Transdermally administered scopolamine vs. dimenhydrinate. II. Effect on different types of nystagmus.

Abstract:

:The effects of transdermally administered scopolamine (TTS-scopolamine) (release rate 5 micrograms/h, one and two patches) and dimenhydrinate (100 mg) on caloric, angular acceleration induced and optokinetic nystagmus were examined in 16 volunteers in a randomized double-blind study. All drugs induced a statistically significant decrease in maximum velocity of caloric nystagmus, as compared with placebo. In the rotatory test, two TTS-scopolamine and dimenhydrinate reduced the vestibular gain significantly. No changes were observed in time constant. In the optokinetic test, all drugs tended to reduce the responses, but a statistically significant reduction was found only after two TTS-scopolamine. The results indicate that the drugs effective against motion sickness reduce the nystagmic response, which at least partly explains the mode of action of the drugs. The target organ of the drugs is presumably the vestibular nucleus, where vestibular and visual impulses are integrated to ensure optimal gain for vestibular orientation reflexes.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Pyykkö I,Schalén L,Matsuoka I

doi

10.3109/00016488509182266

subject

Has Abstract

pub_date

1985-05-01 00:00:00

pages

597-604

issue

5-6

eissn

0001-6489

issn

1651-2251

journal_volume

99

pub_type

临床试验,杂志文章,随机对照试验
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    abstract::Patients with chronic otitis media (COM) were divided into two groups, one to be given Cephalexin (CEX) orally and the other to be given CEX ear drops locally. The counts of viable bacteria in otorrheal samples collected before and after CEX administration were determined. The incidence of decrease in the count of bac...

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    pub_type: 杂志文章

    doi:10.3109/00016488109133264

    authors: Sugiyama M,Tanabe K,Chang KC,Nakai Y

    更新日期:1981-09-01 00:00:00

  • Acute rhinosinusitis - are we forgetting the possibility of a dental origin? A retrospective study of 385 patients.

    abstract::Background: Odontogenic sinusitis (OS) is a common but underdiagnosed form of acute rhinosinusitis (ARS). OS carries no specific characteristics, but unilateral symptoms and certain microbiological as well as radiological findings indicate odontogenic origin. Aims/objectives: We studied the proportion of OS in ARS pat...

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    pub_type: 杂志文章

    doi:10.1080/00016489.2019.1634837

    authors: Wuokko-Landén A,Blomgren K,Välimaa H

    更新日期:2019-09-01 00:00:00

  • MicroRNA-21 promotes the proliferation and invasion of cholesteatoma keratinocytes.

    abstract:CONCLUSIONS:The present study revealed that miR-21 promotes the proliferation and invasion of cholesteatoma keratinocytes. These results provide a partial explanation for the more aggressive clinical behavior observed in cholesteatoma. OBJECTIVE:This study aims to investigate the post-transcriptional regulatory effect...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2016.1202447

    authors: Chen X,Li X,Qin Z

    更新日期:2016-12-01 00:00:00

  • Comparison of vestibular function between large cerebellopontine angle meningioma and schwannoma.

    abstract:CONCLUSION:Abnormal caloric and vestibular evoked myogenic potential (VEMP) responses are frequently encountered with a large cerebellopontine angle (CPA) schwannoma, while normal caloric responses and abnormal VEMPs are noted with a large CPA meningioma. This difference may possibly exist because schwannoma causes ves...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480802126553

    authors: Hu YF,Cheng PW,Young YH

    更新日期:2009-02-01 00:00:00

  • Social handicap among workers with noise-induced hearing loss.

    abstract::A thorough examination of hearing and hearing loss among workers in the saw- and papermill industries in northern Sweden showed that even a serious hearing loss does not give the expected social handicap. ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487609119960

    authors: Diamant H

    更新日期:1976-03-01 00:00:00

  • Human optokinetic after-nystagmus: variability in serial test results.

    abstract::Test-retest variability of values for directional asymmetry in primary and secondary horizontal optokinetic after-nystagmus (OKAN I and OKAN II, respectively) was studied in 16 apparently healthy subjects. OKAN was induced by 60 s of whole-field optokinetic stimulation at speeds of 60 degrees/s and 90 degrees/s in eit...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489209100776

    authors: Brantberg K

    更新日期:1992-01-01 00:00:00

  • Disodium cromoglycate nasal spray in the treatment of perennial rhinitis.

    abstract::In a double-blind crossover trial, 24 patients with perennial rhinitis have been treated with 2% disodium cromoglycate (DSCG) nasal spray. 15 patients preferred DSCG to placebo, 9 patients showed no preference. Analysis of the diary cards showed a significant preference of DSCG in the group which received placebo firs...

    journal_title:Acta oto-laryngologica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00016487709123969

    authors: Balle V,Illum P

    更新日期:1977-09-01 00:00:00

  • The Mondini dysplasia--from early diagnosis to cochlear implant.

