Vestibulo-ocular reflex (VOR) in guinea pigs. Impairment induced by aminoglycoside antibiotics.

Abstract:

:The vestibulo-ocular reflexes (VORs) were studied in guinea pigs receiving daily administration of aminoglycoside antibiotics. The vestibular epithelia were also examined by scanning electron microscope technique (SEM). The treatment with aminoglycosides led to varying degrees of VORs according to (i) the type of aminoglycoside drug; (ii) the duration of the treatment and, (iii) the sensitivity of the various vestibular receptors. Gentamicin caused an earlier and severe reduction of the VOR gain. Dibekacin also caused evident damage, but the onset of its action was delayed. Both drugs affected mainly the vertical responses. Tobramycin and netilmicin altered the VORs slightly. Histological examination revealed damage to the sensory epithelia corresponding to the observed VOR impairments.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Pettorossi VE,Bamonte F,Errico P,Ongini E,Draicchio F,Sabetta F

doi

10.3109/00016488609108622

subject

Has Abstract

pub_date

1986-05-01 00:00:00

pages

378-88

issue

5-6

eissn

0001-6489

issn

1651-2251

journal_volume

101

pub_type

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