Expression of glycoconjugates in normal and Sjögren's syndrome labial glands.

Abstract:

:Glyconjugate expression in formalin-fixed, paraffin-embedded Sjögren's syndrome labial glands (nine cases) was compared with that in normal glands (12 samples) using a wide panel of lectins. Mucous cells expressed mainly mucous-type glycoproteins including sialyl, fucosyl, galactosyl and galactosaminosyl residues, and some N-linked glycoconjugates. Demilunar cells expressed mainly alpha D-mannose, GlcNAc and Gal beta 1.3-GalNAc. Duct cells and cellular glycocalyx expressed O-linked and N-linked residues. Sjögren's syndrome samples showed a statistically significant increase in the expression of GlcNAc. A significantly decreased expression of Gal beta 1,3-GalNAc and alpha D-mannose, residues not usually present in mucous cells, was found (p < 0.05). This suggests that anatomic rather than functional alterations determine mucous cell impairment and the symptoms in Sjögren's syndrome.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Sidagis J,Ueno K,Wang ZH,Hanamure Y,Furuta S,Ohyama M

doi

10.3109/00016489709114217

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

871-7

issue

6

eissn

0001-6489

issn

1651-2251

journal_volume

117

pub_type

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