Abstract:
OBJECTIVE:Acquired centralized tinnitus (ACT) is the most frequent type of chronic tinnitus. We introduce a cognitive neurophysiological ACT hypothesis based on centralized cognitive sensitization processes. MATERIAL AND METHODS:Published cognitive sensitization processes were reviewed using PubMed. Furthermore, a Cochrane analysis was performed. RESULTS:Patients frequently perceive tinnitus as being extremely loud although audiological tinnitus-matching measures reveal that its loudness levels are low. An important principle of central tinnitus processing is that individual tinnitus appraisal is directly linked to neuronal networks in the brain responsible for the production of emotions and cognitions. Cognitive processes may be associated with a reduction in the tinnitus cognition threshold, resulting in hypersensitivity of cognition. The underlying mechanism is known as sensitization and is suggested to be a specific learning process. CONCLUSIONS:ACT may be associated with a specific learning process allowing increased tinnitus awareness and continuous appraisal. The underlying mechanism, the cognitive tinnitus sensitization process, is associated with a decrease in the tinnitus cognition threshold. The sensitization contributes to the extremely loud cognition of the tinnitus signal. The associated audiological cognitive discrepancy can be used clinically and diagnostically to identify patients for cognitive testing. The sensitization model does not require tinnitus hyperactivity.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Zenner HP,Zalaman IMdoi
10.1080/00016480410016333subject
Has Abstractpub_date
2004-05-01 00:00:00pages
436-9issue
4eissn
0001-6489issn
1651-2251journal_volume
124pub_type
杂志文章abstract::Intracellular calcium concentrations ([Ca2+]i) in type I cochlear spiral ganglion cells (SGCs) of the guinea pig were measured by digital imaging microscopy and the Ca(2+)-sensitive dye Fura-2. Extracellular ATP induced elevation of [Ca2+]i in type I SGCs in a concentration-dependent manner. The ATP-induced elevation ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709113435
更新日期:1997-07-01 00:00:00
abstract:CONCLUSION:PET-CT scans seem to be sufficient to rule out residual tumour at the primary site. Patients with positive or equivocal PET findings should be scheduled for endoscopy with biopsy or a second PET-CT scan. OBJECTIVES:Assessment of remission at the primary site, in patients treated with organ preservation ther...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.895038
更新日期:2014-06-01 00:00:00
abstract::Eighteen patients with intracranial skull base tumours diagnosed at CT or MR as neuromas or meningiomas were studied with positron emission tomography (PET) using L-(methyl-11C) methionine. Compared with normal cerebellar tissue, the uptake of methionine in the tumours increased more rapidly and reached a higher level...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709113425
更新日期:1997-07-01 00:00:00
abstract::In a double-blind crossover trial, 24 patients with perennial rhinitis have been treated with 2% disodium cromoglycate (DSCG) nasal spray. 15 patients preferred DSCG to placebo, 9 patients showed no preference. Analysis of the diary cards showed a significant preference of DSCG in the group which received placebo firs...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016487709123969
更新日期:1977-09-01 00:00:00
abstract::683 tumour fragments from 63 head and neck carcinoma patients were cultured in vitro. Two laryngeal carcinomas and two salivary gland carcinomas were established into permanent cell lines. Malignancy of these cultured cells was proved by cloning, by chromosomal analysis and by transplantation into athymic (nu/nu) mice...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309130956
更新日期:1983-03-01 00:00:00
abstract:OBJECTIVES:In this paper we test the concept of combining electrical stimulation for high-frequency sound with acoustic hearing for low-frequency information in the same ear. In addition, we test whether residual hearing can be preserved when an electrode is placed up to 10 mm into the inner ear, and whether the site o...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480410016423
更新日期:2004-05-01 00:00:00
abstract::The gram negative bacteria, nontypable Haemophilus influenzae (NTHi) was used to induce otitis media in a total of 18 chinchillas. Three days post-inoculation, three cohorts of 6 chinchillas each were treated daily for four days with either ceftriaxone, chloramphenicol, or diluent without antibiotics. Middle ear fluid...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709118000
更新日期:1997-01-01 00:00:00