    abstract::The early diagnosis of the Mondini dysplasia by means of electrocochleography and temporal bone polytomography, and the prevention of further hearing loss through the endolymphatic subarachnoid shunt operation, brought new data on the follow-up of patients with this malformation. They were found to present specific me...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488309139454

    authors: Mangabeira-Albernaz PL

    更新日期:1983-05-01 00:00:00

  • Ocular rotation and perception of the horizontal under static tilt conditions in patients without labyrinthine function.

    abstract::In a previous study (1) it was found that in healthy subjects Ocular (Counter) Rotation is mainly due to otolith stimulation and only to a minor extent induced by slanted visual structures. Stimulation of the neck by tilting the trunk laterally upwards did not result in a systematic rotation of the eyes. In the presen...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489109138369

    authors: Bles W,de Graaf B

    更新日期:1991-01-01 00:00:00

  • Combination of head-up sleep and vertical recognition training may cure intractable motion-evoked dizziness with unknown origin.

    abstract::Background: It has been reported that head-up sleep (HUS) prevents free-floating otoliths from entering canals and that vertical recognition training (VRT) promotes vestibular compensation.Aims/objectives: We would like to assess HUS and VRT for intractable motion-evoked dizziness, including possible benign paroxysmal...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2020.1727566

    authors: Kitahara T,Horinaka A,Shiozaki T,Ito T,Wada Y,Yamanaka T,Nario K

    更新日期:2020-06-01 00:00:00

  • A simple objective evaluation and grading for facial paralysis outcomes.

    abstract:CONCLUSION:A simple measuring box to determine lip-shift angle and eye-width narrowing offered simultaneous and objective data on outcome dysfunction. The method is as easy as visual approaches. The method is objective and as easy as visual access. It is practical for routine clinical use in any clinic. OBJECTIVES:The...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2011.626793

    authors: Saito H

    更新日期:2012-01-01 00:00:00

  • Absence of Atoh1 induced partially different cell fates of cochlear and vestibular sensory epithelial cells in mice.

    abstract::Background: Atoh1, also named Math1, is essential for the development of inner ear hair cells. Many studies have confirmed that the absence of Atoh1 resulted in a total loss of inner ear hair cells, which indicates that Atoh1 plays very similar roles in the development of hair cells in the cochlea and vestibule. Objec...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2018.1497855

    authors: Zhang Y,Tang Q,Xue R,Gao J,Yang H,Gao Z,Lin G

    更新日期:2018-11-01 00:00:00

  • Moxifloxacin in the treatment of acute bacterial rhinosinusitis: results of a multicenter, non-interventional study.

    abstract:CONCLUSION:Moxifloxacin was generally well tolerated and highly effective in the treatment of acute bacterial rhinosinusitis (ABS). The incidence of adverse events (AEs) and adverse drug reactions (ADRs) was low. The effectiveness, safety, and tolerability information collected in this study confirm the clinical safety...

    journal_title:Acta oto-laryngologica

    pub_type: 临床试验,杂志文章,多中心研究

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    更新日期:2010-09-01 00:00:00

  • A Japanese family showing high-frequency hearing loss with KCNQ4 and TECTA mutations.

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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2014.890740

    authors: Ishikawa K,Naito T,Nishio SY,Iwasa Y,Nakamura K,Usami S,Ichimura K

    更新日期:2014-06-01 00:00:00

  • Cystine protects cochlear outer hair cells against glutamate toxicity.

    abstract::We previously reported that long-term exposure to glutamate (Glu) induced death of cochlear outer hair cells (OHCs). However, the mechanisms of OHC death induced by Glu were unclear. In the central nervous system, Glu is known to interfere with a cystine-Glu antiporter, leading to a decrease in cystine uptake and redu...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489950180612

    authors: Sunami K,Yamane H,Takayama M,Nakagawa T,Konishi K,Iguchi H

    更新日期:1999-01-01 00:00:00

  • Clinical profile of hearing loss in children with congenital cytomegalovirus (CMV) infection: CMV DNA diagnosis using preserved umbilical cord.

    abstract:CONCLUSIONS:Congenital cytomegalovirus (CMV) infection is a major cause of bilateral and unilateral sensorineural hearing loss (SNHL) in children, accounting for 9.0% of SNHL cases. The diagnostic rate using combined genetic deafness test and CMV DNA detection test was determined to be 46.4% in bilateral profound SNHL....

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2011.583268

    authors: Furutate S,Iwasaki S,Nishio SY,Moteki H,Usami S

    更新日期:2011-09-01 00:00:00

  • Pilot study of a device for measuring instrument forces during endoscopic sinus surgery.

    abstract::ESS is a form of minimal access surgery that includes different tasks and manoeuvres requiring sophisticated psychomotor coordination with varying levels of force application. The avoidance of complications is partially dependent upon reducing surgical force application when operating against vital barriers such as th...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480410016568

    authors: White PS,Nassif R,Saleh H,Drew T

    更新日期:2004-03-01 00:00:00

  • Vestibulo-ocular reflex (VOR) in guinea pigs. Impairment induced by aminoglycoside antibiotics.

