Abstract:
CONCLUSIONS:It has been shown that TRPMs may play a functional role in sensory cell physiology, fluid homeostasis, sensory cell death, and thermosensation in the inner ear, while TRPA1 plays an important role in sensory transduction. OBJECTIVE:To study expression of TRPM1-8 and TRPA1 in the mouse inner ear. MATERIALS AND METHODS:The localization of TRPM1-8 and TRPA1 in the inner ear of normal and gentamicin-treated CBA/J mice was investigated by immunohistochemistry. RESULTS:The stria vascularis displayed a positive immunofluorescent reaction to TRPM1, 2, 3, 6, and 7. In the organ of Corti, outer and inner hair cells (OHCs and IHCs) showed positive immunofluorescence to TRPM1, 2, 3, 6, 7, and 8. Spiral ganglion cells were immunoreactive to TRPM1, 2, 3, 6, 7, and 8. The nerve fibers in the spiral ganglion cells and the nerves innervating the OHCs or IHCs were noticeably immunofluorescent to TRPM8 and TRPA1. In the vestibular end organs, vestibular sensory cells showed immunofluorescence to TRPM1, 2, 3, 6, and 7. The vestibular dark cells showed immunofluorescence to TRPM1, 3, 6, and 7; only the apical portion reacted to TRPM4. The nerve fibers innervating the vestibular sensory cells were distinctly reactive to TRPM8 and TRPA1, while the vestibular ganglion cells reacted to TRPM1, 2, 3, 6, 7, and 8.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Takumida M,Ishibashi T,Hamamoto T,Hirakawa K,Anniko Mdoi
10.1080/00016480802570545subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1050-60issue
10eissn
0001-6489issn
1651-2251pii
906491044journal_volume
129pub_type
杂志文章abstract::A study was performed to evaluate whether vascular reflex participates in mucosal swelling in nasal allergy, by measuring changes in mucosal swelling in both nasal cavities and changes in blood flow in the bilateral inferior turbinates caused by antigenic challenge in one inferior turbinate. On unilateral challenge, t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209128897
更新日期:1982-07-01 00:00:00
abstract::Background: It has been reported that head-up sleep (HUS) prevents free-floating otoliths from entering canals and that vertical recognition training (VRT) promotes vestibular compensation.Aims/objectives: We would like to assess HUS and VRT for intractable motion-evoked dizziness, including possible benign paroxysmal...
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