abstract:CONCLUSION:The results suggested mercury (Hg)-induced anomalies in the brainstem-mediated acoustic stapedius muscle reflex in children. OBJECTIVES:Hg exposure has been associated with hearing impairment and brainstem anomalies. Acoustic stapedius reflex (ASR) thresholds, growth functions, decay/adaptation times, and b...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.617778
更新日期:2012-01-01 00:00:00
abstract::Cochlear blood flow in guinea pigs was assessed using histological assessment of various red blood cell and vessel lumen parameters. Cochlear blood flow was either enhanced by administration of carbogen or inhibited by induced positive airway pressure. The resulting enhancement or reduction of blood flow in the cochle...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709109055
更新日期:1987-07-01 00:00:00
abstract:CONCLUSION:Cochleostomy is the most efficient approach in delivering PEG-b-PCL polymersomes (PMs) to the inner ear. PMs can be delivered to the vestibule by transtympanic injection or cochleostomy. OBJECTIVE:To evaluate the efficiency of delivering PEG-b-PCL PMs into the inner ear using different approaches. METHODS:...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.615066
更新日期:2011-12-01 00:00:00
abstract::The correlation between allergen-induced specific and non-specific (histamine) nasal reactions was studied, especially as regards topical glucocorticosteroid effects on the non-specific reactions. Thirteen patients with strictly seasonal allergic rhinitis participated. A nasal challenge with histamine and three increa...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488909127508
更新日期:1989-03-01 00:00:00
abstract:CONCLUSION:Ear, nose and throat (ENT) involvement is common in Churg-Strauss syndrome (CSS), usually manifesting as allergic rhinitis and chronic rhinosinusitis with or without polyps. Otolaryngologists may play a pivotal role in making an early diagnosis of this disease. OBJECTIVES:CSS is a systemic vasculitic disord...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480500437435
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:ABO blood group status may be a risk factor for some diseases, including hearing loss. Individuals with blood group O show a higher prevalence of hearing loss after industrial noise exposure. Group O individuals with normal hearing show reduced amplitudes in otoacoustic emission recordings. Whether blood gro...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1858236
更新日期:2021-01-11 00:00:00
abstract:CONCLUSIONS:Subtotal facial nerve decompression seems effective to prevent further episodes of facial palsy and promote facial nerve recovery for recurrent facial palsy in Melkersson Rosenthal syndrome (MRS). The main inflammatory sites of recurrent facial palsy in MRS may be the mastoid segment, tympanic segment, geni...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.863431
更新日期:2014-04-01 00:00:00
abstract::Several studies have reported variations in shape and size of stereociliary bundles and in a limited number of observations have associated them to type I and type II hair cells. A systematic study has been undertaken for which a technique was developed in order to identify both cell types and their corresponding hair...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489209137453
更新日期:1992-01-01 00:00:00
abstract::The effect of adaptation of the ear on the SISI test was studied at 500 Hz and 2000 Hz in 43 patients with chronic otitis and in 20 patients with otosclerosis. The mean adaptation was slightly over 10 dB, except in the otosclerosis group at 2000 Hz, for which the value was nearly 20 dB after continuous stimulation at ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487509121302
更新日期:1975-07-01 00:00:00
abstract::Multimodality therapy of advanced malignant tumours of the head and neck includes surgery, radiotherapy and chemotherapy. However, the cure rate for these tumours is low and guidelines for the selection and timing of therapy are needed. For such guidelines, tumour cell kinetic parameter studies, e.g. cell proliferatio...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309130933
更新日期:1983-01-01 00:00:00
abstract:CONCLUSION:Cochlear implantation (CI) for Japanese single-sided deafness patients resulted in improved speech perception, increased sound localization accuracy, and reduced tinnitus handicap. OBJECTIVES:This study reports results for five adult SSD cases with CI, focusing on the benefits they obtained in terms of spee...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,多中心研究
doi:10.3109/00016489.2015.1116046
更新日期:2016-01-01 00:00:00
abstract:CONCLUSION:The results support that chronic electromagnetic field exposure may cause damage by leading to neuronal degeneration of the auditory system. OBJECTIVES:Numerous researches have been done about the risks of exposure to the electromagnetic fields that occur during the use of these devices, especially the effe...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1032434
