Abstract:
:The effects of two sympathomimetic drugs on mucociliary activity and mucosal blood flow in the rabbit maxillary sinus were investigated by using a photo-electric technique (mucociliary activity) and laser Doppler flowmetry (blood flow). The responses produced were compared with effects of ligation of the external carotid artery. The alpha 1-agonist phenylpropanolamine (0.1-100 micrograms/kg) had no effect on the mucociliary activity, whereas the blood flow was reduced by 33.8 +/- 8.9% (mean +/- SE) when the dose was 100 micrograms/kg. The alpha 2-agonist xylometazoline (0.01-10.0 micrograms/kg) reduced mucociliary wave frequency by 21.6 +/- 4.6% (mean +/- SE) (maximum) for the dose 10 micrograms/kg. The blood flow was reduced by xylometazoline in the interval 1.0 to 10.0 micrograms/kg, with a maximum decrease of 65.8 +/- 2.6% (mean +/- SE) for the dose of 10 micrograms/kg. Ligature of the external carotid artery reduced blood flow by 76.0 +/- 4.6% (mean +/- SE), but did not significantly influence the mucociliary wave frequency. It is concluded that the decrease in mucociliary activity induced by alpha 2-adrenoceptor agonists is not due to a reduced blood flow.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Cervin A,Bende M,Lindberg S,Mercke U,Olsson Pdoi
10.3109/00016488809097018subject
Has Abstractpub_date
1988-03-01 00:00:00pages
350-6issue
3-4eissn
0001-6489issn
1651-2251journal_volume
105pub_type
杂志文章abstract::Evidence for a common anatomical and physiological substrate for the generation of the background EEG and the vertex-evoked response led to the hypothesis that the EEG can be interpreted as the output from a time varying filter driven by (a) a noise generator responsible for the background activity, and (b) a pulse ge...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487709128834
更新日期:1977-01-01 00:00:00
abstract::In rabbits the nasal vestibule was surgically occluded on one side. The rabbits were observed for varying periods, maximum 90 days. The mucosa of the septum was removed from both sides, stained by the PAS-alcian blue whole-mount method, and the goblet cells were counted. The difference in goblet-cell density between t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487809124749
更新日期:1978-09-01 00:00:00
abstract:CONCLUSION:The degree of contrast enhancement of the cochlea after intratympanic administration of meglumine gadopentetate (Gd-DTPA) or gadodiamide hydrate (Gd-DTPA-BMA) varies widely among patients with inner ear diseases. There was no morphological change in the stria vascularis after Gd-DTPA or Gd-DTPA-BMA was place...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2010.507781
更新日期:2011-02-01 00:00:00
abstract:CONCLUSIONS:Endoscopic laser microsurgery (ELM) provides comparable oncological outcomes, and improved functional recovery and laryngeal preservation compared with open partial laryngopharyngectomy (OPLP) in patients with early squamous cell carcinoma of the hypopharynx (HPSCC). The use of open surgery is declining. Th...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.805341
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Efficacy of current treatment methods in idiopathic sudden sensorineural hearing loss (ISSNHL) is still unsatisfactory. OBJECTIVE:This study aimed to discover in differences in effect between steroid applications responsible for promoting the prognosis in ISSNHL. MATERIALS AND METHODS:A study was conducted...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2018.1504170
更新日期:2018-11-01 00:00:00
abstract::243 patients with tumours of the minor salivary glands were analysed clinicopathologically. The palate was the most common location for the lesions. Mixed tumours (pleomorphic adenomas) were the most common benign tumour type. Muco-epidermoid carcinoma and adenoid cystic carcinoma were the dominant types of malignant ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709107802
更新日期:1987-05-01 00:00:00
abstract::Synthesis of prostaglandins (PGs) was characterized in the lateral wall (LW) of guinea-pig cochlea. Basal synthesis at 37 degrees C was about 480 pg/LW (12.8 ng X mg-1 protein) for PGI2 and 85 pg/LW (2.3 ng X mg-1 protein) for PGE2, levelling out after 10 min of incubation. Incubation with arachidonic acid (10(-5) M) ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:1987-05-01 00:00:00
abstract::In the guinea pig, the organ of Corti and the spiral ganglion cells were destroyed by administering gentamicin into the inner ear. The antero-ventral cochlear nucleus (AVCN) was studied with electron microscopy 15 and 30 days after treatment. There does not seem to be a specific type of degeneration induced by the dru...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488609108643
