Abstract:
:The effects of transdermally administered scopolamine (TTS-scopolamine) (release rate 5 micrograms/h, one and two patches) and dimenhydrinate (100 mg) on caloric, angular acceleration induced and optokinetic nystagmus were examined in 16 volunteers in a randomized double-blind study. All drugs induced a statistically significant decrease in maximum velocity of caloric nystagmus, as compared with placebo. In the rotatory test, two TTS-scopolamine and dimenhydrinate reduced the vestibular gain significantly. No changes were observed in time constant. In the optokinetic test, all drugs tended to reduce the responses, but a statistically significant reduction was found only after two TTS-scopolamine. The results indicate that the drugs effective against motion sickness reduce the nystagmic response, which at least partly explains the mode of action of the drugs. The target organ of the drugs is presumably the vestibular nucleus, where vestibular and visual impulses are integrated to ensure optimal gain for vestibular orientation reflexes.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Pyykkö I,Schalén L,Matsuoka Idoi
10.3109/00016488509182266subject
Has Abstractpub_date
1985-05-01 00:00:00pages
597-604issue
5-6eissn
0001-6489issn
1651-2251journal_volume
99pub_type
临床试验,杂志文章,随机对照试验abstract::Patients with chronic otitis media (COM) were divided into two groups, one to be given Cephalexin (CEX) orally and the other to be given CEX ear drops locally. The counts of viable bacteria in otorrheal samples collected before and after CEX administration were determined. The incidence of decrease in the count of bac...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488109133264
更新日期:1981-09-01 00:00:00
abstract::Background: Odontogenic sinusitis (OS) is a common but underdiagnosed form of acute rhinosinusitis (ARS). OS carries no specific characteristics, but unilateral symptoms and certain microbiological as well as radiological findings indicate odontogenic origin. Aims/objectives: We studied the proportion of OS in ARS pat...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2019.1634837
更新日期:2019-09-01 00:00:00
abstract:CONCLUSIONS:The present study revealed that miR-21 promotes the proliferation and invasion of cholesteatoma keratinocytes. These results provide a partial explanation for the more aggressive clinical behavior observed in cholesteatoma. OBJECTIVE:This study aims to investigate the post-transcriptional regulatory effect...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1202447
更新日期:2016-12-01 00:00:00
abstract:CONCLUSION:Abnormal caloric and vestibular evoked myogenic potential (VEMP) responses are frequently encountered with a large cerebellopontine angle (CPA) schwannoma, while normal caloric responses and abnormal VEMPs are noted with a large CPA meningioma. This difference may possibly exist because schwannoma causes ves...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480802126553
更新日期:2009-02-01 00:00:00
abstract::A thorough examination of hearing and hearing loss among workers in the saw- and papermill industries in northern Sweden showed that even a serious hearing loss does not give the expected social handicap. ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487609119960
更新日期:1976-03-01 00:00:00
abstract::Test-retest variability of values for directional asymmetry in primary and secondary horizontal optokinetic after-nystagmus (OKAN I and OKAN II, respectively) was studied in 16 apparently healthy subjects. OKAN was induced by 60 s of whole-field optokinetic stimulation at speeds of 60 degrees/s and 90 degrees/s in eit...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489209100776
更新日期:1992-01-01 00:00:00