更新日期:2015-08-01 00:00:00
abstract::Test-retest variability of values for directional asymmetry in primary and secondary horizontal optokinetic after-nystagmus (OKAN I and OKAN II, respectively) was studied in 16 apparently healthy subjects. OKAN was induced by 60 s of whole-field optokinetic stimulation at speeds of 60 degrees/s and 90 degrees/s in eit...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489209100776
更新日期:1992-01-01 00:00:00
abstract:CONCLUSION:The external neck brace (ENB) is a new concept in the improvement of peristomal fixation of an automatic stoma valve (ASV), which was evaluated with a new imaging method. The addition of the ENB to the Flexiderm (FLD) and Xtrabase (XB) adhesives significantly reduced absolute mean differences between the spe...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480903426600
更新日期:2010-07-01 00:00:00
abstract::In human temporal bone specimens the vibrations of the labyrinthine fluid were measured by a piezoelectric system after application of various techniques of otosclerosis surgery. Compared with the amplitude in the case of a normal stapes, the surgical techniques according to Zangemeister, Shea and Schuknect resulted i...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487509124656
更新日期:1975-01-01 00:00:00
abstract:CONCLUSION:This work demonstrated that juvenile nasopharyngeal angiofibromas (JNAs) express high levels of hormone receptors and vascular endothelial growth factor (VEGF) compared with normal nasal mucosa. The interaction between hormone receptors and VEGF may be involved in the initiation and growth of JNA. OBJECTIVE...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.952774
更新日期:2015-01-01 00:00:00
abstract::In order to examine evidence of high activity of pinocytosis in capillaries of the stria vascularis, quantitative morphometry of pinocytotic vesicles was carried out ultrastructurally by the horseradish peroxidase (HRP) tracer method. In guinea pigs, there was a significant difference between the stria vascularis and ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00
abstract:CONCLUSION:Salivary gland diseases should be handled with a high index of suspicion. Although an inference could be drawn it is not clear from this study if primary head and neck cancers (HNCs) have a significant association with HIV/AIDS. OBJECTIVE:HIV/AIDS manifestations and malignancies do occur in the head and nec...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701230936
更新日期:2007-11-01 00:00:00
abstract::Mononuclear host cells isolated from primary laryngeal carcinoma were assessed by means of indirect immunofluorescence with a panel of monoclonal antibodies against various lymphocyte subsets and macrophages. Tumours of various staging groups were examined in parallel with cells isolated from patient and donor periphe...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809119459
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVES:The aim of this prospective study was to assess the usefulness of nasal smear eosinophilia compared with a skin sensitivity test for the diagnosis of allergic rhinitis and to determine the degree of correlation between the tests. MATERIAL AND METHODS:Fifty patients with a clinical history suggestive of nasa...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310002159
更新日期:2003-12-01 00:00:00
abstract::This paper describes an investigation performed to study the middle ear events ensuing from Staphylococcus aureus induced infection in the middle ear cavity of the rat. To obtain an evaluation at both the cell and the tissue level, scanning electron microscopy, transmission electron microscopy and histology were used....
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409107560
更新日期:1984-09-01 00:00:00
abstract::Glyconjugate expression in formalin-fixed, paraffin-embedded Sjögren's syndrome labial glands (nine cases) was compared with that in normal glands (12 samples) using a wide panel of lectins. Mucous cells expressed mainly mucous-type glycoproteins including sialyl, fucosyl, galactosyl and galactosaminosyl residues, and...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709114217
更新日期:1997-11-01 00:00:00
abstract::Histological measures of cochlear vasculature and blood flow were examined in 20 guinea pigs. Sixteen were exposed to octave band noise at 120 dB SPL for 30 min and then permitted to survive after the exposure for 6 h, 18 h, 48 h, or 4 weeks (N = 4 in each group). Control animals were exposed to the laboratory and app...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488509108582
更新日期:1985-07-01 00:00:00