更新日期:1986-07-01 00:00:00
abstract:CONCLUSIONS:This study confirms a high prevalence of human papillomavirus (HPV)-positive tonsillar tumours (52%). The survival of the HPV-positive group was significantly better in males. OBJECTIVES:We assessed the prevalence of HPV in 137 patients with tonsillar carcinomas, measured the p53- and Ki-67-positive tumour...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480903071377
更新日期:2010-02-01 00:00:00
abstract:CONCLUSION:The results of this study suggest that treatment with radical scavengers has the potential to become an effective new therapy for age-related hearing loss. OBJECTIVE:To assess the efficacy of treatment with radical scavengers for age-related hearing loss. SUBJECTS AND METHODS:Rebamipide (300 mg/day), alpha...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480802008215
更新日期:2009-01-01 00:00:00
abstract::The influence of obstructed nasal passages was investigated in l4 patients with allergic rhinitis. Disordered breathing in sleep was found in all patients in the form of periodic breathing, and hypopneic and hyperpneic episodes, associated with characteristic "microarousals' from sleep. Patients had an average of 50 "...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488109133292
更新日期:1981-11-01 00:00:00
abstract:OBJECTIVE:Acquired centralized tinnitus (ACT) is the most frequent type of chronic tinnitus. We introduce a cognitive neurophysiological ACT hypothesis based on centralized cognitive sensitization processes. MATERIAL AND METHODS:Published cognitive sensitization processes were reviewed using PubMed. Furthermore, a Coc...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480410016333
更新日期:2004-05-01 00:00:00
abstract::Enzymatic tracer techniques to study normal and pathologic strial capillary transport pose various problems. The use of electron opaque tracers can circumvent many of these problems. Iron dextran (mol. diam 20--70 A) and ferritin (mol. diam 110 A) were injected intravenously and the mice sacrificed at intervals of 1/2...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488009127103
更新日期:1980-01-01 00:00:00
abstract::The objective of this study was to determine whether methylcobalamin inhibits the ototoxic action of gentamicin. Fourteen pigmented guinea pigs were randomly divided into experimental and control groups. Each animal in the experimental group was given a large single dose of gentamicin (125 mg/kg i.m.), followed by imm...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164801300102752
更新日期:2001-04-01 00:00:00
abstract::The aim of the present study is to construct a reference model with the indication for the attitude, the requirements and the resources needed in order to be able to deal with deafness in the presence of disabilities or associated problems. The study group consisted of 13 adults and 18 children affected by profound de...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/03655230410017193
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:To investigate the outcome of surgically managed laryngeal carcinoma patients attending an outpatient clinic over a 5-year period. MATERIAL AND METHODS:This was an analytical, retrospective, cross-sectional study. A total of 36 laryngeal carcinoma patients who were managed surgically with or without radiothe...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480410018070
更新日期:2004-08-01 00:00:00
abstract:CONCLUSION:After conventional curette adenoidectomy, a significant mass of residual adenoid tissue is observed in about 50% of the cases. The combined approach of conventional curette and endoscopic adenoidectomy with microdebrider assures a complete and accurate removal of the mass. It is an effective and safe method ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480802294377
更新日期:2009-05-01 00:00:00
abstract:CONCLUSION:This study described objective and subjective evaluations of the Nurotron® Venus™ Cochlear Implant System and indicated that this system produced a satisfactory performance. OBJECTIVE:To observe the performance of the Nurotron® Venus™ cochlear implant (CI) system via electrophysiological and psychophysical ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1086022
更新日期:2016-01-01 00:00:00
abstract:CONCLUSION:Photodynamic therapy (PDT) is a viable and safe option for early laryngeal cancer that would be less suitably treated with radiation or trans-oral laser surgery (TLS). The cure rates with PDT appear to be comparable to those of conventional therapy, and the voice outcomes are also comparable. In the case of ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.906748