abstract::In a double-blind crossover trial, 24 patients with perennial rhinitis have been treated with 2% disodium cromoglycate (DSCG) nasal spray. 15 patients preferred DSCG to placebo, 9 patients showed no preference. Analysis of the diary cards showed a significant preference of DSCG in the group which received placebo firs...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016487709123969
更新日期:1977-09-01 00:00:00
abstract::The early diagnosis of the Mondini dysplasia by means of electrocochleography and temporal bone polytomography, and the prevention of further hearing loss through the endolymphatic subarachnoid shunt operation, brought new data on the follow-up of patients with this malformation. They were found to present specific me...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309139454
更新日期:1983-05-01 00:00:00
abstract::In a previous study (1) it was found that in healthy subjects Ocular (Counter) Rotation is mainly due to otolith stimulation and only to a minor extent induced by slanted visual structures. Stimulation of the neck by tilting the trunk laterally upwards did not result in a systematic rotation of the eyes. In the presen...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109138369
更新日期:1991-01-01 00:00:00
abstract::Background: It has been reported that head-up sleep (HUS) prevents free-floating otoliths from entering canals and that vertical recognition training (VRT) promotes vestibular compensation.Aims/objectives: We would like to assess HUS and VRT for intractable motion-evoked dizziness, including possible benign paroxysmal...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1727566
更新日期:2020-06-01 00:00:00
abstract:CONCLUSION:A simple measuring box to determine lip-shift angle and eye-width narrowing offered simultaneous and objective data on outcome dysfunction. The method is as easy as visual approaches. The method is objective and as easy as visual access. It is practical for routine clinical use in any clinic. OBJECTIVES:The...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.626793
更新日期:2012-01-01 00:00:00
abstract::Background: Atoh1, also named Math1, is essential for the development of inner ear hair cells. Many studies have confirmed that the absence of Atoh1 resulted in a total loss of inner ear hair cells, which indicates that Atoh1 plays very similar roles in the development of hair cells in the cochlea and vestibule. Objec...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2018.1497855
更新日期:2018-11-01 00:00:00
abstract:CONCLUSION:Moxifloxacin was generally well tolerated and highly effective in the treatment of acute bacterial rhinosinusitis (ABS). The incidence of adverse events (AEs) and adverse drug reactions (ADRs) was low. The effectiveness, safety, and tolerability information collected in this study confirm the clinical safety...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3109/00016481003629036
更新日期:2010-09-01 00:00:00
abstract:CONCLUSIONS:We describe a Japanese family with high-frequency sensorineural hearing loss (SNHL) harboring a c.211delC mutation in the KCNQ4 gene. Families showing progressive high-frequency SNHL should be investigated for mutations in the KCNQ4 gene. OBJECTIVE:To determine the responsible deafness gene in a Japanese f...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.890740
更新日期:2014-06-01 00:00:00
abstract::We previously reported that long-term exposure to glutamate (Glu) induced death of cochlear outer hair cells (OHCs). However, the mechanisms of OHC death induced by Glu were unclear. In the central nervous system, Glu is known to interfere with a cystine-Glu antiporter, leading to a decrease in cystine uptake and redu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950180612
更新日期:1999-01-01 00:00:00
abstract:CONCLUSIONS:Congenital cytomegalovirus (CMV) infection is a major cause of bilateral and unilateral sensorineural hearing loss (SNHL) in children, accounting for 9.0% of SNHL cases. The diagnostic rate using combined genetic deafness test and CMV DNA detection test was determined to be 46.4% in bilateral profound SNHL....