    abstract::The vestibulo-ocular reflexes (VORs) were studied in guinea pigs receiving daily administration of aminoglycoside antibiotics. The vestibular epithelia were also examined by scanning electron microscope technique (SEM). The treatment with aminoglycosides led to varying degrees of VORs according to (i) the type of amin...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488609108622

    authors: Pettorossi VE,Bamonte F,Errico P,Ongini E,Draicchio F,Sabetta F

    更新日期:1986-05-01 00:00:00

  • Curative effect of cold micro forceps and CO2 laser in the treatment of laryngeal amyloidosis.

    abstract::Background: Amyloidosis is a benign, slowly progressive disease. However, the treatment of laryngeal amyloidosis (LA) has not been studied systematically.Objectives: To investigate the treatment results of cold micro forceps or carbon dioxide laser under microlaryngoscope in the treatment of LA.Methods: A retrospectiv...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2019.1680864

    authors: Wu X,Zhang J,Wei C

    更新日期:2019-12-01 00:00:00

  • Sinonasal cancer and exposure to softwood.

    abstract::In order to study the connection between occupation and sinonasal cancer we have reviewed the files and histological sections of 70 patients (24 females and 46 males) treated at the Department of Oto-rhino-laryngology, National Hospital of Norway. Detailed information concerning previous occupations was obtained by te...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488509119160

    authors: Voss R,Stenersen T,Roald Oppedal B,Boysen M

    更新日期:1985-01-01 00:00:00

  • The role of alternative GJB2 transcription in screening for neonatal sensorineural deafness in Austria.

    abstract:CONCLUSION:Alterations within a novel putative Exon 1a within the gap junction beta 2 (GJB2) gene may play a role in the development of genetic hearing impairment in Austria. OBJECTIVES:Mutations in the GJB2 gene are the most common cause of hereditary sensorineural deafness. Genome-wide screening for alternative tran...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2016.1249946

    authors: Parzefall T,Lucas T,Koenighofer M,Ramsebner R,Frohne A,Czeiger S,Baumgartner WD,Schoefer C,Gstoettner W,Frei K

    更新日期:2017-04-01 00:00:00

  • Critical bands following the selective destruction of cochlear inner and outer hair cells.

    abstract::Critical bandwidths and absolute intensity thresholds were measured in cats before and after kanamycin treatment which induced selective inner and outer hair cell losses. Hair cell losses were measured from cochleograms constructed from surface preparations of the organ of Corti. Results suggested that, for the test f...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487909137179

    authors: Nienhuys TG,Clark GM

    更新日期:1979-01-01 00:00:00

  • Resting potentials in the inner sulcus and tunnel of corti.

    abstract::Under constant visual guidance and closed-circuit television monitoring, electrodes are inserted into the fluid spaces of the organ of Corti. The resting electrical potentials are determined with respect to the neutral voltage of the guinea pig and related to other potentials of the auditory labyrinth. The resting pot...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016487509124690

    authors: Lawrence M

    更新日期:1975-03-01 00:00:00

  • Spiral modiolar vein: its importance in inner ear inflammation.

    abstract::The inner ear responds immunologically to foreign proteins and pathogens introduced into the cochlea. The route of entry of the cells participating in the inner ear inflammatory process is the spiral modiolar vein with its collecting venules. Since this vein is located adjacent to the scala tympani, the end result of ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,评审

    doi:10.3109/00016489009107455

    authors: Harris JP,Fukuda S,Keithley EM

    更新日期:1990-11-01 00:00:00

  • Low serum folate levels: a risk factor for sudden sensorineural hearing loss?

    abstract:OBJECTIVE:Ischemic vascular damage of the inner ear is one of the known causes of sensorineural sudden hearing loss (SSHL). Folate is an emerging risk factor associated with an increased risk of vascular damage. The aim of this study was to investigate whether low serum folate levels are associated with SSHL. MATERIAL...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480410016216

    authors: Cadoni G,Agostino S,Scipione S,Galli J

    更新日期:2004-06-01 00:00:00

  • Abducent nerve paralysis: first clinical sign of clivus metastasis from tonsillar carcinoma.

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    pub_type: 杂志文章

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    更新日期:2008-06-01 00:00:00

  • Middle ear pressure equilibration ability and spontaneous pressure changes in healthy ears with ventilation tubes.

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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

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    更新日期:2005-07-01 00:00:00

  • Noise exposure alters cyclooxygenase 1 (COX-1) and 5-lipoxygenase (5-LO) expression in the guinea pig cochlea.

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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489709113425

    authors: Nyberg G,Bergström M,Enblad P,Lilja A,Muhr C,Långström B

    更新日期:1997-07-01 00:00:00

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    abstract::A platinum-iridium electrode with a Teflon cover tube was chronically implanted through the round window into the scala tympani of the guinea pig. Animals were sacrificed at 30 to 40 weeks after electrode implantation, and the cochleae were observed by scanning electron microscopy or with light microscopy. The results...

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    doi:10.3109/00016488809097005

    authors: Gyo K

    更新日期:1988-03-01 00:00:00