Evidence of direct communication of bone marrow cells with the endolymphatic sac in experimental autoimmune labyrinthitis.

Abstract:

:In experimental autoimmune labyrinthitis, we found that the guinea pigs sensitized with bovine inner ear antigen (IEAg) developed cellular infiltration within the endolymphatic sac (E. sac). In this study, we investigated the distribution of immune mediated cells within bony vascular channels. The channels, which are normally found around the E. sac, are tiny and contain few immune-mediated cells. In contrast, in guinea pigs sensitized with IEAg bony vascular channels were large and contained immune-mediated cells. We hypothesize that immune-mediated cells in these channels are the result of the immune response directed against inner ear antigen, and that some immune-mediated cells seen in the E. sac during inner ear inflammatory events have migrated from the adjacent bone marrow.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Yamanobe S,Harris JP,Keithley EM

doi

10.3109/00016489309135786

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

166-70

issue

2

eissn

0001-6489

issn

1651-2251

journal_volume

113

pub_type

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