 15 patients preferred DSCG to placebo, 9 patients showed no preference. Analysis of the diary cards showed a significant preference of DSCG in the group which received placebo firs...

    journal_title:Acta oto-laryngologica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00016487709123969

    authors: Balle V,Illum P

    更新日期:1977-09-01 00:00:00

  • Comparison of primary musicality development between children with cochlear implants and children with normal hearing.

    abstract::Background: It is beneficial for CI patients listen to music. However it is necessary to take steps to improve the musicality of CI patients.Objectives: The aims of the study were to evaluate the primary musicality of children with cochlear implants versus those with normal hearing.Material and methods: Children parti...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2020.1766699

    authors: Wang M,Xu T,Zhong Y,Zheng Y,Lv J,Luo J,Meng C,Guo Q,Gong S,Chen X

    更新日期:2020-09-01 00:00:00

  • Tonsils and lympho-epithelial structures in the pharynx as immuno-barriers.

    abstract::The tonsils are mucosa-associated lymphoid organs. Several details regarding their normal function and pathological alteration are still unknown. In this review the relationship of the tonsils to similar lymphoid organs is discussed, the possibilities of antigen uptake (M cells and micropores of the crypt epithelium) ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,评审

    doi:

    authors: Surján L Jr

    更新日期:1987-05-01 00:00:00