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.583268
更新日期:2011-09-01 00:00:00
abstract::ESS is a form of minimal access surgery that includes different tasks and manoeuvres requiring sophisticated psychomotor coordination with varying levels of force application. The avoidance of complications is partially dependent upon reducing surgical force application when operating against vital barriers such as th...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480410016568
更新日期:2004-03-01 00:00:00
abstract::The vestibulo-ocular reflexes (VORs) were studied in guinea pigs receiving daily administration of aminoglycoside antibiotics. The vestibular epithelia were also examined by scanning electron microscope technique (SEM). The treatment with aminoglycosides led to varying degrees of VORs according to (i) the type of amin...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488609108622
更新日期:1986-05-01 00:00:00
abstract::Background: Amyloidosis is a benign, slowly progressive disease. However, the treatment of laryngeal amyloidosis (LA) has not been studied systematically.Objectives: To investigate the treatment results of cold micro forceps or carbon dioxide laser under microlaryngoscope in the treatment of LA.Methods: A retrospectiv...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2019.1680864
更新日期:2019-12-01 00:00:00
abstract::In order to study the connection between occupation and sinonasal cancer we have reviewed the files and histological sections of 70 patients (24 females and 46 males) treated at the Department of Oto-rhino-laryngology, National Hospital of Norway. Detailed information concerning previous occupations was obtained by te...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488509119160
更新日期:1985-01-01 00:00:00
abstract:CONCLUSION:Alterations within a novel putative Exon 1a within the gap junction beta 2 (GJB2) gene may play a role in the development of genetic hearing impairment in Austria. OBJECTIVES:Mutations in the GJB2 gene are the most common cause of hereditary sensorineural deafness. Genome-wide screening for alternative tran...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1249946
更新日期:2017-04-01 00:00:00
abstract::Critical bandwidths and absolute intensity thresholds were measured in cats before and after kanamycin treatment which induced selective inner and outer hair cell losses. Hair cell losses were measured from cochleograms constructed from surface preparations of the organ of Corti. Results suggested that, for the test f...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487909137179
更新日期:1979-01-01 00:00:00
abstract::Under constant visual guidance and closed-circuit television monitoring, electrodes are inserted into the fluid spaces of the organ of Corti. The resting electrical potentials are determined with respect to the neutral voltage of the guinea pig and related to other potentials of the auditory labyrinth. The resting pot...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487509124690
更新日期:1975-03-01 00:00:00
abstract::The inner ear responds immunologically to foreign proteins and pathogens introduced into the cochlea. The route of entry of the cells participating in the inner ear inflammatory process is the spiral modiolar vein with its collecting venules. Since this vein is located adjacent to the scala tympani, the end result of ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,评审
doi:10.3109/00016489009107455
更新日期:1990-11-01 00:00:00
abstract:OBJECTIVE:Ischemic vascular damage of the inner ear is one of the known causes of sensorineural sudden hearing loss (SSHL). Folate is an emerging risk factor associated with an increased risk of vascular damage. The aim of this study was to investigate whether low serum folate levels are associated with SSHL. MATERIAL...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480410016216
更新日期:2004-06-01 00:00:00
abstract::It is known that 15-20% of oropharyngeal carcinomas develop distant metastases that involve most commonly lung, liver and bone. Clival metastasis from oropharyngeal squamous cell carcinoma has not been previously reported in the English literature. We describe the rare occurrence of clival metastasis from tonsillar ca...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701687283
更新日期:2008-06-01 00:00:00
abstract:CONCLUSION:The results of this study give support to the theory that opening the middle ear (ME) to the atmosphere leads to a deterioration in its pressure regulation capacity. However, this is probably not the reason why a perforation of the tympanic membrane becomes chronic. OBJECTIVE:Direct, continuous measurement ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480510029374
更新日期:2005-07-01 00:00:00
abstract:CONCLUSION:Changes in the metabolism of arachidonic acid (AA) might be part of a noise-induced compensatory mechanism with regional specificity. OBJECTIVES:The released imbalance of prostaglandins and leukotrienes, both AA metabolites, might result in altered blood flow regulation in the inner ear and probably contrib...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480903168066
更新日期:2010-03-01 00:00:00
abstract::Eighteen patients with intracranial skull base tumours diagnosed at CT or MR as neuromas or meningiomas were studied with positron emission tomography (PET) using L-(methyl-11C) methionine. Compared with normal cerebellar tissue, the uptake of methionine in the tumours increased more rapidly and reached a higher level...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709113425
更新日期:1997-07-01 00:00:00
abstract::A platinum-iridium electrode with a Teflon cover tube was chronically implanted through the round window into the scala tympani of the guinea pig. Animals were sacrificed at 30 to 40 weeks after electrode implantation, and the cochleae were observed by scanning electron microscopy or with light microscopy. The results...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809097005
更新日期:1988-03-01 00:00:00