更新日期:2014-08-01 00:00:00
abstract:CONCLUSION:Human adipose-derived stem cells (ASCs), encapsulated in a fibrin-collagen hydrogel for the coating of an electrode array, produce sufficient amounts of neurotrophic factors and may be suitable for enhancing the bioelectric interface of cochlear implants (CIs). OBJECTIVES:To evaluate different hydrogel comp...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.878809
更新日期:2014-05-01 00:00:00
abstract::A new generation of cochlear implant electrodes has been designed to position the stimulating contacts close to the modiolus in order to reduce power consumption and increase stimulation selectivity. The purpose of this study was to assess electrode position in the cochlea for three recently designed electrodes. Fifte...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480260000021
更新日期:2002-06-01 00:00:00
abstract::Normal human subjects were exposed to repeated optokinetic afternystagmus (OKAN) testing in either one direction or alternating directions of stripe movement. Sessions were conducted at intervals of either one week or several weeks. Repeated exposure to OKAN stimulation in one direction produced significant response d...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488509119150
更新日期:1985-01-01 00:00:00
abstract::Cells can die by two distinct pathways: apoptosis and necrosis. To explore whether intense noise can induce hair cell (HC) death via the apoptotic pathway, we systematically examined morphological changes in guinea pig cochlear HC nuclei stained with Hoechst 33342, a fluorescent dye specifically labelling the nuclear ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:CONCLUSIONS:In order to confirm these preliminary results, a prospective double-blind study has been instituted in Padova University ENT Section to compare the efficacy of sulphurous-arsenical-ferruginous thermal water nasal irrigations vs isotonic sodium chloride solution nasal irrigations after functional endoscopic ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480600951525
更新日期:2007-06-01 00:00:00
abstract:CONCLUSIONS:Our preliminary results indicate that mastoidectomy by reconstruction of the posterior wall and obliteration (MAPRO) avoided the disadvantages of a canal-wall-down mastoidectomy. MAPRO effectively prevented cholesteatoma recurrence, provided an excellent basis for hearing restoration, and was generally wate...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.643456
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Oropharyngeal squamous cell carcinoma (OPSCC) positive for human papillomavirus (HPV) increases wolrd wide. AIMS/OBJECTIVES:The objective for this study has been to evaluate tumor phenotypes and tumor host responses with respect to five-year disease-specific survival (DSS) in HPV(+) and HPV(-) patients. MA...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2018.1497809
更新日期:2018-11-01 00:00:00
abstract::Localization of elements at the cellular and sub-cellular levels was performed with the energy dispersive X-ray microanalysis technique, using shock-frozen, freeze-dried and araldite-embedded mouse (CBA/CBA) cochleae sectioned dry. Anatomical identification occurred in the STEM (scanning transmission electron microsco...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409107585
更新日期:1984-11-01 00:00:00
abstract:CONCLUSIONS:Nasal epithelial cells are constitutively equipped with all Toll-like receptors (TLRs) which are essential for innate immunity. Both mRNA and protein levels of TLR3 expression increased in more differentiated nasal epithelial cells. Considering that the ligand for TLR3 is viral dsRNA, this result is in good...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480601089416
更新日期:2007-04-01 00:00:00
abstract::The effects of two simulated hearing impairments (presbyacusis) on speech perception were investigated in two groups of normally hearing subjects (30 and 48 subjects, respectively). Eight patients with presbyacusis with similar hearing impairment to those in the latter simulation served as the clinical material. Word ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800750000991
更新日期:2000-03-01 00:00:00
abstract:CONCLUSION:On average, adult CI recipients report a moderate sound quality using the Dutch version of the HISQUI19 questionnaire. These results are correlated with their age, speech perception scores, CI aided hearing thresholds, and the SSQ5 and the APHAB questionnaire. BACKGROUND:The general aim of the study was to ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1066934
更新日期:2015-01-01 00:00:00